MOUSE:SHAN3

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Shank3 (synonyms: Kiaa1650, Prosap2)
Protein Name(s)	SH3 and multiple ankyrin repeat domains protein 3 Shank3 Proline-rich synapse-associated protein 2 ProSAP2 SPANK-2
External Links
UniProt	Q4ACU6
EMBL	AJ245904 AB841411 AB841412 AC122401 AC137513 AB231013 AK173228 HQ405757 HQ405758 HQ405759 HQ405760 HQ405761 HQ405762 HQ405763
CCDS	CCDS27754.1
RefSeq	NP_067398.2
UniGene	Mm.146855
PDB	3O5N
PDBsum	3O5N
ProteinModelPortal	Q4ACU6
SMR	Q4ACU6
BioGrid	208407
IntAct	Q4ACU6
PhosphoSite	Q4ACU6
PaxDb	Q4ACU6
PRIDE	Q4ACU6
Ensembl	ENSMUST00000039074 ENSMUST00000066545
GeneID	58234
KEGG	mmu:58234
UCSC	uc007xha.2 uc007xhb.2
CTD	85358
MGI	MGI:1930016
eggNOG	COG0666
GeneTree	ENSGT00510000046474
HOGENOM	HOG000293276
HOVERGEN	HBG054027
InParanoid	Q4ACU6
KO	K15009
OrthoDB	EOG7GBFW2
PhylomeDB	Q4ACU6
TreeFam	TF324593
ChiTaRS	Shank3
EvolutionaryTrace	Q4ACU6
NextBio	314265
PRO	PR:Q4ACU6
Proteomes	UP000000589
Bgee	Q4ACU6
CleanEx	MM_SHANK3
ExpressionAtlas	Q4ACU6
Genevestigator	Q4ACU6
GO	GO:0030054 GO:0060170 GO:0005737 GO:0043197 GO:0060076 GO:0043005 GO:0044309 GO:0097481 GO:0005886 GO:0045211 GO:0030160 GO:0042802 GO:0035255 GO:0008022 GO:0097110 GO:0017124 GO:0008270 GO:0097113 GO:0048854 GO:0060997 GO:0001838 GO:0097117 GO:0007612 GO:0035641 GO:0000165 GO:0007613 GO:0097114 GO:0032232 GO:0045794 GO:0050885 GO:2000969 GO:0060999 GO:2000463 GO:1900451 GO:0048170 GO:0051835 GO:0051968 GO:0097107 GO:2000822 GO:0061001 GO:2000821 GO:1900452 GO:1900271 GO:0035176 GO:0021773 GO:0007416 GO:0071625
Gene3D	1.10.150.50 1.25.40.20 2.30.42.10
InterPro	IPR002110 IPR020683 IPR001478 IPR001660 IPR013761 IPR021129 IPR011511 IPR001452
Pfam	PF12796 PF00595 PF00536 PF07653
SMART	SM00248 SM00228 SM00454 SM00326
SUPFAM	SSF47769 SSF48403 SSF50044 SSF50156
PROSITE	PS50297 PS50088 PS50106 PS50105 PS50002

