MOUSE:SMCA5

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Smarca5 (synonyms: Snf2h)
Protein Name(s)	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 Sucrose nonfermenting protein 2 homolog mSnf2h
External Links
UniProt	Q91ZW3
EMBL	AF375046 AF325921 BC021922 BC053069 AK039811 AK052320
CCDS	CCDS22442.1
RefSeq	NP_444354.2
UniGene	Mm.246803 Mm.474173
ProteinModelPortal	Q91ZW3
SMR	Q91ZW3
BioGrid	220300
DIP	DIP-36073N
IntAct	Q91ZW3
MINT	MINT-1867515
PhosphoSite	Q91ZW3
MaxQB	Q91ZW3
PaxDb	Q91ZW3
PRIDE	Q91ZW3
Ensembl	ENSMUST00000043359
GeneID	93762
KEGG	mmu:93762
UCSC	uc009mja.2
CTD	8467
MGI	MGI:1935129
eggNOG	COG0553
GeneTree	ENSGT00680000100002
HOGENOM	HOG000192862
HOVERGEN	HBG056329
InParanoid	Q91ZW3
KO	K11654
OMA	CTRFEES
OrthoDB	EOG71K625
PhylomeDB	Q91ZW3
TreeFam	TF300674
Reactome	REACT_198597 REACT_200667 REACT_214440
NextBio	351651
PRO	PR:Q91ZW3
Proteomes	UP000000589
Bgee	Q91ZW3
Genevestigator	Q91ZW3
GO	GO:0005677 GO:0000793 GO:0031010 GO:0043596 GO:0005634 GO:0016589 GO:0031213 GO:0005524 GO:0016887 GO:0003682 GO:0003677 GO:0004386 GO:0043044 GO:0006333 GO:0006338 GO:0000183 GO:0006352 GO:0006302 GO:0006334 GO:0016584 GO:0045893
Gene3D	1.10.10.60 3.40.50.300
InterPro	IPR020838 IPR014001 IPR001650 IPR009057 IPR029915 IPR015194 IPR027417 IPR001005 IPR017884 IPR015195 IPR000330
PANTHER	PTHR10799:SF575
Pfam	PF13892 PF09110 PF00271 PF09111 PF00176
SMART	SM00487 SM00490 SM00717
SUPFAM	SSF101224 SSF46689 SSF52540
PROSITE	PS51192 PS51194 PS51293

