MOUSE:SDC4

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Sdc4
Protein Name(s)	Syndecan-4 SYND4 Ryudocan core protein
External Links
UniProt	O35988
EMBL	D89571 D89572 BC005679
CCDS	CCDS17036.1
PIR	JC5613
RefSeq	NP_035651.1
UniGene	Mm.3815
ProteinModelPortal	O35988
SMR	O35988
STRING	10090.ENSMUSP00000017153
ChEMBL	CHEMBL2062355
PhosphoSite	O35988
MaxQB	O35988
PaxDb	O35988
PRIDE	O35988
Ensembl	ENSMUST00000017153
GeneID	20971
KEGG	mmu:20971
UCSC	uc008nuq.1
CTD	6385
MGI	MGI:1349164
eggNOG	NOG83582
HOGENOM	HOG000263414
HOVERGEN	HBG004501
InParanoid	O35988
KO	K16338
OMA	NHIPERA
OrthoDB	EOG7RV9HS
PhylomeDB	O35988
TreeFam	TF320463
Reactome	REACT_196489 REACT_196644 REACT_198569 REACT_198654 REACT_198967 REACT_268952 REACT_269282 REACT_270174 REACT_271374
ChiTaRS	Sdc4
NextBio	299938
PMAP-CutDB	O35988
PRO	PR:O35988
Proteomes	UP000000589
Bgee	O35988
CleanEx	MM_SDC4
ExpressionAtlas	O35988
Genevestigator	O35988
GO	GO:0009986 GO:0043034 GO:0070062 GO:0005925 GO:0005796 GO:0016021 GO:0045121 GO:0070053 GO:0051894 GO:0045860 GO:0051496 GO:0001657
InterPro	IPR003585 IPR001050 IPR027789
PANTHER	PTHR10915
Pfam	PF01034
SMART	SM00294
PROSITE	PS00964

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0010762	regulation of fibroblast migration	PMID:25074804^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000099415 ZFIN:ZDB-GENE-061111-1	P	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1349162 MGI:MGI:1349164 PANTHER:PTN000099415 RGD:3650 UniProtKB:P18827 WB:WBGene00004749	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903553	positive regulation of extracellular exosome assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P31431	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903543	positive regulation of exosomal secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P31431	P	Seeded From UniProt	complete
enables	GO:0070053	thrombospondin receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P31431	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060122	inner ear receptor cell stereocilium organization	PMID:23760952^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2135272	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051894	positive regulation of focal adhesion assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3650	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051496	positive regulation of stress fiber assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3650	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045860	positive regulation of protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3650	P	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3650	C	Seeded From UniProt	complete
part_of	GO:0043034	costamere	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3650	C	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P31431	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3650	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042130	negative regulation of T cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P31431	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042060	wound healing	PMID:23760952^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2135272	P	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:15381701^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3650	C	Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3650	C	Seeded From UniProt	complete
enables	GO:0005080	protein kinase C binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3650	F	Seeded From UniProt	complete
enables	GO:0001968	fibronectin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3650	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001843	neural tube closure	PMID:23760952^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2135272	P	Seeded From UniProt	complete
involved_in	GO:1903553	positive regulation of extracellular exosome assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31431 ensembl:ENSP00000361818	P	Seeded From UniProt	complete
involved_in	GO:1903543	positive regulation of exosomal secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31431 ensembl:ENSP00000361818	P	Seeded From UniProt	complete
enables	GO:0070053	thrombospondin receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31431 ensembl:ENSP00000361818	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31431 ensembl:ENSP00000361818	F	Seeded From UniProt	complete
involved_in	GO:0042130	negative regulation of T cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31431 ensembl:ENSP00000361818	P	Seeded From UniProt	complete
involved_in	GO:0051894	positive regulation of focal adhesion assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34901 ensembl:ENSRNOP00000019386	P	Seeded From UniProt	complete
involved_in	GO:0051496	positive regulation of stress fiber assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34901 ensembl:ENSRNOP00000019386	P	Seeded From UniProt	complete
involved_in	GO:0045860	positive regulation of protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34901 ensembl:ENSRNOP00000019386	P	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34901 ensembl:ENSRNOP00000019386	C	Seeded From UniProt	complete
part_of	GO:0043034	costamere	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34901 ensembl:ENSRNOP00000019386	C	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34901 ensembl:ENSRNOP00000019386	F	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34901 ensembl:ENSRNOP00000019386	C	Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34901 ensembl:ENSRNOP00000019386	C	Seeded From UniProt	complete
enables	GO:0005080	protein kinase C binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34901 ensembl:ENSRNOP00000019386	F	Seeded From UniProt	complete
enables	GO:0001968	fibronectin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34901 ensembl:ENSRNOP00000019386	F	Seeded From UniProt	complete
involved_in	GO:0001657	ureteric bud development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34901 ensembl:ENSRNOP00000019386	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001050	C	Seeded From UniProt	complete
part_of	GO:0005796	Golgi lumen	Reactome:R-MMU-2024090	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Williamson, RC et al. (2014) Coronin-1C and RCC2 guide mesenchymal migration by trafficking Rac1 and controlling GEF exposure. J. Cell. Sci. 127 4292-307 PubMed GONUTS page
↑ ^2.0 ^2.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Escobedo, N et al. (2013) Syndecan 4 interacts genetically with Vangl2 to regulate neural tube closure and planar cell polarity. Development 140 3008-17 PubMed GONUTS page
↑ Jasuja, R et al. (2004) Cell-surface heparan sulfate proteoglycans potentiate chordin antagonism of bone morphogenetic protein signaling and are necessary for cellular uptake of chordin. J. Biol. Chem. 279 51289-97 PubMed GONUTS page

[PMID:25074804-1] Williamson, RC et al. (2014) Coronin-1C and RCC2 guide mesenchymal migration by trafficking Rac1 and controlling GEF exposure. J. Cell. Sci. 127 4292-307 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23760952-3] 3.0 ^3.1 ^3.2 Escobedo, N et al. (2013) Syndecan 4 interacts genetically with Vangl2 to regulate neural tube closure and planar cell polarity. Development 140 3008-17 PubMed GONUTS page

[PMID:15381701-4] Jasuja, R et al. (2004) Cell-surface heparan sulfate proteoglycans potentiate chordin antagonism of bone morphogenetic protein signaling and are necessary for cellular uptake of chordin. J. Biol. Chem. 279 51289-97 PubMed GONUTS page

[1]

[2]

[3]

[4]

MOUSE:SDC4

Contents

Annotations

Notes

References

c

e

f

g

i

m

n

p

r

s

t

u

v

w

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools