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MOUSE:SULF2

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Sulf2
Protein Name(s) Extracellular sulfatase Sulf-2

mSulf-2

External Links
UniProt Q8CFG0
EMBL AY101177
AK008108
AK028874
AK034712
AK036685
AK049170
AK081643
AK133336
AK165183
AL589873
BC027238
BC141086
CCDS CCDS17086.1
RefSeq NP_001239507.1
NP_001239508.1
NP_082348.2
XP_006500272.1
XP_006500273.1
XP_006500274.1
UniGene Mm.1011
ProteinModelPortal Q8CFG0
SMR Q8CFG0
PhosphoSite Q8CFG0
MaxQB Q8CFG0
PaxDb Q8CFG0
PRIDE Q8CFG0
Ensembl ENSMUST00000088086
ENSMUST00000109249
GeneID 72043
KEGG mmu:72043
UCSC uc008nyk.2
CTD 55959
MGI MGI:1919293
eggNOG COG3119
GeneTree ENSGT00400000022041
HOVERGEN HBG056431
InParanoid Q8CFG0
KO K14607
OMA PKYYGQG
OrthoDB EOG7FR7H6
TreeFam TF313545
ChiTaRS Sulf2
NextBio 335292
PRO PR:Q8CFG0
Proteomes UP000000589
Bgee Q8CFG0
CleanEx MM_SULF2
Genevestigator Q8CFG0
GO GO:0009986
GO:0005783
GO:0005615
GO:0005795
GO:0005886
GO:0004065
GO:0005509
GO:0008449
GO:0060348
GO:0051216
GO:0002063
GO:0048706
GO:0014846
GO:0035860
GO:0032836
GO:0003094
GO:0030201
GO:0060384
GO:0001822
GO:0040037
GO:0030177
GO:0010575
GO:0006790
Gene3D 3.40.720.10
InterPro IPR017849
IPR017850
IPR014615
IPR024609
IPR000917
IPR024607
Pfam PF12548
PF00884
PIRSF PIRSF036665
SUPFAM SSF53649
PROSITE PS00523

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0060348

bone development

17593974

ECO:0000315

P

Fig 4: Embryos deficient for both Sulf1 and Sulf2 had distinct bone development defects, such as sternabrae asymmetry/fusion. Table 1 shows that mice deficient for either Sulf1 or Sulf2 alone were viable, fertile and normal so the genes are redundant/overlap in function.

Missing: reference

GO:0008543

fibroblast growth factor receptor signaling pathway

17593974

ECO:0000315

P

Fig 5: sulfatase-deficient mouse embryonic fibroblasts were hypersensitive to both FGF1 and FGF2, demonstrating sulfatases are involved with modulation of FGF signalling.

Missing: reference

GO:0072001

renal system development

17593974

ECO:0000315

P

Fig 3: Embryos deficient for both Sulf1 and Sulf2 had kidney hypoplasia. Table 1 shows that mice deficient for either Sulf1 or Sulf2 alone were viable, fertile and normal so the genes are redundant/overlap in function.

Missing: reference

involved_in

GO:0060348

bone development

PMID:17593974[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q8K007

P

Seeded From UniProt

complete

involved_in

GO:0040037

negative regulation of fibroblast growth factor receptor signaling pathway

PMID:17593974[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q8K007

P

Seeded From UniProt

complete

involved_in

GO:0001822

kidney development

PMID:17593974[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q8K007

P

Seeded From UniProt

complete

involved_in

GO:0060384

innervation

PMID:17720696[2]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q8K007

P

Seeded From UniProt

complete

involved_in

GO:0051216

cartilage development

PMID:20479257[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048706

embryonic skeletal system development

PMID:18213582[4]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q8CFG0

P

Seeded From UniProt

complete

involved_in

GO:0040037

negative regulation of fibroblast growth factor receptor signaling pathway

PMID:21719793[5]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q8K007

P

occurs_in:(CL:0000653)

Seeded From UniProt

complete

involved_in

GO:0035860

glial cell-derived neurotrophic factor receptor signaling pathway

PMID:17720696[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032836

glomerular basement membrane development

PMID:21719793[5]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q8K007

P

Seeded From UniProt

complete

involved_in

GO:0030201

heparan sulfate proteoglycan metabolic process

PMID:18687675[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0014846

esophagus smooth muscle contraction

PMID:17720696[2]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q8K007

P

Seeded From UniProt

complete

involved_in

GO:0010575

positive regulation of vascular endothelial growth factor production

PMID:21719793[5]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q8K007

P

occurs_in:(CL:0000653)

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8IWU5

C

Seeded From UniProt

complete

enables

GO:0008449

N-acetylglucosamine-6-sulfatase activity

PMID:18687675[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21719793[5]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000653)

Seeded From UniProt

complete

enables

GO:0004065

arylsulfatase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8IWU5

F

Seeded From UniProt

complete

involved_in

GO:0003094

glomerular filtration

PMID:21719793[5]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q8K007

P

Seeded From UniProt

complete

involved_in

GO:0002063

chondrocyte development

PMID:20479257[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0040037

negative regulation of fibroblast growth factor receptor signaling pathway

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1919293
MGI:MGI:2138563
PANTHER:PTN001308943
UniProtKB:Q8IWU6

P

Seeded From UniProt

complete

involved_in

GO:0032836

glomerular basement membrane development

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1919293
MGI:MGI:2138563
PANTHER:PTN001308943