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005677	chromatin silencing complex	PMID:16085498^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000183	chromatin silencing at rDNA	PMID:16085498^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1990830	cellular response to leukemia inhibitory factor	PMID:20439489^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:16880268^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0043596	nuclear replication fork	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60264	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043044	ATP-dependent chromatin remodeling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60264	P		Seeded From UniProt	complete
contributes_to	GO:0042393	histone binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60264	F		Seeded From UniProt	complete
part_of	GO:0031213	RSF complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60264	C		Seeded From UniProt	complete
part_of	GO:0031010	ISWI-type complex	PMID:22154806^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:E9Q2Z1	C	part_of:(EMAPA:17972)	Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60264	F		Seeded From UniProt	complete
part_of	GO:0016589	NURF complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60264	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016584	nucleosome positioning	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60264	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006352	DNA-templated transcription, initiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60264	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006338	chromatin remodeling	PMID:11532953^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2151152	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006338	chromatin remodeling	PMID:11980720^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006338	chromatin remodeling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60264	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006334	nucleosome assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60264	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006333	chromatin assembly or disassembly	PMID:11980720^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16880268^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11980720^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60264	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60264	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60264	F		Seeded From UniProt	complete
part_of	GO:0001650	fibrillar center	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60264	C		Seeded From UniProt	complete
part_of	GO:0000793	condensed chromosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60264	C		Seeded From UniProt	complete
part_of	GO:0043596	nuclear replication fork	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60264 ensembl:ENSP00000283131	C		Seeded From UniProt	complete
involved_in	GO:0043044	ATP-dependent chromatin remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60264 ensembl:ENSP00000283131	P		Seeded From UniProt	complete
enables	GO:0042393	histone binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60264 ensembl:ENSP00000283131	F		Seeded From UniProt	complete
part_of	GO:0031213	RSF complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60264 ensembl:ENSP00000283131	C		Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60264 ensembl:ENSP00000283131	F		Seeded From UniProt	complete
part_of	GO:0016589	NURF complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60264 ensembl:ENSP00000283131	C		Seeded From UniProt	complete
involved_in	GO:0016584	nucleosome positioning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60264 ensembl:ENSP00000283131	P		Seeded From UniProt	complete
involved_in	GO:0006352	DNA-templated transcription, initiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60264 ensembl:ENSP00000283131	P		Seeded From UniProt	complete
involved_in	GO:0006338	chromatin remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60264 ensembl:ENSP00000283131	P		Seeded From UniProt	complete
involved_in	GO:0006334	nucleosome assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60264 ensembl:ENSP00000283131	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60264 ensembl:ENSP00000283131	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60264 ensembl:ENSP00000283131	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60264 ensembl:ENSP00000283131	F		Seeded From UniProt	complete
part_of	GO:0001650	fibrillar center	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60264 ensembl:ENSP00000283131	C		Seeded From UniProt	complete
part_of	GO:0000793	condensed chromosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60264 ensembl:ENSP00000283131	C		Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015195	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009057 InterPro:IPR020838	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000330 InterPro:IPR015195	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015195	C		Seeded From UniProt	complete
involved_in	GO:0006338	chromatin remodeling	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015195	P		Seeded From UniProt	complete
part_of	GO:0016589	NURF complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029915	C		Seeded From UniProt	complete
enables	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015195	F		Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029915	F		Seeded From UniProt	complete
enables	GO:0031491	nucleosome binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015194	F		Seeded From UniProt	complete
involved_in	GO:0043044	ATP-dependent chromatin remodeling	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015194 InterPro:IPR029915	P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-573383 Reactome:R-MMU-573376 Reactome:R-MMU-573336	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:11980720^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0004386	helicase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0347	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Zhou, Y & Grummt, I (2005) The PHD finger/bromodomain of NoRC interacts with acetylated histone H4K16 and is sufficient for rDNA silencing. Curr. Biol. 15 1434-8 PubMed GONUTS page
↑ Tarantino, C et al. (2010) miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. FASEB J. 24 3255-63 PubMed GONUTS page
↑ ^3.0 ^3.1 Torres-Padilla, ME & Zernicka-Goetz, M (2006) Role of TIF1alpha as a modulator of embryonic transcription in the mouse zygote. J. Cell Biol. 174 329-38 PubMed GONUTS page
↑ Thompson, PJ et al. (2012) CECR2 is involved in spermatogenesis and forms a complex with SNF2H in the testis. J. Mol. Biol. 415 793-806 PubMed GONUTS page
↑ Strohner, R et al. (2001) NoRC--a novel member of mammalian ISWI-containing chromatin remodeling machines. EMBO J. 20 4892-900 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Bozhenok, L et al. (2002) WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci. EMBO J. 21 2231-41 PubMed GONUTS page

[PMID:16085498-1] 1.0 ^1.1 Zhou, Y & Grummt, I (2005) The PHD finger/bromodomain of NoRC interacts with acetylated histone H4K16 and is sufficient for rDNA silencing. Curr. Biol. 15 1434-8 PubMed GONUTS page

[PMID:20439489-2] Tarantino, C et al. (2010) miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. FASEB J. 24 3255-63 PubMed GONUTS page

[PMID:16880268-3] 3.0 ^3.1 Torres-Padilla, ME & Zernicka-Goetz, M (2006) Role of TIF1alpha as a modulator of embryonic transcription in the mouse zygote. J. Cell Biol. 174 329-38 PubMed GONUTS page

[PMID:22154806-4] Thompson, PJ et al. (2012) CECR2 is involved in spermatogenesis and forms a complex with SNF2H in the testis. J. Mol. Biol. 415 793-806 PubMed GONUTS page

[PMID:11532953-5] Strohner, R et al. (2001) NoRC--a novel member of mammalian ISWI-containing chromatin remodeling machines. EMBO J. 20 4892-900 PubMed GONUTS page

[PMID:11980720-6] 6.0 ^6.1 ^6.2 ^6.3 Bozhenok, L et al. (2002) WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci. EMBO J. 21 2231-41 PubMed GONUTS page

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MOUSE:SMCA5

Contents

Annotations

Notes

References

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