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MYCTU:ESXA

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Species (Taxon ID) Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). (83332)
Gene Name(s) esxA (synonyms: esaT6)
Protein Name(s) 6 kDa early secretory antigenic target

ESAT-6

External Links
UniProt P9WNK7
EMBL X79562
AF420491
AY207398
DQ451152
DQ451153
DQ451154
DQ451155
DQ451156
DQ451157
DQ451158
DQ451159
AL123456
AF004671
PIR A70803
RefSeq WP_003399963.1
YP_178023.1
PDB 1WA8
3FAV
PDBsum 1WA8
3FAV
ProteinModelPortal P9WNK7
SMR P9WNK7
DIP DIP-61227N
IntAct P9WNK7
STRING 83332.Rv3875
PaxDb P9WNK7
EnsemblBacteria CCP46704
GeneID 886209
KEGG mtu:Rv3875
TubercuList Rv3875
eggNOG COG4842
KO K14956
OMA FNQNTEG
Proteomes UP000001584
GO GO:0005618
GO:0005737
GO:0005576
GO:0005886
GO:0046812
GO:0042803
GO:0052027
GO:0052083
GO:0009405
GO:0044315
InterPro IPR010310
Pfam PF06013
SUPFAM SSF140453
TIGRFAMs TIGR03930

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0032757

positive regulation of interleukin-8 production

PMID:23867456[1]

ECO:0000314

P

in Figure 1E,H, Introduction of Esat-6 increased Interleukin-8 protein levels.

complete
CACAO 11398

GO:0032689

negative regulation of interferon-gamma production

PMID:19265145[2]

ECO:0000314

P

Figure 4B

complete
CACAO 11402

GO:0050868

negative regulation of T cell activation

PMID:19265145[2]

ECO:0000314

P

Figure 7 shows that the protein down regulates early T cell activation markers

complete
CACAO 11405

GO:0044414

suppression of host defenses

PMID:19265145[2]

ECO:0000314

P

Figure 3, figure 4 (D-F). The protein suppresses important cytokines vital for host defenses.

complete
CACAO 11407

GO:0052085

negative regulation by symbiont of host T-cell mediated immune response

PMID:19265145[2]

ECO:0000314

P

Figure 4 (D-F)

complete
CACAO 11410

enables

GO:0042803

protein homodimerization activity

PMID:16844784[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P9WNK7

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:14532352[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:17443846[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0052083

negative regulation by symbiont of host cell-mediated immune response

PMID:20006311[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0052027

modulation by symbiont of host signal transduction pathway

PMID:20006311[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0046812

host cell surface binding

PMID:15973432[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0044315

protein secretion by the type VII secretion system

PMID:14756778[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009405

pathogenesis

PMID:14756778[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:7729876[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005618

cell wall

PMID:7729876[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0044764

multi-organism cellular process

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0046812

P

Seeded From UniProt

complete

part_of

GO:0005618

cell wall

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0134
UniProtKB-SubCell:SL-0041

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0030430

host cell cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1035
UniProtKB-SubCell:SL-0381

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0033644

host cell membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1043

C

Seeded From UniProt

complete

involved_in

GO:0009405

pathogenesis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0843

P

Seeded From UniProt

complete

part_of

GO:0020002

host cell plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1032
UniProtKB-SubCell:SL-0375

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

part_of

GO:0044165

host cell endoplasmic reticulum

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1038
UniProtKB-SubCell:SL-0388

C

Seeded From UniProt

complete

part_of

GO:0044228

host cell surface

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0378

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Boggaram, V et al. (2013) Early secreted antigenic target of 6 kDa (ESAT-6) protein of Mycobacterium tuberculosis induces interleukin-8 (IL-8) expression in lung epithelial cells via protein kinase signaling and reactive oxygen species. J. Biol. Chem. 288 25500-11 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Wang, X et al. (2009) ESAT-6 inhibits production of IFN-gamma by Mycobacterium tuberculosis-responsive human T cells. J. Immunol. 182 3668-77 PubMed GONUTS page
  3. ↑ Singh, A et al. (2006) Dissecting virulence pathways of Mycobacterium tuberculosis through protein-protein association. Proc. Natl. Acad. Sci. U.S.A. 103 11346-51 PubMed GONUTS page
  4. ↑ Gu, S et al. (2003) Comprehensive proteomic profiling of the membrane constituents of a Mycobacterium tuberculosis strain. Mol. Cell Proteomics 2 1284-96 PubMed GONUTS page
  5. ↑ Målen, H et al. (2007) Comprehensive analysis of exported proteins from Mycobacterium tuberculosis H37Rv. Proteomics 7 1702-18 PubMed GONUTS page
  6. ↑ 6.0 6.1 Samten, B et al. (2009) Mycobacterium tuberculosis ESX-1 system-secreted protein ESAT-6 but not CFP10 inhibits human T-cell immune responses. Tuberculosis (Edinb) 89 Suppl 1 S74-6 PubMed GONUTS page
  7. ↑ Renshaw, PS et al. (2005) Structure and function of the complex formed by the tuberculosis virulence factors CFP-10 and ESAT-6. EMBO J. 24 2491-8 PubMed GONUTS page
  8. ↑ 8.0 8.1 Guinn, KM et al. (2004) Individual RD1-region genes are required for export of ESAT-6/CFP-10 and for virulence of Mycobacterium tuberculosis. Mol. Microbiol. 51 359-70 PubMed GONUTS page
  9. ↑ 9.0 9.1 Sørensen, AL et al. (1995) Purification and characterization of a low-molecular-mass T-cell antigen secreted by Mycobacterium tuberculosis. Infect. Immun. 63 1710-7 PubMed GONUTS page
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