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0019717	synaptosome	PMID:21795692^[1]	ECO:0000315			C		Mouse hippocampal neurons, figure 1C and D, there was reduction of shank3 protein in synaptosomes in hippocampal culture.	complete CACAO 3088
	GO:0061001	regulation of dendritic spine morphogenesis	PMID:21795692^[1]	ECO:0000315			P		Figure 2C and 2D showed reduction in spinal number and width, also there was an increase in length in knockout Shank3 mouse hippocampal neurons.	complete CACAO 3089
	GO:0043406	positive regulation of MAP kinase activity	PMID:21795692^[1]	ECO:0000315			P		Figure 3A, B shows that knockout Shank3 mice impaired ERK1/2 phosphorylation in neurons.	complete CACAO 3090
	GO:0032793	positive regulation of CREB transcription factor activity	PMID:21795692^[1]	ECO:0000315			P		Figure 3A, B shows that knockout Shank3 mice impaired CREB phosphorylation in neurons.	complete CACAO 3091
	GO:2000463	positive regulation of excitatory postsynaptic membrane potential	PMID:21795692^[1]	ECO:0000315			P		Figure 5A-F, Knockdown Shank3 reduced mEPSC frequency	complete CACAO 3092
	GO:0051968	positive regulation of synaptic transmission, glutamatergic	PMID:21795692^[1]	ECO:0000315			P		Figure 5A-F, Knockdown Shank3 reduced mEPSC frequency. Figure 6A-D showed LTD mediated through mGluR5 impaired in Shank3 mutant mice.	complete CACAO 3093
	GO:0060292	long term synaptic depression	PMID:21795692^[1]	ECO:0000315			P		Figure 6A-d shows that when DHPG is used to induce LTD in mEPSC in neurons with Shank3 expression but LTD was impaired when Shank3 was knocked down.	complete CACAO 3094
	GO:0097113	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor clustering	PMID:21795692^[1]	ECO:0000315			P		Figure 6E and F, showed decrease in mutant Shank3 mice of GluR1 subunit of AMPA receptor cluster at plasma membrane of dendrites.	complete CACAO 3095
	GO:0035176	social behavior	PMID:21558424^[2]	ECO:0000315			P		Control mice showed more affiliation with novel social stimulus than mutant Shank3 mice, figure 2A and B. Also when mice given choice of interacting with social or non-social stimulus, mutant Shank3 mice failed to show social affiliation compared to control. Similar results seen in figure 2C, mutant mice did not initiate the first social interaction.	complete CACAO 3113
	GO:0071625	vocalization behavior	PMID:21558424^[2]	ECO:0000315			P		Ultrasonic vocalization investigated. Control Shank3 mice showed more vocal (figure 2G) and complex calls than mutant mice (figure 2H). Control mice showed more long duration calls than mutant Shank3 mice but the opposite was seen in mutant Shank3 where more short duration calls were made compared to wild type (figure 2I and J)	complete CACAO 3114
	GO:0050885	neuromuscular process controlling balance	PMID:21558424^[2]	ECO:0000315			P		To test motor coordination, foot misplacement test was done where there is a arena comprised of 16 parallel stainless-steel rods spaced 6 mm apart. A touch-sensor is used to record when the mouse foot slipped (losing balance) between the bars and was recorded as a foot-fault. Figure 3A showed mutant mice had more foot faults than control.	complete CACAO 3115
	GO:0040011	locomotion	PMID:21558424^[2]	ECO:0000315			P		Locomotion was decreased in mutant Shank3 mice compared to control (figure 3C)	complete CACAO 3116
	GO:0007612	learning	PMID:21558424^[2]	ECO:0000315			P		Figure 3D and E showed that control increase in latency to fall off an accelerating rotorod compared to mutant male Shank3 mice where the latency did not change indicating no learning was taking place.	complete CACAO 3117
	GO:2000821	regulation of grooming behavior	PMID:21558424^[2]	ECO:0000315			P		Shank3 mutant mice showed more self grooming behaviour compared to control, figure 3H	complete CACAO 3118
	GO:0035640	exploration behavior	PMID:21558424^[2]	ECO:0000315			P		Novel object exploration was investigated from inside and outside the nest. Shank3 control mice made contact with novel object more often from outside than inside the nest whereas mutant Shank3 mice made contact with novel object more from inside the nest than outside the nest. Indicating less exploration behaviour in mutant mice compared to control. Similar results seen in figure 3G mutant mice made same location of contact against novel object where as control mice made contact as different locations of the novel object.	complete CACAO 3119
	GO:0007613	memory	PMID:21558424^[2]	ECO:0000315			P		Morse water maze, mutant Shank3 mice showed more circular search swim patterns to the platform than control mice (supplementary material figure S4F top right). Also figure 4A right, when platform was changed, swim distance was the same for both control and mutant on day 7 but swim distance decreased after that for control but not for mutants. Figure 4A left showed that decline in swim distance over the first 3 day was less rapid in mutant Shank3 mice compared to control. Similar result seen in figure 4D, E G, H.	complete CACAO 3120
	GO:0060997	dendritic spine morphogenesis	PMID:21558424^[2]	ECO:0000315			P		Figure 5C shows mutant Shank3 mice had longer dendritic spine compared to control. Figure 5I and J showed spine density was reduced and length was increased in CA1 hippocampus in four week old mice. Similar result seen in week 10 mice (figure 5K and L)	complete CACAO 3121
	GO:0097117	guanylate kinase-associated protein clustering	PMID:21558424^[2]	ECO:0000315			P		Figure 6A and C, A decrease of PSD proteins in postsynaptic density fraction. There was a decrease in GKAP protein.	complete CACAO 3122
	GO:0097113	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor clustering	PMID:21558424^[2]	ECO:0000315			P		Figure 6B and D, A decrease of receptor subunit in synaptosome membrane fraction. There was a decrease in GluA1 subunit in mutant Shank3 mice compared to control. Similar results was seen in figure 6E, confirmed by quantitative analyses.	complete CACAO 3123
	GO:0097114	N-methyl-D-aspartate receptor clustering	PMID:21558424^[2]	ECO:0000315			P		Figure 6B and D, A decrease of receptor subunit in synaptosome membrane fraction. There was a decrease in NR2A subunit in mutant Shank3 mice compared to control.	complete CACAO 3124
	GO:0060291	long-term synaptic potentiation	PMID:21558424^[2]	ECO:0000315			P		Figure 7A, mutant Shank3 mice showed reduced hippocampal long term potentiation compared to control.	complete CACAO 3125
enables	GO:0043621	protein self-association	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9JLU4	F		Seeded From UniProt	complete
