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MOUSE:YBOX1
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Ybx1 (synonyms: Msy-1, Msy1, Nsep1, Yb1) | |
| Protein Name(s) | Nuclease-sensitive element-binding protein 1
CCAAT-binding transcription factor I subunit A CBF-A DNA-binding protein B DBPB Enhancer factor I subunit A EFI-A Y-box transcription factor Y-box-binding protein 1 YB-1 | |
| External Links | ||
| UniProt | P62960 | |
| EMBL | M60419 M62867 X57621 BC013450 BC013620 BC029747 BC031472 BC061634 | |
| CCDS | CCDS18579.1 | |
| PIR | I58195 | |
| RefSeq | NP_035862.2 | |
| UniGene | Mm.258204 | |
| ProteinModelPortal | P62960 | |
| SMR | P62960 | |
| BioGrid | 204613 | |
| DIP | DIP-34256N | |
| IntAct | P62960 | |
| MINT | MINT-1212991 | |
| PhosphoSite | P62960 | |
| MaxQB | P62960 | |
| PaxDb | P62960 | |
| PRIDE | P62960 | |
| Ensembl | ENSMUST00000079644 | |
| GeneID | 22608 | |
| KEGG | mmu:22608 | |
| UCSC | uc008ulu.1 | |
| CTD | 4904 | |
| MGI | MGI:99146 | |
| eggNOG | COG1278 | |
| HOGENOM | HOG000116439 | |
| HOVERGEN | HBG008757 | |
| InParanoid | P62960 | |
| KO | K09276 | |
| OMA | RRYPPYY | |
| OrthoDB | EOG7TBC44 | |
| PhylomeDB | P62960 | |
| TreeFam | TF317306 | |
| Reactome | REACT_260226 | |
| ChiTaRS | Ybx1 | |
| NextBio | 302963 | |
| PRO | PR:P62960 | |
| Proteomes | UP000000589 | |
| Bgee | P62960 | |
| CleanEx | MM_YBX1 | |
| ExpressionAtlas | P62960 | |
| Genevestigator | P62960 | |
| GO | GO:0070937 GO:0005737 GO:0010494 GO:0070062 GO:0071204 GO:0031965 GO:0005634 GO:0030529 GO:0005689 GO:0044822 GO:0003723 GO:0003697 GO:0070934 GO:0001701 GO:0006397 GO:0051154 GO:0000122 GO:0051781 GO:0006355 GO:0008380 GO:0006351 | |
| Gene3D | 2.40.50.140 | |
| InterPro | IPR019844 IPR011129 IPR002059 IPR012340 | |
| Pfam | PF00313 | |
| PRINTS | PR00050 | |
| SMART | SM00357 | |
| SUPFAM | SSF50249 | |
| PROSITE | PS00352 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0030308 |
negative regulation of cell growth |
ECO:0000314 |
P |
Figure 2 shows "downregulation of YB-1 upon glial differentiation." |
complete | |||||
|
part_of |
GO:0071204 |
histone pre-mRNA 3'end processing complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070934 |
CRD-mediated mRNA stabilization |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:1990904 |
ribonucleoprotein complex |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0010494 |
cytoplasmic stress granule |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:1990904 |
ribonucleoprotein complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:1990124 |
messenger ribonucleoprotein complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:61843 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1903608 |
protein localization to cytoplasmic stress granule |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0098761 |
cellular response to interleukin-7 |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070937 |
CRD-mediated mRNA stability complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0070934 |
CRD-mediated mRNA stabilization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0051154 |
negative regulation of striated muscle cell differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0051020 |
GTPase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:61843 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0046627 |
negative regulation of insulin receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:61843 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:61843 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:61843 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043231 |
intracellular membrane-bounded organelle |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:61843 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:61843 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031965 |
nuclear membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030425 |
dendrite |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:61843 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0010494 |
cytoplasmic stress granule |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:61843 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008134 |
transcription factor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:61843 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:61843 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005689 |
U12-type spliceosomal complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:97168 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:61843 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003729 |
mRNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:61843 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:61843 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003697 |
single-stranded DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003697 |
single-stranded DNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:61843 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003682 |
chromatin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_direct_input:(MGI:MGI:98834) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0002039 |
p53 binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:61843 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0001701 |
