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MYCTU:ACR

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Species (Taxon ID) Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). (83332)
Gene Name(s) hspX (synonyms: acr)
Protein Name(s) Alpha-crystallin

Acr 14 kDa antigen 16 kDa antigen HSP 16.3 Nox16

External Links
UniProt P9WMK1
EMBL S79751
M76712
AL123456
PIR F70942
RefSeq NP_216547.1
WP_003410189.1
ProteinModelPortal P9WMK1
SMR P9WMK1
IntAct P9WMK1
STRING 83332.Rv2031c
PaxDb P9WMK1
EnsemblBacteria CCP44804
GeneID 887579
KEGG mtu:Rv2031c
TubercuList Rv2031c
eggNOG COG0071
OMA AGYDKGI
PhylomeDB P9WMK1
Proteomes UP000001584
GO GO:0005618
GO:0005829
GO:0005576
GO:0005886
GO:0044183
GO:0071456
GO:0009267
GO:0044121
GO:0045926
GO:0046777
GO:0006457
GO:0009408
GO:0075136
GO:0052572
GO:0001666
GO:0010039
GO:0051409
Gene3D 2.60.40.790
InterPro IPR002068
IPR031107
IPR008978
PANTHER PTHR11527
Pfam PF00011
SUPFAM SSF49764
PROSITE PS01031

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0030308

negative regulation of cell growth

PMID:26835592[1]

ECO:0000315

P

Heat shock protein (hspX) is a molecular chaperone which has been shown to increase latency of infection and slow the growth of Mycobacterium tuberculosis.

complete
CACAO 11356

involved_in

GO:0075136

response to host

PMID:20011113[2]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0052572

response to host immune response

PMID:12953091[3]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:15525680[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:14532352[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:15525680[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005618

cell wall

PMID:20825248[6]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005618

cell wall

PMID:15525680[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0001666

response to hypoxia

PMID:20011113[2]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071456

cellular response to hypoxia

PMID:18434250[7]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051409

response to nitrosative stress

PMID:9864257[8]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046777

protein autophosphorylation

PMID:15256556[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045926

negative regulation of growth

PMID:16428728[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0044183

protein folding chaperone

PMID:10210195[11]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0044183

protein folding chaperone

PMID:8755875[12]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0044183

protein folding chaperone

PMID:8636160[13]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0044121

growth of symbiont in host organelle

PMID:9689123[14]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010039

response to iron ion

PMID:9864233[15]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009408

response to heat

PMID:11952782[16]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009267

cellular response to starvation

PMID:11929527[17]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006457

protein folding

PMID:11952782[16]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:1563797[18]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0001666

response to hypoxia

PMID:12057942[19]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001666

response to hypoxia

PMID:15528667[20]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001666

response to hypoxia

PMID:11416222[21]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001666

response to hypoxia

PMID:8755875[12]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0005618

cell wall

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0134
UniProtKB-SubCell:SL-0041