involved_in	GO:0061001	regulation of dendritic spine morphogenesis	PMID:21795692^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060291	long-term synaptic potentiation	PMID:21558424^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097114	NMDA glutamate receptor clustering	PMID:21558424^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097113	AMPA glutamate receptor clustering	PMID:21558424^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097117	guanylate kinase-associated protein clustering	PMID:21558424^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060997	dendritic spine morphogenesis	PMID:21558424^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007613	memory	PMID:21558424^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035640	exploration behavior	PMID:21558424^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000821	regulation of grooming behavior	PMID:21558424^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007612	learning	PMID:21558424^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0040011	locomotion	PMID:21558424^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050885	neuromuscular process controlling balance	PMID:21558424^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071625	vocalization behavior	PMID:21558424^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035176	social behavior	PMID:21558424^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097113	AMPA glutamate receptor clustering	PMID:21795692^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060292	long-term synaptic depression	PMID:21795692^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051968	positive regulation of synaptic transmission, glutamatergic	PMID:21795692^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	PMID:21795692^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900273	positive regulation of long-term synaptic potentiation	PMID:21167025^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000969	positive regulation of AMPA receptor activity	PMID:21423165^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000822	regulation of behavioral fear response	PMID:21423165^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000821	regulation of grooming behavior	PMID:21558424^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000821	regulation of grooming behavior	PMID:21423165^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	PMID:21795692^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	PMID:21423165^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	PMID:21167025^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900452	regulation of long-term synaptic depression	PMID:21795692^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:1900451	positive regulation of glutamate receptor signaling pathway	PMID:21795692^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:1900271	regulation of long-term synaptic potentiation	PMID:21558424^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9JLU4	C		Seeded From UniProt	complete
involved_in	GO:0097117	guanylate kinase-associated protein clustering	PMID:21558424^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097114	NMDA glutamate receptor clustering	PMID:21558424^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097113	AMPA glutamate receptor clustering	PMID:21558424^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097113	AMPA glutamate receptor clustering	PMID:21795692^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	PMID:16606358^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q62108	F		Seeded From UniProt	complete
involved_in	GO:0097107	postsynaptic density assembly	PMID:21423165^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071625	vocalization behavior	PMID:21558424^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071625	vocalization behavior	PMID:21167025^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061001	regulation of dendritic spine morphogenesis	PMID:21795692^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0060999	positive regulation of dendritic spine development	PMID:21795692^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0060997	dendritic spine morphogenesis	PMID:21558424^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060997	dendritic spine morphogenesis	PMID:21423165^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060997	dendritic spine morphogenesis	PMID:21167025^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0060170	ciliary membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9JLU4	C		Seeded From UniProt	complete
part_of	GO:0060076	excitatory synapse	PMID:21423165^[4]	ECO:0000305	curator inference used in manual assertion	GO:0051968	C		Seeded From UniProt	complete
involved_in	GO:0051968	positive regulation of synaptic transmission, glutamatergic	PMID:21795692^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0051968	positive regulation of synaptic transmission, glutamatergic	PMID:21423165^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051968	positive regulation of synaptic transmission, glutamatergic	PMID:21167025^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051835	positive regulation of synapse structural plasticity	PMID:21167025^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050885	neuromuscular process controlling balance	PMID:21558424^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048854	brain morphogenesis	PMID:21423165^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048170	positive regulation of long-term neuronal synaptic plasticity	PMID:21167025^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045794	negative regulation of cell volume	PMID:21423165^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002319) occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
part_of	GO:0044309	neuron spine	PMID:16606358^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21795692^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0035641	locomotory exploration behavior	PMID:21558424^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035641	locomotory exploration behavior	PMID:21423165^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035255	ionotropic glutamate receptor binding	PMID:15207857^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q61625	F		Seeded From UniProt	complete
enables	GO:0035255	ionotropic glutamate receptor binding	PMID:16606358^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P23818	F		Seeded From UniProt	complete
