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MOUSE:TS1R2

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Tas1r2 (synonyms: Gpr71, T1r2, Tr2)
Protein Name(s) Taste receptor type 1 member 2

G-protein coupled receptor 71 Sweet taste receptor T1R2

External Links
UniProt Q925I4
EMBL AF337041
AY032623
AL831790
CCDS CCDS18849.1
RefSeq NP_114079.1
UniGene Mm.190612
ProteinModelPortal Q925I4
SMR Q925I4
IntAct Q925I4
STRING 10090.ENSMUSP00000030510
PhosphoSitePlus Q925I4
PaxDb Q925I4
PRIDE Q925I4
Ensembl ENSMUST00000030510
GeneID 83770
KEGG mmu:83770
UCSC uc008vmr.1
CTD 80834
MGI MGI:1933546
eggNOG KOG1056
ENOG410XR6W
GeneTree ENSGT00940000156136
HOGENOM HOG000038047
HOVERGEN HBG108601
InParanoid Q925I4
KO K04625
OMA CCFECID
OrthoDB 136715at2759
PhylomeDB Q925I4
TreeFam TF331269
Reactome R-MMU-418594
R-MMU-420499
ChiTaRS Tas1r2
PRO PR:Q925I4
Proteomes UP000000589
Bgee ENSMUSG00000028738
ExpressionAtlas Q925I4
Genevisible Q925I4
GO GO:0005887
GO:0043235
GO:1903767
GO:0004930
GO:0038023
GO:0033041
GO:0008527
GO:0001582
GO:0032467
GO:0050916
Gene3D 2.10.50.30
InterPro IPR001828
IPR000337
IPR011500
IPR038550
IPR017978
IPR000068
IPR017979
IPR028082
PANTHER PTHR24061
Pfam PF00003
PF01094
PF07562
PRINTS PR00248
SUPFAM SSF53822
PROSITE PS00980
PS50259

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

Contributes to

GO:0033041

sweet taste receptor activity

PMID:11509186[1]

ECO:0001565

cell-based assay evidence

F

Dose responses (normalized to responses observed from the highest concentration per compound) were observed for the sweet compounds GA-2, saccharin, acesulfame-K, and sucrose in the receptor combination T1R2+3 (Fig 6b), matching the biological thresholds observed in vivo (Fig 6a). Dose responses were not observed for bitter or umami compounds (Fig 6b)

complete
CACAO 13558

GO:0033041

sweet taste receptor activity

PMID:11509186[1]

ECO:0001249

fluorescence evidence used in manual assertion

F

To demonstrate specificity of the sweet taste receptor, the pathway of G-protein coupled receptors linked to the receptor was modified to increase intracellular calcium which was observed using the fluorescent FURA-2 calcium indicator dye. An increase in cellular calcium was observed (normalized to responses observed from the highest concentration per compound) in the sweet compounds GA-2, saccharin, acesulfame-K, and sucrose in the receptor combination T1R2+3 (Fig 6b), matching the biological thresholds observed in vivo (Fig 6a). Dose responses were not observed for bitter or umami compounds (Fig 6b). As intracellular calcium was not shown to increase upon exposure to any compound other than sugar and artificial sweeteners, the function of T1Rs as a sweet taste receptors is maintained.

complete
CACAO 13619

part_of

GO:1903767

sweet taste receptor complex

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001528071
UniProtKB:Q8TE23

C

Seeded From UniProt

complete

involved_in

GO:0050916

sensory perception of sweet taste

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1933546
PANTHER:PTN001528071
RGD:61894
UniProtKB:Q8TE23

P

Seeded From UniProt

complete

enables

GO:0038023

signaling receptor activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002373557
ZFIN:ZDB-GENE-050419-65

F

Seeded From UniProt

complete

contributes_to

GO:0033041

sweet taste receptor activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001528071
UniProtKB:Q8TE23

F

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002373557
UniProtKB:P41180

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2429498
PANTHER:PTN002373557
UniProtKB:P41180

F

Seeded From UniProt

complete

part_of

GO:1903767

sweet taste receptor complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8TE23

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050916

sensory perception of sweet taste

PMID:20943918[3]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:2385070

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050916

sensory perception of sweet taste

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8TE23

P

Seeded From UniProt

complete

part_of

GO:0043235

receptor complex

PMID:23382219[4]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8TE23

C

Seeded From UniProt

complete

contributes_to

GO:0033041

sweet taste receptor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8TE23

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032467

positive regulation of cytokinesis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8TE23

P

Seeded From UniProt

complete

enables

GO:0008527

taste receptor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8TE23

F

Seeded From UniProt

complete

contributes_to

GO:0008527

taste receptor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8TE23

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001582

detection of chemical stimulus involved in sensory perception of sweet taste

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8TE23

P

Seeded From UniProt

complete

part_of

GO:1903767

sweet taste receptor complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8TE23
ensembl:ENSP00000364520

C

Seeded From UniProt

complete

involved_in

GO:0050916

sensory perception of sweet taste

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8TE23
ensembl:ENSP00000364520

P

Seeded From UniProt

complete

part_of

GO:0043235

receptor complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8TE23
ensembl:ENSP00000364520

C

Seeded From UniProt

complete

enables

GO:0033041

sweet taste receptor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8TE23
ensembl:ENSP00000364520

F

Seeded From UniProt

complete

involved_in

GO:0032467

positive regulation of cytokinesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8TE23
ensembl:ENSP00000364520

P

Seeded From UniProt

complete

enables

GO:0008527

taste receptor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8TE23
ensembl:ENSP00000364520

F

Seeded From UniProt

complete

involved_in

GO:0001582

detection of chemical stimulus involved in sensory perception of sweet taste

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8TE23
ensembl:ENSP00000364520

P

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000068
InterPro:IPR000337
InterPro:IPR011500
InterPro:IPR017978
InterPro:IPR017979

F

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000068
InterPro:IPR000337
InterPro:IPR011500
InterPro:IPR017978
InterPro:IPR017979

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000068
InterPro:IPR000337
InterPro:IPR017978
InterPro:IPR017979

C

Seeded From UniProt

complete

involved_in

GO:0050896

response to stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0716

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0050909

sensory perception of taste

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0919

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0807

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

P

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Nelson, G et al. (2001) Mammalian sweet taste receptors. Cell 106 381-90 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ Ilegems, E et al. (2010) REEP2 enhances sweet receptor function by recruitment to lipid rafts. J. Neurosci. 30 13774-83 PubMed GONUTS page
  4. ↑ Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page
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