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MOUSE:TULP3
Contents
Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
Gene Name(s) | Tulp3 | |
Protein Name(s) | Tubby-related protein 3
Tubby-like protein 3 | |
External Links | ||
UniProt | O88413 | |
EMBL | AF045582 AB016963 BC060068 | |
CCDS | CCDS39647.1 | |
RefSeq | NP_035787.1 | |
UniGene | Mm.291783 Mm.439490 | |
ProteinModelPortal | O88413 | |
SMR | O88413 | |
BioGrid | 204384 | |
STRING | 10090.ENSMUSP00000001562 | |
PhosphoSite | O88413 | |
MaxQB | O88413 | |
PRIDE | O88413 | |
Ensembl | ENSMUST00000001562 | |
GeneID | 22158 | |
KEGG | mmu:22158 | |
UCSC | uc009edh.1 | |
CTD | 7289 | |
MGI | MGI:1329045 | |
eggNOG | NOG286778 | |
GeneTree | ENSGT00610000085970 | |
HOGENOM | HOG000016044 | |
HOVERGEN | HBG018010 | |
InParanoid | O88413 | |
OMA | AFEDETM | |
OrthoDB | EOG77HDDQ | |
PhylomeDB | O88413 | |
TreeFam | TF314076 | |
Reactome | REACT_269412 | |
NextBio | 302086 | |
PRO | PR:O88413 | |
Proteomes | UP000000589 | |
Bgee | O88413 | |
CleanEx | MM_TULP3 | |
Genevestigator | O88413 | |
GO | GO:0005930 GO:0097546 GO:0005929 GO:0005576 GO:0030991 GO:0005730 GO:0005634 GO:0005886 GO:0072372 GO:0035091 GO:0009952 GO:0060348 GO:0007420 GO:0060434 GO:0021953 GO:0021904 GO:0031076 GO:0042733 GO:0048702 GO:0061548 GO:0060173 GO:0045879 GO:1901621 GO:0021914 GO:0001843 GO:0021915 GO:0001841 GO:0008277 GO:0008589 GO:0060831 | |
Gene3D | 3.20.90.10 | |
InterPro | IPR000007 IPR025659 IPR018066 IPR005398 | |
Pfam | PF01167 | |
PRINTS | PR01573 PR01574 | |
SUPFAM | SSF54518 | |
PROSITE | PS01200 PS01201 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0035085 |
cilium axoneme |
ECO:0000314 |
C |
Fig 4A shows Tulp3 at tips of cilia, therefore localises to ciliary tips in WT |
complete | |||||
enables |
GO:0120160 |
intraciliary transport particle A binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005929 |
cilium |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0035091 |
phosphatidylinositol binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008277 |
regulation of G protein-coupled receptor signaling pathway |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:1903546 |
protein localization to photoreceptor outer segment |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:109571 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0097500 |
receptor localization to non-motile cilium |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2651573 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0061512 |
protein localization to cilium |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0015721 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0035091 |
phosphatidylinositol binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000421275 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0005929 |
cilium |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0015721 |
C |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:1901621 |
negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2388066 |
P |
occurs_in:(EMAPA:16530) |
Seeded From UniProt |
complete | |
enables |
GO:0120160 |
intraciliary transport particle A binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0120160 |
intraciliary transport particle A binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0097731 |
9+0 non-motile cilium |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0097546 |
ciliary base |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0061548 |
ganglion development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2388066 |
P |
occurs_in:(EMAPA:16668) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0061512 |
protein localization to cilium |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_input:(GO:0002133)|has_input:(MGI:MGI:99578)|has_input:(MGI:MGI:2685054)|has_input:(MGI:MGI:2155808)|has_input:(MGI:MGI:1099818) |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0061512 |
protein localization to cilium |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0060831 |
smoothened signaling pathway involved in dorsal/ventral neural tube patterning |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3664273 |
P |
occurs_in:(EMAPA:16530) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0060434 |
bronchus morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2388066 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0060348 |
bone development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2388066 |
P |
occurs_in:(EMAPA:17214) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0060173 |
limb development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:98297 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0060173 |
limb development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3664273 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0048702 |
embryonic neurocranium morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2388066 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0045879 |
negative regulation of smoothened signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2388066 |
P |
occurs_in:(EMAPA:31858)|occurs_in:(EMAPA:16406) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0045879 |
negative regulation of smoothened signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3664273 |
P |
regulates_o_occurs_in:(EMAPA:16530) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0045879 |
negative regulation of smoothened signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0044877 |
protein-containing complex binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0042733 |
embryonic digit morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2388066 |
P |
occurs_in:(EMAPA:32725) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0042733 |
embryonic digit morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2388066 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0035091 |
phosphatidylinositol binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0031076 |
