MOUSE:WDR5

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Wdr5 (synonyms: Big, Big3)
Protein Name(s)	WD repeat-containing protein 5 BMP2-induced 3-kb gene protein WD repeat-containing protein BIG-3
External Links
UniProt	P61965
EMBL	AF416510 AK075937 BC008547 BC016103 BC025801
CCDS	CCDS15829.1
RefSeq	NP_543124.1 XP_006497735.1
UniGene	Mm.28265
PDB	2XL2 2XL3
PDBsum	2XL2 2XL3
ProteinModelPortal	P61965
SMR	P61965
BioGrid	228326
ComplexPortal	CPX-1025 CPX-1029 CPX-875
CORUM	P61965
DIP	DIP-38618N
ELM	P61965
IntAct	P61965
MINT	P61965
STRING	10090.ENSMUSP00000109585
iPTMnet	P61965
PhosphoSitePlus	P61965
EPD	P61965
MaxQB	P61965
PaxDb	P61965
PeptideAtlas	P61965
PRIDE	P61965
Ensembl	ENSMUST00000113952
GeneID	140858
KEGG	mmu:140858
UCSC	uc012bsw.2
CTD	11091
MGI	MGI:2155884
eggNOG	KOG0266 ENOG410XP3K
GeneTree	ENSGT00810000125363
HOGENOM	HOG000091642
HOVERGEN	HBG055117
InParanoid	P61965
KO	K14963
OMA	DNPICSH
OrthoDB	EOG091G0CM2
PhylomeDB	P61965
TreeFam	TF314125
Reactome	R-MMU-3214841 R-MMU-3214847 R-MMU-3214858 R-MMU-8936459 R-MMU-8951664
EvolutionaryTrace	P61965
PRO	PR:P61965
Proteomes	UP000000589
Bgee	ENSMUSG00000026917
CleanEx	MM_WDR5
ExpressionAtlas	P61965
Genevisible	P61965
GO	GO:0005671 GO:0036064 GO:0000123 GO:0035097 GO:0005622 GO:0071339 GO:0044666 GO:0005654 GO:0005634 GO:0048188 GO:0046972 GO:0043995 GO:0043996 GO:0042800 GO:0035064 GO:0060271 GO:0043966 GO:0051568 GO:0043984 GO:0043981 GO:0043982 GO:0031175 GO:0035948 GO:0001501 GO:0006351
Gene3D	2.130.10.10
InterPro	IPR020472 IPR015943 IPR001680 IPR019775 IPR017986 IPR036322 IPR037834
PANTHER	PTHR22847:SF560
Pfam	PF00400
PRINTS	PR00320
SMART	SM00320
SUPFAM	SSF50978
PROSITE	PS00678 PS50082 PS50294

