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MOUSE:UCHL5

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Uchl5 (synonyms: Uch37)
Protein Name(s) Ubiquitin carboxyl-terminal hydrolase isozyme L5

UCH-L5 Ubiquitin C-terminal hydrolase UCH37 Ubiquitin thioesterase L5

External Links
UniProt Q9WUP7
EMBL AF148447
AF175903
AK017925
AK011117
AK007860
BC006891
CCDS CCDS15346.1
RefSeq NP_001153338.1
NP_062508.2
UniGene Mm.261004
ProteinModelPortal Q9WUP7
SMR Q9WUP7
BioGrid 207842
IntAct Q9WUP7
MEROPS C12.005
PhosphoSite Q9WUP7
REPRODUCTION-2DPAGE Q9WUP7
MaxQB Q9WUP7
PaxDb Q9WUP7
PRIDE Q9WUP7
Ensembl ENSMUST00000018333
ENSMUST00000189936
GeneID 56207
KEGG mmu:56207
UCSC uc007cxe.2
uc007cxf.2
CTD 51377
MGI MGI:1914848
eggNOG NOG321645
GeneTree ENSGT00510000046560
HOGENOM HOG000203918
HOVERGEN HBG056021
InParanoid Q9WUP7
KO K05610
OMA DEDAFHF
OrthoDB EOG7M3J11
PhylomeDB Q9WUP7
TreeFam TF313976
Reactome REACT_215733
ChiTaRS Uchl5
NextBio 312039
PRO PR:Q9WUP7
Proteomes UP000000589
Bgee Q9WUP7
CleanEx MM_UCHL5
Genevestigator Q9WUP7
GO GO:0005829
GO:0005634
GO:0000502
GO:0008242
GO:0004221
GO:0004843
GO:0006310
GO:0006281
GO:0048853
GO:0021670
GO:0030901
GO:0016579
GO:0006355
GO:0006351
GO:0006511
Gene3D 3.40.532.10
InterPro IPR001578
IPR017390
PANTHER PTHR10589
Pfam PF01088
PIRSF PIRSF038120
PRINTS PR00707

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0030901

midbrain development

21048919

ECO:0000315

P

Disorganized neuronal growth was most evident in the area of the... midbrain, with formation of irregular neuronal rosettes and folds in place of the normal periventricular laminae (Figure 2).

Missing: reference

GO:0048853

forebrain morphogenesis

21048919

ECO:0000315

P

Disorganized neuronal growth was most evident in the area of the forebrain..., with formation of irregular neuronal rosettes and folds in place of the normal periventricular laminae (Figure 2).

Missing: reference

GO:0009790

embryo development

21048919

ECO:0000315

P

Complete deletion of Uch37 resulted in prenatal lethality, since no homozygous neonates were identified among 64 pups produced by 10 litters of Uch37 +/- mice. Timed breeding of Uch37 +/- mice showed that Uch372/2 embryos were underdeveloped and were undergoing resorption from as early as day 8.5.

Missing: reference

GO:0021670

lateral ventricle development

21048919

ECO:0000315

P

The developmental lesions in the brain were characterized by the apparent absence of well defined lateral ventricles,(Figure 2).

Missing: reference

involved_in

GO:0048853

forebrain morphogenesis

PMID:21048919[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030901

midbrain development

PMID:21048919[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0021670

lateral ventricle development

PMID:21048919[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

colocalizes_with

GO:0031011

Ino80 complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9Y5K5

C

Seeded From UniProt

complete

involved_in

GO:0016579

protein deubiquitination

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9Y5K5

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9Y5K5

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9Y5K5

C

Seeded From UniProt

complete

enables

GO:0004843

thiol-dependent ubiquitin-specific protease activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9Y5K5

F

Seeded From UniProt

complete

involved_in

GO:0016579

protein deubiquitination

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0010288
FB:FBgn0011327
MGI:MGI:1355274
PANTHER:PTN000063280
UniProtKB:P09936
UniProtKB:P15374
UniProtKB:Q8IIJ6
UniProtKB:Q8IKM8
UniProtKB:Q92560
UniProtKB:Q9Y5K5

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103149
PANTHER:PTN000063280
TAIR:locus:2171312
UniProtKB:P09936
UniProtKB:Q92560

C

Seeded From UniProt

complete

enables

GO:0004843

thiol-dependent ubiquitin-specific protease activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0010288
FB:FBgn0011327
FB:FBgn0262166
MGI:MGI:103149
PANTHER:PTN000063280
PomBase:SPBC409.06
SGD:S000003860
TAIR:locus:2018516
UniProtKB:P09936
UniProtKB:P15374
UniProtKB:Q92560
UniProtKB:Q9Y5K5

F

Seeded From UniProt

complete

enables

GO:0070628

proteasome binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y5K5

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0061136

regulation of proteasomal protein catabolic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y5K5

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032435

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y5K5

P

Seeded From UniProt

complete

part_of

GO:0031597

cytosolic proteasome complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1305414

C

Seeded From UniProt

complete

part_of

GO:0031011

Ino80 complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y5K5

C

Seeded From UniProt

complete

colocalizes_with

GO:0031011

Ino80 complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y5K5

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0016579

protein deubiquitination

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y5K5

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y5K5

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y5K5

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y5K5

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y5K5

C

Seeded From UniProt

complete

enables

GO:0004866

endopeptidase inhibitor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y5K5

F

Seeded From UniProt

complete

enables

GO:0004843

thiol-dependent ubiquitin-specific protease activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y5K5

F

Seeded From UniProt

complete

involved_in

GO:0010951

negative regulation of endopeptidase activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004866

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5LJA5
ensembl:ENSP00000356421

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5LJA5
ensembl:ENSP00000356421

C

Seeded From UniProt

complete

part_of

GO:0031597

cytosolic proteasome complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A0A0G2K2A5
ensembl:ENSRNOP00000072164

C

Seeded From UniProt

complete

enables

GO:0004843

thiol-dependent ubiquitin-specific protease activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001578
InterPro:IPR017390
InterPro:IPR033837
InterPro:IPR036959

F

Seeded From UniProt

complete

involved_in

GO:0006511

ubiquitin-dependent protein catabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001578
InterPro:IPR036959

P

Seeded From UniProt

complete

involved_in

GO:0016579

protein deubiquitination

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017390
InterPro:IPR033837

P

Seeded From UniProt

complete

part_of

GO:0031011

Ino80 complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033837

C

Seeded From UniProt

complete

enables

GO:0070628

proteasome binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033837

F

Seeded From UniProt

complete

enables

GO:0036459

thiol-dependent ubiquitinyl hydrolase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.4.19.12

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-NUL-2179313
Reactome:R-NUL-2179307

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

enables

GO:0004843

thiol-dependent ubiquitin-specific protease activity

Reactome:R-NUL-2179313

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

enables

GO:0008234

cysteine-type peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0788

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0006310

DNA recombination

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0233

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

part_of

GO:0000502

proteasome complex

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0647

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Al-Shami, A et al. (2010) Regulators of the proteasome pathway, Uch37 and Rpn13, play distinct roles in mouse development. PLoS ONE 5 e13654 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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