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MOUSE:TYRP1
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Tyrp1 (synonyms: Tyrp-1) | |
| Protein Name(s) | 5,6-dihydroxyindole-2-carboxylic acid oxidase
DHICA oxidase Brown locus protein Catalase B Tyrosinase-related protein 1 TRP TRP-1 TRP1 | |
| External Links | ||
| UniProt | P07147 | |
| EMBL | X03687 BC076598 | |
| CCDS | CCDS18290.1 | |
| PIR | A24933 | |
| RefSeq | NP_001268943.1 NP_001268944.1 NP_112479.1 | |
| UniGene | Mm.30438 | |
| ProteinModelPortal | P07147 | |
| SMR | P07147 | |
| IntAct | P07147 | |
| PhosphoSite | P07147 | |
| MaxQB | P07147 | |
| PRIDE | P07147 | |
| Ensembl | ENSMUST00000006151 ENSMUST00000102831 | |
| GeneID | 22178 | |
| KEGG | mmu:22178 | |
| UCSC | uc008tjq.2 | |
| CTD | 7306 | |
| MGI | MGI:98881 | |
| eggNOG | NOG86242 | |
| HOGENOM | HOG000118376 | |
| HOVERGEN | HBG003553 | |
| InParanoid | P07147 | |
| KO | K00506 | |
| OMA | YYSVKKT | |
| PhylomeDB | P07147 | |
| TreeFam | TF315865 | |
| BioCyc | MetaCyc:MONOMER-15620 | |
| UniPathway | UPA00785 | |
| ChiTaRS | Tyrp1 | |
| NextBio | 302135 | |
| PRO | PR:P07147 | |
| Proteomes | UP000000589 | |
| Bgee | P07147 | |
| CleanEx | MM_TYRP1 | |
| ExpressionAtlas | P07147 | |
| Genevestigator | P07147 | |
| GO | GO:0030669 GO:0010008 GO:0016021 GO:0042470 GO:0033162 GO:0005507 GO:0016716 GO:0046982 GO:0042803 GO:0043438 GO:0006583 GO:0006582 GO:0030318 GO:0032438 GO:0043473 | |
| Gene3D | 1.10.1280.10 | |
| InterPro | IPR015559 IPR002227 IPR008922 | |
| PANTHER | PTHR11474:SF3 | |
| Pfam | PF00264 | |
| PRINTS | PR00092 | |
| SUPFAM | SSF48056 | |
| PROSITE | PS00497 PS00498 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0048023 |
positive regulation of melanin biosynthetic process |
ECO:0000316 |
UniProtKB:Q03288 UniProtKB:Q60696
|
P |
Based on results in Table 2 |
complete | ||||
|
enables |
GO:0004503 |
monophenol monooxygenase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042470 |
melanosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048023 |
positive regulation of melanin biosynthetic process |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046982 |
protein heterodimerization activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042470 |
melanosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0033162 |
melanosome membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043473 |
pigmentation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:98881 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0042470 |
melanosome |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:98881 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032438 |
melanosome organization |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:98881 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030318 |
melanocyte differentiation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:98881 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0097708 |
intracellular vesicle |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0048023 |
positive regulation of melanin biosynthetic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0043473 |
pigmentation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1855962 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0043473 |
pigmentation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1855960 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0043473 |
pigmentation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1855960 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0043438 |
acetoacetic acid metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1855960 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0042470 |
melanosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032438 |
melanosome organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1855960 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030669 |
clathrin-coated endocytic vesicle membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0030318 |
melanocyte differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1855962 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0010008 |
endosome membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006582 |
melanin metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1855960 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004503 |
monophenol monooxygenase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0097708 |
intracellular vesicle |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P17643 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048023 |
positive regulation of melanin biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P17643 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030669 |
clathrin-coated endocytic vesicle membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P17643 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0010008 |
endosome membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P17643 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P17643 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004503 |
monophenol monooxygenase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P17643 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006583 |
melanin biosynthetic process from tyrosine |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042438 |
melanin biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0470 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004497 |
monooxygenase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0033162 |
melanosome membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042470 |
melanosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Hellström, AR et al. (2011) Inactivation of Pmel alters melanosome shape but has only a subtle effect on visible pigmentation. PLoS Genet. 7 e1002285 PubMed GONUTS page
- ↑ Marubashi, S et al. (2016) RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and Regulates Melanogenic Enzyme Trafficking in Melanocytes. J. Biol. Chem. 291 1427-40 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Jiménez-Cervantes, C et al. (1998) Molecular interactions within the melanogenic complex: formation of heterodimers of tyrosinase and TRP1 from B16 mouse melanoma. Biochem. Biophys. Res. Commun. 253 761-7 PubMed GONUTS page
- ↑ Setty, SR et al. (2007) BLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organelles. Mol. Biol. Cell 18 768-80 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 6.0 6.1 Moore, KJ et al. (1990) Interaction of the murine dilute suppressor gene (dsu) with fourteen coat color mutations. Genetics 125 421-30 PubMed GONUTS page
- ↑ Markert, CL & Silvers, WK (1956) The Effects of Genotype and Cell Environment on Melanoblast Differentiation in the House Mouse. Genetics 41 429-50 PubMed GONUTS page
- ↑ COLEMAN, DL (1962) Effect of genic substitution on the incorporation of tyrosine into the melanin of mouse skin. Arch. Biochem. Biophys. 96 562-8 PubMed GONUTS page
- ↑ Ozeki, H et al. (1995) Chemical characterization of hair melanins in various coat-color mutants of mice. J. Invest. Dermatol. 105 361-6 PubMed GONUTS page
- ↑ Ohbayashi, N et al. (2012) Melanoregulin regulates retrograde melanosome transport through interaction with the RILP-p150Glued complex in melanocytes. J. Cell. Sci. 125 1508-18 PubMed GONUTS page
- ↑ 11.0 11.1 Hirobe, T et al. (1998) Effects of genic substitution at the agouti, brown, albino, dilute, and pink-eyed dilution loci on the proliferation and differentiation of mouse epidermal melanocytes in serum-free culture. Eur. J. Cell Biol. 75 184-91 PubMed GONUTS page
g
m
- Mammalia
- GO:0006583 ! melanin biosynthetic process from tyrosine
- GO:0042438 ! melanin biosynthetic process
- GO:0006582 ! melanin metabolic process
- GO:0030318 ! melanocyte differentiation
- GO:0042470 ! melanosome
- GO:0033162 ! melanosome membrane
- GO:0032438 ! melanosome organization
- GO:0016020 ! membrane
- GO:0046872 ! metal ion binding
- Metazoa
- GO:0004497 ! monooxygenase activity
- Muridae
- Murinae
- Muroidea
- Mus
- Mus musculus
p
r
