MOUSE:TENR

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Tnr
Protein Name(s)	Tenascin-R TN-R Janusin Neural recognition molecule J1-160/180 Restrictin
External Links
UniProt	Q8BYI9
EMBL	AK039390 BC132392 BC138043 AJ005844
CCDS	CCDS15403.1
RefSeq	NP_071707.2 XP_006496805.1 XP_006496806.1 XP_006496807.1
UniGene	Mm.44701 Mm.483249
ProteinModelPortal	Q8BYI9
SMR	Q8BYI9
IntAct	Q8BYI9
MINT	MINT-4113482
PhosphoSite	Q8BYI9
MaxQB	Q8BYI9
PaxDb	Q8BYI9
PRIDE	Q8BYI9
Ensembl	ENSMUST00000111669
GeneID	21960
KEGG	mmu:21960
UCSC	uc007dea.2
CTD	7143
MGI	MGI:99516
eggNOG	NOG311251
GeneTree	ENSGT00770000120463
HOGENOM	HOG000234355
HOVERGEN	HBG008949
InParanoid	Q8BYI9
KO	K06252
OMA	KACPCAS
OrthoDB	EOG7X9G60
TreeFam	TF329915
Reactome	REACT_196606
ChiTaRS	Tnr
NextBio	301652
PRO	PR:Q8BYI9
Proteomes	UP000000589
Bgee	Q8BYI9
CleanEx	MM_TNR
Genevestigator	Q8BYI9
GO	GO:0009986 GO:0005737 GO:0045121 GO:0005634 GO:0072534 GO:0005578 GO:0046625 GO:0008306 GO:0030198 GO:0035641 GO:0060291 GO:0030517 GO:0048692 GO:0022408 GO:0010977 GO:0050805 GO:0050885 GO:0007158 GO:0051968 GO:0051971 GO:0050804 GO:0050808 GO:0022029
Gene3D	2.60.40.10 3.90.215.10 4.10.530.10
InterPro	IPR000742 IPR013032 IPR013111 IPR014716 IPR014715 IPR002181 IPR003961 IPR013783
Pfam	PF07974 PF00147 PF00041
SMART	SM00181 SM00186 SM00060
SUPFAM	SSF49265 SSF56496
PROSITE	PS00022 PS01186 PS51406 PS50853

