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MOUSE:SNTA1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Snta1 (synonyms: Snt1)
Protein Name(s) Alpha-1-syntrophin

59 kDa dystrophin-associated protein A1 acidic component 1 Syntrophin-1

External Links
UniProt Q61234
EMBL U00677
BC018546
PIR I84771
UniGene Mm.1541
PDB 1QAV
1Z86
1Z87
2ADZ
2PDZ
4HOP
PDBsum 1QAV
1Z86
1Z87
2ADZ
2PDZ
4HOP
ProteinModelPortal Q61234
SMR Q61234
DIP DIP-32898N
IntAct Q61234
MINT MINT-99385
PhosphoSite Q61234
MaxQB Q61234
PaxDb Q61234
PRIDE Q61234
Ensembl ENSMUST00000028991
MGI MGI:101772
eggNOG NOG318350
GeneTree ENSGT00550000074581
HOGENOM HOG000231596
HOVERGEN HBG054204
InParanoid Q61234
OMA PYDAELS
PhylomeDB Q61234
TreeFam TF317932
EvolutionaryTrace Q61234
PRO PR:Q61234
Proteomes UP000000589
Bgee Q61234
CleanEx MM_SNTA1
ExpressionAtlas Q61234
Genevestigator Q61234
GO GO:0030054
GO:0005737
GO:0005856
GO:0031594
GO:0045211
GO:0043234
GO:0042383
GO:0044325
GO:0017080
GO:1902083
GO:0007528
GO:0002027
GO:1902305
GO:0003117
GO:0060307
GO:0086005
Gene3D 2.30.42.10
InterPro IPR001478
IPR001849
IPR028552
IPR015482
PANTHER PTHR10554
PTHR10554:SF6
Pfam PF00595
SMART SM00228
SM00233
SUPFAM SSF50156
PROSITE PS50106
PS50003

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0044325

ion channel binding

PMID:18591664[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9JJV9

F

occurs_in:(UBERON:0000948)

Seeded From UniProt

complete

part_of

GO:0045202

synapse

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101771
MGI:MGI:101772
MGI:MGI:101781
PANTHER:PTN000058491
RGD:1307068

C

Seeded From UniProt

complete

part_of

GO:0042383

sarcolemma

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101772
PANTHER:PTN002576378
RGD:1307068

C

Seeded From UniProt

complete

part_of

GO:0031594

neuromuscular junction

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002576378
RGD:1307068

C

Seeded From UniProt

complete

part_of

GO:0016010

dystrophin-associated glycoprotein complex

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000830970
WB:WBGene00006062

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1902305

regulation of sodium ion transmembrane transport

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q13424

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1902083

negative regulation of peptidyl-cysteine S-nitrosylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q13424

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0086005

ventricular cardiac muscle cell action potential

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q13424

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060307

regulation of ventricular cardiac muscle cell membrane repolarization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q13424

P

Seeded From UniProt

complete

enables

GO:0051117

ATPase binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q13424

F

Seeded From UniProt

complete

enables

GO:0050998

nitric-oxide synthase binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q13424

F

Seeded From UniProt

complete

part_of

GO:0045211

postsynaptic membrane

PMID:10995443[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0044325

ion channel binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q13424

F

Seeded From UniProt

complete

part_of

GO:0042383

sarcolemma

PMID:11115849[4]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:19146)
  • part_of:(CL:0000188)

Seeded From UniProt

complete

part_of

GO:0042383

sarcolemma

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1307068

C

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

PMID:18468998[5]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q29RY0

C

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q13424

C

Seeded From UniProt

complete

part_of

GO:0031594

neuromuscular junction

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1307068

C

Seeded From UniProt

complete

enables

GO:0030165

PDZ domain binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1307068

F

Seeded From UniProt

complete

contributes_to

GO:0017080

sodium channel regulator activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q13424

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007528

neuromuscular junction development

PMID:10995443[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2179769

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0003117

regulation of vasoconstriction by circulating norepinephrine

PMID:12600881[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2179769

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002027

regulation of heart rate

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q13424

P

Seeded From UniProt

complete

enables

GO:0005198

structural molecule activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015482

F

Seeded From UniProt

complete

enables

GO:0005516

calmodulin binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0112

F

Seeded From UniProt

complete

part_of

GO:0030054

cell junction

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0965
UniProtKB-SubCell:SL-0038

C

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206
UniProtKB-SubCell:SL-0090

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003

C

Seeded From UniProt

complete

enables

GO:0003779

actin binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0009

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

part_of

GO:0042383

sarcolemma

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0238

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Ueda, K et al. (2008) Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex. Proc. Natl. Acad. Sci. U.S.A. 105 9355-60 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ 3.0 3.1 Adams, ME et al. (2000) Absence of alpha-syntrophin leads to structurally aberrant neuromuscular synapses deficient in utrophin. J. Cell Biol. 150 1385-98 PubMed GONUTS page
  4. ↑ Hagiwara, Y et al. (2000) Caveolin-3 deficiency causes muscle degeneration in mice. Hum. Mol. Genet. 9 3047-54 PubMed GONUTS page
  5. ↑ Lyssand, JS et al. (2008) Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome. J. Biol. Chem. 283 18792-800 PubMed GONUTS page
  6. ↑ Thomas, GD et al. (2003) Vasomodulation by skeletal muscle-derived nitric oxide requires alpha-syntrophin-mediated sarcolemmal localization of neuronal Nitric oxide synthase. Circ. Res. 92 554-60 PubMed GONUTS page
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