MOUSE:ROBO1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Robo1 (synonyms: Dutt1)
Protein Name(s)	Roundabout homolog 1
External Links
UniProt	O89026
EMBL	Y17793
CCDS	CCDS37376.1
PIR	T30805
RefSeq	NP_062286.2
UniGene	Mm.310772
ProteinModelPortal	O89026
SMR	O89026
BioGrid	202949
PhosphoSite	O89026
MaxQB	O89026
PaxDb	O89026
PRIDE	O89026
DNASU	19876
GeneID	19876
KEGG	mmu:19876
CTD	6091
MGI	MGI:1274781
eggNOG	NOG238978
HOGENOM	HOG000010267
HOVERGEN	HBG073476
InParanoid	O89026
KO	K06753
PhylomeDB	O89026
Reactome	REACT_260181
ChiTaRS	Robo1
NextBio	297362
PRO	PR:O89026
Proteomes	UP000000589
CleanEx	MM_ROBO1
Genevestigator	O89026
GO	GO:0030673 GO:0016021 GO:0005886 GO:0007411 GO:0016199 GO:0060763 GO:0008285 GO:0021891
Gene3D	2.60.40.10
InterPro	IPR003961 IPR007110 IPR013783 IPR013098 IPR003598 IPR003596
Pfam	PF00041 PF07679
SMART	SM00060 SM00408 SM00406
SUPFAM	SSF49265
PROSITE	PS50853 PS50835

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0048842	positive regulation of axon extension involved in axon guidance	PMID:21118670^[1]	ECO:0000315			P		Figure 4 suggests ROBO1 aids in positive regulation of axon guidance.	complete CACAO 6355
involved_in	GO:0035481	positive regulation of Notch signaling pathway involved in heart induction	PMID:25691540^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0004145)	Seeded From UniProt	complete
involved_in	GO:0003148	outflow tract septum morphogenesis	PMID:25691540^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q7TPD3	P	part_of:(GO:0035904)	Seeded From UniProt	complete
involved_in	GO:0003180	aortic valve morphogenesis	PMID:25691540^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q7TPD3	P	results_in_morphogenesis_of:(UBERON:0011742)	Seeded From UniProt	complete
involved_in	GO:0035904	aorta development	PMID:25691540^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q7TPD3	P		Seeded From UniProt	complete
involved_in	GO:0003272	endocardial cushion formation	PMID:25691540^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q7TPD3	P	part_of:(GO:0003180)	Seeded From UniProt	complete
involved_in	GO:0060412	ventricular septum morphogenesis	PMID:25691540^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q7TPD3	P		Seeded From UniProt	complete
involved_in	GO:0035385	Roundabout signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y6N7	P		Seeded From UniProt	complete
involved_in	GO:0035025	positive regulation of Rho protein signal transduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y6N7	P		Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y6N7	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:25691540^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSMUSG00000022528) occurs_in:(UBERON:0004145) happens_during:(GO:0003170)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:25691540^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSMUSG00000032744) occurs_in:(UBERON:0004145) happens_during:(GO:0003170)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:25691540^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSMUSG00000040289) occurs_in:(UBERON:0004145) happens_during:(GO:0003170)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:25691540^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSMUSG00000026923) occurs_in:(UBERON:0004145) happens_during:(GO:0003170)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:25691540^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSMUSG00000056427) occurs_in:(UBERON:0004145) happens_during:(GO:0003170)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:25691540^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSMUSG00000052516) occurs_in:(UBERON:0004145) happens_during:(GO:0003170)	Seeded From UniProt	complete
involved_in	GO:0003184	pulmonary valve morphogenesis	PMID:25691540^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q7TPD3	P	results_in_morphogenesis_of:(UBERON:0011745)	Seeded From UniProt	complete
involved_in	GO:0021891	olfactory bulb interneuron development	PMID:17360927^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q7TPD3	P		Seeded From UniProt	complete
involved_in	GO:0016199	axon midline choice point recognition	PMID:18986510^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q7TPD3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900748	positive regulation of vascular endothelial growth factor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6N7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070100	negative regulation of chemokine-mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6N7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060976	coronary vasculature development	PMID:25807483^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060763	mammary duct terminal end bud growth	PMID:16439476^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3043142	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050925	negative regulation of negative chemotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6N7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050772	positive regulation of axonogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6N7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048814	regulation of dendrite morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61941	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043406	positive regulation of MAP kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6N7	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61941	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6N7	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035385	Roundabout signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6N7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035025	positive regulation of Rho protein signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6N7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033600	negative regulation of mammary gland epithelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6N7	P		Seeded From UniProt	complete
part_of	GO:0030673	axolemma	PMID:15084255^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17577) part_of:(CL:0000678)	Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61941	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030336	negative regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6N7	P		Seeded From UniProt	complete
enables	GO:0030275	LRR domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6N7	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021836	chemorepulsion involved in postnatal olfactory bulb interneuron migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6N7	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6N7	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:18829537^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3043142	P		Seeded From UniProt	complete
enables	GO:0008046	axon guidance receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61941	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:25807483^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007411	axon guidance	PMID:15091338^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1343102	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007411	axon guidance	PMID:15084255^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007411	axon guidance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61941	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6N7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6N7	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6N7	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6N7	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003281	ventricular septum development	PMID:25807483^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002042	cell migration involved in sprouting angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6N7	P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032986	P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032986	P		Seeded From UniProt	complete
involved_in	GO:0035385	Roundabout signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032986	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-MMU-9014847 Reactome:R-MMU-9011080 Reactome:R-MMU-9010950 Reactome:R-MMU-9010235 Reactome:R-MMU-8985829 Reactome:R-MMU-8985822	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0145	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0279	C		Seeded From UniProt	complete
part_of	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0099	C		Seeded From UniProt	complete
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Notes

