ONCMY:MCR

Species (Taxon ID)	Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri). (8022)
Gene Name(s)	nr3c2 (synonyms: mlr)
Protein Name(s)	Mineralocorticoid receptor MR Nuclear receptor subfamily 3 group C member 2
External Links
UniProt	Q9IAC6
EMBL	AF209873
SMR	Q9IAC6
SABIO-RK	Q9IAC6
GO	GO:0045177 GO:1990794 GO:0005623 GO:0005737 GO:0005829 GO:0016020 GO:0005634 GO:1903878 GO:1903876 GO:1903879 GO:1903880 GO:1903877 GO:0001046 GO:1903875 GO:1903794 GO:0031963 GO:0098531 GO:0008270 GO:0043433 GO:0010628 GO:1903496 GO:0051414
Gene3D	1.10.565.10 3.30.50.10
InterPro	IPR035500 IPR000536 IPR001723 IPR001628 IPR013088
Pfam	PF00104 PF00105
PRINTS	PR00398
SMART	SM00430 SM00399
SUPFAM	SSF48508
PROSITE	PS51843 PS51030

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:1903880	17alpha-hydroxyprogesterone binding	PMID:10802282^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt
enables	GO:1903879	11beta-hydroxyprogesterone binding	PMID:10802282^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt
enables	GO:1903878	11-deoxycorticosterone binding	PMID:10802282^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt
enables	GO:1903877	21-deoxycortisol binding	PMID:10802282^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt
enables	GO:1903876	11-deoxycortisol binding	PMID:10802282^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt
enables	GO:1903875	corticosterone binding	PMID:10802282^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt
part_of	GO:0005829	cytosol	PMID:10802282^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt
part_of	GO:0016020	membrane	PMID:10802282^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt
enables	GO:1903794	cortisol binding	PMID:10802282^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt
involved_in	GO:0043401	steroid hormone mediated signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003707	P		Seeded From UniProt
involved_in	GO:0043402	glucocorticoid mediated signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0031963	P		Seeded From UniProt
involved_in	GO:0042921	glucocorticoid receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0031963	P		Seeded From UniProt
part_of	GO:0005737	cytoplasm	PMID:18489781^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000216) part_of:(UBERON:0004806)	Seeded From UniProt
part_of	GO:0005634	nucleus	PMID:18489781^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000216) part_of:(UBERON:0004806)	Seeded From UniProt
part_of	GO:0005623	cell	PMID:21343325^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002535)\|part_of:(UBERON:0002113)	Seeded From UniProt
part_of	GO:1990794	basolateral part of cell	PMID:21343325^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000584)	Seeded From UniProt
part_of	GO:0045177	apical part of cell	PMID:21343325^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000584)	Seeded From UniProt
part_of	GO:0005634	nucleus	PMID:26108487^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt
enables	GO:0098531	ligand-activated transcription factor activity	PMID:26108487^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	PMID:26108487^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P49843)\|has_regulation_target:(UniProtKB:Q6RKQ3)	Seeded From UniProt
involved_in	GO:1903496	response to 11-deoxycorticosterone	PMID:26108487^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt
involved_in	GO:0010628	positive regulation of gene expression	PMID:26108487^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt
involved_in	GO:0051414	response to cortisol	PMID:26108487^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt
enables	GO:0031963	cortisol receptor activity	PMID:26108487^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt
enables	GO:0001046	core promoter sequence-specific DNA binding	PMID:26108487^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR013088	F		Seeded From UniProt
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F		Seeded From UniProt
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR001723 InterPro:IPR013088	P		Seeded From UniProt
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR001723	C		Seeded From UniProt
enables	GO:0003707	steroid hormone receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001723	F		Seeded From UniProt
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F		Seeded From UniProt
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001723	F		Seeded From UniProt
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F		Seeded From UniProt
enables	GO:0005496	steroid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0754	F		Seeded From UniProt
enables	GO:1903880	17alpha-hydroxyprogesterone binding	PMID:10802282^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt
enables	GO:1903879	11beta-hydroxyprogesterone binding	PMID:10802282^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt
enables	GO:1903878	11-deoxycorticosterone binding	PMID:10802282^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt
enables	GO:1903877	21-deoxycortisol binding	PMID:10802282^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt
enables	GO:1903876	11-deoxycortisol binding	PMID:10802282^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt
enables	GO:1903875	corticosterone binding	PMID:10802282^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt
part_of	GO:0005829	cytosol	PMID:10802282^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt
part_of	GO:0016020	membrane	PMID:10802282^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt
enables	GO:1903794	cortisol binding	PMID:10802282^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt
involved_in	GO:0043401	steroid hormone mediated signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003707	P		Seeded From UniProt
involved_in	GO:0043402	glucocorticoid mediated signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0031963	P		Seeded From UniProt
involved_in	GO:0042921	glucocorticoid receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0031963	P		Seeded From UniProt
part_of	GO:0005737	cytoplasm	PMID:18489781^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000216) part_of:(UBERON:0004806)	Seeded From UniProt
part_of	GO:0005634	nucleus	PMID:18489781^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000216) part_of:(UBERON:0004806)	Seeded From UniProt
part_of	GO:0005623	cell	PMID:21343325^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002535)\|part_of:(UBERON:0002113)	Seeded From UniProt
part_of	GO:1990794	basolateral part of cell	PMID:21343325^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000584)	Seeded From UniProt
part_of	GO:0045177	apical part of cell	PMID:21343325^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000584)	Seeded From UniProt
part_of	GO:0005634	nucleus	PMID:26108487^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt
enables	GO:0098531	ligand-activated transcription factor activity	PMID:26108487^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	PMID:26108487^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P49843)\|has_regulation_target:(UniProtKB:Q6RKQ3)	Seeded From UniProt
involved_in	GO:1903496	response to 11-deoxycorticosterone	PMID:26108487^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt
involved_in	GO:0010628	positive regulation of gene expression	PMID:26108487^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt
involved_in	GO:0051414	response to cortisol	PMID:26108487^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt
enables	GO:0031963	cortisol receptor activity	PMID:26108487^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt
enables	GO:0001046	core promoter sequence-specific DNA binding	PMID:26108487^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR013088	F		Seeded From UniProt
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F		Seeded From UniProt
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR001723 InterPro:IPR013088	P		Seeded From UniProt
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR001723	C		Seeded From UniProt
enables	GO:0003707	steroid hormone receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001723	F		Seeded From UniProt
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F		Seeded From UniProt
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001723	F		Seeded From UniProt
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F		Seeded From UniProt
part_of	GO:0005737	cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0086	C		Seeded From UniProt
part_of	GO:0005634	nucleus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0191	C		Seeded From UniProt
	GO:0031963	cortisol receptor activity	PMID:15486226^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		FIG. 6. Transactivation properties of rtMRa and rtMRb in response to cortisol (F) and DOC. For experimental details, please see legend of Fig. 5.	complete CACAO 13785
	GO:0031963	cortisol receptor activity	PMID:15486226^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		FIG. 6. Transactivation properties of rtMRa and rtMRb in response to cortisol (F) and DOC. For experimental details, please see legend of Fig. 5.	complete CACAO 13784
enables	GO:0005496	steroid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0754	F		Seeded From UniProt
	GO:0031963	cortisol receptor activity	PMID:10802282^[1]	ECO:0000315	direct assay evidence used in manual assertion		F		Fig. 2. Alignment of the predicted amino acid sequence of rainbow trout mineralocorticoid-like receptor (rtMR) with the corresponding mineralocorticoid receptor (MR) sequences of Xenopus laevis (xMR), Tupaia belangeri (tMR), Rattus norvegicus (rMR), and Homo sapiens (hMR). Uniprot: nr3c2 mlr	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 ^1.17 ^1.18 Colombe, L et al. (2000) A mineralocorticoid-like receptor in the rainbow trout, Oncorhynchus mykiss: cloning and characterization of its steroid binding domain. Steroids 65 319-28 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Milla, S et al. (2008) Plasma 11-deoxycorticosterone (DOC) and mineralocorticoid receptor testicular expression during rainbow trout Oncorhynchus mykiss spermiation: implication with 17alpha, 20beta-dihydroxyprogesterone on the milt fluidity? Reprod. Biol. Endocrinol. 6 19 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Kiilerich, P et al. (2011) Implication of the mineralocorticoid axis in rainbow trout osmoregulation during salinity acclimation. J. Endocrinol. 209 221-35 PubMed GONUTS page
↑ ^4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 ^4.14 ^4.15 Kiilerich, P et al. (2015) Interaction between the trout mineralocorticoid and glucocorticoid receptors in vitro. J. Mol. Endocrinol. 55 55-68 PubMed GONUTS page
↑ ^5.0 ^5.1 Sturm, A et al. (2005) 11-deoxycorticosterone is a potent agonist of the rainbow trout (Oncorhynchus mykiss) mineralocorticoid receptor. Endocrinology 146 47-55 PubMed GONUTS page

