ORYSJ:MEL1

Species (Taxon ID)	Oryza sativa subsp. japonica (Rice). (39947)
Gene Name(s)	MEL1 (synonyms: MEAL1)
Protein Name(s)	Protein argonaute MEL1 Protein MEIOSIS ARRESTED AT LEPTOTENE 1 OsMEL1
External Links
UniProt	Q851R2
EMBL	AB297928 AC104321 DP000009 AP008209 AP014959
RefSeq	XP_015629235.1
UniGene	Os.80058
ProteinModelPortal	Q851R2
STRING	39947.LOC_Os03g58600.1
PaxDb	Q851R2
EnsemblPlants	OS03T0800200-00
GeneID	4334449
Gramene	OS03T0800200-00
KEGG	osa:4334449
eggNOG	KOG1041 ENOG410XP07
HOGENOM	HOG000116043
InParanoid	Q851R2
KO	K11593
OMA	TNPNNIE
OrthoDB	EOG093600M2
Reactome	[www.reactome.org/content/detail/R-OSA-426486 R-OSA-426486] [www.reactome.org/content/detail/R-OSA-426496 R-OSA-426496] [www.reactome.org/content/detail/R-OSA-5578749 R-OSA-5578749]
Proteomes	UP000059680
Genevisible	Q851R2
GO	GO:0005730 GO:0005731 GO:0035197 GO:0007143 GO:0031047 GO:0033169 GO:0007140 GO:0009561 GO:0055046
Gene3D	3.30.420.10
InterPro	IPR014811 IPR032472 IPR032473 IPR032474 IPR003100 IPR003165 IPR012337
Pfam	PF08699 PF16488 PF16487 PF16486 PF02170 PF02171
SMART	SM01163 SM00949 SM00950
SUPFAM	SSF101690 SSF53098
PROSITE	PS50821 PS50822

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:1900111	positive regulation of histone H3-K9 dimethylation	PMID:27521428	ECO:0000315			P		Fig. 3 Part F demonstrates a positive regulation of H3K9 dimethylation in regards to the wildtype MEL1 during pre-leptotene and post-leptotene meiotic phases. The mutant phenotype for MEL1 showed reduced levels of H3K9 dimethylation. The organism is Oryza sativa, and the gene is referred to as mel1 throughout the experiment and by Uniprot.	complete CACAO 12330
	GO:2000616	negative regulation of histone H3-K9 acetylation	PMID:27521428	ECO:0000315			P		Fig. 3 Part L demonstrates a negative regulation of H3-K9 acetylation, where the mel1 mutant showed relatively increased levels of H3-K9 acetylation between pre and post leptotene phases. The organism is Oryza sativa and the gene is referred to as mel1 by Uniprot and the experiment.	complete CACAO 12333
	GO:0061866	negative regulation of histone H3-S10 phosphorylation	PMID:27521428	ECO:0000315			P		Fig. 5 Part A-I demonstrates a negative regulation of H3-S10 phosphorylation, where the mel1 mutant showed relatively increased levels of H3-S10 phosphorylation between pre and post leptotene phases. The organism is Oryza sativa and the gene is referred to as mel1 by Uniprot and the experiment. A new term was requested: "negative regulation of histone H3-S10 phosphorylation" at https://github.com/geneontology/go-ontology/issues/13327	complete CACAO 12490
	GO:1903343	positive regulation of meiotic DNA double-strand break formation	PMID:27521428	ECO:0000315			P		Fig. 1 Part D shows a lack of double stand break formation during the meiotic leptotene state in a mel1 mutant. This is in comparison to the wild type cell in Fig. 1 Part A, and indicates a positive regulation of meiotic DNA double stand break formation. The protein is referred to as mel1 by both UniProt and the journal. The organism is Oryza sativa.	complete CACAO 12509
involved_in	GO:0055046	microgametogenesis	PMID:17675402	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035197	siRNA binding	PMID:17675402	ECO:0000250	sequence similarity evidence used in manual assertion		F		Seeded From UniProt	Missing: with/from
involved_in	GO:0033169	histone H3-K9 demethylation	PMID:17675402	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009561	megagametogenesis	PMID:17675402	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007143	female meiotic nuclear division	PMID:17675402	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007140	male meiotic nuclear division	PMID:17675402	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17675402	ECO:0000245	automatically integrated combinatorial evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17675402	ECO:0000245	automatically integrated combinatorial evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17675402	ECO:0000245	automatically integrated combinatorial evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17675402	ECO:0000245	automatically integrated combinatorial evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005731	nucleolus organizer region	PMID:17675402	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:17675402	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003165 InterPro:IPR036397	F		Seeded From UniProt	complete
involved_in	GO:0051321	meiotic cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0469	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C		Seeded From UniProt	complete
involved_in	GO:0031047	gene silencing by RNA	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0943	P		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0188	C		Seeded From UniProt	complete
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References

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