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MOUSE:SIR5
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Sirt5 (synonyms: Sir2l5) | |
| Protein Name(s) | NAD-dependent protein deacylase sirtuin-5, mitochondrial (ECO:0000255 with HAMAP-Rule:MF_03160)
Regulatory protein SIR2 homolog 5 (ECO:0000255 with HAMAP-Rule:MF_03160) SIR2-like protein 5 (ECO:0000255 with HAMAP-Rule:MF_03160) | |
| External Links | ||
| UniProt | Q8K2C6 | |
| EMBL | BC031770 | |
| CCDS | CCDS26478.1 | |
| RefSeq | NP_849179.1 | |
| UniGene | Mm.35325 | |
| ProteinModelPortal | Q8K2C6 | |
| SMR | Q8K2C6 | |
| IntAct | Q8K2C6 | |
| MINT | MINT-4134742 | |
| PhosphoSite | Q8K2C6 | |
| MaxQB | Q8K2C6 | |
| PaxDb | Q8K2C6 | |
| PRIDE | Q8K2C6 | |
| Ensembl | ENSMUST00000066804 | |
| GeneID | 68346 | |
| KEGG | mmu:68346 | |
| UCSC | uc007qfz.1 | |
| CTD | 23408 | |
| MGI | MGI:1915596 | |
| eggNOG | COG0846 | |
| GeneTree | ENSGT00740000115330 | |
| HOGENOM | HOG000085950 | |
| HOVERGEN | HBG056009 | |
| InParanoid | Q8K2C6 | |
| KO | K11415 | |
| OMA | LIHMHGE | |
| OrthoDB | EOG77Q4XG | |
| PhylomeDB | Q8K2C6 | |
| TreeFam | TF106183 | |
| NextBio | 327033 | |
| PRO | PR:Q8K2C6 | |
| Proteomes | UP000000589 | |
| Bgee | Q8K2C6 | |
| ExpressionAtlas | Q8K2C6 | |
| Genevestigator | Q8K2C6 | |
| GO | GO:0005829 GO:0005758 GO:0005759 GO:0005739 GO:0005634 GO:0070403 GO:0036054 GO:0036055 GO:0008270 GO:2000378 GO:0036047 GO:0036049 GO:0006476 GO:0036048 | |
| Gene3D | 3.30.1600.10 3.40.50.1220 | |
| HAMAP | MF_01121 | |
| InterPro | IPR029035 IPR003000 IPR026591 IPR027546 IPR026590 | |
| PANTHER | PTHR11085 | |
| Pfam | PF02146 | |
| SUPFAM | SSF52467 | |
| PROSITE | PS50305 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0005743 |
mitochondrial inner membrane |
ECO:0000314 |
C |
Fig. 1 |
complete | |||||
|
involved_in |
GO:0036046 |
protein demalonylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0036055 |
protein-succinyllysine desuccinylase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0036054 |
protein-malonyllysine demalonylase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0036048 |
protein desuccinylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0061698 |
protein deglutarylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0061697 |
protein-glutaryllysine deglutarylase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0036055 |
protein-succinyllysine desuccinylase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010566 |
regulation of ketone biosynthetic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0036048 |
protein desuccinylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005743 |
mitochondrial inner membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0036055 |
protein-succinyllysine desuccinylase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0036055 |
protein-succinyllysine desuccinylase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0036055 |
protein-succinyllysine desuccinylase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0036054 |
protein-malonyllysine demalonylase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0036049 |
peptidyl-lysine desuccinylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0036049 |
peptidyl-lysine desuccinylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0036048 |
protein desuccinylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0036047 |
peptidyl-lysine demalonylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
NOT|involved_in |
GO:0006476 |
protein deacetylation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006476 |
protein deacetylation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005759 |
mitochondrial matrix |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005758 |
mitochondrial intermembrane space |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:2000378 |
negative regulation of reactive oxygen species metabolic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0070403 |
NAD+ binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0061698 |
protein deglutarylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0061697 |
protein-glutaryllysine deglutarylase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0036055 |
protein-succinyllysine desuccinylase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0036054 |
protein-malonyllysine demalonylase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0036049 |
peptidyl-lysine desuccinylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0036048 |
protein desuccinylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0036047 |
peptidyl-lysine demalonylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0036046 |
protein demalonylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0010667 |
negative regulation of cardiac muscle cell apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1303285 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005759 |
mitochondrial matrix |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005758 |
mitochondrial intermembrane space |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0061699 |
peptidyl-lysine deglutarylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0061697 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0061699 |
