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MOUSE:TMOD1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Tmod1 (synonyms: Tmod)
Protein Name(s) Tropomodulin-1

Erythrocyte tropomodulin E-Tmod

External Links
UniProt P49813
EMBL S76831
AF287746
AF287738
AF287739
AF287740
AF287741
AF287742
AF287743
AF287744
AF287745
AL732615
CH466565
BC106849
BC106850
CCDS CCDS18143.1
RefSeq NP_068683.1
UniGene Mm.249594
Mm.331588
ProteinModelPortal P49813
SMR P49813
BioGrid 204233
IntAct P49813
MINT MINT-4138079
PhosphoSite P49813
MaxQB P49813
PaxDb P49813
PRIDE P49813
Ensembl ENSMUST00000107773
GeneID 21916
KEGG mmu:21916
UCSC uc008ste.1
CTD 7111
MGI MGI:98775
eggNOG NOG329422
GeneTree ENSGT00760000119226
HOGENOM HOG000261624
HOVERGEN HBG056172
InParanoid P49813
KO K10370
OMA STIVNKQ
OrthoDB EOG7D59Q1
TreeFam TF315841
Reactome REACT_232053
ChiTaRS Tmod1
NextBio 301472
PRO PR:P49813
Proteomes UP000000589
Bgee P49813
CleanEx MM_TMOD1
ExpressionAtlas P49813
Genevestigator P49813
GO GO:0008180
GO:0030863
GO:0005856
GO:0016020
GO:0030016
GO:0005523
GO:0008344
GO:0006936
GO:0030239
InterPro IPR004934
IPR030135
PANTHER PTHR10901
PTHR10901:SF8
Pfam PF03250

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0070307

lens fiber cell development

PMID:23144950[1]

ECO:0000316

UniProtKB:Q6NVD9


P

Figure 1, 3 & 4.

complete
CACAO 7915

part_of

GO:0030017

sarcomere

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P28289

C

Seeded From UniProt

complete

part_of

GO:0030016

myofibril

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P28289

C

Seeded From UniProt

complete

part_of

GO:0005884

actin filament

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P28289

C

Seeded From UniProt

complete

enables

GO:0003779

actin binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P28289

F

Seeded From UniProt

complete

involved_in

GO:0070307

lens fiber cell development

PMID:23144950[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q6NVD9

P

Seeded From UniProt

complete

involved_in

GO:0030239

myofibril assembly

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98775
PANTHER:PTN000096564

P

Seeded From UniProt

complete

part_of

GO:0030016

myofibril

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98775
PANTHER:PTN000096564
UniProtKB:P28289
UniProtKB:P29536
UniProtKB:Q6P5Q4

C

Seeded From UniProt

complete

involved_in

GO:0006936

muscle contraction

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98775
PANTHER:PTN000096567
ZFIN:ZDB-GENE-090313-353

P

Seeded From UniProt

complete

part_of

GO:0005865

striated muscle thin filament

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1355285
MGI:MGI:1355315
PANTHER:PTN000096567
UniProtKB:H9KZU7
UniProtKB:P28289
UniProtKB:Q0VAK6
UniProtKB:Q9NZQ9

C

Seeded From UniProt

complete

enables

GO:0005523

tropomyosin binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1355285
MGI:MGI:1355315
MGI:MGI:98775
PANTHER:PTN000096563
RGD:3874
RGD:61948
UniProtKB:Q0VAK6
UniProtKB:Q6P5Q4

F

Seeded From UniProt

complete

part_of

GO:0030863

cortical cytoskeleton

PMID:18723693[3]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000232)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030239

myofibril assembly

PMID:14657235[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2687078

P

occurs_in:(EMAPA:16105)

Seeded From UniProt

complete

part_of

GO:0030017

sarcomere

PMID:24840128[5]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000746)

Seeded From UniProt

complete

part_of

GO:0030017

sarcomere

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P28289

C

Seeded From UniProt

complete

part_of

GO:0030016

myofibril

PMID:14657235[4]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:16105)

Seeded From UniProt

complete

part_of

GO:0030016

myofibril

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P28289

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:18723693[3]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000232)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008344

adult locomotory behavior

PMID:20368620[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2687078

P

Seeded From UniProt

complete

colocalizes_with

GO:0008180

COP9 signalosome

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P28289

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006936

muscle contraction

PMID:20368620[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2687078

P

Seeded From UniProt

complete

part_of

GO:0005884

actin filament

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P28289

C

Seeded From UniProt

complete

part_of

GO:0005865

striated muscle thin filament

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P28289

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3874

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3874

C

Seeded From UniProt

complete

enables

GO:0005523

tropomyosin binding

PMID:20368620[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005523

tropomyosin binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3874

F

Seeded From UniProt

complete

enables

GO:0003779

actin binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P28289

F

Seeded From UniProt

complete

part_of

GO:0030017

sarcomere

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28289
ensembl:ENSP00000259365

C

Seeded From UniProt

complete

part_of

GO:0030016

myofibril

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28289
ensembl:ENSP00000259365

C

Seeded From UniProt

complete

part_of

GO:0008180

COP9 signalosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28289
ensembl:ENSP00000259365

C

Seeded From UniProt

complete

part_of

GO:0005884

actin filament

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28289
ensembl:ENSP00000259365

C

Seeded From UniProt

complete

part_of

GO:0005865

striated muscle thin filament

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28289
ensembl:ENSP00000259365

C

Seeded From UniProt

complete

enables

GO:0003779

actin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28289
ensembl:ENSP00000259365

F

Seeded From UniProt

complete

enables

GO:0005523

tropomyosin binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004934
InterPro:IPR030135

F

Seeded From UniProt

complete

enables

GO:0051015

actin filament binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030135

F

Seeded From UniProt

complete

involved_in

GO:0051694

pointed-end actin filament capping

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004934
InterPro:IPR030135

P

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

PMID:8618961[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003779

actin binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0009

F

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206
UniProtKB-SubCell:SL-0090

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Gokhin, DS et al. (2012) Tmod1 and CP49 synergize to control the fiber cell geometry, transparency, and mechanical stiffness of the mouse lens. PLoS ONE 7 e48734 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ 3.0 3.1 Robledo, RF et al. (2008) Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice. Blood 112 4298-307 PubMed GONUTS page
  4. ↑ 4.0 4.1 Fritz-Six, KL et al. (2003) Aberrant myofibril assembly in tropomodulin1 null mice leads to aborted heart development and embryonic lethality. J. Cell Biol. 163 1033-44 PubMed GONUTS page
  5. ↑ Yuan, B et al. (2014) A cardiomyocyte-specific Wdr1 knockout demonstrates essential functional roles for actin disassembly during myocardial growth and maintenance in mice. Am. J. Pathol. 184 1967-80 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Gokhin, DS et al. (2010) Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiology. J. Cell Biol. 189 95-109 PubMed GONUTS page
  7. ↑ Schiaffino, S & Reggiani, C (1996) Molecular diversity of myofibrillar proteins: gene regulation and functional significance. Physiol. Rev. 76 371-423 PubMed GONUTS page
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