MOUSE:TRPV4

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Trpv4 (synonyms: Trp12, Vrl2, Vroac)
Protein Name(s)	Transient receptor potential cation channel subfamily V member 4 TrpV4 Osm-9-like TRP channel 4 OTRPC4 Transient receptor potential protein 12 TRP12 Vanilloid receptor-like channel 2 Vanilloid receptor-like protein 2 Vanilloid receptor-related osmotically-activated channel VR-OAC
External Links
UniProt	Q9EPK8
EMBL	AF263522 AJ296078 AF208026 AB021875 AF279672 BC127052
CCDS	CCDS19568.1
RefSeq	NP_071300.2
UniGene	Mm.266450
ProteinModelPortal	Q9EPK8
SMR	Q9EPK8
DIP	DIP-44011N
IntAct	Q9EPK8
MINT	MINT-4050076
BindingDB	Q9EPK8
ChEMBL	CHEMBL6126
GuidetoPHARMACOLOGY	510
PhosphoSite	Q9EPK8
PaxDb	Q9EPK8
PRIDE	Q9EPK8
Ensembl	ENSMUST00000071968 ENSMUST00000112225
GeneID	63873
KEGG	mmu:63873
UCSC	uc008yzu.1
CTD	59341
MGI	MGI:1926945
eggNOG	NOG278734
GeneTree	ENSGT00550000074425
HOGENOM	HOG000234630
HOVERGEN	HBG054085
InParanoid	Q9EPK8
KO	K04973
OMA	NTLYFTR
OrthoDB	EOG70S74P
PhylomeDB	Q9EPK8
TreeFam	TF314711
Reactome	REACT_227861
NextBio	319803
PRO	PR:Q9EPK8
Proteomes	UP000000589
Bgee	Q9EPK8
ExpressionAtlas	Q9EPK8
Genevestigator	Q9EPK8
GO	GO:0005912 GO:0009986 GO:0005929 GO:0030864 GO:0005881 GO:0031410 GO:0030175 GO:0005925 GO:0030426 GO:0016021 GO:0030027 GO:0005886 GO:0032587 GO:0005524 GO:0005262 GO:0005516 GO:0005261 GO:0005034 GO:0019901 GO:0042169 GO:0031532 GO:0007015 GO:0070509 GO:0007043 GO:0006874 GO:0071476 GO:0034605 GO:0071470 GO:0043622 GO:0042538 GO:0046785 GO:0010977 GO:0007231 GO:0007204 GO:0031117 GO:0047484 GO:0006970 GO:0030103
Gene3D	1.25.40.20
InterPro	IPR002110 IPR020683 IPR005821 IPR004729 IPR008347 IPR008348
PANTHER	PTHR10582:SF4
Pfam	PF12796 PF00520
PRINTS	PR01768 PR01769
SMART	SM00248
SUPFAM	SSF48403
TIGRFAMs	TIGR00870
PROSITE	PS50297 PS50088

