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PASMD:TOXA

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Species (Taxon ID) Pasteurella multocida. (747)
Gene Name(s) toxA
Protein Name(s) Dermonecrotic toxin

DNT Mitogenic toxin PMT

External Links
UniProt P17452
EMBL X51512
X52478
Z28388
X57775
AF240778
PIR S12998
PDB 2EBF
2EBH
2EC5
PDBsum 2EBF
2EBH
2EC5
ProteinModelPortal P17452
SMR P17452
TCDB 1.C.57.3.1
EvolutionaryTrace P17452
GO GO:0005737
GO:0033644
GO:0016021
GO:0001907
InterPro IPR020972
Pfam PF11647

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0001907

killing by symbiont of host cells

PMID:2680987[1]

ECO:0000314

P

Table 1: PMT and rPMT were injected into guinea pigs to determine the dermonecrotic effects

complete
CACAO 7287

enables

GO:0005543

phospholipid binding

PMID:20534589[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004620

phospholipase activity

PMID:20534589[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:1990216

positive regulation by symbiont of host transcription

PMID:20534589[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0020002

host cell plasma membrane

PMID:20534589[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0001907

killing by symbiont of host cells

PMID:2680987[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009405

pathogenesis

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0090729

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

enables

GO:0090729

toxin activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0800

F

Seeded From UniProt

complete

part_of

GO:0033644

host cell membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1043
UniProtKB-SubCell:SL-0380

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Petersen, SK & Foged, NT (1989) Cloning and expression of the Pasteurella multocida toxin gene, toxA, in Escherichia coli. Infect. Immun. 57 3907-13 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Kamitani, S et al. (2010) Characterization of the membrane-targeting C1 domain in Pasteurella multocida toxin. J. Biol. Chem. 285 25467-75 PubMed GONUTS page