GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
MOUSE:ZFP64
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Zfp64 | |
| Protein Name(s) | Zinc finger protein 64
Zfp-64 | |
| External Links | ||
| UniProt | Q99KE8 | |
| EMBL | U49046 AK010444 BC004695 | |
| UniGene | Mm.2095 Mm.482454 | |
| ProteinModelPortal | Q99KE8 | |
| SMR | Q99KE8 | |
| MaxQB | Q99KE8 | |
| PRIDE | Q99KE8 | |
| Ensembl | ENSMUST00000109161 | |
| MGI | MGI:107342 | |
| eggNOG | COG5048 | |
| GeneTree | ENSGT00530000063079 | |
| HOGENOM | HOG000230887 | |
| HOVERGEN | HBG056373 | |
| InParanoid | Q99KE8 | |
| PhylomeDB | Q99KE8 | |
| PRO | PR:Q99KE8 | |
| Proteomes | UP000000589 | |
| Bgee | Q99KE8 | |
| CleanEx | MM_ZFP64 | |
| ExpressionAtlas | Q99KE8 | |
| Genevestigator | Q99KE8 | |
| GO | GO:0005634 GO:0003677 GO:0046872 GO:0007275 GO:0048026 GO:0006355 GO:0006351 | |
| Gene3D | 3.30.160.60 | |
| InterPro | IPR007087 IPR015880 IPR013087 | |
| Pfam | PF00096 | |
| SMART | SM00355 | |
| PROSITE | PS00028 PS50157 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0032760 |
positive regulation of tumor necrosis factor production |
ECO:0000314 |
P |
The overexpression of ZFP64 and stimulated with LPS resulted in increased amounts of Tumor necrosis Factor production alpha as shown in Figure 2 A graph 1 elisa indicating that ZFP64 is a positive regulator of tumor necrosis factor production in RAW264.7 cells. |
complete | |||||
| GO:0032760 |
positive regulation of tumor necrosis factor production |
ECO:0000315 |
P |
In mouse macrophages siRNA was used to decrease ZFP64 production thus resulting in Figure 2B graph 1 showing with stimulation by LPS decreased amounts of Tumor Necrosis Factor Alpha is made thus showing that ZFP64 when present is a positive regulator of tumor necrosis factor alpha production. |
complete | |||||
| GO:0032755 |
positive regulation of interleukin-6 production |
ECO:0000314 |
P |
Elisa after overexpression of ZFP64 in RAW264.7 cells shows in figure 2A graph 2 that interleukin-6 (IL-6) production has been increased from the normal Raw264.7 cells indicating ZFP64 positively regulates interleukin-6 production. |
complete | |||||
| GO:0032755 |
positive regulation of interleukin-6 production |
ECO:0000315 |
P |
Elisa was run after using siRNA to decrease expression of ZFP64 resulting in Figure 2B graph 2 showing decreased expression of Interleukin-6 indicating that ZFP64 positively regulates Interleukin-6 production. |
complete | |||||
| GO:0032728 |
positive regulation of interferon-beta production |
ECO:0000314 |
P |
Figure 2A graph 3 of ELISA shows when ZFP64 is overexpressed, interferon beta production increases thus indicating that ZFP64 positively regulates interferon-beta production inRAW264.7 cells. |
complete | |||||
| GO:0032728 |
positive regulation of interferon-beta production |
ECO:0000315 |
P |
In figure 2B graph 3 elisa when siRNA was insereted to decrease ZFP64 expression shows that interferon-beta production decreases indicating that ZFP64 positively regulates interferon-beta production. |
complete | |||||
|
involved_in |
GO:0032728 |
positive regulation of interferon-beta production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032728 |
positive regulation of interferon-beta production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032755 |
positive regulation of interleukin-6 production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032755 |
positive regulation of interleukin-6 production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032760 |
positive regulation of tumor necrosis factor production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032760 |
positive regulation of tumor necrosis factor production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
colocalizes_with |
GO:0035097 |
histone methyltransferase complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2682313 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010468 |
regulation of gene expression |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0032473 |
P |
Seeded From UniProt |
complete | ||
|
colocalizes_with |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:104897 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000979 |
RNA polymerase II core promoter sequence-specific DNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:104897 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0048026 |
positive regulation of mRNA splicing, via spliceosome |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003676 |
nucleic acid binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 Wang, C et al. (2013) Zinc finger protein 64 promotes Toll-like receptor-triggered proinflammatory and type I interferon production in macrophages by enhancing p65 subunit activation. J. Biol. Chem. 288 24600-8 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Zheng, S et al. (2013) A broadly applicable high-throughput screening strategy identifies new regulators of Dlg4 (Psd-95) alternative splicing. Genome Res. 23 998-1007 PubMed GONUTS page
g
m
p
r