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0002024	diet induced thermogenesis	PMID:23021218^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050729	positive regulation of inflammatory response	PMID:23021218^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0001013) causally_upstream_of:(GO:0010759)	Seeded From UniProt	complete
involved_in	GO:0010759	positive regulation of macrophage chemotaxis	PMID:23021218^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0001013)	Seeded From UniProt	complete
NOT\|involved_in	GO:1900744	regulation of p38MAPK cascade	PMID:23021218^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:23021218^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000136) happens_during:(GO:0071277)	Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	PMID:23021218^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000136)	Seeded From UniProt	complete
involved_in	GO:2000340	positive regulation of chemokine (C-X-C motif) ligand 1 production	PMID:23021218^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000136) part_of:(GO:0070374)	Seeded From UniProt	complete
involved_in	GO:2000778	positive regulation of interleukin-6 secretion	PMID:23021218^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000136)	Seeded From UniProt	complete
involved_in	GO:0071651	positive regulation of chemokine (C-C motif) ligand 5 production	PMID:23021218^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000136)	Seeded From UniProt	complete
involved_in	GO:0071642	positive regulation of macrophage inflammatory protein 1 alpha production	PMID:23021218^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000136) part_of:(GO:0070374)	Seeded From UniProt	complete
involved_in	GO:0071639	positive regulation of monocyte chemotactic protein-1 production	PMID:23021218^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000136)	Seeded From UniProt	complete
involved_in	GO:1903759	signal transduction involved in regulation of aerobic respiration	PMID:23021218^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000136)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:23021218^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000136) has_regulation_target:(UniProtKB:Q03366) has_regulation_target:(UniProtKB:P12032) has_regulation_target:(UniProtKB:Q9QUN7) has_regulation_target:(UniProtKB:P29533) has_regulation_target:(UniProtKB:P06804)	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:23021218^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000136) has_regulation_target:(UniProtKB:O70343) has_regulation_target:(UniProtKB:P12242) has_regulation_target:(UniProtKB:P56392) has_regulation_target:(UniProtKB:P48772) has_regulation_target:(UniProtKB:P62897) has_regulation_target:(UniProtKB:P19783)\|occurs_in(UBERON:0002190) has_regulation_target:(UniProtKB:P19783) has_regulation_target:(UniProtKB:P48772) has_regulation_target:(UniProtKB:O70343) has_regulation_target:(UniProtKB:P12242) has_regulation_target:(UniProtKB:O70302) has_regulation_target:(UniProtKB:Q8VHJ7)\|occurs_in(UBERON:0010412) has_regulation_target:(UniProtKB:Q8VHJ7) has_regulation_target:(UniProtKB:P62897) has_regulation_target:(UniProtKB:P19783) has_regulation_target:(UniProtKB:P12787) has_regulation_target:(UniProtKB:P25962)	Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	PMID:23021218^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(CL:0000136) happens_during:(GO:0071477)	Seeded From UniProt	complete
involved_in	GO:0071477	cellular hypotonic salinity response	PMID:23021218^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000136) causally_upstream_of:(GO:0005262)	Seeded From UniProt	complete
involved_in	GO:0043117	positive regulation of vascular permeability	PMID:23136043^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	PMID:23021218^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032868	response to insulin	PMID:23021218^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|involved_in	GO:0032496	response to lipopolysaccharide	PMID:23021218^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|involved_in	GO:0070542	response to fatty acid	PMID:23021218^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097009	energy homeostasis	PMID:23021218^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903444	negative regulation of brown fat cell differentiation	PMID:23021218^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002190)	Seeded From UniProt	complete
involved_in	GO:0071476	cellular hypotonic response	PMID:12538589^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070509	calcium ion import	PMID:12538589^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042169	SH2 domain binding	PMID:12538589^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P39688	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:12538589^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P07948	F		Seeded From UniProt	complete
involved_in	GO:0007231	osmosensory signaling pathway	PMID:12538589^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:12538589^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	PMID:12538589^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071470	cellular response to osmotic stress	PMID:18174177^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	PMID:18174177^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007043	cell-cell junction assembly	PMID:20413591^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	PMID:18174177^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HBA0	P		Seeded From UniProt	complete
part_of	GO:0005912	adherens junction	PMID:20413591^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:20413591^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HBA0	C		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HBA0	F		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	PMID:18174177^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005261	cation channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HBA0	F		Seeded From UniProt	complete
involved_in	GO:0071476	cellular hypotonic response	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1926945 PANTHER:PTN000061708 UniProtKB:F1RIT1 UniProtKB:Q9HBA0	P		Seeded From UniProt	complete
involved_in	GO:0007231	osmosensory signaling pathway	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1926945 PANTHER:PTN000061708	P		Seeded From UniProt	complete
involved_in	GO:0007015	actin filament organization	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000061708 RGD:69337 UniProtKB:F1RIT1	P		Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1926945 PANTHER:PTN000061708 UniProtKB:Q9HBA0	P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1926945 PANTHER:PTN000061708 UniProtKB:F1RIT1	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000061616 RGD:628841 RGD:69335 UniProtKB:Q9H1D0 UniProtKB:Q9NQA5	C		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1341787 MGI:MGI:1341836 MGI:MGI:1926945 MGI:MGI:1927259 MGI:MGI:2429764 PANTHER:PTN000832860 RGD:620636 RGD:69335 RGD:69337 SGD:S000005613 UniProtKB:F1RIT1 UniProtKB:Q9H1D0 UniProtKB:Q9HBA0 UniProtKB:Q9NQA5 WB:WBGene00003889	F		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1341787 MGI:MGI:2181407 PANTHER:PTN000061616	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097497	blood vessel endothelial cell delamination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HBA0	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071476	cellular hypotonic response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HBA0	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070588	calcium ion transmembrane transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HBA0	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070588	calcium ion transmembrane transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69337	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070509	calcium ion import	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69337	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060351	cartilage development involved in endochondral bone morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HBA0	P		Seeded From UniProt	complete
enables	GO:0051015	actin filament binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69337	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050891	multicellular organismal water homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HBA0	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050891	multicellular organismal water homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69337	P		Seeded From UniProt	complete
enables	GO:0048487	beta-tubulin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69337	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0047484	regulation of response to osmotic stress	PMID:12777254^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2667379	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046785	microtubule polymerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69337	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043622	cortical microtubule organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69337	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043117	positive regulation of vascular permeability	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HBA0	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043117	positive regulation of vascular permeability	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69337	P		Seeded From UniProt	complete
enables	GO:0043014	alpha-tubulin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69337	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HBA0	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042538	hyperosmotic salinity response	PMID:12777254^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2667379	P		Seeded From UniProt	complete
part_of	GO:0032587	ruffle membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69337	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031532	actin cytoskeleton reorganization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69337	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69337	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031117	positive regulation of microtubule depolymerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69337	P		Seeded From UniProt	complete
part_of	GO:0030864	cortical actin cytoskeleton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69337	C		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69337	C		Seeded From UniProt	complete