[PMID:10802282-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 ^1.17 ^1.18 Colombe, L et al. (2000) A mineralocorticoid-like receptor in the rainbow trout, Oncorhynchus mykiss: cloning and characterization of its steroid binding domain. Steroids 65 319-28 PubMed GONUTS page

[PMID:18489781-2] 2.0 ^2.1 ^2.2 ^2.3 Milla, S et al. (2008) Plasma 11-deoxycorticosterone (DOC) and mineralocorticoid receptor testicular expression during rainbow trout Oncorhynchus mykiss spermiation: implication with 17alpha, 20beta-dihydroxyprogesterone on the milt fluidity? Reprod. Biol. Endocrinol. 6 19 PubMed GONUTS page

[PMID:21343325-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Kiilerich, P et al. (2011) Implication of the mineralocorticoid axis in rainbow trout osmoregulation during salinity acclimation. J. Endocrinol. 209 221-35 PubMed GONUTS page

[PMID:26108487-4] 4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 ^4.14 ^4.15 Kiilerich, P et al. (2015) Interaction between the trout mineralocorticoid and glucocorticoid receptors in vitro. J. Mol. Endocrinol. 55 55-68 PubMed GONUTS page

[PMID:15486226-5] 5.0 ^5.1 Sturm, A et al. (2005) 11-deoxycorticosterone is a potent agonist of the rainbow trout (Oncorhynchus mykiss) mineralocorticoid receptor. Endocrinology 146 47-55 PubMed GONUTS page

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ONCMY:MCR

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