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MOUSE:TRPC1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Trpc1 (synonyms: Trp1, Trrp1)
Protein Name(s) Short transient receptor potential channel 1

TrpC1 Transient receptor protein 1 TRP-1 mTrp1 Trp-related protein 1

External Links
UniProt Q61056
EMBL U73625
U95167
AF191551
U40980
RefSeq NP_035773.1
XP_006511117.1
UniGene Mm.149633
ProteinModelPortal Q61056
BioGrid 204327
IntAct Q61056
MINT MINT-4997241
PhosphoSite Q61056
PRIDE Q61056
GeneID 22063
KEGG mmu:22063
UCSC uc009rbj.1
CTD 7220
MGI MGI:109528
eggNOG NOG245138
HOGENOM HOG000020589
HOVERGEN HBG068337
InParanoid Q61056
KO K04964
Reactome REACT_188194
REACT_227861
REACT_230631
NextBio 301872
PRO PR:Q61056
Proteomes UP000000589
Bgee Q61056
ExpressionAtlas Q61056
Genevestigator Q61056
GO GO:0016323
GO:0043034
GO:0005737
GO:0016021
GO:0045121
GO:0043234
GO:0043235
GO:0030017
GO:0070679
GO:0015279
GO:0051480
GO:0051281
GO:0051592
GO:0046541
Gene3D 1.25.40.20
InterPro IPR002110
IPR020683
IPR005821
IPR004729
IPR013555
IPR005457
IPR002153
PANTHER PTHR10117
PTHR10117:SF3
Pfam PF12796
PF00520
PF08344
PRINTS PR01097
PR01642
SMART SM00248
SUPFAM SSF48403
TIGRFAMs TIGR00870

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0070679

inositol 1,4,5 trisphosphate binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:109524
MGI:MGI:109525
MGI:MGI:109527
PANTHER:PTN000012230
UniProtKB:P48995
UniProtKB:Q13507
UniProtKB:Q9Y210

F

Seeded From UniProt

complete

involved_in

GO:0070588

calcium ion transmembrane transport

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003861
FB:FBgn0005614
PANTHER:PTN000012230
UniProtKB:Q13507

P

Seeded From UniProt

complete

involved_in

GO:0051480

regulation of cytosolic calcium ion concentration

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000012230
UniProtKB:P48995

P

Seeded From UniProt

complete

part_of

GO:0034703

cation channel complex

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003861
FB:FBgn0005614
FB:FBgn0032593
PANTHER:PTN000012230

C

Seeded From UniProt

complete

enables

GO:0015279

store-operated calcium channel activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:109523
MGI:MGI:109525
MGI:MGI:109527
MGI:MGI:109528
PANTHER:PTN000012230
UniProtKB:Q9UBN4
WB:WBGene00004976

F

Seeded From UniProt

complete

involved_in

GO:0006828

manganese ion transport

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1349470
PANTHER:PTN000012230

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000012230
RGD:621276
UniProtKB:Q13507
WB:WBGene00004976

C

Seeded From UniProt

complete

enables

GO:0070679

inositol 1,4,5 trisphosphate binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P48995

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051592

response to calcium ion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P48995

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051480

regulation of cytosolic calcium ion concentration

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P48995

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051281

positive regulation of release of sequestered calcium ion into cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P48995

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046541

saliva secretion

PMID:17956991[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3764882

P

has_participant:(EMAPA:17751)

Seeded From UniProt

complete

part_of

GO:0045121

membrane raft

PMID:17416589[3]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:16728)
  • part_of:(CL:0000115)

Seeded From UniProt

complete

enables

GO:0044325

ion channel binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P48995

F

Seeded From UniProt

complete

part_of

GO:0043235

receptor complex

PMID:23382219[4]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P48995

C

Seeded From UniProt

complete

part_of

GO:0043034

costamere

PMID:18268005[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042438

melanin biosynthetic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P48995

P

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

PMID:17416589[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P11881
UniProtKB:P49817
UniProtKB:Q9QUQ5

C

  • part_of:(EMAPA:16728)
  • part_of:(CL:0000115)

Seeded From UniProt

complete

part_of

GO:0030017

sarcomere

PMID:18268005[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016323

basolateral plasma membrane

PMID:17956991[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3764882

C

part_of:(EMAPA:18812)

Seeded From UniProt

complete

enables

GO:0015279

store-operated calcium channel activity

PMID:17956991[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3764882

F

  • occurs_in:(EMAPA:18812)
  • occurs_in:(CL:0000622)

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P48995

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:15044151[6]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000650)

Seeded From UniProt

complete

enables

GO:0005261

cation channel activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P48995

F

Seeded From UniProt

complete

enables

GO:0005216

ion channel activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005821

F

Seeded From UniProt

complete

enables

GO:0005262

calcium channel activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002153
InterPro:IPR005457

F

Seeded From UniProt

complete

involved_in

GO:0006811

ion transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005821

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002153
InterPro:IPR005821

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005457

C

Seeded From UniProt

complete

involved_in

GO:0055085

transmembrane transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005821

P

Seeded From UniProt

complete

involved_in

GO:0070588

calcium ion transmembrane transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002153
InterPro:IPR005457

P

Seeded From UniProt

complete

involved_in

GO:0070588

calcium ion transmembrane transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0107

P

Seeded From UniProt

complete

enables

GO:0005262

calcium channel activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0107

F

Seeded From UniProt

complete

involved_in

GO:0006816

calcium ion transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0109

P

Seeded From UniProt

complete

involved_in

GO:0006811

ion transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0406

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Liu, X et al. (2007) Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1(-/-) mice. Proc. Natl. Acad. Sci. U.S.A. 104 17542-7 PubMed GONUTS page
  3. ↑ 3.0 3.1 Murata, T et al. (2007) Genetic evidence supporting caveolae microdomain regulation of calcium entry in endothelial cells. J. Biol. Chem. 282 16631-43 PubMed GONUTS page
  4. ↑ Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page
  5. ↑ 5.0 5.1 Stiber, JA et al. (2008) Mice lacking Homer 1 exhibit a skeletal myopathy characterized by abnormal transient receptor potential channel activity. Mol. Cell. Biol. 28 2637-47 PubMed GONUTS page
  6. ↑ Wang, X et al. (2004) TRPC4 forms store-operated Ca2+ channels in mouse mesangial cells. Am. J. Physiol., Cell Physiol. 287 C357-64 PubMed GONUTS page
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