involved_in	GO:0035176	social behavior	PMID:21558424^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035176	social behavior	PMID:21423165^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035176	social behavior	PMID:21167025^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030160	GKAP/Homer scaffold activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9JLU4	F		Seeded From UniProt	complete
involved_in	GO:0021773	striatal medium spiny neuron differentiation	PMID:21423165^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9JLU4	F		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9JLU4	F		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:16606358^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P23818	F		Seeded From UniProt	complete
involved_in	GO:0007613	memory	PMID:21558424^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007612	learning	PMID:21558424^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007416	synapse assembly	PMID:21423165^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	PMID:16606358^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(GO:0044309) part_of:(CL:0010012)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:27161151^[7]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(UBERON:0000061) part_of:(UBERON:0002435)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:27161151^[7]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0000061) part_of:(UBERON:0002435)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:27161151^[7]	ECO:0001225	knockout evidence used in manual assertion		C	part_of:(UBERON:0000061) part_of:(UBERON:0002435)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:27161151^[7]	ECO:0000279	western blot evidence used in manual assertion		C	part_of:(UBERON:0000061) part_of:(UBERON:0002435)	Seeded From UniProt	complete
enables	GO:0098919	structural constituent of postsynaptic density	PMID:27161151^[7]	ECO:0006042	cell fractionation evidence used in manual assertion		F	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002435)	Seeded From UniProt	complete
enables	GO:0098919	structural constituent of postsynaptic density	PMID:27161151^[7]	ECO:0005589	confocal microscopy evidence used in manual assertion		F	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002435)	Seeded From UniProt	complete
enables	GO:0098919	structural constituent of postsynaptic density	PMID:27161151^[7]	ECO:0001225	knockout evidence used in manual assertion		F	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002435)	Seeded From UniProt	complete
enables	GO:0098919	structural constituent of postsynaptic density	PMID:27161151^[7]	ECO:0000279	western blot evidence used in manual assertion		F	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002435)	Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1930016 MGI:MGI:3613677 PANTHER:PTN001191880	P		Seeded From UniProt	complete
involved_in	GO:2000311	regulation of AMPA receptor activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:3613677 PANTHER:PTN001191880	P		Seeded From UniProt	complete
involved_in	GO:0097107	postsynaptic density assembly	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1930016 PANTHER:PTN001191880	P		Seeded From UniProt	complete
involved_in	GO:0060999	positive regulation of dendritic spine development	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1930016 PANTHER:PTN001191880 RGD:621011	P		Seeded From UniProt	complete
involved_in	GO:0060997	dendritic spine morphogenesis	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1930016 MGI:MGI:3613677 PANTHER:PTN001191880	P		Seeded From UniProt	complete
involved_in	GO:0060291	long-term synaptic potentiation	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1930016 MGI:MGI:2671987 PANTHER:PTN001191880	P		Seeded From UniProt	complete
involved_in	GO:0051968	positive regulation of synaptic transmission, glutamatergic	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1930016 MGI:MGI:2671987 PANTHER:PTN001191880	P		Seeded From UniProt	complete
involved_in	GO:0051124	synaptic growth at neuromuscular junction	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0040752 PANTHER:PTN001191880	P		Seeded From UniProt	complete
involved_in	GO:0048854	brain morphogenesis	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1930016 PANTHER:PTN001191880 ZFIN:ZDB-GENE-060503-369	P		Seeded From UniProt	complete
colocalizes_with	GO:0045211	postsynaptic membrane	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2671987 MGI:MGI:3613677 PANTHER:PTN001191880 RGD:621011	C		Seeded From UniProt	complete
part_of	GO:0044309	neuron spine	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1930016 PANTHER:PTN001191880	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2671987 MGI:MGI:3613677 PANTHER:PTN001191880 RGD:621011	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1930016 MGI:MGI:2671987 MGI:MGI:3613677 PANTHER:PTN001191880	C		Seeded From UniProt	complete
enables	GO:0035255	ionotropic glutamate receptor binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1930016 MGI:MGI:2671987 MGI:MGI:3613677 PANTHER:PTN001191878 RGD:621011	F		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:3613677 PANTHER:PTN001191880	C		Seeded From UniProt	complete
enables	GO:0030160	GKAP/Homer scaffold activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:3613677 PANTHER:PTN001191878 RGD:621011 RGD:69264	F		Seeded From UniProt	complete
enables	GO:0030159	receptor signaling complex adaptor activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001191878 RGD:621011	F		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0040752 MGI:MGI:3613677 PANTHER:PTN001191880 RGD:628772 RGD:69264	C		Seeded From UniProt	complete
colocalizes_with	GO:0008328	ionotropic glutamate receptor complex	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2671987 MGI:MGI:3613677 PANTHER:PTN001191878	C		Seeded From UniProt	complete
involved_in	GO:0007416	synapse assembly	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1930016 MGI:MGI:2671987 PANTHER:PTN001191880	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904717	regulation of AMPA glutamate receptor clustering	PMID:21558424^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5056336	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900451	positive regulation of glutamate receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69264	P		Seeded From UniProt	complete
part_of	GO:0099092	postsynaptic density, intracellular component	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69264	C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69264	C		Seeded From UniProt	complete