P

Seeded From UniProt

complete

involved_in

GO:0030201

heparan sulfate proteoglycan metabolic process

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1919293
MGI:MGI:2138563
PANTHER:PTN001308943
UniProtKB:Q8IWU5
UniProtKB:Q8IWU6

P

Seeded From UniProt

complete

involved_in

GO:0030177

positive regulation of Wnt signaling pathway

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1919293
PANTHER:PTN001308943
UniProtKB:Q8IWU5
UniProtKB:Q8IWU6

P

Seeded From UniProt

complete

involved_in

GO:0010575

positive regulation of vascular endothelial growth factor production

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1919293
MGI:MGI:2138563
PANTHER:PTN001308943

P

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000038172
RGD:708554
UniProtKB:Q8IWU5
UniProtKB:Q8IWU6

C

Seeded From UniProt

complete

enables

GO:0008449

N-acetylglucosamine-6-sulfatase activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1919293
MGI:MGI:2138563
PANTHER:PTN000038170
RGD:1305877
UniProtKB:Q8IWU5
UniProtKB:Q8IWU6
UniProtKB:Q9VEX0

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1919293
MGI:MGI:2138563
PANTHER:PTN000038172

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000038172
RGD:708554
UniProtKB:Q8IWU5
UniProtKB:Q8IWU6

C

Seeded From UniProt

complete

enables

GO:0005539

glycosaminoglycan binding

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000038170
RGD:1305877

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2000345

regulation of hepatocyte proliferation

PMID:23740243[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3587954

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0097421

liver regeneration

PMID:23740243[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3587954

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0090263

positive regulation of canonical Wnt signaling pathway

PMID:23740243[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3587954

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030201

heparan sulfate proteoglycan metabolic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8IWU5

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030177

positive regulation of Wnt signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8IWU5

P

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8IWU5

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009611

response to wounding

PMID:23740243[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3587954

P

Seeded From UniProt

complete

enables

GO:0008449

N-acetylglucosamine-6-sulfatase activity

PMID:12368295[9]

ECO:0000266

sequence orthology evidence used in manual assertion

EMBL:AY101176

F

Seeded From UniProt

complete

enables

GO:0008449

N-acetylglucosamine-6-sulfatase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8IWU5

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006790

sulfur compound metabolic process

PMID:12368295[9]

ECO:0000266

sequence orthology evidence used in manual assertion

EMBL:AY101176

P

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8IWU5

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:12368295[9]

ECO:0000266

sequence orthology evidence used in manual assertion

EMBL:AY101176

C

Seeded From UniProt

complete

enables

GO:0004065

arylsulfatase activity

PMID:12368295[9]

ECO:0000266

sequence orthology evidence used in manual assertion

EMBL:AY101176

F

Seeded From UniProt

complete

enables

GO:0004065

arylsulfatase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8IWU5

F

Seeded From UniProt

complete

involved_in

GO:0030201

heparan sulfate proteoglycan metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8IWU5
ensembl:ENSP00000353007

P

Seeded From UniProt

complete

involved_in

GO:0030177

positive regulation of Wnt signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8IWU5
ensembl:ENSP00000353007

P

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8IWU5
ensembl:ENSP00000353007

C

Seeded From UniProt

complete

enables

GO:0008449

N-acetylglucosamine-6-sulfatase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8IWU5
ensembl:ENSP00000353007

F

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8IWU5
ensembl:ENSP00000353007

C

Seeded From UniProt

complete

enables

GO:0004065

arylsulfatase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8IWU5
ensembl:ENSP00000353007

F

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017849
InterPro:IPR017850

F

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR014615

F

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR014615

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR014615

C

Seeded From UniProt

complete

enables

GO:0008484

sulfuric ester hydrolase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000917
InterPro:IPR014615

F

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR014615

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0256
UniProtKB-SubCell:SL-0095

C

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0333

C

Seeded From UniProt

complete

part_of

GO:0005795

Golgi stack

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0135

C

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0310

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Holst, CR et al. (2007) Secreted sulfatases Sulf1 and Sulf2 have overlapping yet essential roles in mouse neonatal survival. PLoS ONE 2 e575 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Ai, X et al. (2007) SULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling for esophageal innervation. Development 134 3327-38 PubMed GONUTS page
  3. ↑ 3.0 3.1 Otsuki, S et al. (2010) Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways. Proc. Natl. Acad. Sci. U.S.A. 107 10202-7 PubMed GONUTS page
  4. ↑ Ratzka, A et al. (2008) Redundant function of the heparan sulfate 6-O-endosulfatases Sulf1 and Sulf2 during skeletal development. Dev. Dyn. 237 339-53 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 Schumacher, VA et al. (2011) WT1-dependent sulfatase expression maintains the normal glomerular filtration barrier. J. Am. Soc. Nephrol. 22 1286-96 PubMed GONUTS page
  6. ↑ 6.0 6.1 Lamanna, WC et al. (2008) Sulf loss influences N-, 2-O-, and 6-O-sulfation of multiple heparan sulfate proteoglycans and modulates fibroblast growth factor signaling. J. Biol. Chem. 283 27724-35 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 7.7 7.8 7.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 8.3 Nakamura, I et al. (2013) Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration. J. Biol. Chem. 288 21389-98 PubMed GONUTS page
  9. ↑ 9.0 9.1 9.2 9.3 Morimoto-Tomita, M et al. (2002) Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans. J. Biol. Chem. 277 49175-85 PubMed GONUTS page
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