MOUSE:SRY

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Sry (synonyms: Tdf, Tdy)
Protein Name(s)	Sex-determining region Y protein Testis-determining factor
External Links
UniProt	Q05738
EMBL	X67204 U03645 X55491
CCDS	CCDS30545.1
PIR	S35565 S43344
RefSeq	NP_035694.1
UniGene	Mm.377114
ProteinModelPortal	Q05738
SMR	Q05738
MINT	MINT-1367342
STRING	10090.ENSMUSP00000088717
PhosphoSite	Q05738
PRIDE	Q05738
Ensembl	ENSMUST00000091178
GeneID	21674
KEGG	mmu:21674
UCSC	uc012hrv.1
CTD	6736
MGI	MGI:98660
eggNOG	NOG321816
HOVERGEN	HBG008712
InParanoid	Q05738
KO	K09266
OMA	QQFHDHH
OrthoDB	EOG7RNK18
NextBio	300962
PRO	PR:Q05738
Proteomes	UP000000589
Bgee	Q05738
CleanEx	MM_SRY
ExpressionAtlas	Q05738
Genevestigator	Q05738
GO	GO:0005737 GO:0016607 GO:0044798 GO:0005634 GO:0003677 GO:0008301 GO:0046982 GO:0000981 GO:0030154 GO:0008584 GO:0030238 GO:0010629 GO:0000122 GO:0007530 GO:0006366
Gene3D	1.10.30.10
InterPro	IPR009071
Pfam	PF00505
SMART	SM00398
SUPFAM	SSF47095
PROSITE	PS50118

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0007548	sex differentiation	PMID:7600978^[1]	ECO:0000314			P		Figure 1. A SRY transcrips in the developing male gonads and the adult testies.	complete CACAO 6502
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q05066	P		Seeded From UniProt	complete
enables	GO:0008301	DNA binding, bending	PMID:7774816^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2654070 MGI:MGI:98363 PANTHER:PTN000741613 RGD:3759	P		Seeded From UniProt	complete
part_of	GO:0044798	nuclear transcription factor complex	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103559 MGI:MGI:107543 MGI:MGI:98362 MGI:MGI:98363 MGI:MGI:98364 MGI:MGI:98366 MGI:MGI:98660 PANTHER:PTN000030384	C		Seeded From UniProt	complete
involved_in	GO:0030238	male sex determination	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98660 PANTHER:PTN001306320 RGD:3759	P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000030745 ZFIN:ZDB-GENE-980526-333	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98363 PANTHER:PTN000030384	P		Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000030745 ZFIN:ZDB-GENE-980526-333	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103559 MGI:MGI:107543 MGI:MGI:2654070 MGI:MGI:98364 PANTHER:PTN000030384 UniProtKB:P48431 UniProtKB:Q06945	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000411 FB:FBgn0005612 FB:FBgn0005613 FB:FBgn0029123 FB:FBgn0036411 MGI:MGI:103559 MGI:MGI:107543 MGI:MGI:98357 MGI:MGI:98359 MGI:MGI:98363 MGI:MGI:98364 MGI:MGI:98366 MGI:MGI:98369 MGI:MGI:98660 PANTHER:PTN000030384 RGD:1565646 RGD:3759 RGD:69351 UniProtKB:P35713 UniProtKB:P35716 UniProtKB:P48430 UniProtKB:P48431 UniProtKB:Q05066 UniProtKB:Q06945 UniProtKB:Q9BT81 UniProtKB:Q9H6I2 WB:WBGene00004771	C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103559 MGI:MGI:107543 MGI:MGI:98362 MGI:MGI:98363 MGI:MGI:98364 MGI:MGI:98366 MGI:MGI:98660 PANTHER:PTN000030384 ZFIN:ZDB-GENE-990715-6	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98363 MGI:MGI:98660 PANTHER:PTN000741613 UniProtKB:Q9W7R5	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:22344693^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0044798	nuclear transcription factor complex	PMID:22344693^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030238	male sex determination	PMID:16700629^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104723 MGI:MGI:98371	P	has_participant:(EMAPA:17383)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030238	male sex determination	PMID:15879091^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1352460	P	has_participant:(EMAPA:17972)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	PMID:11869290^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008584	male gonad development	PMID:19457926^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	results_in_development_of:(EMAPA:17972)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007530	sex determination	PMID:9486644^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1352460	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22514746^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16185683^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17381)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15469996^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:8625802^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:22344693^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:19850934^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98660	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017253	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017253	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017253	C		Seeded From UniProt	complete
involved_in	GO:0030238	male sex determination	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017253	P		Seeded From UniProt	complete
involved_in	GO:0007548	sex differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0726	P		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0112	F		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0186	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Hacker, A et al. (1995) Expression of Sry, the mouse sex determining gene. Development 121 1603-14 PubMed GONUTS page
↑ Giese, K et al. (1995) Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions. Genes Dev. 9 995-1008 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 ^3.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Ng, CK et al. (2012) Deciphering the Sox-Oct partner code by quantitative cooperativity measurements. Nucleic Acids Res. 40 4933-41 PubMed GONUTS page
↑ Kim, Y et al. (2006) Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination. PLoS Biol. 4 e187 PubMed GONUTS page
↑ Gomez, G et al. (2005) TGF-beta 1 inhibits mast cell Fc epsilon RI expression. J. Immunol. 174 5987-93 PubMed GONUTS page
↑ Nishino, K et al. (2002) Matrix metalloproteinases regulate mesonephric cell migration in developing XY gonads which correlates with the inhibition of tissue inhibitor of metalloproteinase-3 by Sry. Dev. Growth Differ. 44 35-43 PubMed GONUTS page
↑ Buaas, FW et al. (2009) The transcription co-factor CITED2 functions during sex determination and early gonad development. Hum. Mol. Genet. 18 2989-3001 PubMed GONUTS page
↑ Swain, A et al. (1998) Dax1 antagonizes Sry action in mammalian sex determination. Nature 391 761-7 PubMed GONUTS page
↑ Zerlanko, BJ et al. (2012) Premature senescence and increased TGFβ signaling in the absence of Tgif1. PLoS ONE 7 e35460 PubMed GONUTS page
↑ Wilhelm, D et al. (2005) Sertoli cell differentiation is induced both cell-autonomously and through prostaglandin signaling during mammalian sex determination. Dev. Biol. 287 111-24 PubMed GONUTS page
↑ Oh, HJ et al. (2005) Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein. Biol. Reprod. 72 407-15 PubMed GONUTS page
↑ Collignon, J et al. (1996) A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2. Development 122 509-20 PubMed GONUTS page
↑ Peng, H et al. (2009) Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery. J. Biol. Chem. 284 35670-80 PubMed GONUTS page

