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MOUSE:ZN521

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Znf521 (synonyms: Evi3, Zfp521)
Protein Name(s) Zinc finger protein 521

Ecotropic viral integration site 3 protein

External Links
UniProt Q6KAS7
EMBL AY147406
AK131130
BC021376
AK077697
AK081096
CCDS CCDS37740.1
RefSeq NP_663467.1
UniGene Mm.40325
ProteinModelPortal Q6KAS7
SMR Q6KAS7
BioGrid 230369
IntAct Q6KAS7
MaxQB Q6KAS7
PRIDE Q6KAS7
Ensembl ENSMUST00000025288
GeneID 225207
KEGG mmu:225207
UCSC uc008edc.1
CTD 225207
MGI MGI:95459
eggNOG COG5048
GeneTree ENSGT00760000118980
HOGENOM HOG000155793
HOVERGEN HBG052773
InParanoid Q6KAS7
OMA PAGEYIC
OrthoDB EOG7NGQB0
PhylomeDB Q6KAS7
TreeFam TF331504
NextBio 377576
PRO PR:Q6KAS7
Proteomes UP000000589
Bgee Q6KAS7
CleanEx MM_ZFP521
Genevestigator Q6KAS7
GO GO:0005634
GO:0003677
GO:0046872
GO:0030154
GO:0007275
GO:0006355
GO:0006351
Gene3D 3.30.160.60
InterPro IPR007087
IPR015880
IPR013087
Pfam PF00096
SMART SM00355
PROSITE PS00028
PS50157

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0045814

negative regulation of gene expression, epigenetic

PMID:19049973[1]

ECO:0000270

P

Figure 1

complete
CACAO 3723

colocalizes_with

GO:0035097

histone methyltransferase complex

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2682313
PANTHER:PTN001228570
UniProtKB:Q9H4Z2

C

Seeded From UniProt

complete

involved_in

GO:0010468

regulation of gene expression

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0032473
MGI:MGI:2682313
PANTHER:PTN001228570
WB:WBGene00003218

P

Seeded From UniProt

complete

colocalizes_with

GO:0005634

nucleus

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104897
MGI:MGI:107690
MGI:MGI:2682313
PANTHER:PTN001228570
UniProtKB:Q13127
UniProtKB:Q7Z3K3
UniProtKB:Q8N8E2
UniProtKB:Q9H4Z2
UniProtKB:Q9Y4E5

C

Seeded From UniProt

complete

enables

GO:0000979

RNA polymerase II core promoter sequence-specific DNA binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104897
PANTHER:PTN001228570

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048663

neuron fate commitment

PMID:25834056[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

results_in_commitment_to:(CL:0000199)

Seeded From UniProt

complete

enables

GO:0019904

protein domain specific binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96K83

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:12393497[4]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96K83

C

Seeded From UniProt

complete

enables

GO:0019904

protein domain specific binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96K83
ensembl:ENSP00000354794

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96K83
ensembl:ENSP00000354794

C

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013087

F

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-MMU-9008136

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Matsubara, E et al. (2009) The role of zinc finger protein 521/early hematopoietic zinc finger protein in erythroid cell differentiation. J. Biol. Chem. 284 3480-7 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. Lou, S et al. (2015) Incoherent feed-forward regulatory loops control segregation of C-mechanoreceptors, nociceptors, and pruriceptors. J. Neurosci. 35 5317-29 PubMed GONUTS page
  4. Warming, S et al. (2003) Evi3, a common retroviral integration site in murine B-cell lymphoma, encodes an EBFAZ-related Krüppel-like zinc finger protein. Blood 101 1934-40 PubMed GONUTS page