MOUSE:SOX3

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Sox3 (synonyms: Sox-3)
Protein Name(s)	Transcription factor SOX-3
External Links
UniProt	P53784
EMBL	X94125 AF434675 AB108674
PIR	S10948
UniGene	Mm.35784
ProteinModelPortal	P53784
SMR	P53784
PhosphoSite	P53784
MaxQB	P53784
PaxDb	P53784
PRIDE	P53784
MGI	MGI:98365
eggNOG	NOG321816
HOGENOM	HOG000231647
HOVERGEN	HBG105663
InParanoid	P53784
ChiTaRS	Sox3
PRO	PR:P53784
Proteomes	UP000000589
Bgee	P53784
CleanEx	MM_SOX3
ExpressionAtlas	P53784
Genevestigator	P53784
GO	GO:0005634 GO:0003677 GO:0000979 GO:0001106 GO:0003700 GO:0060324 GO:0030900 GO:0021854 GO:0045665 GO:0000122 GO:0048666 GO:0009887 GO:0021983 GO:0007423 GO:0060009 GO:0007530 GO:0048515
Gene3D	1.10.30.10
InterPro	IPR009071 IPR029550 IPR022097
PANTHER	PTHR10270:SF111
Pfam	PF00505 PF12336
SMART	SM00398
SUPFAM	SSF47095
PROSITE	PS50118

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0060324	face development	PMID:17728342^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060009	Sertoli cell development	PMID:11875113^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045665	negative regulation of neuron differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48433	P		Seeded From UniProt	complete
involved_in	GO:0021983	pituitary gland development	PMID:14981518^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021854	hypothalamus development	PMID:14981518^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007530	sex determination	PMID:21183788^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007423	sensory organ development	PMID:17728342^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	PMID:11875113^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	PMID:11875113^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0044798	nuclear transcription factor complex	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103559 MGI:MGI:107543 MGI:MGI:98362 MGI:MGI:98363 MGI:MGI:98364 MGI:MGI:98366 MGI:MGI:98660 PANTHER:PTN000030384	C		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000030745 ZFIN:ZDB-GENE-980526-333	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98363 PANTHER:PTN000030384	P		Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000030745 ZFIN:ZDB-GENE-980526-333	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103559 MGI:MGI:107543 MGI:MGI:2654070 MGI:MGI:98364 PANTHER:PTN000030384 UniProtKB:P48431 UniProtKB:Q06945	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000411 FB:FBgn0005612 FB:FBgn0005613 FB:FBgn0029123 FB:FBgn0036411 MGI:MGI:103559 MGI:MGI:107543 MGI:MGI:98357 MGI:MGI:98359 MGI:MGI:98363 MGI:MGI:98364 MGI:MGI:98366 MGI:MGI:98369 MGI:MGI:98660 PANTHER:PTN000030384 RGD:1565646 RGD:3759 RGD:69351 UniProtKB:P35713 UniProtKB:P35716 UniProtKB:P48430 UniProtKB:P48431 UniProtKB:Q05066 UniProtKB:Q06945 UniProtKB:Q9BT81 UniProtKB:Q9H6I2 WB:WBGene00004771	C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103559 MGI:MGI:107543 MGI:MGI:98362 MGI:MGI:98363 MGI:MGI:98364 MGI:MGI:98366 MGI:MGI:98660 PANTHER:PTN000030384 ZFIN:ZDB-GENE-990715-6	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048515	spermatid differentiation	PMID:15893302^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2682663	P	occurs_in:(EMAPA:17972) results_in_acquisition_of_features_of:(CL:0000018)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030900	forebrain development	PMID:14981518^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3036671	P	results_in_development_of:(EMAPA:17536)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009887	animal organ morphogenesis	PMID:14981518^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3036671	P	has_participant:(EMAPA:16725)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007530	sex determination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41225	P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41225	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:8625802^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0000981	P		Seeded From UniProt	complete
involved_in	GO:1903507	negative regulation of nucleic acid-templated transcription	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003714	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR022097	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Rizzoti, K & Lovell-Badge, R (2007) SOX3 activity during pharyngeal segmentation is required for craniofacial morphogenesis. Development 134 3437-48 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Shen, JH & Ingraham, HA (2002) Regulation of the orphan nuclear receptor steroidogenic factor 1 by Sox proteins. Mol. Endocrinol. 16 529-40 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Rizzoti, K et al. (2004) SOX3 is required during the formation of the hypothalamo-pituitary axis. Nat. Genet. 36 247-55 PubMed GONUTS page
↑ Sutton, E et al. (2011) Identification of SOX3 as an XX male sex reversal gene in mice and humans. J. Clin. Invest. 121 328-41 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Raverot, G et al. (2005) Sox3 expression in undifferentiated spermatogonia is required for the progression of spermatogenesis. Dev. Biol. 283 215-25 PubMed GONUTS page
↑ Collignon, J et al. (1996) A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2. Development 122 509-20 PubMed GONUTS page

[PMID:17728342-1] 1.0 ^1.1 Rizzoti, K & Lovell-Badge, R (2007) SOX3 activity during pharyngeal segmentation is required for craniofacial morphogenesis. Development 134 3437-48 PubMed GONUTS page

[PMID:11875113-2] 2.0 ^2.1 ^2.2 Shen, JH & Ingraham, HA (2002) Regulation of the orphan nuclear receptor steroidogenic factor 1 by Sox proteins. Mol. Endocrinol. 16 529-40 PubMed GONUTS page

[PMID:14981518-3] 3.0 ^3.1 ^3.2 ^3.3 Rizzoti, K et al. (2004) SOX3 is required during the formation of the hypothalamo-pituitary axis. Nat. Genet. 36 247-55 PubMed GONUTS page

[PMID:21183788-4] Sutton, E et al. (2011) Identification of SOX3 as an XX male sex reversal gene in mice and humans. J. Clin. Invest. 121 328-41 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15893302-6] Raverot, G et al. (2005) Sox3 expression in undifferentiated spermatogonia is required for the progression of spermatogenesis. Dev. Biol. 283 215-25 PubMed GONUTS page

[PMID:8625802-7] Collignon, J et al. (1996) A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2. Development 122 509-20 PubMed GONUTS page

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MOUSE:SOX3

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