ONCMY:B0M1K7

Species (Taxon ID)	Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri). (8022)
Gene Name(s)	lep (ECO:0000313 with EMBL:BAG09232.1)
Protein Name(s)	Leptin (ECO:0000313 with EMBL:BAG09232.1)
External Links
UniProt	B0M1K7
EMBL	AB354909 FM211190 FR905531
RefSeq	NP_001139362.1
GeneID	100136133
CTD	3952
OrthoDB	1232231at2759
Proteomes	UP000193380
GO	GO:0005623 GO:0005615 GO:0048471 GO:0005179 GO:0051427 GO:0032148 GO:0042755 GO:0010467 GO:0038108 GO:0032929 GO:0014065 GO:0010628 GO:0042327 GO:0043491 GO:0001932 GO:0042594
InterPro	IPR009079 IPR000065
PANTHER	PTHR11724
Pfam	PF02024
SUPFAM	SSF47266

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes
involved_in	GO:0042327	positive regulation of phosphorylation	PMID:26667900^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0000435)\|occurs_in:(UBERON:0002271)\|occurs_in:(UBERON:2000581)	Seeded From UniProt
involved_in	GO:0038108	negative regulation of appetite by leptin-mediated signaling pathway	PMID:26667900^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000065	P		Seeded From UniProt
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000065	C		Seeded From UniProt
involved_in	GO:0010628	positive regulation of gene expression	PMID:26667900^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0001898)	Seeded From UniProt
involved_in	GO:0014065	phosphatidylinositol 3-kinase signaling	PMID:26667900^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0001898)	Seeded From UniProt
involved_in	GO:0032148	activation of protein kinase B activity	PMID:26667900^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0001898)	Seeded From UniProt
involved_in	GO:0043491	protein kinase B signaling	PMID:26667900^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0001898)	Seeded From UniProt
part_of	GO:0005623	cell	PMID:19793092^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0014454)	Seeded From UniProt
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:19793092^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001280) part_of:(UBERON:0004058) part_of:(UBERON:0001283)	Seeded From UniProt
part_of	GO:0005615	extracellular space	PMID:19793092^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt
involved_in	GO:0042594	response to starvation	PMID:19362558^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt
enables	GO:0051427	hormone receptor binding	PMID:24797628^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000182)	Seeded From UniProt
involved_in	GO:0032929	negative regulation of superoxide anion generation	PMID:23932941^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt
involved_in	GO:0001932	regulation of protein phosphorylation	PMID:23932941^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt
part_of	GO:0005615	extracellular space	PMID:19362558^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt
involved_in	GO:0010467	gene expression	PMID:18539064^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt
involved_in	GO:0038108	negative regulation of appetite by leptin-mediated signaling pathway	PMID:18539064^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt
involved_in	GO:0042755	eating behavior	PMID:18539064^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt
enables	GO:0051427	hormone receptor binding	PMID:23645152^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt
enables	GO:0005179	hormone activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000065	F		Seeded From UniProt
involved_in	GO:0042327	positive regulation of phosphorylation	PMID:26667900^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0000435)\|occurs_in:(UBERON:0002271)\|occurs_in:(UBERON:2000581)	Seeded From UniProt
involved_in	GO:0038108	negative regulation of appetite by leptin-mediated signaling pathway	PMID:26667900^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000065	P		Seeded From UniProt
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000065	C		Seeded From UniProt
involved_in	GO:0010628	positive regulation of gene expression	PMID:26667900^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0001898)	Seeded From UniProt
involved_in	GO:0014065	phosphatidylinositol 3-kinase signaling	PMID:26667900^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0001898)	Seeded From UniProt
involved_in	GO:0032148	activation of protein kinase B activity	PMID:26667900^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0001898)	Seeded From UniProt
involved_in	GO:0043491	protein kinase B signaling	PMID:26667900^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0001898)	Seeded From UniProt
part_of	GO:0005623	cell	PMID:19793092^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0014454)	Seeded From UniProt
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:19793092^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001280) part_of:(UBERON:0004058) part_of:(UBERON:0001283)	Seeded From UniProt
part_of	GO:0005615	extracellular space	PMID:19793092^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt
involved_in	GO:0042594	response to starvation	PMID:19362558^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt
enables	GO:0051427	hormone receptor binding	PMID:24797628^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000182)	Seeded From UniProt
involved_in	GO:0032929	negative regulation of superoxide anion generation	PMID:23932941^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt
involved_in	GO:0001932	regulation of protein phosphorylation	PMID:23932941^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt
part_of	GO:0005615	extracellular space	PMID:19362558^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt
involved_in	GO:0010467	gene expression	PMID:18539064^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt
involved_in	GO:0038108	negative regulation of appetite by leptin-mediated signaling pathway	PMID:18539064^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt
involved_in	GO:0042755	eating behavior	PMID:18539064^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt
enables	GO:0051427	hormone receptor binding	PMID:23645152^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt
enables	GO:0005179	hormone activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000065	F		Seeded From UniProt
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 Gong, N et al. (2016) Acute anorexigenic action of leptin in rainbow trout is mediated by the hypothalamic Pi3k pathway. J. Mol. Endocrinol. 56 227-38 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Pfundt, B et al. (2009) Leptin mRNA and protein immunoreactivity in adipose tissue and liver of rainbow trout (Oncorhynchus mykiss) and immunohistochemical localization in liver. Anat Histol Embryol 38 406-10 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Kling, P et al. (2009) A homologous salmonid leptin radioimmunoassay indicates elevated plasma leptin levels during fasting of rainbow trout. Gen. Comp. Endocrinol. 162 307-12 PubMed GONUTS page
↑ ^4.0 ^4.1 Gong, N & Björnsson, BT (2014) Leptin signaling in the rainbow trout central nervous system is modulated by a truncated leptin receptor isoform. Endocrinology 155 2445-55 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Mariano, G et al. (2013) Effects of recombinant trout leptin in superoxide production and NF-κB/MAPK phosphorylation in blood leukocytes. Peptides 48 59-69 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Murashita, K et al. (2008) Production of recombinant leptin and its effects on food intake in rainbow trout (Oncorhynchus mykiss). Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 150 377-84 PubMed GONUTS page
↑ ^7.0 ^7.1 Gong, N et al. (2013) Alternative splice variants of the rainbow trout leptin receptor encode multiple circulating leptin-binding proteins. Endocrinology 154 2331-40 PubMed GONUTS page