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0071339	MLL1 complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61964	C		Seeded From UniProt	complete
involved_in	GO:0051568	histone H3-K4 methylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61964	P		Seeded From UniProt	complete
part_of	GO:0048188	Set1C/COMPASS complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61964	C		Seeded From UniProt	complete
contributes_to	GO:0046972	histone acetyltransferase activity (H4-K16 specific)	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61964	F		Seeded From UniProt	complete
contributes_to	GO:0043996	histone acetyltransferase activity (H4-K8 specific)	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61964	F		Seeded From UniProt	complete
contributes_to	GO:0043995	histone acetyltransferase activity (H4-K5 specific)	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61964	F		Seeded From UniProt	complete
involved_in	GO:0043984	histone H4-K16 acetylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61964	P		Seeded From UniProt	complete
involved_in	GO:0043982	histone H4-K8 acetylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61964	P		Seeded From UniProt	complete
involved_in	GO:0043981	histone H4-K5 acetylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61964	P		Seeded From UniProt	complete
part_of	GO:0035097	histone methyltransferase complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61964	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15860628^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000123	histone acetyltransferase complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61964	C		Seeded From UniProt	complete
involved_in	GO:0051568	histone H3-K4 methylation	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0040066 MGI:MGI:2155884 PANTHER:PTN001483578 UniProtKB:P61964 WB:WBGene00006474	P		Seeded From UniProt	complete
part_of	GO:0048188	Set1C/COMPASS complex	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0040066 PANTHER:PTN001483578 TAIR:locus:2097435 UniProtKB:P61964	C		Seeded From UniProt	complete
enables	GO:0042393	histone binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001483578 TAIR:locus:2097435 UniProtKB:P61964	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0040066 MGI:MGI:2155884 PANTHER:PTN001483578 RGD:1305159 TAIR:locus:2097435 UniProtKB:P61964 WB:WBGene00006474	C		Seeded From UniProt	complete
part_of	GO:0071339	MLL1 complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61964	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051568	histone H3-K4 methylation	PMID:24051374^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051568	histone H3-K4 methylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61964	P		Seeded From UniProt	complete
part_of	GO:0048188	Set1C/COMPASS complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61964	C		Seeded From UniProt	complete
contributes_to	GO:0046972	histone acetyltransferase activity (H4-K16 specific)	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61964	F		Seeded From UniProt	complete
part_of	GO:0044666	MLL3/4 complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61964	C		Seeded From UniProt	complete
contributes_to	GO:0043996	histone acetyltransferase activity (H4-K8 specific)	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61964	F		Seeded From UniProt	complete
contributes_to	GO:0043995	histone acetyltransferase activity (H4-K5 specific)	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61964	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043984	histone H4-K16 acetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61964	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043982	histone H4-K8 acetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61964	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043981	histone H4-K5 acetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61964	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043966	histone H3 acetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61964	P		Seeded From UniProt	complete
contributes_to	GO:0042800	histone methyltransferase activity (H3-K4 specific)	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61964	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035948	positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter	PMID:24051374^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1343094 MGI:MGI:95674	P	occurs_in:(EMAPA:16846) regulates_o_occurs_in:(EMAPA:16846) has_regulation_target:(MGI:MGI:97501) has_regulation_target:(MGI:MGI:95607)	Seeded From UniProt	complete
part_of	GO:0035097	histone methyltransferase complex	PMID:17500065^[4]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61964	C		Seeded From UniProt	complete
part_of	GO:0035097	histone methyltransferase complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61964	C		Seeded From UniProt	complete
enables	GO:0035064	methylated histone binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61964	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031175	neuron projection development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305159	P		Seeded From UniProt	complete
part_of	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61964	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61964	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22514746^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19103755^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17500065^[4]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61964	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305159	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001501	skeletal system development	PMID:11551928^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0000123	histone acetyltransferase complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61964	C		Seeded From UniProt	complete
