MOUSE:RYR3

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ryr3
Protein Name(s)	Ryanodine receptor 3 RYR-3 RyR3 Brain ryanodine receptor-calcium release channel Brain-type ryanodine receptor Type 3 ryanodine receptor
External Links
UniProt	A2AGL3
EMBL	AL929348 AL672250 AL691423 AL732316 BX649564 AL691423 AL672250 AL732316 BX649564 AL732316 AL672250 AL691423 BX649564 BX649564 AL672250 AL691423 AL732316 D84237 AF111166 AK132464 X83934 U23756 D38218
PIR	I48743 S56107
UniGene	Mm.436657
ProteinModelPortal	A2AGL3
SMR	A2AGL3
ChEMBL	CHEMBL2365
MaxQB	A2AGL3
PaxDb	A2AGL3
PRIDE	A2AGL3
Ensembl	ENSMUST00000080673
MGI	MGI:99684
eggNOG	NOG247670
GeneTree	ENSGT00760000119152
HOGENOM	HOG000231428
HOVERGEN	HBG006699
InParanoid	A2AGL3
OrthoDB	EOG71K622
PhylomeDB	A2AGL3
Reactome	REACT_196640
ChiTaRS	Ryr3
PRO	PR:A2AGL3
Proteomes	UP000000589
Bgee	A2AGL3
ExpressionAtlas	A2AGL3
Genevestigator	A2AGL3
GO	GO:0016021 GO:0030314 GO:0033017 GO:0005509 GO:0005219 GO:0070588 GO:0006874 GO:0071318 GO:0071313 GO:0071277 GO:0071286 GO:0051289 GO:0006941
Gene3D	1.10.238.10 1.25.10.30
InterPro	IPR001870 IPR013320 IPR011992 IPR002048 IPR014821 IPR005821 IPR016093 IPR013662 IPR000699 IPR013333 IPR003032 IPR015925 IPR009460 IPR003877
PANTHER	PTHR13715
Pfam	PF08709 PF00520 PF02815 PF08454 PF06459 PF01365 PF02026 PF00622
PRINTS	PR00795
SMART	SM00472 SM00449
SUPFAM	SSF100909 SSF49899 SSF82109
PROSITE	PS50188 PS50919