[PMID:26667900-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 Gong, N et al. (2016) Acute anorexigenic action of leptin in rainbow trout is mediated by the hypothalamic Pi3k pathway. J. Mol. Endocrinol. 56 227-38 PubMed GONUTS page

[PMID:19793092-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Pfundt, B et al. (2009) Leptin mRNA and protein immunoreactivity in adipose tissue and liver of rainbow trout (Oncorhynchus mykiss) and immunohistochemical localization in liver. Anat Histol Embryol 38 406-10 PubMed GONUTS page

[PMID:19362558-3] 3.0 ^3.1 ^3.2 ^3.3 Kling, P et al. (2009) A homologous salmonid leptin radioimmunoassay indicates elevated plasma leptin levels during fasting of rainbow trout. Gen. Comp. Endocrinol. 162 307-12 PubMed GONUTS page

[PMID:24797628-4] 4.0 ^4.1 Gong, N & Björnsson, BT (2014) Leptin signaling in the rainbow trout central nervous system is modulated by a truncated leptin receptor isoform. Endocrinology 155 2445-55 PubMed GONUTS page

[PMID:23932941-5] 5.0 ^5.1 ^5.2 ^5.3 Mariano, G et al. (2013) Effects of recombinant trout leptin in superoxide production and NF-κB/MAPK phosphorylation in blood leukocytes. Peptides 48 59-69 PubMed GONUTS page

[PMID:18539064-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Murashita, K et al. (2008) Production of recombinant leptin and its effects on food intake in rainbow trout (Oncorhynchus mykiss). Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 150 377-84 PubMed GONUTS page

[PMID:23645152-7] 7.0 ^7.1 Gong, N et al. (2013) Alternative splice variants of the rainbow trout leptin receptor encode multiple circulating leptin-binding proteins. Endocrinology 154 2331-40 PubMed GONUTS page

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ONCMY:B0M1K7

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