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MOUSE:SOX3
Contents
Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
Gene Name(s) | Sox3 (synonyms: Sox-3) | |
Protein Name(s) | Transcription factor SOX-3 | |
External Links | ||
UniProt | P53784 | |
EMBL | X94125 AF434675 AB108674 | |
PIR | S10948 | |
UniGene | Mm.35784 | |
ProteinModelPortal | P53784 | |
SMR | P53784 | |
PhosphoSite | P53784 | |
MaxQB | P53784 | |
PaxDb | P53784 | |
PRIDE | P53784 | |
MGI | MGI:98365 | |
eggNOG | NOG321816 | |
HOGENOM | HOG000231647 | |
HOVERGEN | HBG105663 | |
InParanoid | P53784 | |
ChiTaRS | Sox3 | |
PRO | PR:P53784 | |
Proteomes | UP000000589 | |
Bgee | P53784 | |
CleanEx | MM_SOX3 | |
ExpressionAtlas | P53784 | |
Genevestigator | P53784 | |
GO | GO:0005634 GO:0003677 GO:0000979 GO:0001106 GO:0003700 GO:0060324 GO:0030900 GO:0021854 GO:0045665 GO:0000122 GO:0048666 GO:0009887 GO:0021983 GO:0007423 GO:0060009 GO:0007530 GO:0048515 | |
Gene3D | 1.10.30.10 | |
InterPro | IPR009071 IPR029550 IPR022097 | |
PANTHER | PTHR10270:SF111 | |
Pfam | PF00505 PF12336 | |
SMART | SM00398 | |
SUPFAM | SSF47095 | |
PROSITE | PS50118 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
involved_in |
GO:0060324 |
face development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060009 |
Sertoli cell development |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045665 |
negative regulation of neuron differentiation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0021983 |
pituitary gland development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0021854 |
hypothalamus development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007530 |
sex determination |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007423 |
sensory organ development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0003714 |
transcription corepressor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0000979 |
RNA polymerase II core promoter sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0044798 |
nuclear transcription factor complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:103559 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030182 |
neuron differentiation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000030745 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030154 |
cell differentiation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:98363 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007417 |
central nervous system development |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000030745 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:103559 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0000411 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:103559 |
F |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0048515 |
spermatid differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2682663 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0030900 |
forebrain development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3036671 |
P |
results_in_development_of:(EMAPA:17536) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0009887 |
animal organ morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3036671 |
P |
has_participant:(EMAPA:16725) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0007530 |
sex determination |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006357 |
regulation of transcription by RNA polymerase II |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0000981 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1903507 |
negative regulation of nucleic acid-templated transcription |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0003714 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Rizzoti, K & Lovell-Badge, R (2007) SOX3 activity during pharyngeal segmentation is required for craniofacial morphogenesis. Development 134 3437-48 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Shen, JH & Ingraham, HA (2002) Regulation of the orphan nuclear receptor steroidogenic factor 1 by Sox proteins. Mol. Endocrinol. 16 529-40 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Rizzoti, K et al. (2004) SOX3 is required during the formation of the hypothalamo-pituitary axis. Nat. Genet. 36 247-55 PubMed GONUTS page
- ↑ Sutton, E et al. (2011) Identification of SOX3 as an XX male sex reversal gene in mice and humans. J. Clin. Invest. 121 328-41 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Raverot, G et al. (2005) Sox3 expression in undifferentiated spermatogonia is required for the progression of spermatogenesis. Dev. Biol. 283 215-25 PubMed GONUTS page
- ↑ Collignon, J et al. (1996) A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2. Development 122 509-20 PubMed GONUTS page
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