MOUSE:RSAD2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Rsad2 (ECO:0000312 with MGI:MGI:1929628) (synonyms: Vig1 (ECO:0000312 with EMBL:AAL50054.1))
Protein Name(s)	Radical S-adenosyl methionine domain-containing protein 2 Viperin Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible
External Links
UniProt	Q8CBB9
EMBL	AF236064 AK036373 AK150069 AK150406 AK150425 AK150525 AK150616 AK150684 AK150731 AK150767 AK150783 AK150788 AK150812 AK150835 AK151140 AK151185 AK151191 AK151206 AK151286 AK151308 AK151339 AK151389 AK151410 AK151412 AK151414 AK151476 AK151502 AK151538 AK151767 AK151770 AK151825 AK151833 AK151846 AK151906 AK151909 AK151940 AK151954 AK151971 AK152050 AK152065 AK152075 AK152235 AK152239 AK152241 AK152310 AK152354 AK152493 AK152600 AK152601 AK152631 AK152644 AK152664 AK152796 AK152861 AK152880 AK152895 AK152934 AK152962 AK153003 AK153024 AK153062 AK153077 AK153078 AK153232 AK153234 AK153306 AK153318 AK153324 AK153435 AK153556 AK159147 CT010378 BC057868 AF442152
CCDS	CCDS25848.1
RefSeq	NP_067359.2
UniGene	Mm.24045
ProteinModelPortal	Q8CBB9
SMR	Q8CBB9
BioGrid	208378
PhosphoSite	Q8CBB9
PRIDE	Q8CBB9
Ensembl	ENSMUST00000020970
GeneID	58185
KEGG	mmu:58185
UCSC	uc007nfh.2
CTD	91543
MGI	MGI:1929628
eggNOG	NOG72023
GeneTree	ENSGT00390000013670
HOVERGEN	HBG053099
InParanoid	Q8CBB9
KO	K15045
OMA	CLLIEGE
OrthoDB	EOG7FFMRW
PhylomeDB	Q8CBB9
TreeFam	TF300085
NextBio	314147
PRO	PR:Q8CBB9
Proteomes	UP000000589
Bgee	Q8CBB9
CleanEx	MM_RSAD2
ExpressionAtlas	Q8CBB9
Genevestigator	Q8CBB9
GO	GO:0005789 GO:0005811 GO:0005743 GO:0005741 GO:0051539 GO:0003824 GO:0046872 GO:0043621 GO:0035710 GO:0043367 GO:0051607 GO:0045087 GO:0050709 GO:0045071 GO:0001503 GO:2000553 GO:0034157 GO:0034165 GO:0030278 GO:0009615
Gene3D	3.20.20.70
InterPro	IPR013785 IPR006638 IPR007197 IPR026372
Pfam	PF04055
SMART	SM00729
TIGRFAMs	TIGR04278