peptidyl-lysine deglutarylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0061697 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0061699 |
peptidyl-lysine deglutarylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0061697 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031667 |
response to nutrient levels |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q68FX9 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010667 |
negative regulation of cardiac muscle cell apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q68FX9 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:2000378 |
negative regulation of reactive oxygen species metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9NXA8 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0070403 |
NAD+ binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9NXA8 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0061698 |
protein deglutarylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9NXA8 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0061697 |
protein-glutaryllysine deglutarylase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9NXA8 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0036055 |
protein-succinyllysine desuccinylase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9NXA8 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0036054 |
protein-malonyllysine demalonylase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9NXA8 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0036049 |
peptidyl-lysine desuccinylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9NXA8 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0036048 |
protein desuccinylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9NXA8 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0036047 |
peptidyl-lysine demalonylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9NXA8 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0036046 |
protein demalonylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9NXA8 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9NXA8 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9NXA8 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005759 |
mitochondrial matrix |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9NXA8 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005758 |
mitochondrial intermembrane space |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9NXA8 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9NXA8 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:A0A024R012 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0036054 |
protein-malonyllysine demalonylase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0036055 |
protein-succinyllysine desuccinylase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0070403 |
NAD+ binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000375859 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0036054 |
protein-malonyllysine demalonylase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000375859 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0036055 |
protein-succinyllysine desuccinylase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000375859 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000375859 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0070403 |
NAD+ binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000375859 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Nakamura, Y et al. (2008) Localization of mouse mitochondrial SIRT proteins: shift of SIRT3 to nucleus by co-expression with SIRT5. Biochem. Biophys. Res. Commun. 366 174-9 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Tan, M et al. (2014) Lysine glutarylation is a protein posttranslational modification regulated by SIRT5. Cell Metab. 19 605-17 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Rardin, MJ et al. (2013) SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks. Cell Metab. 18 920-33 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Park, J et al. (2013) SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol. Cell 50 919-30 PubMed GONUTS page
- ↑ 5.0 5.1 Du, J et al. (2011) Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science 334 806-9 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Peng, C et al. (2011) The first identification of lysine malonylation substrates and its regulatory enzyme. Mol. Cell Proteomics 10 M111.012658 PubMed GONUTS page
- ↑ Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page
- ↑ Martin, J et al. (2016) Nutritional stress exacerbates hepatic steatosis induced by deletion of the histidine nucleotide-binding (Hint2) mitochondrial protein. Am. J. Physiol. Gastrointest. Liver Physiol. 310 G497-509 PubMed GONUTS page
- ↑ Lombard, DB et al. (2007) Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol. Cell. Biol. 27 8807-14 PubMed GONUTS page
g
m
n
p
- GO:0036047 ! peptidyl-lysine demalonylation
- GO:0036049 ! peptidyl-lysine desuccinylation
- GO:0061697 ! protein-glutaryllysine deglutarylase activity
- GO:0036054 ! protein-malonyllysine demalonylase activity
- GO:0036055 ! protein-succinyllysine desuccinylase activity
- GO:0006476 ! protein deacetylation
- GO:0061698 ! protein deglutarylation
- GO:0036046 ! protein demalonylation
- GO:0036048 ! protein desuccinylation
r