part_of	GO:0030175	filopodium	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69337	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030103	vasopressin secretion	PMID:12777254^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2667379	P		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69337	C		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HBA0	F		Seeded From UniProt	complete
enables	GO:0015275	stretch-activated, cation-selective, calcium channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HBA0	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010977	negative regulation of neuron projection development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69337	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69337	C		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69337	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007231	osmosensory signaling pathway	PMID:12777254^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2667379	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007231	osmosensory signaling pathway	PMID:11025659^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HBA0	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69337	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007015	actin filament organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69337	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006971	hypotonic response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69337	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006970	response to osmotic stress	PMID:11025659^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HBA0	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006816	calcium ion transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HBA0	P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:15858826^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:29043) part_of:(CL:0000067)	Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69337	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:14517216^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HBA0	C		Seeded From UniProt	complete
colocalizes_with	GO:0005881	cytoplasmic microtubule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69337	C		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HBA0	F		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	PMID:14517216^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	PMID:11025659^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HBA0	F		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69337	F		Seeded From UniProt	complete
enables	GO:0005261	cation channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HBA0	F		Seeded From UniProt	complete
enables	GO:0005261	cation channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69337	F		Seeded From UniProt	complete
enables	GO:0005080	protein kinase C binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69337	F		Seeded From UniProt	complete
enables	GO:0005034	osmosensor activity	PMID:12777254^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2667379	F		Seeded From UniProt	complete
enables	GO:0005034	osmosensor activity	PMID:11025659^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69337	F		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	P		Seeded From UniProt	complete
involved_in	GO:0070509	calcium ion import	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	P		Seeded From UniProt	complete
enables	GO:0051015	actin filament binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	F		Seeded From UniProt	complete
involved_in	GO:0050891	multicellular organismal water homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	P		Seeded From UniProt	complete
enables	GO:0048487	beta-tubulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	F		Seeded From UniProt	complete
involved_in	GO:0046785	microtubule polymerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	P		Seeded From UniProt	complete
involved_in	GO:0043622	cortical microtubule organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	P		Seeded From UniProt	complete
involved_in	GO:0043117	positive regulation of vascular permeability	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	P		Seeded From UniProt	complete
enables	GO:0043014	alpha-tubulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	F		Seeded From UniProt	complete
part_of	GO:0032587	ruffle membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	C		Seeded From UniProt	complete
involved_in	GO:0031532	actin cytoskeleton reorganization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	C		Seeded From UniProt	complete
involved_in	GO:0031117	positive regulation of microtubule depolymerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	P		Seeded From UniProt	complete
part_of	GO:0030864	cortical actin cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	C		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	C		Seeded From UniProt	complete
part_of	GO:0030175	filopodium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	C		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	C		Seeded From UniProt	complete
involved_in	GO:0010977	negative regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	C		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	F		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	P		Seeded From UniProt	complete
involved_in	GO:0007015	actin filament organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	P		Seeded From UniProt	complete
involved_in	GO:0006971	hypotonic response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	C		Seeded From UniProt	complete
part_of	GO:0005881	cytoplasmic microtubule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	C		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	F		Seeded From UniProt	complete
enables	GO:0005261	cation channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	F		Seeded From UniProt	complete
enables	GO:0005080	protein kinase C binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	F		Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ8 ensembl:ENSRNOP00000001586	F		Seeded From UniProt	complete
involved_in	GO:0097497	blood vessel endothelial cell delamination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBA0 ensembl:ENSP00000406191	P		Seeded From UniProt	complete
involved_in	GO:0071476	cellular hypotonic response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBA0 ensembl:ENSP00000406191	P		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBA0 ensembl:ENSP00000406191	P		Seeded From UniProt	complete
involved_in	GO:0060351	cartilage development involved in endochondral bone morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBA0 ensembl:ENSP00000406191	P		Seeded From UniProt	complete
involved_in	GO:0050891	multicellular organismal water homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBA0 ensembl:ENSP00000406191	P		Seeded From UniProt	complete
involved_in	GO:0043117	positive regulation of vascular permeability	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBA0 ensembl:ENSP00000406191	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBA0 ensembl:ENSP00000406191	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBA0 ensembl:ENSP00000406191	F		Seeded From UniProt	complete
enables	GO:0015275	stretch-activated, cation-selective, calcium channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBA0 ensembl:ENSP00000406191	F		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBA0 ensembl:ENSP00000406191	P		Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBA0 ensembl:ENSP00000406191	P		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBA0 ensembl:ENSP00000406191	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBA0 ensembl:ENSP00000406191	C		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBA0 ensembl:ENSP00000406191	F		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBA0 ensembl:ENSP00000406191	F		Seeded From UniProt	complete
enables	GO:0005261	cation channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBA0 ensembl:ENSP00000406191	F		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821 InterPro:IPR008347 InterPro:IPR008348 InterPro:IPR024862	F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821 InterPro:IPR008347 InterPro:IPR008348 InterPro:IPR024862	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008347 InterPro:IPR008348 InterPro:IPR024862	C		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0112	F		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0969 UniProtKB-SubCell:SL-0066	C		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0109	P		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0107	F		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0107	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005912	adherens junction	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0009	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0015	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 ^1.17 ^1.18 ^1.19 ^1.20 ^1.21 Ye, L et al. (2012) TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell 151 96-110 PubMed GONUTS page
↑ Thorneloe, KS et al. (2012) An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure. Sci Transl Med 4 159ra148 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Xu, H et al. (2003) Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress. J. Biol. Chem. 278 11520-7 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 D'hoedt, D et al. (2008) Stimulus-specific modulation of the cation channel TRPV4 by PACSIN 3. J. Biol. Chem. 283 6272-80 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Sokabe, T et al. (2010) The TRPV4 channel contributes to intercellular junction formation in keratinocytes. J. Biol. Chem. 285 18749-58 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Mizuno, A et al. (2003) Impaired osmotic sensation in mice lacking TRPV4. Am. J. Physiol., Cell Physiol. 285 C96-101 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Strotmann, R et al. (2000) OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity. Nat. Cell Biol. 2 695-702 PubMed GONUTS page
↑ Teilmann, SC et al. (2005) Localization of transient receptor potential ion channels in primary and motile cilia of the female murine reproductive organs. Mol. Reprod. Dev. 71 444-52 PubMed GONUTS page
↑ ^10.0 ^10.1 Suzuki, M et al. (2003) Microtubule-associated [corrected] protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4). J. Biol. Chem. 278 51448-53 PubMed GONUTS page

