MOUSE:VTNC

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Vtn
Protein Name(s)	Vitronectin VN S-protein Serum-spreading factor
External Links
UniProt	P29788
EMBL	X72091 M77123 X63003 AF440693 AK011736 AK090325 AL591177 CH466556 BC012690
CCDS	CCDS25106.1
PIR	S19894
RefSeq	NP_035837.1
UniGene	Mm.3667
ProteinModelPortal	P29788
SMR	P29788
IntAct	P29788
MINT	MINT-4121605
STRING	10090.ENSMUSP00000017488
PhosphoSite	P29788
MaxQB	P29788
PaxDb	P29788
PRIDE	P29788
Ensembl	ENSMUST00000017488
GeneID	22370
KEGG	mmu:22370
UCSC	uc007kjk.2
CTD	7448
MGI	MGI:98940
eggNOG	NOG245064
GeneTree	ENSGT00530000063751
HOGENOM	HOG000133161
HOVERGEN	HBG002902
InParanoid	P29788
KO	K06251
OMA	LFWGRSS
OrthoDB	EOG7MH0ZG
PhylomeDB	P29788
TreeFam	TF332780
Reactome	REACT_196606 REACT_196644 REACT_198562 REACT_198998 REACT_216309
ChiTaRS	Vtn
NextBio	302703
PRO	PR:P29788
Proteomes	UP000000589
Bgee	P29788
CleanEx	MM_VTN
Genevestigator	P29788
GO	GO:0072562 GO:0070062 GO:0005578 GO:0050840 GO:0008201 GO:0030247 GO:0005044 GO:0033627 GO:0007160 GO:0030198 GO:0006955 GO:0010951 GO:0010811 GO:0050731 GO:0032092 GO:0048260 GO:0014911 GO:0061302
Gene3D	2.110.10.10
InterPro	IPR000585 IPR018487 IPR018486 IPR020436 IPR001212
Pfam	PF00045 PF01033
PRINTS	PR00022
SMART	SM00120 SM00201
SUPFAM	SSF50923
PROSITE	PS00024 PS51642 PS00524 PS50958