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Mosavat, A et al. (2016) Fused Mycobacterium tuberculosis multi-stage immunogens with an Fc-delivery system as a promising approach for the development of a tuberculosis vaccine. Infect. Genet. Evol. 39 163-172 PubMed GONUTS page
  2. ↑ 2.0 2.1 Ramage, HR et al. (2009) Comprehensive functional analysis of Mycobacterium tuberculosis toxin-antitoxin systems: implications for pathogenesis, stress responses, and evolution. PLoS Genet. 5 e1000767 PubMed GONUTS page
  3. ↑ Schnappinger, D et al. (2003) Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment. J. Exp. Med. 198 693-704 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Mawuenyega, KG et al. (2005) Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling. Mol. Biol. Cell 16 396-404 PubMed GONUTS page
  5. ↑ Gu, S et al. (2003) Comprehensive proteomic profiling of the membrane constituents of a Mycobacterium tuberculosis strain. Mol. Cell Proteomics 2 1284-96 PubMed GONUTS page
  6. ↑ Wolfe, LM et al. (2010) Proteomic definition of the cell wall of Mycobacterium tuberculosis. J. Proteome Res. 9 5816-26 PubMed GONUTS page
  7. ↑ Saxena, A et al. (2008) Identification of genes of Mycobacterium tuberculosis upregulated during anaerobic persistence by fluorescence and kanamycin resistance selection. Tuberculosis (Edinb) 88 518-25 PubMed GONUTS page
  8. ↑ Garbe, TR et al. (1999) Response to reactive nitrogen intermediates in Mycobacterium tuberculosis: induction of the 16-kilodalton alpha-crystallin homolog by exposure to nitric oxide donors. Infect. Immun. 67 460-5 PubMed GONUTS page
  9. ↑ Preneta, R et al. (2004) Autophosphorylation of the 16 kDa and 70 kDa antigens (Hsp 16.3 and Hsp 70) of Mycobacterium tuberculosis. Microbiology (Reading, Engl.) 150 2135-41 PubMed GONUTS page
  10. ↑ Hu, Y et al. (2006) Deletion of the Mycobacterium tuberculosis alpha-crystallin-like hspX gene causes increased bacterial growth in vivo. Infect. Immun. 74 861-8 PubMed GONUTS page
  11. ↑ Yang, H et al. (1999) The Mycobacterium tuberculosis small heat shock protein Hsp16.3 exposes hydrophobic surfaces at mild conditions: conformational flexibility and molecular chaperone activity. Protein Sci. 8 174-9 PubMed GONUTS page
  12. ↑ 12.0 12.1 Yuan, Y et al. (1996) Stationary phase-associated protein expression in Mycobacterium tuberculosis: function of the mycobacterial alpha-crystallin homolog. J. Bacteriol. 178 4484-92 PubMed GONUTS page
  13. ↑ Chang, Z et al. (1996) Mycobacterium tuberculosis 16-kDa antigen (Hsp16.3) functions as an oligomeric structure in vitro to suppress thermal aggregation. J. Biol. Chem. 271 7218-23 PubMed GONUTS page
  14. ↑ Yuan, Y et al. (1998) The 16-kDa alpha-crystallin (Acr) protein of Mycobacterium tuberculosis is required for growth in macrophages. Proc. Natl. Acad. Sci. U.S.A. 95 9578-83 PubMed GONUTS page
  15. ↑ Wong, DK et al. (1999) Identification of fur, aconitase, and other proteins expressed by Mycobacterium tuberculosis under conditions of low and high concentrations of iron by combined two-dimensional gel electrophoresis and mass spectrometry. Infect. Immun. 67 327-36 PubMed GONUTS page
  16. ↑ 16.0 16.1 Valdez, MM et al. (2002) Functional similarities between the small heat shock proteins Mycobacterium tuberculosis HSP 16.3 and human alphaB-crystallin. Eur. J. Biochem. 269 1806-13 PubMed GONUTS page
  17. ↑ Betts, JC et al. (2002) Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling. Mol. Microbiol. 43 717-31 PubMed GONUTS page
  18. ↑ Lee, BY et al. (1992) Characterization of the major membrane protein of virulent Mycobacterium tuberculosis. Infect. Immun. 60 2066-74 PubMed GONUTS page
  19. ↑ Rosenkrands, I et al. (2002) Hypoxic response of Mycobacterium tuberculosis studied by metabolic labeling and proteome analysis of cellular and extracellular proteins. J. Bacteriol. 184 3485-91 PubMed GONUTS page
  20. ↑ Starck, J et al. (2004) Comparative proteome analysis of Mycobacterium tuberculosis grown under aerobic and anaerobic conditions. Microbiology (Reading, Engl.) 150 3821-9 PubMed GONUTS page
  21. ↑ Sherman, DR et al. (2001) Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding alpha -crystallin. Proc. Natl. Acad. Sci. U.S.A. 98 7534-9 PubMed GONUTS page
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