ROBOs are a family of receptors for the Slit family of chemorepellants. Slit/ROBO signaling is involved in preventing axons from going to inappropriate locations^[1].

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Dugan, JP et al. (2011) Midbrain dopaminergic axons are guided longitudinally through the diencephalon by Slit/Robo signals. Mol. Cell. Neurosci. 46 347-56 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 Mommersteeg, MT et al. (2015) Disrupted Slit-Robo signalling results in membranous ventricular septum defects and bicuspid aortic valves. Cardiovasc. Res. 106 55-66 PubMed GONUTS page
↑ Fouquet, C et al. (2007) Robo1 and robo2 control the development of the lateral olfactory tract. J. Neurosci. 27 3037-45 PubMed GONUTS page
↑ Tamada, A et al. (2008) Crucial roles of Robo proteins in midline crossing of cerebellofugal axons and lack of their up-regulation after midline crossing. Neural Dev 3 29 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Li, Y et al. (2015) Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Nature 521 520-4 PubMed GONUTS page
↑ Strickland, P et al. (2006) Slit2 and netrin 1 act synergistically as adhesive cues to generate tubular bi-layers during ductal morphogenesis. Development 133 823-32 PubMed GONUTS page
↑ ^7.0 ^7.1 Sabatier, C et al. (2004) The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons. Cell 117 157-69 PubMed GONUTS page
↑ Marlow, R et al. (2008) SLITs suppress tumor growth in vivo by silencing Sdf1/Cxcr4 within breast epithelium. Cancer Res. 68 7819-27 PubMed GONUTS page
↑ Long, H et al. (2004) Conserved roles for Slit and Robo proteins in midline commissural axon guidance. Neuron 42 213-23 PubMed GONUTS page

[PMID:21118670-1] 1.0 ^1.1 Dugan, JP et al. (2011) Midbrain dopaminergic axons are guided longitudinally through the diencephalon by Slit/Robo signals. Mol. Cell. Neurosci. 46 347-56 PubMed GONUTS page

[PMID:25691540-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 Mommersteeg, MT et al. (2015) Disrupted Slit-Robo signalling results in membranous ventricular septum defects and bicuspid aortic valves. Cardiovasc. Res. 106 55-66 PubMed GONUTS page

[PMID:17360927-3] Fouquet, C et al. (2007) Robo1 and robo2 control the development of the lateral olfactory tract. J. Neurosci. 27 3037-45 PubMed GONUTS page

[PMID:18986510-4] Tamada, A et al. (2008) Crucial roles of Robo proteins in midline crossing of cerebellofugal axons and lack of their up-regulation after midline crossing. Neural Dev 3 29 PubMed GONUTS page

[PMID:25807483-5] 5.0 ^5.1 ^5.2 Li, Y et al. (2015) Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Nature 521 520-4 PubMed GONUTS page

[PMID:16439476-6] Strickland, P et al. (2006) Slit2 and netrin 1 act synergistically as adhesive cues to generate tubular bi-layers during ductal morphogenesis. Development 133 823-32 PubMed GONUTS page

[PMID:15084255-7] 7.0 ^7.1 Sabatier, C et al. (2004) The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons. Cell 117 157-69 PubMed GONUTS page

[PMID:18829537-8] Marlow, R et al. (2008) SLITs suppress tumor growth in vivo by silencing Sdf1/Cxcr4 within breast epithelium. Cancer Res. 68 7819-27 PubMed GONUTS page

[PMID:15091338-9] Long, H et al. (2004) Conserved roles for Slit and Robo proteins in midline commissural axon guidance. Neuron 42 213-23 PubMed GONUTS page

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MOUSE:ROBO1

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