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0098978	glutamatergic synapse	PMID:11377840^[1]	ECO:0001225	knockout evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	PMID:11377840^[1]	ECO:0001225	knockout evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	PMID:11377840^[1]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	PMID:11377840^[1]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0098685) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
part_of	GO:0098966	perisynaptic extracellular matrix	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3886	C		Seeded From UniProt	complete
part_of	GO:0098686	hippocampal mossy fiber to CA3 synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3886	C		Seeded From UniProt	complete
part_of	GO:0072534	perineuronal net	PMID:10341229^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17575)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060291	long-term synaptic potentiation	PMID:17537973^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154583	P	has_participant:(EMAPA:32768)\|has_participant:(EMAPA:32769)\|has_participant:(EMAPA:32770)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060291	long-term synaptic potentiation	PMID:11161481^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154583	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051971	positive regulation of transmission of nerve impulse	PMID:10341229^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154583	P	occurs_in:(EMAPA:17575)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051968	positive regulation of synaptic transmission, glutamatergic	PMID:11161481^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154583	P	regulates_o_occurs_in:(EMAPA:32768) regulates_o_has_participant:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050885	neuromuscular process controlling balance	PMID:12882316^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154583	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050808	synapse organization	PMID:16262627^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154583	P	occurs_in:(EMAPA:32768)\|occurs_in:(EMAPA:17544)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050805	negative regulation of synaptic transmission	PMID:15033179^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154583	P	regulates_o_has_participant:(EMAPA:32768) regulates_o_has_participant:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050804	modulation of chemical synaptic transmission	PMID:11377840^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154583	P	regulates_o_occurs_in:(EMAPA:32768) regulates_o_has_participant:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048692	negative regulation of axon extension involved in regeneration	PMID:16870730^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154583	P	regulates_o_occurs_in:(CL:0000100)	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:12056833^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035641	locomotory exploration behavior	PMID:14529817^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154583	P		Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	PMID:7530142^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17575)	Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	PMID:19141078^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	adjacent_to:(CL:0000117)	Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3886	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030517	negative regulation of axon extension	PMID:16831557^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:17787) regulates_o_occurs_in:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030198	extracellular matrix organization	PMID:16870730^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154583	P	occurs_in:(EMAPA:17577)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030198	extracellular matrix organization	PMID:11077416^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154583	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030198	extracellular matrix organization	PMID:10341229^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154583	P	occurs_in:(EMAPA:17575)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022408	negative regulation of cell-cell adhesion	PMID:15034584^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154583	P	regulates_o_has_participant:(EMAPA:32809) regulates_o_has_participant:(CL:0000337)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022408	negative regulation of cell-cell adhesion	PMID:16831557^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_has_participant:(EMAPA:17787) regulates_o_has_participant:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022029	telencephalon cell migration	PMID:15034584^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154583	P	occurs_in:(EMAPA:32809) results_in_movement_of:(CL:0000337)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010977	negative regulation of neuron projection development	PMID:9405406^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:12056833^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008306	associative learning	PMID:12882316^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154583	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007162	negative regulation of cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3886	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007158	neuron cell-cell adhesion	PMID:15034584^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154583	P		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3886	F		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033079	P		Seeded From UniProt	complete
involved_in	GO:0050767	regulation of neurogenesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033079	P		Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033079	C		Seeded From UniProt	complete
enables	GO:0046625	sphingolipid binding	PMID:12056833^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Bukalo, O et al. (2001) Modification of extracellular matrix by enzymatic removal of chondroitin sulfate and by lack of tenascin-R differentially affects several forms of synaptic plasticity in the hippocampus. Neuroscience 104 359-69 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Weber, P et al. (1999) Mice deficient for tenascin-R display alterations of the extracellular matrix and decreased axonal conduction velocities in the CNS. J. Neurosci. 19 4245-62 PubMed GONUTS page
↑ Bukalo, O et al. (2007) Hippocampal metaplasticity induced by deficiency in the extracellular matrix glycoprotein tenascin-R. J. Neurosci. 27 6019-28 PubMed GONUTS page
↑ ^4.0 ^4.1 Saghatelyan, AK et al. (2001) Reduced perisomatic inhibition, increased excitatory transmission, and impaired long-term potentiation in mice deficient for the extracellular matrix glycoprotein tenascin-R. Mol. Cell. Neurosci. 17 226-40 PubMed GONUTS page
↑ ^5.0 ^5.1 Montag-Sallaz, M & Montag, D (2003) Severe cognitive and motor coordination deficits in tenascin-R-deficient mice. Genes Brain Behav. 2 20-31 PubMed GONUTS page
↑ Syková, E et al. (2005) Reduced extracellular space in the brain of tenascin-R- and HNK-1-sulphotransferase deficient mice. Eur. J. Neurosci. 22 1873-80 PubMed GONUTS page
↑ Gurevicius, K et al. (2004) Enhanced cortical and hippocampal neuronal excitability in mice deficient in the extracellular matrix glycoprotein tenascin-R. Mol. Cell. Neurosci. 25 515-23 PubMed GONUTS page
↑ ^8.0 ^8.1 Apostolova, I et al. (2006) Tenascin-R restricts posttraumatic remodeling of motoneuron innervation and functional recovery after spinal cord injury in adult mice. J. Neurosci. 26 7849-59 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Kappler, J et al. (2002) Tenascins are associated with lipid rafts isolated from mouse brain. Biochem. Biophys. Res. Commun. 294 742-7 PubMed GONUTS page
↑ Freitag, S et al. (2003) Behavioral alterations in mice deficient for the extracellular matrix glycoprotein tenascin-R. Behav. Brain Res. 145 189-207 PubMed GONUTS page
↑ Schachner, M et al. (1994) The perplexing multifunctionality of janusin, a tenascin-related molecule. Perspect Dev Neurobiol 2 33-41 PubMed GONUTS page
↑ Bekku, Y et al. (2009) Brevican distinctively assembles extracellular components at the large diameter nodes of Ranvier in the CNS. J. Neurochem. 108 1266-76 PubMed GONUTS page
↑ ^13.0 ^13.1 Pesheva, P et al. (2006) Early coevolution of adhesive but not antiadhesive tenascin-R ligand-receptor pairs in vertebrates: a phylogenetic study. Mol. Cell. Neurosci. 32 366-86 PubMed GONUTS page
↑ Brückner, G et al. (2000) Postnatal development of perineuronal nets in wild-type mice and in a mutant deficient in tenascin-R. J. Comp. Neurol. 428 616-29 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Saghatelyan, A et al. (2004) Tenascin-R mediates activity-dependent recruitment of neuroblasts in the adult mouse forebrain. Nat. Neurosci. 7 347-56 PubMed GONUTS page
↑ Xiao, ZC et al. (1997) Isolation of a tenascin-R binding protein from mouse brain membranes. A phosphacan-related chondroitin sulfate proteoglycan. J. Biol. Chem. 272 32092-101 PubMed GONUTS page