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0005783	endoplasmic reticulum	PMID:23160199^[1]	ECO:0000314			C	Fig.5	complete CACAO 7021
part_of	GO:0005783	endoplasmic reticulum	PMID:23160199^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:2000553	positive regulation of T-helper 2 cell cytokine production	PMID:19047684^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	PMID:17686841^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0051539	4 iron, 4 sulfur cluster binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8WXG1	F	Seeded From UniProt	complete
involved_in	GO:0050709	negative regulation of protein secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8WXG1	P	Seeded From UniProt	complete
involved_in	GO:0045071	negative regulation of viral genome replication	PMID:21880757^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0043621	protein self-association	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8WXG1	F	Seeded From UniProt	complete
involved_in	GO:0043367	CD4-positive, alpha-beta T cell differentiation	PMID:19047684^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035710	CD4-positive, alpha-beta T cell activation	PMID:19047684^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034165	positive regulation of toll-like receptor 9 signaling pathway	PMID:21435586^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034157	positive regulation of toll-like receptor 7 signaling pathway	PMID:21435586^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009615	response to virus	PMID:21880757^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	PMID:19920176^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	PMID:21435586^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8WXG1	C	Seeded From UniProt	complete
enables	GO:0003674	molecular_function	GO_REF:0000015	ECO:0000307	no biological data found used in manual assertion		F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051607	defense response to virus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8WXG1	P	Seeded From UniProt	complete
enables	GO:0051539	4 iron, 4 sulfur cluster binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8WXG1	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050709	negative regulation of protein secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8WXG1	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045071	negative regulation of viral genome replication	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8WXG1	P	Seeded From UniProt	complete
enables	GO:0043621	protein self-association	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8WXG1	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030278	regulation of ossification	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620495	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009615	response to virus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8WXG1	P	Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8WXG1	C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8WXG1	C	Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8WXG1	C	Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8WXG1	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8WXG1	C	Seeded From UniProt	complete
part_of	GO:0001650	fibrillar center	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8WXG1	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001503	ossification	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620495	P	Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8WXG1 ensembl:ENSP00000371471	P	Seeded From UniProt	complete
enables	GO:0051539	4 iron, 4 sulfur cluster binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8WXG1 ensembl:ENSP00000371471	F	Seeded From UniProt	complete
involved_in	GO:0050709	negative regulation of protein secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8WXG1 ensembl:ENSP00000371471	P	Seeded From UniProt	complete
involved_in	GO:0045071	negative regulation of viral genome replication	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8WXG1 ensembl:ENSP00000371471	P	Seeded From UniProt	complete
enables	GO:0043621	protein self-association	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8WXG1 ensembl:ENSP00000371471	F	Seeded From UniProt	complete
involved_in	GO:0009615	response to virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8WXG1 ensembl:ENSP00000371471	P	Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8WXG1 ensembl:ENSP00000371471	C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8WXG1 ensembl:ENSP00000371471	C	Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8WXG1 ensembl:ENSP00000371471	C	Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8WXG1 ensembl:ENSP00000371471	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8WXG1 ensembl:ENSP00000371471	C	Seeded From UniProt	complete
part_of	GO:0001650	fibrillar center	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8WXG1 ensembl:ENSP00000371471	C	Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006638 InterPro:IPR007197 InterPro:IPR013785	F	Seeded From UniProt	complete
enables	GO:0051536	iron-sulfur cluster binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006638 InterPro:IPR007197	F	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C	Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P	Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0551 UniProtKB-SubCell:SL-0154	C	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P	Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0051	P	Seeded From UniProt	complete
enables	GO:0051539	4 iron, 4 sulfur cluster binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0004	F	Seeded From UniProt	complete
enables	GO:0051536	iron-sulfur cluster binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0411	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Teng, TS et al. (2012) Viperin restricts chikungunya virus replication and pathology. J. Clin. Invest. 122 4447-60 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Qiu, LQ et al. (2009) Viperin is required for optimal Th2 responses and T-cell receptor-mediated activation of NF-kappaB and AP-1. Blood 113 3520-9 PubMed GONUTS page
↑ Zhang, Y et al. (2007) Identification and characterization of interferon-induced proteins that inhibit alphavirus replication. J. Virol. 81 11246-55 PubMed GONUTS page
↑ ^4.0 ^4.1 Szretter, KJ et al. (2011) The interferon-inducible gene viperin restricts West Nile virus pathogenesis. J. Virol. 85 11557-66 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Saitoh, T et al. (2011) Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells. Immunity 34 352-63 PubMed GONUTS page
↑ Hinson, ER & Cresswell, P (2009) The antiviral protein, viperin, localizes to lipid droplets via its N-terminal amphipathic alpha-helix. Proc. Natl. Acad. Sci. U.S.A. 106 20452-7 PubMed GONUTS page

[PMID:23160199-1] 1.0 ^1.1 Teng, TS et al. (2012) Viperin restricts chikungunya virus replication and pathology. J. Clin. Invest. 122 4447-60 PubMed GONUTS page

[PMID:19047684-2] 2.0 ^2.1 ^2.2 Qiu, LQ et al. (2009) Viperin is required for optimal Th2 responses and T-cell receptor-mediated activation of NF-kappaB and AP-1. Blood 113 3520-9 PubMed GONUTS page

[PMID:17686841-3] Zhang, Y et al. (2007) Identification and characterization of interferon-induced proteins that inhibit alphavirus replication. J. Virol. 81 11246-55 PubMed GONUTS page

[PMID:21880757-4] 4.0 ^4.1 Szretter, KJ et al. (2011) The interferon-inducible gene viperin restricts West Nile virus pathogenesis. J. Virol. 85 11557-66 PubMed GONUTS page

[PMID:21435586-5] 5.0 ^5.1 ^5.2 Saitoh, T et al. (2011) Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells. Immunity 34 352-63 PubMed GONUTS page

[PMID:19920176-6] Hinson, ER & Cresswell, P (2009) The antiviral protein, viperin, localizes to lipid droplets via its N-terminal amphipathic alpha-helix. Proc. Natl. Acad. Sci. U.S.A. 106 20452-7 PubMed GONUTS page

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MOUSE:RSAD2

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Notes

References

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