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MOUSE:TULP3

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Tulp3
Protein Name(s) Tubby-related protein 3

Tubby-like protein 3

External Links
UniProt O88413
EMBL AF045582
AB016963
BC060068
CCDS CCDS39647.1
RefSeq NP_035787.1
UniGene Mm.291783
Mm.439490
ProteinModelPortal O88413
SMR O88413
BioGrid 204384
STRING 10090.ENSMUSP00000001562
PhosphoSite O88413
MaxQB O88413
PRIDE O88413
Ensembl ENSMUST00000001562
GeneID 22158
KEGG mmu:22158
UCSC uc009edh.1
CTD 7289
MGI MGI:1329045
eggNOG NOG286778
GeneTree ENSGT00610000085970
HOGENOM HOG000016044
HOVERGEN HBG018010
InParanoid O88413
OMA AFEDETM
OrthoDB EOG77HDDQ
PhylomeDB O88413
TreeFam TF314076
Reactome REACT_269412
NextBio 302086
PRO PR:O88413
Proteomes UP000000589
Bgee O88413
CleanEx MM_TULP3
Genevestigator O88413
GO GO:0005930
GO:0097546
GO:0005929
GO:0005576
GO:0030991
GO:0005730
GO:0005634
GO:0005886
GO:0072372
GO:0035091
GO:0009952
GO:0060348
GO:0007420
GO:0060434
GO:0021953
GO:0021904
GO:0031076
GO:0042733
GO:0048702
GO:0061548
GO:0060173
GO:0045879
GO:1901621
GO:0021914
GO:0001843
GO:0021915
GO:0001841
GO:0008277
GO:0008589
GO:0060831
Gene3D 3.20.90.10
InterPro IPR000007
IPR025659
IPR018066
IPR005398
Pfam PF01167
PRINTS PR01573
PR01574
SUPFAM SSF54518
PROSITE PS01200
PS01201

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0035085

cilium axoneme

PMID:21209331[1]

ECO:0000314

C

Fig 4A shows Tulp3 at tips of cilia, therefore localises to ciliary tips in WT

complete
CACAO 2881

enables

GO:0120160

intraciliary transport particle A binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O75386

F

Seeded From UniProt

complete

part_of

GO:0005929

cilium

PMID:21209331[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0035091

phosphatidylinositol binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O75386

F

Seeded From UniProt

complete

involved_in

GO:0008277

regulation of G protein-coupled receptor signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O75386

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O75386

C

Seeded From UniProt

complete

involved_in

GO:1903546

protein localization to photoreceptor outer segment

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:109571
MGI:MGI:2651573
PANTHER:PTN000421365

P

Seeded From UniProt

complete

involved_in

GO:0097500

receptor localization to non-motile cilium

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2651573
PANTHER:PTN000421365

P

Seeded From UniProt

complete

involved_in

GO:0061512

protein localization to cilium

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0015721
PANTHER:PTN000421275

P

Seeded From UniProt

complete

enables

GO:0035091

phosphatidylinositol binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000421275
UniProtKB:O75386

F

Seeded From UniProt

complete

part_of

GO:0005929

cilium

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0015721
MGI:MGI:1329045
PANTHER:PTN000421275
UniProtKB:O75386

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1901621

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

PMID:19334287[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2388066

P

occurs_in:(EMAPA:16530)

Seeded From UniProt

complete

enables

GO:0120160

intraciliary transport particle A binding

PMID:28154160[4]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75386

F

Seeded From UniProt

complete

enables

GO:0120160

intraciliary transport particle A binding

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75386

F

Seeded From UniProt

complete

part_of

GO:0097731

9+0 non-motile cilium

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75386

C

Seeded From UniProt

complete

part_of

GO:0097546

ciliary base

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75386

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0061548

ganglion development

PMID:11406614[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2388066

P

occurs_in:(EMAPA:16668)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0061512

protein localization to cilium

PMID:28154160[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_input:(GO:0002133)|has_input:(MGI:MGI:99578)|has_input:(MGI:MGI:2685054)|has_input:(MGI:MGI:2155808)|has_input:(MGI:MGI:1099818)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0061512

protein localization to cilium

PMID:28154160[4]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75386

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060831

smoothened signaling pathway involved in dorsal/ventral neural tube patterning

PMID:19223390[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3664273

P

occurs_in:(EMAPA:16530)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060434

bronchus morphogenesis

PMID:19286674[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2388066

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060348

bone development

PMID:11406614[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2388066

P

occurs_in:(EMAPA:17214)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060173

limb development

PMID:19223390[6]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:98297

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060173

limb development

PMID:19223390[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3664273

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048702

embryonic neurocranium morphogenesis

PMID:19286674[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2388066

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045879

negative regulation of smoothened signaling pathway

PMID:19334287[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2388066

P

occurs_in:(EMAPA:31858)|occurs_in:(EMAPA:16406)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045879

negative regulation of smoothened signaling pathway

PMID:19223390[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3664273

P

regulates_o_occurs_in:(EMAPA:16530)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045879

negative regulation of smoothened signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75386