enables	GO:0098919	structural constituent of postsynaptic density	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69264	F		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69264	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071625	vocalization behavior	PMID:21558424^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5056336	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071625	vocalization behavior	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BYB0	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060997	dendritic spine morphogenesis	PMID:21558424^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5056336	P		Seeded From UniProt	complete
part_of	GO:0060170	ciliary membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69264	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051259	protein complex oligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69264	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050807	regulation of synapse organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69264	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048167	regulation of synaptic plasticity	PMID:21558424^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5056336	P	occurs_in:(EMAPA:32768) occurs_in:(GO:1990021)	Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69264	C		Seeded From UniProt	complete
enables	GO:0043621	protein self-association	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69264	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69264	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042297	vocal learning	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BYB0	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035176	social behavior	PMID:21558424^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5056336	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035176	social behavior	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BYB0	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032232	negative regulation of actin filament bundle assembly	PMID:19208628^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030534	adult behavior	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BYB0	P		Seeded From UniProt	complete
enables	GO:0030160	GKAP/Homer scaffold activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69264	F		Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69264	F		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69264	C		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69264	F		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69264	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007626	locomotory behavior	PMID:21558424^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5056336	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007612	learning	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BYB0	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007611	learning or memory	PMID:21558424^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5056336	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001838	embryonic epithelial tube formation	PMID:15569713^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97902	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000165	MAPK cascade	PMID:15569713^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95805 MGI:MGI:97902	P		Seeded From UniProt	complete
involved_in	GO:0099562	maintenance of postsynaptic density structure	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0098919	P		Seeded From UniProt	complete
involved_in	GO:0099562	maintenance of postsynaptic density structure	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0098919	P		Seeded From UniProt	complete
involved_in	GO:0099562	maintenance of postsynaptic density structure	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0098919	P		Seeded From UniProt	complete
involved_in	GO:0099562	maintenance of postsynaptic density structure	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0098919	P		Seeded From UniProt	complete
involved_in	GO:0099562	maintenance of postsynaptic density structure	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0098919	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:26627310^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0009	F		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770 UniProtKB-SubCell:SL-0258	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0297	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0284	C		Seeded From UniProt	complete
part_of	GO:0120038	plasma membrane bounded cell projection part	PMID:26627310^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0017146	NMDA selective glutamate receptor complex	PMID:26627310^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 ^1.17 ^1.18 ^1.19 ^1.20 Verpelli, C et al. (2011) Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses. J. Biol. Chem. 286 34839-50 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 ^2.15 ^2.16 ^2.17 ^2.18 ^2.19 ^2.20 ^2.21 ^2.22 ^2.23 ^2.24 ^2.25 ^2.26 ^2.27 ^2.28 ^2.29 ^2.30 ^2.31 ^2.32 ^2.33 ^2.34 ^2.35 ^2.36 ^2.37 ^2.38 ^2.39 ^2.40 ^2.41 ^2.42 ^2.43 ^2.44 Wang, X et al. (2011) Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3. Hum. Mol. Genet. 20 3093-108 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Bozdagi, O et al. (2010) Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication. Mol Autism 1 15 PubMed GONUTS page
↑ ^4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 Peça, J et al. (2011) Shank3 mutant mice display autistic-like behaviours and striatal dysfunction. Nature 472 437-42 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Uchino, S et al. (2006) Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor. J. Neurochem. 97 1203-14 PubMed GONUTS page
↑ Uemura, T et al. (2004) Direct interaction of GluRdelta2 with Shank scaffold proteins in cerebellar Purkinje cells. Mol. Cell. Neurosci. 26 330-41 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Wang, X et al. (2016) Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism. Nat Commun 7 11459 PubMed GONUTS page
↑ ^8.00 ^8.01 ^8.02 ^8.03 ^8.04 ^8.05 ^8.06 ^8.07 ^8.08 ^8.09 ^8.10 ^8.11 ^8.12 ^8.13 ^8.14 ^8.15 ^8.16 ^8.17 ^8.18 ^8.19 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Sawallisch, C et al. (2009) The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity. J. Biol. Chem. 284 9225-36 PubMed GONUTS page
↑ ^10.0 ^10.1 Schuetz, G et al. (2004) The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells. J. Cell Biol. 167 945-52 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Berg, JM et al. (2015) JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse. Neuron 88 1173-1191 PubMed GONUTS page

