MOUSE:TRIPC

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Trip12
Protein Name(s)	E3 ubiquitin-protein ligase TRIP12 Thyroid receptor-interacting protein 12 TR-interacting protein 12 TRIP-12
External Links
UniProt	G5E870
EMBL	AC123882 CH466629 CH466629 CH466629 AK034814 AK134397 AK158807 BC034113
CCDS	CCDS35633.1
RefSeq	NP_598736.4
UniGene	Mm.209265
IntAct	G5E870
MINT	MINT-4116730
MaxQB	G5E870
PRIDE	G5E870
Ensembl	ENSMUST00000027421 ENSMUST00000186465 ENSMUST00000186894
GeneID	14897
KEGG	mmu:14897
UCSC	uc007bsy.1
CTD	9320
MGI	MGI:1309481
GeneTree	ENSGT00530000063470
InParanoid	G5E870
KO	K10590
OMA	RTESSCI
OrthoDB	EOG7H791G
TreeFam	TF323674
Reactome	REACT_199115
UniPathway	UPA00143
ChiTaRS	Trip12
NextBio	287187
PRO	PR:G5E870
Proteomes	UP000000589
Bgee	G5E870
ExpressionAtlas	G5E870
GO	GO:0005737 GO:0005654 GO:0005634 GO:0016874 GO:0004842 GO:0006974 GO:0006281 GO:0009790 GO:2000780 GO:1901315 GO:0042787
Gene3D	1.25.10.10
InterPro	IPR011989 IPR016024 IPR000569 IPR004170
Pfam	PF00632 PF02825
SMART	SM00119
SUPFAM	SSF48371 SSF56204
PROSITE	PS50237 PS50918

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0032688	negative regulation of interferon-beta production	PMID:22945920^[1]	ECO:0000314			P	Figure 1.E and 1.F, TRIP expression decreased overall amount of interferon being made when compared to control.	complete CACAO 8524
involved_in	GO:2000780	negative regulation of double-strand break repair	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q14669	P	Seeded From UniProt	complete
involved_in	GO:1901315	negative regulation of histone H2A K63-linked ubiquitination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q14669	P	Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q14669	P	Seeded From UniProt	complete
involved_in	GO:0045995	regulation of embryonic development	PMID:22028794^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q14669	P	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q14669	C	Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q14669	F	Seeded From UniProt	complete
involved_in	GO:1901315	negative regulation of histone H2A K63-linked ubiquitination	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000134292 UniProtKB:Q14669	P	Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000134292 UniProtKB:Q14669	C	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000134292 UniProtKB:Q14669	P	Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000134292 UniProtKB:Q14669	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000780	negative regulation of double-strand break repair	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14669	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901315	negative regulation of histone H2A K63-linked ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14669	P	Seeded From UniProt	complete
enables	GO:0046966	thyroid hormone receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14669	F	Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14669	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14669	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006511	ubiquitin-dependent protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14669	P	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14669	C	Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14669	F	Seeded From UniProt	complete
involved_in	GO:2000780	negative regulation of double-strand break repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14669 ensembl:ENSP00000373696	P	Seeded From UniProt	complete
involved_in	GO:1901315	negative regulation of histone H2A K63-linked ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14669 ensembl:ENSP00000373696	P	Seeded From UniProt	complete
enables	GO:0046966	thyroid hormone receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14669 ensembl:ENSP00000373696	F	Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14669 ensembl:ENSP00000373696	C	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14669 ensembl:ENSP00000373696	P	Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14669 ensembl:ENSP00000373696	P	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14669 ensembl:ENSP00000373696	C	Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14669 ensembl:ENSP00000373696	F	Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000569 InterPro:IPR035983	F	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018123	F	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0190	C	Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00143	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Zhang, M et al. (2012) TRAF-interacting protein (TRIP) negatively regulates IFN-β production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1. J. Exp. Med. 209 1703-11 PubMed GONUTS page
↑ Kajiro, M et al. (2011) The E3 ubiquitin ligase activity of Trip12 is essential for mouse embryogenesis. PLoS ONE 6 e25871 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22945920-1] Zhang, M et al. (2012) TRAF-interacting protein (TRIP) negatively regulates IFN-β production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1. J. Exp. Med. 209 1703-11 PubMed GONUTS page

[PMID:22028794-2] Kajiro, M et al. (2011) The E3 ubiquitin ligase activity of Trip12 is essential for mouse embryogenesis. PLoS ONE 6 e25871 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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MOUSE:TRIPC

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References

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