[PMID:7600978-1] Hacker, A et al. (1995) Expression of Sry, the mouse sex determining gene. Development 121 1603-14 PubMed GONUTS page

[PMID:7774816-2] Giese, K et al. (1995) Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions. Genes Dev. 9 995-1008 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 ^3.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22344693-4] 4.0 ^4.1 ^4.2 Ng, CK et al. (2012) Deciphering the Sox-Oct partner code by quantitative cooperativity measurements. Nucleic Acids Res. 40 4933-41 PubMed GONUTS page

[PMID:16700629-5] Kim, Y et al. (2006) Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination. PLoS Biol. 4 e187 PubMed GONUTS page

[PMID:15879091-6] Gomez, G et al. (2005) TGF-beta 1 inhibits mast cell Fc epsilon RI expression. J. Immunol. 174 5987-93 PubMed GONUTS page

[PMID:11869290-7] Nishino, K et al. (2002) Matrix metalloproteinases regulate mesonephric cell migration in developing XY gonads which correlates with the inhibition of tissue inhibitor of metalloproteinase-3 by Sry. Dev. Growth Differ. 44 35-43 PubMed GONUTS page

[PMID:19457926-8] Buaas, FW et al. (2009) The transcription co-factor CITED2 functions during sex determination and early gonad development. Hum. Mol. Genet. 18 2989-3001 PubMed GONUTS page

[PMID:9486644-9] Swain, A et al. (1998) Dax1 antagonizes Sry action in mammalian sex determination. Nature 391 761-7 PubMed GONUTS page

[PMID:22514746-10] Zerlanko, BJ et al. (2012) Premature senescence and increased TGFβ signaling in the absence of Tgif1. PLoS ONE 7 e35460 PubMed GONUTS page

[PMID:16185683-11] Wilhelm, D et al. (2005) Sertoli cell differentiation is induced both cell-autonomously and through prostaglandin signaling during mammalian sex determination. Dev. Biol. 287 111-24 PubMed GONUTS page

[PMID:15469996-12] Oh, HJ et al. (2005) Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein. Biol. Reprod. 72 407-15 PubMed GONUTS page

[PMID:8625802-13] Collignon, J et al. (1996) A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2. Development 122 509-20 PubMed GONUTS page

[PMID:19850934-14] Peng, H et al. (2009) Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery. J. Biol. Chem. 284 35670-80 PubMed GONUTS page

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MOUSE:SRY

Contents

Annotations

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References

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