[PMID:23021218-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 ^1.17 ^1.18 ^1.19 ^1.20 ^1.21 Ye, L et al. (2012) TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell 151 96-110 PubMed GONUTS page

[PMID:23136043-2] Thorneloe, KS et al. (2012) An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure. Sci Transl Med 4 159ra148 PubMed GONUTS page

[PMID:12538589-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Xu, H et al. (2003) Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress. J. Biol. Chem. 278 11520-7 PubMed GONUTS page

[PMID:18174177-4] 4.0 ^4.1 ^4.2 ^4.3 D'hoedt, D et al. (2008) Stimulus-specific modulation of the cation channel TRPV4 by PACSIN 3. J. Biol. Chem. 283 6272-80 PubMed GONUTS page

[PMID:20413591-5] 5.0 ^5.1 ^5.2 Sokabe, T et al. (2010) The TRPV4 channel contributes to intercellular junction formation in keratinocytes. J. Biol. Chem. 285 18749-58 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12777254-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Mizuno, A et al. (2003) Impaired osmotic sensation in mice lacking TRPV4. Am. J. Physiol., Cell Physiol. 285 C96-101 PubMed GONUTS page

[PMID:11025659-8] 8.0 ^8.1 ^8.2 ^8.3 Strotmann, R et al. (2000) OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity. Nat. Cell Biol. 2 695-702 PubMed GONUTS page

[PMID:15858826-9] Teilmann, SC et al. (2005) Localization of transient receptor potential ion channels in primary and motile cilia of the female murine reproductive organs. Mol. Reprod. Dev. 71 444-52 PubMed GONUTS page

[PMID:14517216-10] 10.0 ^10.1 Suzuki, M et al. (2003) Microtubule-associated [corrected] protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4). J. Biol. Chem. 278 51448-53 PubMed GONUTS page

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MOUSE:TRPV4

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