P

Seeded From UniProt

complete

enables

GO:0044877

protein-containing complex binding

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75386

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042733

embryonic digit morphogenesis

PMID:19334287[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2388066

P

occurs_in:(EMAPA:32725)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042733

embryonic digit morphogenesis

PMID:19286674[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2388066

P

Seeded From UniProt

complete

enables

GO:0035091

phosphatidylinositol binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75386

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031076

embryonic camera-type eye development

PMID:19286674[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2388066

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021953

central nervous system neuron differentiation

PMID:19286674[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2388066

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021915

neural tube development

PMID:19286674[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2388066

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021914

negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning

PMID:19286674[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2388066

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021904

dorsal/ventral neural tube patterning

PMID:19286674[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2388066

P

Seeded From UniProt

complete

enables

GO:0019899

enzyme binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75386

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009952

anterior/posterior pattern specification

PMID:19334287[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2388066

P

occurs_in:(EMAPA:16405)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008589

regulation of smoothened signaling pathway

PMID:19286674[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2388066

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008277

regulation of G protein-coupled receptor signaling pathway

PMID:28154160[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008277

regulation of G protein-coupled receptor signaling pathway

PMID:28154160[4]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75386

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008277

regulation of G protein-coupled receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75386

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007420

brain development

PMID:19286674[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2388066

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007420

brain development

PMID:11406614[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2388066

P

occurs_in:(EMAPA:16471)

Seeded From UniProt

complete

part_of

GO:0005930

axoneme

PMID:19286674[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005929

cilium

PMID:19286674[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005929

cilium

PMID:28154160[4]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75386

C

Seeded From UniProt

complete

part_of

GO:0005929

cilium

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75386

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:28154160[4]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75386

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75386

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75386

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75386

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001843

neural tube closure

PMID:19223390[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3664273

P

has_participant:(EMAPA:16530)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001841

neural tube formation

PMID:11406614[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2388066

P

occurs_in:(EMAPA:16530)

Seeded From UniProt

complete

enables

GO:0001664

G protein-coupled receptor binding

PMID:28154160[4]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75386

F

Seeded From UniProt

complete

enables

GO:0120160

intraciliary transport particle A binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O75386
ensembl:ENSP00000380321

F

Seeded From UniProt

complete

part_of

GO:0097731

9+0 non-motile cilium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O75386
ensembl:ENSP00000380321

C

Seeded From UniProt

complete

part_of

GO:0097546

ciliary base

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O75386
ensembl:ENSP00000380321

C

Seeded From UniProt

complete

involved_in

GO:0061512

protein localization to cilium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O75386
ensembl:ENSP00000380321

P

Seeded From UniProt

complete

involved_in

GO:0045879

negative regulation of smoothened signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O75386
ensembl:ENSP00000380321

P

Seeded From UniProt

complete

enables

GO:0044877

protein-containing complex binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O75386
ensembl:ENSP00000380321

F

Seeded From UniProt

complete

enables

GO:0035091

phosphatidylinositol binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O75386
ensembl:ENSP00000380321

F

Seeded From UniProt

complete

enables

GO:0019899

enzyme binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O75386
ensembl:ENSP00000380321

F

Seeded From UniProt

complete

involved_in

GO:0008277

regulation of G protein-coupled receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O75386
ensembl:ENSP00000380321

P

Seeded From UniProt

complete

part_of

GO:0005929

cilium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O75386
ensembl:ENSP00000380321

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O75386
ensembl:ENSP00000380321

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O75386
ensembl:ENSP00000380321

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O75386
ensembl:ENSP00000380321

C

Seeded From UniProt

complete

enables

GO:0001664

G protein-coupled receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O75386
ensembl:ENSP00000380321

F

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0005929

cilium

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0969
UniProtKB-SubCell:SL-0066

C

Seeded From UniProt

complete

part_of

GO:0042995

cell projection

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0966

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Qin, J et al. (2011) Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components. Proc. Natl. Acad. Sci. U.S.A. 108 1456-61 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Cameron, DA et al. (2009) Tulp3 is a critical repressor of mouse hedgehog signaling. Dev. Dyn. 238 1140-9 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 Badgandi, HB et al. (2017) Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins. J. Cell Biol. 216 743-760 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 Ikeda, A et al. (2001) Neural tube defects and neuroepithelial cell death in Tulp3 knockout mice. Hum. Mol. Genet. 10 1325-34 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 Patterson, VL et al. (2009) Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway. Hum. Mol. Genet. 18 1719-39 PubMed GONUTS page
  7. 7.00 7.01 7.02 7.03 7.04 7.05 7.06 7.07 7.08 7.09 7.10 7.11 Norman, RX et al. (2009) Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling. Hum. Mol. Genet. 18 1740-54 PubMed GONUTS page