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MYCTU:CYSM
Contents
| Species (Taxon ID) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). (83332) | |
| Gene Name(s) | cysM | |
| Protein Name(s) | O-phosphoserine sulfhydrylase
OPS sulfhydrylase CysO-thiocarboxylate-dependent cysteine synthase Cysteine synthase B CSase B O-phosphoserine-specific cysteine synthase [CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase | |
| External Links | ||
| UniProt | P9WP53 | |
| EMBL | AL123456 | |
| PIR | D70771 | |
| RefSeq | NP_215852.1 YP_006514714.1 | |
| PDB | 3DKI 3DWG 3DWI 3FGP | |
| PDBsum | 3DKI 3DWG 3DWI 3FGP | |
| ProteinModelPortal | P9WP53 | |
| SMR | P9WP53 | |
| GeneID | 13319922 886867 | |
| KEGG | mtu:Rv1336 mtv:RVBD_1336 | |
| TubercuList | Rv1336 | |
| KO | K12339 | |
| OMA | MIQAFGA | |
| PhylomeDB | P9WP53 | |
| Reactome | REACT_27306 | |
| UniPathway | UPA00136 | |
| Proteomes | UP000001584 | |
| GO | GO:0043234 GO:0004124 GO:0033847 GO:0030170 GO:0006535 | |
| InterPro | IPR005856 IPR001216 IPR001926 | |
| Pfam | PF00291 | |
| SUPFAM | SSF53686 | |
| TIGRFAMs | TIGR01136 | |
| PROSITE | PS00901 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0033847 |
O-phosphoserine sulfhydrylase activity |
ECO:0000314 |
F |
Table 3 shows the kinetic parameters of CysM synthase activity |
complete | |||||
|
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0033847 |
O-phosphoserine sulfhydrylase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030170 |
pyridoxal phosphate binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006535 |
cysteine biosynthetic process from serine |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0080146 |
L-cysteine desulfhydrase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10192 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0030170 |
pyridoxal phosphate binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10192 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006535 |
cysteine biosynthetic process from serine |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10192 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000034104 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004124 |
cysteine synthase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10192 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004124 |
cysteine synthase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006535 |
cysteine biosynthetic process from serine |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006535 |
cysteine biosynthetic process from serine |
Reactome:R-MTU-936654 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-MTU-936665 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0019344 |
cysteine biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0198 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008652 |
cellular amino acid biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Agren, D et al. (2008) Cysteine synthase (CysM) of Mycobacterium tuberculosis is an O-phosphoserine sulfhydrylase: evidence for an alternative cysteine biosynthesis pathway in mycobacteria. J. Biol. Chem. 283 31567-74 PubMed GONUTS page
- ↑ Jurgenson, CT et al. (2008) Crystal structure of a sulfur carrier protein complex found in the cysteine biosynthetic pathway of Mycobacterium tuberculosis. Biochemistry 47 10354-64 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