[PMID:21795692-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 ^1.17 ^1.18 ^1.19 ^1.20 Verpelli, C et al. (2011) Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses. J. Biol. Chem. 286 34839-50 PubMed GONUTS page

[PMID:21558424-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 ^2.15 ^2.16 ^2.17 ^2.18 ^2.19 ^2.20 ^2.21 ^2.22 ^2.23 ^2.24 ^2.25 ^2.26 ^2.27 ^2.28 ^2.29 ^2.30 ^2.31 ^2.32 ^2.33 ^2.34 ^2.35 ^2.36 ^2.37 ^2.38 ^2.39 ^2.40 ^2.41 ^2.42 ^2.43 ^2.44 Wang, X et al. (2011) Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3. Hum. Mol. Genet. 20 3093-108 PubMed GONUTS page

[PMID:21167025-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Bozdagi, O et al. (2010) Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication. Mol Autism 1 15 PubMed GONUTS page

[PMID:21423165-4] 4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 Peça, J et al. (2011) Shank3 mutant mice display autistic-like behaviours and striatal dysfunction. Nature 472 437-42 PubMed GONUTS page

[PMID:16606358-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Uchino, S et al. (2006) Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor. J. Neurochem. 97 1203-14 PubMed GONUTS page

[PMID:15207857-6] Uemura, T et al. (2004) Direct interaction of GluRdelta2 with Shank scaffold proteins in cerebellar Purkinje cells. Mol. Cell. Neurosci. 26 330-41 PubMed GONUTS page

[PMID:27161151-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Wang, X et al. (2016) Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism. Nat Commun 7 11459 PubMed GONUTS page

[PMID:21873635-8] 8.00 ^8.01 ^8.02 ^8.03 ^8.04 ^8.05 ^8.06 ^8.07 ^8.08 ^8.09 ^8.10 ^8.11 ^8.12 ^8.13 ^8.14 ^8.15 ^8.16 ^8.17 ^8.18 ^8.19 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19208628-9] Sawallisch, C et al. (2009) The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity. J. Biol. Chem. 284 9225-36 PubMed GONUTS page

[PMID:15569713-10] 10.0 ^10.1 Schuetz, G et al. (2004) The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells. J. Cell Biol. 167 945-52 PubMed GONUTS page

[PMID:26627310-11] 11.0 ^11.1 ^11.2 Berg, JM et al. (2015) JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse. Neuron 88 1173-1191 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

MOUSE:SHAN3

Contents

Annotations

Notes

References

a

b

c

d

e

g

i

l

m

n

o

p

r

s

v

z

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools