GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
MOUSE:UPP1
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Upp1 (synonyms: Up, Upp) | |
| Protein Name(s) | Uridine phosphorylase 1
UPase 1 UrdPase 1 | |
| External Links | ||
| UniProt | P52624 | |
| EMBL | D44464 BC036559 | |
| CCDS | CCDS24432.1 | |
| PIR | A57501 | |
| RefSeq | NP_001152873.1 NP_001152874.1 NP_033503.2 XP_006514730.1 | |
| UniGene | Mm.4610 | |
| ProteinModelPortal | P52624 | |
| SMR | P52624 | |
| IntAct | P52624 | |
| MINT | MINT-4139554 | |
| BindingDB | P52624 | |
| ChEMBL | CHEMBL3718 | |
| PhosphoSite | P52624 | |
| MaxQB | P52624 | |
| PaxDb | P52624 | |
| PRIDE | P52624 | |
| Ensembl | ENSMUST00000020677 ENSMUST00000101525 ENSMUST00000164791 | |
| GeneID | 22271 | |
| KEGG | mmu:22271 | |
| UCSC | uc007hzw.2 | |
| CTD | 7378 | |
| MGI | MGI:1097668 | |
| eggNOG | COG2820 | |
| HOGENOM | HOG000231747 | |
| HOVERGEN | HBG047725 | |
| InParanoid | P52624 | |
| KO | K00757 | |
| OMA | EYLRAAY | |
| OrthoDB | EOG79W961 | |
| PhylomeDB | P52624 | |
| TreeFam | TF314310 | |
| Reactome | REACT_241108 REACT_259385 | |
| UniPathway | UPA00574 | |
| NextBio | 302379 | |
| PRO | PR:P52624 | |
| Proteomes | UP000000589 | |
| Bgee | P52624 | |
| CleanEx | MM_UPP1 | |
| ExpressionAtlas | P52624 | |
| Genevestigator | P52624 | |
| GO | GO:0005737 GO:0004850 GO:0042149 GO:0009166 GO:0006220 GO:0044206 GO:0046108 | |
| Gene3D | 3.40.50.1580 | |
| InterPro | IPR018017 IPR018016 IPR000845 IPR010059 | |
| PANTHER | PTHR21234 | |
| Pfam | PF01048 | |
| SUPFAM | SSF53167 | |
| TIGRFAMs | TIGR01719 | |
| PROSITE | PS01232 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0006218 |
uridine catabolic process |
ECO:0000314 |
P |
As shown in figure 1, a mutant of uridine phosphorylase in the liver with markedly higher enzymatic content led to a significant increase in beta alanine content in the liver compared to the wild type. |
complete | |||||
|
involved_in |
GO:0006218 |
uridine catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0046108 |
uridine metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3586525 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0006220 |
pyrimidine nucleotide metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3586525 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004850 |
uridine phosphorylase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q16831 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q16831 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042149 |
cellular response to glucose starvation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q499V1 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003824 |
catalytic activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004850 |
uridine phosphorylase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009116 |
nucleoside metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009166 |
nucleotide catabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016763 |
transferase activity, transferring pentosyl groups |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004850 |
uridine phosphorylase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016757 |
transferase activity, transferring glycosyl groups |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0044206 |
UMP salvage |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00574 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Le, TT et al. (2013) Disruption of uridine homeostasis links liver pyrimidine metabolism to lipid accumulation. J. Lipid Res. 54 1044-57 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Cao, D et al. (2005) Abnormalities in uridine homeostatic regulation and pyrimidine nucleotide metabolism as a consequence of the deletion of the uridine phosphorylase gene. J. Biol. Chem. 280 21169-75 PubMed GONUTS page
c
n
r
u
