MOUSE:UBS3B

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ubash3b (synonyms: Sts1)
Protein Name(s)	Ubiquitin-associated and SH3 domain-containing protein B Cbl-interacting protein p70 Suppressor of T-cell receptor signaling 1 STS-1 T-cell ubiquitin ligand 2 TULA-2 Tyrosine-protein phosphatase STS1/TULA2
External Links
UniProt	Q8BGG7
EMBL	AB075602 AK013361 AK034450 AK035764 AK133948 AK151895 AK152013 AK154576 BC053436
CCDS	CCDS23085.1
RefSeq	NP_789830.1 XP_006510700.1
UniGene	Mm.133615
PDB	2H0Q 2IKQ 3MBK
PDBsum	2H0Q 2IKQ 3MBK
ProteinModelPortal	Q8BGG7
SMR	Q8BGG7
BioGrid	215592
IntAct	Q8BGG7
STRING	10090.ENSMUSP00000043865
PhosphoSite	Q8BGG7
MaxQB	Q8BGG7
PaxDb	Q8BGG7
PRIDE	Q8BGG7
Ensembl	ENSMUST00000044155 ENSMUST00000151485
GeneID	72828
KEGG	mmu:72828
UCSC	uc009pag.1
CTD	84959
MGI	MGI:1920078
eggNOG	NOG276661
GeneTree	ENSGT00390000018249
HOGENOM	HOG000012936
HOVERGEN	HBG018025
InParanoid	Q8BGG7
OMA	DCPITVF
OrthoDB	EOG7P5T0D
PhylomeDB	Q8BGG7
TreeFam	TF313334
ChiTaRS	Ubash3b
EvolutionaryTrace	Q8BGG7
NextBio	337005
PRO	PR:Q8BGG7
Proteomes	UP000000589
Bgee	Q8BGG7
CleanEx	MM_UBASH3B
ExpressionAtlas	Q8BGG7
Genevestigator	Q8BGG7
GO	GO:0005737 GO:0005634 GO:0004725 GO:0090331 GO:0006469 GO:0035335 GO:0051279
Gene3D	3.40.50.1240
InterPro	IPR013078 IPR029033 IPR001452 IPR009060 IPR015940 IPR000449
Pfam	PF00300 PF14604 PF00627
SMART	SM00326 SM00165
SUPFAM	SSF46934 SSF50044 SSF53254
PROSITE	PS50002 PS50030

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0045670	regulation of osteoclast differentiation	PMID:23149425^[1]	ECO:0000315			P		Fig. 2 Absence of TULA proteins results in increased osteoclast numbers in ex vivo cultures.	complete CACAO 6071
	GO:0045670	regulation of osteoclast differentiation	PMID:23149425^[1]	ECO:0000315			P		Fig. 3 Numbers of osteoclast precursors are increased in DKO mice	complete CACAO 6072
involved_in	GO:0045670	regulation of osteoclast differentiation	PMID:23149425^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070527	platelet aggregation	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1920078 PANTHER:PTN000420280	P		Seeded From UniProt	complete
involved_in	GO:0051279	regulation of release of sequestered calcium ion into cytosol	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1920078 PANTHER:PTN000420280	P		Seeded From UniProt	complete
involved_in	GO:0045779	negative regulation of bone resorption	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1920078 PANTHER:PTN000420280	P		Seeded From UniProt	complete
involved_in	GO:0045670	regulation of osteoclast differentiation	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1920078 PANTHER:PTN000420280	P		Seeded From UniProt	complete
involved_in	GO:0038065	collagen-activated signaling pathway	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1920078 PANTHER:PTN000420280	P		Seeded From UniProt	complete
involved_in	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1920078 PANTHER:PTN000420280	P		Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1920078 PANTHER:PTN000420280	P		Seeded From UniProt	complete
enables	GO:0016791	phosphatase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001444215 SGD:S000005052 SGD:S000005636	F		Seeded From UniProt	complete
involved_in	GO:0009968	negative regulation of signal transduction	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1920078 PANTHER:PTN000420260	P		Seeded From UniProt	complete
involved_in	GO:0006469	negative regulation of protein kinase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1920078 PANTHER:PTN000420280	P		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1920078 PANTHER:PTN000420280	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090331	negative regulation of platelet aggregation	PMID:20585042^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070527	platelet aggregation	PMID:27609517^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2670555	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051279	regulation of release of sequestered calcium ion into cytosol	PMID:20585042^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000233)	Seeded From UniProt	complete
enables	GO:0051219	phosphoprotein binding	PMID:27609517^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000233)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045779	negative regulation of bone resorption	PMID:23149425^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045671	negative regulation of osteoclast differentiation	PMID:23149425^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043393	regulation of protein binding	PMID:27609517^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2670555	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8TF42	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0038065	collagen-activated signaling pathway	PMID:27609517^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2670555	P	occurs_in:(CL:0000233)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway	PMID:27609517^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2670555	P	occurs_in:(CL:0000233)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035335	peptidyl-tyrosine dephosphorylation	PMID:20585042^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000233) has_direct_input:(MGI:MGI:99515)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035335	peptidyl-tyrosine dephosphorylation	PMID:27609517^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(PR:000049793)	Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1310357	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030168	platelet activation	PMID:27609517^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2670555	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009968	negative regulation of signal transduction	PMID:23149425^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006469	negative regulation of protein kinase activity	PMID:20585042^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006469	negative regulation of protein kinase activity	PMID:27609517^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(PR:000049793)	Seeded From UniProt	complete
part_of	GO:0005575	cellular_component	GO_REF:0000015	ECO:0000307	no biological data found used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	PMID:23149425^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_input:(MGI:MGI:99515) occurs_in:(CL:0000092)	Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	PMID:27609517^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(PR:000049793)	Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LV21 ensembl:ENSRNOP00000010873	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8TF42 ensembl:ENSP00000284273	F		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.3.48	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0904	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Back, SH et al. (2013) TULA-2, a novel histidine phosphatase, regulates bone remodeling by modulating osteoclast function. Cell. Mol. Life Sci. 70 1269-84 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Thomas, DH et al. (2010) A novel histidine tyrosine phosphatase, TULA-2, associates with Syk and negatively regulates GPVI signaling in platelets. Blood 116 2570-8 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Reppschläger, K et al. (2016) TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk. J. Biol. Chem. 291 22427-22441 PubMed GONUTS page

[PMID:23149425-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Back, SH et al. (2013) TULA-2, a novel histidine phosphatase, regulates bone remodeling by modulating osteoclast function. Cell. Mol. Life Sci. 70 1269-84 PubMed GONUTS page

[PMID:21873635-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20585042-3] 3.0 ^3.1 ^3.2 ^3.3 Thomas, DH et al. (2010) A novel histidine tyrosine phosphatase, TULA-2, associates with Syk and negatively regulates GPVI signaling in platelets. Blood 116 2570-8 PubMed GONUTS page

[PMID:27609517-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Reppschläger, K et al. (2016) TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk. J. Biol. Chem. 291 22427-22441 PubMed GONUTS page

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MOUSE:UBS3B

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References

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