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MOUSE:SCTR

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Sctr
Protein Name(s) Secretin receptor

SCT-R

External Links
UniProt Q5FWI2
EMBL BC089355
AY255623
RefSeq NP_001012322.2
XP_006529750.1
UniGene Mm.189223
ProteinModelPortal Q5FWI2
SMR Q5FWI2
STRING 10090.ENSMUSP00000072660
GuidetoPHARMACOLOGY 252
PRIDE Q5FWI2
Ensembl ENSMUST00000189037
GeneID 319229
KEGG mmu:319229
UCSC uc007cjb.1
CTD 6344
MGI MGI:2441720
eggNOG NOG244152
GeneTree ENSGT00760000118800
HOGENOM HOG000008249
HOVERGEN HBG008318
InParanoid Q5FWI2
KO K04588
PhylomeDB Q5FWI2
Reactome REACT_231304
REACT_242871
NextBio 394424
PRO PR:Q5FWI2
Proteomes UP000000589
Bgee Q5FWI2
CleanEx MM_SCTR
ExpressionAtlas Q5FWI2
Genevestigator Q5FWI2
GO GO:0005881
GO:0016021
GO:0005886
GO:0004930
InterPro IPR017981
IPR001879
IPR000832
IPR017983
IPR002144
PANTHER PTHR12011:SF29
Pfam PF00002
PF02793
PRINTS PR00249
PR00490
SMART SM00008
PROSITE PS00649
PS50227
PS50261

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0043950

positive regulation of cAMP-mediated signaling

PMID:30449620[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0015055

secretin receptor activity

PMID:30449620[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0050996

positive regulation of lipid catabolic process

PMID:30449620[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032098

regulation of appetite

PMID:30449620[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031667

response to nutrient levels

PMID:30449620[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002024

diet induced thermogenesis

PMID:30449620[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048167

regulation of synaptic plasticity

PMID:17008357[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050996

positive regulation of lipid catabolic process

PMID:24273196[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032098

regulation of appetite

PMID:20927047[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070295

renal water absorption

PMID:17283064[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009992

cellular water homeostasis

PMID:17283064[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005881

cytoplasmic microtubule

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P47872

C

Seeded From UniProt

complete

enables

GO:0017046

peptide hormone binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95710
PANTHER:PTN000244369
RGD:2669
RGD:2689
RGD:2703
RGD:3442
UniProtKB:P32241
UniProtKB:P47872
UniProtKB:Q02643
UniProtKB:Q03431
ZFIN:ZDB-GENE-991123-8

F

Seeded From UniProt

complete

enables

GO:0015055

secretin receptor activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000244557
RGD:621342
UniProtKB:P47872

F

Seeded From UniProt

complete

enables

GO:0008528

G protein-coupled peptide receptor activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000244369
RGD:2703

F

Seeded From UniProt

complete

involved_in

GO:0007420

brain development

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000244557
RGD:621342

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043950

positive regulation of cAMP-mediated signaling

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:621342

P

Seeded From UniProt

complete

enables

GO:0042277

peptide binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:621342

F

Seeded From UniProt

complete

enables

GO:0017046

peptide hormone binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P47872

F

Seeded From UniProt

complete

enables

GO:0015055

secretin receptor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P47872

F

Seeded From UniProt

complete

enables

GO:0015055

secretin receptor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:621342

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P47872

P

Seeded From UniProt

complete

part_of

GO:0005881

cytoplasmic microtubule

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P47872

C

Seeded From UniProt

complete

enables

GO:0004888

transmembrane signaling receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017981

F

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000832
InterPro:IPR001879
InterPro:IPR002144
InterPro:IPR017983
InterPro:IPR036445

F

Seeded From UniProt

complete

involved_in

GO:0007166

cell surface receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017981

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000832
InterPro:IPR017983

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001879
InterPro:IPR002144
InterPro:IPR036445

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000832
InterPro:IPR017981

C

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0807

P

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Li, Y et al. (2018) Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation. Cell 175 1561-1574.e12 PubMed GONUTS page
  2. ↑ Nishijima, I et al. (2006) Secretin receptor-deficient mice exhibit impaired synaptic plasticity and social behavior. Hum. Mol. Genet. 15 3241-50 PubMed GONUTS page
  3. ↑ Sekar, R & Chow, BK (2014) Lipolytic actions of secretin in mouse adipocytes. J. Lipid Res. 55 190-200 PubMed GONUTS page
  4. ↑ Cheng, CY et al. (2011) Central and peripheral administration of secretin inhibits food intake in mice through the activation of the melanocortin system. Neuropsychopharmacology 36 459-71 PubMed GONUTS page
  5. ↑ 5.0 5.1 Chu, JY et al. (2007) Phenotypes developed in secretin receptor-null mice indicated a role for secretin in regulating renal water reabsorption. Mol. Cell. Biol. 27 2499-511 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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