[PMID:11377840-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Bukalo, O et al. (2001) Modification of extracellular matrix by enzymatic removal of chondroitin sulfate and by lack of tenascin-R differentially affects several forms of synaptic plasticity in the hippocampus. Neuroscience 104 359-69 PubMed GONUTS page

[PMID:10341229-2] 2.0 ^2.1 ^2.2 Weber, P et al. (1999) Mice deficient for tenascin-R display alterations of the extracellular matrix and decreased axonal conduction velocities in the CNS. J. Neurosci. 19 4245-62 PubMed GONUTS page

[PMID:17537973-3] Bukalo, O et al. (2007) Hippocampal metaplasticity induced by deficiency in the extracellular matrix glycoprotein tenascin-R. J. Neurosci. 27 6019-28 PubMed GONUTS page

[PMID:11161481-4] 4.0 ^4.1 Saghatelyan, AK et al. (2001) Reduced perisomatic inhibition, increased excitatory transmission, and impaired long-term potentiation in mice deficient for the extracellular matrix glycoprotein tenascin-R. Mol. Cell. Neurosci. 17 226-40 PubMed GONUTS page

[PMID:12882316-5] 5.0 ^5.1 Montag-Sallaz, M & Montag, D (2003) Severe cognitive and motor coordination deficits in tenascin-R-deficient mice. Genes Brain Behav. 2 20-31 PubMed GONUTS page

[PMID:16262627-6] Syková, E et al. (2005) Reduced extracellular space in the brain of tenascin-R- and HNK-1-sulphotransferase deficient mice. Eur. J. Neurosci. 22 1873-80 PubMed GONUTS page

[PMID:15033179-7] Gurevicius, K et al. (2004) Enhanced cortical and hippocampal neuronal excitability in mice deficient in the extracellular matrix glycoprotein tenascin-R. Mol. Cell. Neurosci. 25 515-23 PubMed GONUTS page

[PMID:16870730-8] 8.0 ^8.1 Apostolova, I et al. (2006) Tenascin-R restricts posttraumatic remodeling of motoneuron innervation and functional recovery after spinal cord injury in adult mice. J. Neurosci. 26 7849-59 PubMed GONUTS page

[PMID:12056833-9] 9.0 ^9.1 ^9.2 Kappler, J et al. (2002) Tenascins are associated with lipid rafts isolated from mouse brain. Biochem. Biophys. Res. Commun. 294 742-7 PubMed GONUTS page

[PMID:14529817-10] Freitag, S et al. (2003) Behavioral alterations in mice deficient for the extracellular matrix glycoprotein tenascin-R. Behav. Brain Res. 145 189-207 PubMed GONUTS page

[PMID:7530142-11] Schachner, M et al. (1994) The perplexing multifunctionality of janusin, a tenascin-related molecule. Perspect Dev Neurobiol 2 33-41 PubMed GONUTS page

[PMID:19141078-12] Bekku, Y et al. (2009) Brevican distinctively assembles extracellular components at the large diameter nodes of Ranvier in the CNS. J. Neurochem. 108 1266-76 PubMed GONUTS page

[PMID:16831557-13] 13.0 ^13.1 Pesheva, P et al. (2006) Early coevolution of adhesive but not antiadhesive tenascin-R ligand-receptor pairs in vertebrates: a phylogenetic study. Mol. Cell. Neurosci. 32 366-86 PubMed GONUTS page

[PMID:11077416-14] Brückner, G et al. (2000) Postnatal development of perineuronal nets in wild-type mice and in a mutant deficient in tenascin-R. J. Comp. Neurol. 428 616-29 PubMed GONUTS page

[PMID:15034584-15] 15.0 ^15.1 ^15.2 Saghatelyan, A et al. (2004) Tenascin-R mediates activity-dependent recruitment of neuroblasts in the adult mouse forebrain. Nat. Neurosci. 7 347-56 PubMed GONUTS page

[PMID:9405406-16] Xiao, ZC et al. (1997) Isolation of a tenascin-R binding protein from mouse brain membranes. A phosphacan-related chondroitin sulfate proteoglycan. J. Biol. Chem. 272 32092-101 PubMed GONUTS page

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MOUSE:TENR

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