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0071318	cellular response to ATP	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9TS33	P		Seeded From UniProt	complete
involved_in	GO:0071313	cellular response to caffeine	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9TS33	P		Seeded From UniProt	complete
involved_in	GO:0071286	cellular response to magnesium ion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9TS33	P		Seeded From UniProt	complete
involved_in	GO:0071277	cellular response to calcium ion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9TS33	P		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9TS33	P		Seeded From UniProt	complete
involved_in	GO:0051289	protein homotetramerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9TS33	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9TS33	C		Seeded From UniProt	complete
enables	GO:0005219	ryanodine-sensitive calcium-release channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9TS33	F		Seeded From UniProt	complete
involved_in	GO:0051209	release of sequestered calcium ion into cytosol	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010051 MGI:MGI:96623 MGI:MGI:99659 PANTHER:PTN001416417 RGD:1586637 RGD:2933 RGD:69649 UniProtKB:P21817 UniProtKB:Q92736	P		Seeded From UniProt	complete
enables	GO:0048763	calcium-induced calcium release activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000346461 RGD:620314 RGD:68952 UniProtKB:P21817 UniProtKB:Q92736	F		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000346461 RGD:1586637 RGD:620314	C		Seeded From UniProt	complete
part_of	GO:0034704	calcium channel complex	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99685 PANTHER:PTN000346461 UniProtKB:Q92736	C		Seeded From UniProt	complete
part_of	GO:0033017	sarcoplasmic reticulum membrane	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99659 MGI:MGI:99684 MGI:MGI:99685 PANTHER:PTN000346461 RGD:1586637 RGD:620314 UniProtKB:P21817	C		Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000346459 dictyBase:DDB_G0292564	C		Seeded From UniProt	complete
part_of	GO:0030018	Z disc	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99685 PANTHER:PTN000346461 RGD:620314 UniProtKB:Q92736	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001416417 RGD:2933 RGD:620314 UniProtKB:P21817 UniProtKB:Q14571 UniProtKB:Q14573	C		Seeded From UniProt	complete
part_of	GO:0005790	smooth endoplasmic reticulum	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99659 MGI:MGI:99685 PANTHER:PTN000346461	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001416417 RGD:2934 RGD:69649	F		Seeded From UniProt	complete
enables	GO:0005219	ryanodine-sensitive calcium-release channel activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99659 MGI:MGI:99685 PANTHER:PTN000346461 RGD:1586637 RGD:620314 RGD:68952 UniProtKB:P21817 UniProtKB:Q92736 ZFIN:ZDB-GENE-070705-417	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051481	negative regulation of cytosolic calcium ion concentration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68952	P		Seeded From UniProt	complete
enables	GO:0048763	calcium-induced calcium release activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68952	F		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68952	C		Seeded From UniProt	complete
part_of	GO:0033017	sarcoplasmic reticulum membrane	PMID:14592808^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030314	junctional membrane complex	PMID:10444070^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:19318) part_of:(CL:0000188)\|part_of:(EMAPA:19144) part_of:(CL:0000188)\|part_of:(EMAPA:17701) part_of:(CL:0000188)	Seeded From UniProt	complete
enables	GO:0015278	calcium-release channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15413	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006941	striated muscle contraction	PMID:9384575^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181794	P	occurs_in:(EMAPA:17701)\|occurs_in:(EMAPA:36191)\|occurs_in:(EMAPA:35786)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006874	cellular calcium ion homeostasis	PMID:9384575^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181794	P	occurs_in:(EMAPA:17701)\|occurs_in:(EMAPA:36191)\|occurs_in:(EMAPA:35786)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006816	calcium ion transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15413	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68952	C		Seeded From UniProt	complete
enables	GO:0005219	ryanodine-sensitive calcium-release channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68952	F		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	F		Seeded From UniProt	complete
enables	GO:0005219	ryanodine-sensitive calcium-release channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009460 InterPro:IPR013333	F		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000699	F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002048	F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013333 InterPro:IPR015925	P		Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009460	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000699 InterPro:IPR005821 InterPro:IPR016093 InterPro:IPR036300	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009460	C		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000699	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0107	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0107	P		Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0703 UniProtKB-SubCell:SL-0239	C		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0112	F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0492	C		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0109	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
part_of	GO:0033017	sarcoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0241	C		Seeded From UniProt	complete
part_of	GO:0031090	organelle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0165	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Wang, YX et al. (2004) FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells. Am. J. Physiol., Cell Physiol. 286 C538-46 PubMed GONUTS page
↑ Flucher, BE et al. (1999) Type 3 and type 1 ryanodine receptors are localized in triads of the same mammalian skeletal muscle fibers. J. Cell Biol. 146 621-30 PubMed GONUTS page
↑ ^4.0 ^4.1 Bertocchini, F et al. (1997) Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles. EMBO J. 16 6956-63 PubMed GONUTS page

[PMID:21873635-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:14592808-2] Wang, YX et al. (2004) FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells. Am. J. Physiol., Cell Physiol. 286 C538-46 PubMed GONUTS page

[PMID:10444070-3] Flucher, BE et al. (1999) Type 3 and type 1 ryanodine receptors are localized in triads of the same mammalian skeletal muscle fibers. J. Cell Biol. 146 621-30 PubMed GONUTS page

[PMID:9384575-4] 4.0 ^4.1 Bertocchini, F et al. (1997) Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles. EMBO J. 16 6956-63 PubMed GONUTS page

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MOUSE:RYR3

Contents

Annotations

Notes

References

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