in utero embryonic development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:2137670 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0001701 |
in utero embryonic development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3581780 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0001228 |
DNA-binding transcription activator activity, RNA polymerase II-specific |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000978 |
RNA polymerase II proximal promoter sequence-specific DNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:97168 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:61843 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:1990904 |
ribonucleoprotein complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P67809 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1903608 |
protein localization to cytoplasmic stress granule |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P67809 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0070937 |
CRD-mediated mRNA stability complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P67809 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0070934 |
CRD-mediated mRNA stabilization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P67809 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0051020 |
GTPase binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P67809 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P67809 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043231 |
intracellular membrane-bounded organelle |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P67809 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031965 |
nuclear membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P67809 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0010494 |
cytoplasmic stress granule |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P67809 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P67809 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P67809 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P67809 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005689 |
U12-type spliceosomal complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P67809 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P67809 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P67809 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0001228 |
DNA-binding transcription activator activity, RNA polymerase II-specific |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P67809 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000978 |
RNA polymerase II proximal promoter sequence-specific DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P67809 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003676 |
nucleic acid binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008380 |
RNA splicing |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006397 |
mRNA processing |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051781 |
positive regulation of cell division |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Fotovati, A et al. (2011) YB-1 bridges neural stem cells and brain tumor-initiating cells via its roles in differentiation and cell growth. Cancer Res. 71 5569-78 PubMed GONUTS page
- ↑ Yang, XC et al. (2009) Three proteins of the U7-specific Sm ring function as the molecular ruler to determine the site of 3'-end processing in mammalian histone pre-mRNA. Mol. Cell. Biol. 29 4045-56 PubMed GONUTS page
- ↑ Aiello, FB et al. (2018) IL-7-induced phosphorylation of the adaptor Crk-like and other targets. Cell. Signal. 47 131-141 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Song, YJ & Lee, H (2010) YB1/p32, a nuclear Y-box binding protein 1, is a novel regulator of myoblast differentiation that interacts with Msx1 homeoprotein. Exp. Cell Res. 316 517-29 PubMed GONUTS page
- ↑ Subramanian, SV et al. (2004) Induction of vascular smooth muscle alpha-actin gene transcription in transforming growth factor beta1-activated myofibroblasts mediated by dynamic interplay between the Pur repressor proteins and Sp1/Smad coactivators. Mol. Biol. Cell 15 4532-43 PubMed GONUTS page
- ↑ Fantauzzo, KA & Soriano, P (2014) PI3K-mediated PDGFRα signaling regulates survival and proliferation in skeletal development through p53-dependent intracellular pathways. Genes Dev. 28 1005-17 PubMed GONUTS page
- ↑ 7.0 7.1 Lu, ZH et al. (2006) Cold shock domain family members YB-1 and MSY4 share essential functions during murine embryogenesis. Mol. Cell. Biol. 26 8410-7 PubMed GONUTS page
c
d
m
n
- GO:0000122 ! negative regulation of transcription by RNA polymerase II
- GO:0030308 ! negative regulation of cell growth
- GO:0043066 ! negative regulation of apoptotic process
- GO:0051154 ! negative regulation of striated muscle cell differentiation
- GO:0046627 ! negative regulation of insulin receptor signaling pathway
- GO:0043025 ! neuronal cell body
- GO:0031965 ! nuclear membrane
- GO:0003676 ! nucleic acid binding
- GO:0005634 ! nucleus
p
- GO:0002039 ! p53 binding
- GO:0048471 ! perinuclear region of cytoplasm
- GO:0051781 ! positive regulation of cell division
- GO:0008284 ! positive regulation of cell population proliferation
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:1903608 ! protein localization to cytoplasmic stress granule
r
