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MOUSE:TBPL2

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Tbpl2 (ECO:0000312 with MGI:MGI:2684058)
Protein Name(s) TATA box-binding protein-like protein 2

TBP-like protein 2 TATA box-binding protein-related factor 3 TBP-related factor 3

External Links
UniProt Q6SJ95
EMBL AY457924
BK005773
AL844838
AL844838
BC100305
BC119160
CCDS CCDS15732.1
RefSeq NP_001276618.1
NP_951014.1
UniGene Mm.301625
ProteinModelPortal Q6SJ95
SMR Q6SJ95
IntAct Q6SJ95
PRIDE Q6SJ95
Ensembl ENSMUST00000080453
GeneID 227606
KEGG mmu:227606
UCSC uc008iol.1
CTD 387332
MGI MGI:2684058
eggNOG COG2101
GeneTree ENSGT00410000025389
HOGENOM HOG000105164
HOVERGEN HBG044997
InParanoid Q6SJ95
KO K03120
OMA ECCGIVP
OrthoDB EOG7XWPPF
PhylomeDB Q6SJ95
TreeFam TF300102
NextBio 378650
PRO PR:Q6SJ95
Proteomes UP000000589
Bgee Q6SJ95
CleanEx MM_TBPL2
ExpressionAtlas Q6SJ95
Genevestigator Q6SJ95
GO GO:0005737
GO:0005634
GO:0003677
GO:0003700
GO:0006352
GO:0007275
GO:0045892
Gene3D 3.30.310.10
HAMAP MF_00408
InterPro IPR012295
IPR000814
PANTHER PTHR10126
Pfam PF00352
PRINTS PR00686
PROSITE PS00351

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005515

protein binding

PMID:19759265[1]

ECO:0000269

F

Figure 1. Tbp2-deficient females do not ovulate upon hormonal stimulation. Control and Tbp2-deficient 4-6 - wk-old females were induced for superovulation with intraperitoneal injection of PMSG followed by administration of hCG 48 h later.

complete

involved_in

GO:0070898

RNA polymerase III preinitiation complex assembly

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000013138
SGD:S000000950

P

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003687
FB:FBgn0010287
PANTHER:PTN000013136
UniProtKB:P20226
WB:WBGene00006542

F

Seeded From UniProt

complete

involved_in

GO:0006366

transcription by RNA polymerase II

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003687
FB:FBgn0261793
MGI:MGI:101838
PANTHER:PTN000013136
UniProtKB:P20226
UniProtKB:P52653
UniProtKB:Q8I440
ZFIN:ZDB-GENE-030616-563
ZFIN:ZDB-GENE-040520-2

P

Seeded From UniProt

complete

part_of

GO:0005669

transcription factor TFIID complex

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003687
PANTHER:PTN000013137
PomBase:SPAC29E6.08
RGD:67398
SGD:S000000950
UniProtKB:P20226
UniProtKB:Q8I440

C

Seeded From UniProt

complete

part_of

GO:0005667

transcription factor complex

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000189736
FB:FBgn0010287
FB:FBgn0261793
PANTHER:PTN000013136

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0261793
MGI:MGI:2684058
PANTHER:PTN000013136
RGD:67398
WB:WBGene00006542

F

Seeded From UniProt

complete

enables

GO:0001016

RNA polymerase III regulatory region DNA binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000013138
SGD:S000000950

F

Seeded From UniProt

complete

enables

GO:0000979

RNA polymerase II core promoter sequence-specific DNA binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0261793
PANTHER:PTN000013136
PomBase:SPAC29E6.08
SGD:S000000950

F

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003687
FB:FBgn0010287
MGI:MGI:101838
PANTHER:PTN000013136
UniProtKB:P62380

F

Seeded From UniProt

complete

part_of

GO:0000126

transcription factor TFIIIB complex

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003687
PANTHER:PTN000013138
SGD:S000000950
dictyBase:DDB_G0275617

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045892

negative regulation of transcription, DNA-templated

PMID:17109819[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:17109819[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q6SJ96

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:17641088[4]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:30755)
  • part_of:(CL:0000023)|part_of:(EMAPA:35628)
  • part_of:(CL:0000023)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:17109819[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q6SJ96

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:17109819[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:17109819[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6SJ96
ensembl:ENSP00000247219

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6SJ96
ensembl:ENSP00000247219

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000814
InterPro:IPR033710

F

Seeded From UniProt

complete

involved_in

GO:0006352

DNA-templated transcription, initiation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000814
InterPro:IPR033710

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Gazdag, E et al. (2009) TBP2 is essential for germ cell development by regulating transcription and chromatin condensation in the oocyte. Genes Dev. 23 2210-23 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 Tanaka, Y et al. (2007) Transcriptional repression of the mouse wee1 gene by TBP-related factor 2. Biochem. Biophys. Res. Commun. 352 21-8 PubMed GONUTS page
  4. Gazdag, E et al. (2007) Analysis of TATA-binding protein 2 (TBP2) and TBP expression suggests different roles for the two proteins in regulation of gene expression during oogenesis and early mouse development. Reproduction 134 51-62 PubMed GONUTS page