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MOUSE:SOX3

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Sox3 (synonyms: Sox-3)
Protein Name(s) Transcription factor SOX-3
External Links
UniProt P53784
EMBL X94125
AF434675
AB108674
PIR S10948
UniGene Mm.35784
ProteinModelPortal P53784
SMR P53784
PhosphoSite P53784
MaxQB P53784
PaxDb P53784
PRIDE P53784
MGI MGI:98365
eggNOG NOG321816
HOGENOM HOG000231647
HOVERGEN HBG105663
InParanoid P53784
ChiTaRS Sox3
PRO PR:P53784
Proteomes UP000000589
Bgee P53784
CleanEx MM_SOX3
ExpressionAtlas P53784
Genevestigator P53784
GO GO:0005634
GO:0003677
GO:0000979
GO:0001106
GO:0003700
GO:0060324
GO:0030900
GO:0021854
GO:0045665
GO:0000122
GO:0048666
GO:0009887
GO:0021983
GO:0007423
GO:0060009
GO:0007530
GO:0048515
Gene3D 1.10.30.10
InterPro IPR009071
IPR029550
IPR022097
PANTHER PTHR10270:SF111
Pfam PF00505
PF12336
SMART SM00398
SUPFAM SSF47095
PROSITE PS50118

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0060324

face development

PMID:17728342[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060009

Sertoli cell development

PMID:11875113[2]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045665

negative regulation of neuron differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P48433

P

Seeded From UniProt

complete

involved_in

GO:0021983

pituitary gland development

PMID:14981518[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0021854

hypothalamus development

PMID:14981518[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007530

sex determination

PMID:21183788[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007423

sensory organ development

PMID:17728342[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003714

transcription corepressor activity

PMID:11875113[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000979

RNA polymerase II core promoter sequence-specific DNA binding

PMID:11875113[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0044798

nuclear transcription factor complex

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103559
MGI:MGI:107543
MGI:MGI:98362
MGI:MGI:98363
MGI:MGI:98364
MGI:MGI:98366
MGI:MGI:98660
PANTHER:PTN000030384

C

Seeded From UniProt

complete

involved_in

GO:0030182

neuron differentiation

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000030745
ZFIN:ZDB-GENE-980526-333

P

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98363
PANTHER:PTN000030384

P

Seeded From UniProt

complete

involved_in

GO:0007417

central nervous system development

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000030745
ZFIN:ZDB-GENE-980526-333

P

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103559
MGI:MGI:107543
MGI:MGI:2654070
MGI:MGI:98364
PANTHER:PTN000030384
UniProtKB:P48431
UniProtKB:Q06945

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000411
FB:FBgn0005612
FB:FBgn0005613
FB:FBgn0029123
FB:FBgn0036411
MGI:MGI:103559
MGI:MGI:107543
MGI:MGI:98357
MGI:MGI:98359
MGI:MGI:98363
MGI:MGI:98364
MGI:MGI:98366
MGI:MGI:98369
MGI:MGI:98660
PANTHER:PTN000030384
RGD:1565646
RGD:3759
RGD:69351
UniProtKB:P35713
UniProtKB:P35716
UniProtKB:P48430
UniProtKB:P48431
UniProtKB:Q05066
UniProtKB:Q06945
UniProtKB:Q9BT81
UniProtKB:Q9H6I2
WB:WBGene00004771

C

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103559
MGI:MGI:107543
MGI:MGI:98362
MGI:MGI:98363
MGI:MGI:98364
MGI:MGI:98366
MGI:MGI:98660
PANTHER:PTN000030384
ZFIN:ZDB-GENE-990715-6

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048515

spermatid differentiation

PMID:15893302[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2682663

P

  • occurs_in:(EMAPA:17972)
  • results_in_acquisition_of_features_of:(CL:0000018)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030900

forebrain development

PMID:14981518[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3036671

P

results_in_development_of:(EMAPA:17536)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009887

animal organ morphogenesis

PMID:14981518[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3036671

P

has_participant:(EMAPA:16725)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007530

sex determination

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P41225

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P41225

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:8625802[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0000981

P

Seeded From UniProt

complete

involved_in

GO:1903507

negative regulation of nucleic acid-templated transcription

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0003714

P

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR022097

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Rizzoti, K & Lovell-Badge, R (2007) SOX3 activity during pharyngeal segmentation is required for craniofacial morphogenesis. Development 134 3437-48 PubMed GONUTS page
  2. 2.0 2.1 2.2 Shen, JH & Ingraham, HA (2002) Regulation of the orphan nuclear receptor steroidogenic factor 1 by Sox proteins. Mol. Endocrinol. 16 529-40 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Rizzoti, K et al. (2004) SOX3 is required during the formation of the hypothalamo-pituitary axis. Nat. Genet. 36 247-55 PubMed GONUTS page
  4. Sutton, E et al. (2011) Identification of SOX3 as an XX male sex reversal gene in mice and humans. J. Clin. Invest. 121 328-41 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 5.5 5.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. Raverot, G et al. (2005) Sox3 expression in undifferentiated spermatogonia is required for the progression of spermatogenesis. Dev. Biol. 283 215-25 PubMed GONUTS page
  7. Collignon, J et al. (1996) A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2. Development 122 509-20 PubMed GONUTS page