part_of	GO:0071339	MLL1 complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61964 ensembl:ENSP00000351446	C		Seeded From UniProt	complete
involved_in	GO:0051568	histone H3-K4 methylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61964 ensembl:ENSP00000351446	P		Seeded From UniProt	complete
part_of	GO:0048188	Set1C/COMPASS complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61964 ensembl:ENSP00000351446	C		Seeded From UniProt	complete
enables	GO:0046972	histone acetyltransferase activity (H4-K16 specific)	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61964 ensembl:ENSP00000351446	F		Seeded From UniProt	complete
part_of	GO:0044666	MLL3/4 complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61964 ensembl:ENSP00000351446	C		Seeded From UniProt	complete
enables	GO:0043996	histone acetyltransferase activity (H4-K8 specific)	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61964 ensembl:ENSP00000351446	F		Seeded From UniProt	complete
enables	GO:0043995	histone acetyltransferase activity (H4-K5 specific)	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61964 ensembl:ENSP00000351446	F		Seeded From UniProt	complete
involved_in	GO:0043984	histone H4-K16 acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61964 ensembl:ENSP00000351446	P		Seeded From UniProt	complete
involved_in	GO:0043982	histone H4-K8 acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61964 ensembl:ENSP00000351446	P		Seeded From UniProt	complete
involved_in	GO:0043981	histone H4-K5 acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61964 ensembl:ENSP00000351446	P		Seeded From UniProt	complete
involved_in	GO:0043966	histone H3 acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61964 ensembl:ENSP00000351446	P		Seeded From UniProt	complete
enables	GO:0042800	histone methyltransferase activity (H3-K4 specific)	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61964 ensembl:ENSP00000351446	F		Seeded From UniProt	complete
part_of	GO:0035097	histone methyltransferase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61964 ensembl:ENSP00000351446	C		Seeded From UniProt	complete
enables	GO:0035064	methylated histone binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61964 ensembl:ENSP00000351446	F		Seeded From UniProt	complete
part_of	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61964 ensembl:ENSP00000351446	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61964 ensembl:ENSP00000351446	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61964 ensembl:ENSP00000351446	C		Seeded From UniProt	complete
part_of	GO:0000123	histone acetyltransferase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61964 ensembl:ENSP00000351446	C		Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q498M4 ensembl:ENSRNOP00000011556	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q498M4 ensembl:ENSRNOP00000011556	C		Seeded From UniProt	complete
part_of	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex	PMID:20508642^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-6810170 Reactome:R-MMU-6810169 Reactome:R-MMU-6810150 Reactome:R-MMU-5693628 Reactome:R-MMU-5621012 Reactome:R-MMU-5621004 Reactome:R-MMU-5619441 Reactome:R-MMU-5619440 Reactome:R-MMU-5619437 Reactome:R-MMU-5619436 Reactome:R-MMU-5619434 Reactome:R-MMU-5619430 Reactome:R-MMU-5619424 Reactome:R-MMU-5619411 Reactome:R-MMU-5617990 Reactome:R-MMU-5617960	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Brown, SA et al. (2005) PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator. Science 308 693-6 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 Ravnskjaer, K et al. (2013) Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects. J. Clin. Invest. 123 4318-28 PubMed GONUTS page
↑ ^4.0 ^4.1 Cho, YW et al. (2007) PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J. Biol. Chem. 282 20395-406 PubMed GONUTS page
↑ Zerlanko, BJ et al. (2012) Premature senescence and increased TGFβ signaling in the absence of Tgif1. PLoS ONE 7 e35460 PubMed GONUTS page
↑ Guelman, S et al. (2009) The double-histone-acetyltransferase complex ATAC is essential for mammalian development. Mol. Cell. Biol. 29 1176-88 PubMed GONUTS page
↑ Gori, F et al. (2001) Cloning and characterization of a novel WD-40 repeat protein that dramatically accelerates osteoblastic differentiation. J. Biol. Chem. 276 46515-22 PubMed GONUTS page
↑ Krebs, AR et al. (2010) ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes. EMBO Rep. 11 541-7 PubMed GONUTS page

[PMID:15860628-1] Brown, SA et al. (2005) PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator. Science 308 693-6 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24051374-3] 3.0 ^3.1 Ravnskjaer, K et al. (2013) Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects. J. Clin. Invest. 123 4318-28 PubMed GONUTS page

[PMID:17500065-4] 4.0 ^4.1 Cho, YW et al. (2007) PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J. Biol. Chem. 282 20395-406 PubMed GONUTS page

[PMID:22514746-5] Zerlanko, BJ et al. (2012) Premature senescence and increased TGFβ signaling in the absence of Tgif1. PLoS ONE 7 e35460 PubMed GONUTS page

[PMID:19103755-6] Guelman, S et al. (2009) The double-histone-acetyltransferase complex ATAC is essential for mammalian development. Mol. Cell. Biol. 29 1176-88 PubMed GONUTS page

[PMID:11551928-7] Gori, F et al. (2001) Cloning and characterization of a novel WD-40 repeat protein that dramatically accelerates osteoblastic differentiation. J. Biol. Chem. 276 46515-22 PubMed GONUTS page

[PMID:20508642-8] Krebs, AR et al. (2010) ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes. EMBO Rep. 11 541-7 PubMed GONUTS page

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MOUSE:WDR5

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Notes

References

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