embryonic camera-type eye development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2388066 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0021953 |
central nervous system neuron differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2388066 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0021915 |
neural tube development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2388066 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0021914 |
negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2388066 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0021904 |
dorsal/ventral neural tube patterning |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2388066 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0019899 |
enzyme binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0009952 |
anterior/posterior pattern specification |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2388066 |
P |
occurs_in:(EMAPA:16405) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0008589 |
regulation of smoothened signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2388066 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0008277 |
regulation of G protein-coupled receptor signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0008277 |
regulation of G protein-coupled receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0008277 |
regulation of G protein-coupled receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0007420 |
brain development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2388066 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0007420 |
brain development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2388066 |
P |
occurs_in:(EMAPA:16471) |
Seeded From UniProt |
complete | |
part_of |
GO:0005930 |
axoneme |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005929 |
cilium |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005929 |
cilium |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005929 |
cilium |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005730 |
nucleolus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0001843 |
neural tube closure |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3664273 |
P |
has_participant:(EMAPA:16530) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0001841 |
neural tube formation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2388066 |
P |
occurs_in:(EMAPA:16530) |
Seeded From UniProt |
complete | |
enables |
GO:0001664 |
G protein-coupled receptor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0120160 |
intraciliary transport particle A binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O75386 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0097731 |
9+0 non-motile cilium |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O75386 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0097546 |
ciliary base |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O75386 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0061512 |
protein localization to cilium |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O75386 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045879 |
negative regulation of smoothened signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O75386 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0044877 |
protein-containing complex binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O75386 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0035091 |
phosphatidylinositol binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O75386 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0019899 |
enzyme binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O75386 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0008277 |
regulation of G protein-coupled receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O75386 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005929 |
cilium |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O75386 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O75386 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005730 |
nucleolus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O75386 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O75386 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0001664 |
G protein-coupled receptor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O75386 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005929 |
cilium |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0042995 |
cell projection |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Qin, J et al. (2011) Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components. Proc. Natl. Acad. Sci. U.S.A. 108 1456-61 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Cameron, DA et al. (2009) Tulp3 is a critical repressor of mouse hedgehog signaling. Dev. Dyn. 238 1140-9 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 Badgandi, HB et al. (2017) Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins. J. Cell Biol. 216 743-760 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Ikeda, A et al. (2001) Neural tube defects and neuroepithelial cell death in Tulp3 knockout mice. Hum. Mol. Genet. 10 1325-34 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 Patterson, VL et al. (2009) Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway. Hum. Mol. Genet. 18 1719-39 PubMed GONUTS page
- ↑ 7.00 7.01 7.02 7.03 7.04 7.05 7.06 7.07 7.08 7.09 7.10 7.11 Norman, RX et al. (2009) Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling. Hum. Mol. Genet. 18 1740-54 PubMed GONUTS page
c
e
m
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- GO:0021914 ! negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning
- GO:0045879 ! negative regulation of smoothened signaling pathway
- GO:1901621 ! negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
- GO:0001841 ! neural tube formation
- GO:0001843 ! neural tube closure
- GO:0021915 ! neural tube development
- GO:0005730 ! nucleolus
- GO:0005634 ! nucleus
p
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