MOUSE:TEN4

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Tenm4 (synonyms: Doc4, Kiaa1302, Odz4, Tnm4)
Protein Name(s)	Teneurin-4 Ten-4 Downstream of CHOP4 Protein Odd Oz/ten-m homolog 4 Tenascin-M4 Ten-m4 Teneurin transmembrane protein 4
External Links
UniProt	Q3UHK6
EMBL	AF059485 AB025413 AK147579 AK147329 AK162046 AK122490
CCDS	CCDS40024.1
PIR	T14271
RefSeq	NP_035988.2 XP_006507872.1 XP_006507873.1 XP_006507874.1
UniGene	Mm.254610 Mm.391678
ProteinModelPortal	Q3UHK6
SMR	Q3UHK6
IntAct	Q3UHK6
PhosphoSite	Q3UHK6
MaxQB	Q3UHK6
PaxDb	Q3UHK6
PRIDE	Q3UHK6
Ensembl	ENSMUST00000107162 ENSMUST00000107165 ENSMUST00000107166
GeneID	23966
KEGG	mmu:23966
UCSC	uc009iio.1 uc009iip.1 uc009iiq.1
CTD	26011
MGI	MGI:2447063
eggNOG	NOG323120
GeneTree	ENSGT00760000119131
HOGENOM	HOG000231701
HOVERGEN	HBG080306
InParanoid	Q3UHK6
OMA	QFVSQQP
OrthoDB	EOG7H791C
PhylomeDB	Q3UHK6
TreeFam	TF316833
NextBio	303833
PRO	PR:Q3UHK6
Proteomes	UP000000589
Bgee	Q3UHK6
CleanEx	MM_ODZ4
ExpressionAtlas	Q3UHK6
Genevestigator	Q3UHK6
GO	GO:0005737 GO:0005887 GO:0043005 GO:0005634 GO:0042803 GO:0060912 GO:0060038 GO:0032289 GO:0001702 GO:0048666 GO:2000543 GO:0031643 GO:0048714 GO:0097264 GO:0007165
Gene3D	2.120.10.30
InterPro	IPR011042 IPR008969 IPR000742 IPR013032 IPR013111 IPR022385 IPR027691 IPR009471 IPR028916 IPR006530
PANTHER	PTHR11219:SF9
Pfam	PF07974 PF12661 PF05593 PF06484 PF15636
SMART	SM00181
SUPFAM	SSF49464
TIGRFAMs	TIGR03696 TIGR01643
PROSITE	PS00022 PS01186 PS50026 PS51361

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6N022	C		Seeded From UniProt	complete
involved_in	GO:0048666	neuron development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6N022	P		Seeded From UniProt	complete
involved_in	GO:0031641	regulation of myelination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6N022	P		Seeded From UniProt	complete
involved_in	GO:0032289	central nervous system myelin formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6N022	P		Seeded From UniProt	complete
involved_in	GO:2000543	positive regulation of gastrulation	PMID:15489520^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048714	positive regulation of oligodendrocyte differentiation	PMID:22915103^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:22915103^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:12000766^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032289	central nervous system myelin formation	PMID:22915103^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031643	positive regulation of myelination	PMID:22915103^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:22915103^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22915103^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0050839	cell adhesion molecule binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000131466 RGD:727907 UniProtKB:Q9NT68	F		Seeded From UniProt	complete
involved_in	GO:0048666	neuron development	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000131466 UniProtKB:Q6N022	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1345183 MGI:MGI:1345184 MGI:MGI:1345185 PANTHER:PTN000131466	F		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2447063 PANTHER:PTN000131466 RGD:727907	C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1345183 MGI:MGI:1345184 MGI:MGI:1345185 MGI:MGI:2447063 PANTHER:PTN000131466	F		Seeded From UniProt	complete
involved_in	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000131466 RGD:727907 UniProtKB:Q9NT68	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060912	cardiac cell fate specification	PMID:17350578^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3655239	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060038	cardiac muscle cell proliferation	PMID:17350578^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3655239	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048666	neuron development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6N022	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032289	central nervous system myelin formation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6N022	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031641	regulation of myelination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6N022	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:9649432^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6N022	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001702	gastrulation with mouth forming second	PMID:15489520^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2449635	P	has_participant:(EMAPA:16039)	Seeded From UniProt	complete
involved_in	GO:0048666	neuron development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6N022 ensembl:ENSP00000278550	P		Seeded From UniProt	complete
involved_in	GO:0032289	central nervous system myelin formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6N022 ensembl:ENSP00000278550	P		Seeded From UniProt	complete
involved_in	GO:0031641	regulation of myelination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6N022 ensembl:ENSP00000278550	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6N022 ensembl:ENSP00000278550	C		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009471	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009471	C		Seeded From UniProt	complete
involved_in	GO:0048666	neuron development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027688	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966 UniProtKB-SubCell:SL-0280	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Lossie, AC et al. (2005) Mutation of l7Rn3 shows that Odz4 is required for mouse gastrulation. Genetics 169 285-99 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Suzuki, N et al. (2012) Teneurin-4 is a novel regulator of oligodendrocyte differentiation and myelination of small-diameter axons in the CNS. J. Neurosci. 32 11586-99 PubMed GONUTS page
↑ Feng, K et al. (2002) All four members of the Ten-m/Odz family of transmembrane proteins form dimers. J. Biol. Chem. 277 26128-35 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^5.0 ^5.1 Prall, OW et al. (2007) An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell 128 947-59 PubMed GONUTS page
↑ Wang, XZ et al. (1998) Identification of novel stress-induced genes downstream of chop. EMBO J. 17 3619-30 PubMed GONUTS page

[PMID:15489520-1] 1.0 ^1.1 Lossie, AC et al. (2005) Mutation of l7Rn3 shows that Odz4 is required for mouse gastrulation. Genetics 169 285-99 PubMed GONUTS page

[PMID:22915103-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Suzuki, N et al. (2012) Teneurin-4 is a novel regulator of oligodendrocyte differentiation and myelination of small-diameter axons in the CNS. J. Neurosci. 32 11586-99 PubMed GONUTS page

[PMID:12000766-3] Feng, K et al. (2002) All four members of the Ten-m/Odz family of transmembrane proteins form dimers. J. Biol. Chem. 277 26128-35 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17350578-5] 5.0 ^5.1 Prall, OW et al. (2007) An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell 128 947-59 PubMed GONUTS page

[PMID:9649432-6] Wang, XZ et al. (1998) Identification of novel stress-induced genes downstream of chop. EMBO J. 17 3619-30 PubMed GONUTS page

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MOUSE:TEN4

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