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0048709	oligodendrocyte differentiation	PMID:23155445^[1]	ECO:0000314			P		Figure 7a	complete CACAO 6269
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:28071719^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0000006)	Seeded From UniProt	complete
enables	GO:0005201	extracellular matrix structural constituent	PMID:28071719^[2]	ECO:0007666	automatically integrated combinatorial computational and experimental evidence used in manual assertion		F	occurs_in:(UBERON:0000006)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:22159717^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0002048)\|part_of:(UBERON:0001155)	Seeded From UniProt	complete
enables	GO:0005201	extracellular matrix structural constituent	PMID:22159717^[3]	ECO:0007666	automatically integrated combinatorial computational and experimental evidence used in manual assertion		F	occurs_in:(UBERON:0002048)\|occurs_in:(UBERON:0001155)	Seeded From UniProt	complete
involved_in	GO:0048709	oligodendrocyte differentiation	PMID:23155445^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097421	liver regeneration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3967	P		Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04004	C		Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3967	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061302	smooth muscle cell-matrix adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04004	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051258	protein polymerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3967	P		Seeded From UniProt	complete
enables	GO:0050840	extracellular matrix binding	PMID:18757743^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04004	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048260	positive regulation of receptor-mediated endocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04004	P		Seeded From UniProt	complete
part_of	GO:0048237	rough endoplasmic reticulum lumen	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3967	C		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04004	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3967	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035987	endodermal cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04004	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033627	cell adhesion mediated by integrin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04004	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032092	positive regulation of protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04004	P		Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	PMID:15728191^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030198	extracellular matrix organization	PMID:18757743^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016477	cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04004	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014911	positive regulation of smooth muscle cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04004	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010951	negative regulation of endopeptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04004	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010811	positive regulation of cell-substrate adhesion	PMID:18757743^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008283	cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04004	P		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3967	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007160	cell-matrix adhesion	PMID:15728191^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007160	cell-matrix adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04004	P		Seeded From UniProt	complete
part_of	GO:0005796	Golgi lumen	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3967	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04004	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3967	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04004	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3967	C		Seeded From UniProt	complete
part_of	GO:0005604	basement membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3967	C		Seeded From UniProt	complete
enables	GO:0005518	collagen binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3967	F		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04004	F		Seeded From UniProt	complete
involved_in	GO:0016192	vesicle-mediated transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005044	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D9ZGG2 ensembl:ENSP00000226218	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D9ZGG2 ensembl:ENSP00000226218	C		Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04004 ensembl:ENSP00000226218	C		Seeded From UniProt	complete
involved_in	GO:0061302	smooth muscle cell-matrix adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04004 ensembl:ENSP00000226218	P		Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04004 ensembl:ENSP00000226218	P		Seeded From UniProt	complete
involved_in	GO:0048260	positive regulation of receptor-mediated endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04004 ensembl:ENSP00000226218	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04004 ensembl:ENSP00000226218	C		Seeded From UniProt	complete
involved_in	GO:0035987	endodermal cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04004 ensembl:ENSP00000226218	P		Seeded From UniProt	complete
involved_in	GO:0033627	cell adhesion mediated by integrin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04004 ensembl:ENSP00000226218	P		Seeded From UniProt	complete
involved_in	GO:0032092	positive regulation of protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04004 ensembl:ENSP00000226218	P		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04004 ensembl:ENSP00000226218	P		Seeded From UniProt	complete
involved_in	GO:0014911	positive regulation of smooth muscle cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04004 ensembl:ENSP00000226218	P		Seeded From UniProt	complete
involved_in	GO:0010951	negative regulation of endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04004 ensembl:ENSP00000226218	P		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04004 ensembl:ENSP00000226218	P		Seeded From UniProt	complete
involved_in	GO:0007160	cell-matrix adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04004 ensembl:ENSP00000226218	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04004 ensembl:ENSP00000226218	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04004 ensembl:ENSP00000226218	C		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04004 ensembl:ENSP00000226218	F		Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQ11 ensembl:ENSRNOP00000075508	C		Seeded From UniProt	complete
involved_in	GO:0051258	protein polymerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQ11 ensembl:ENSRNOP00000075508	P		Seeded From UniProt	complete
part_of	GO:0048237	rough endoplasmic reticulum lumen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQ11 ensembl:ENSRNOP00000075508	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQ11 ensembl:ENSRNOP00000075508	F		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQ11 ensembl:ENSRNOP00000075508	F		Seeded From UniProt	complete
part_of	GO:0005796	Golgi lumen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQ11 ensembl:ENSRNOP00000075508	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQ11 ensembl:ENSRNOP00000075508	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQ11 ensembl:ENSRNOP00000075508	C		Seeded From UniProt	complete
part_of	GO:0005604	basement membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQ11 ensembl:ENSRNOP00000075508	C		Seeded From UniProt	complete
enables	GO:0005518	collagen binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQ11 ensembl:ENSRNOP00000075508	F		Seeded From UniProt	complete
involved_in	GO:0097421	liver regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQ11 ensembl:ENSRNOP00000075508	P		Seeded From UniProt	complete
enables	GO:0005044	scavenger receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001212 InterPro:IPR020436 InterPro:IPR036024	F		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001212 InterPro:IPR020436 InterPro:IPR036024	P		Seeded From UniProt	complete
enables	GO:0030247	polysaccharide binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001212 InterPro:IPR020436 InterPro:IPR036024	F		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0358	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0112	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Bouslama-Oueghlani, L et al. (2012) Purkinje cell maturation participates in the control of oligodendrocyte differentiation: role of sonic hedgehog and vitronectin. PLoS ONE 7 e49015 PubMed GONUTS page
↑ ^2.0 ^2.1 Naba, A et al. (2017) Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep 7 40495 PubMed GONUTS page
↑ ^3.0 ^3.1 Naba, A et al. (2012) The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Mol. Cell Proteomics 11 M111.014647 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Manabe, R et al. (2008) Transcriptome-based systematic identification of extracellular matrix proteins. Proc. Natl. Acad. Sci. U.S.A. 105 12849-54 PubMed GONUTS page
↑ ^5.0 ^5.1 Pratt, SJ et al. (2005) The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration. J. Cell Biol. 168 813-24 PubMed GONUTS page

[PMID:23155445-1] 1.0 ^1.1 Bouslama-Oueghlani, L et al. (2012) Purkinje cell maturation participates in the control of oligodendrocyte differentiation: role of sonic hedgehog and vitronectin. PLoS ONE 7 e49015 PubMed GONUTS page

[PMID:28071719-2] 2.0 ^2.1 Naba, A et al. (2017) Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep 7 40495 PubMed GONUTS page

[PMID:22159717-3] 3.0 ^3.1 Naba, A et al. (2012) The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Mol. Cell Proteomics 11 M111.014647 PubMed GONUTS page

[PMID:18757743-4] 4.0 ^4.1 ^4.2 Manabe, R et al. (2008) Transcriptome-based systematic identification of extracellular matrix proteins. Proc. Natl. Acad. Sci. U.S.A. 105 12849-54 PubMed GONUTS page

[PMID:15728191-5] 5.0 ^5.1 Pratt, SJ et al. (2005) The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration. J. Cell Biol. 168 813-24 PubMed GONUTS page

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MOUSE:VTNC

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References

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