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MOUSE:RHOX5

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Rhox5 (synonyms: Pem)
Protein Name(s) Homeobox protein Rhox5

Homeobox protein Pem Placenta and embryonic expression protein Reproductive homeobox on chromosome X 5

External Links
UniProt P52651
EMBL M32484
U50747
CCDS CCDS57752.1
PIR A49770
UniGene Mm.423066
ProteinModelPortal P52651
SMR P52651
PhosphoSite P52651
MaxQB P52651
PRIDE P52651
MGI MGI:97538
HOVERGEN HBG008166
InParanoid P52651
PRO PR:P52651
Proteomes UP000000589
CleanEx MM_RHOX5
Genevestigator P52651
GO GO:0005737
GO:0005634
GO:0003677
GO:0035234
GO:0000122
GO:0030317
Gene3D 1.10.10.60
InterPro IPR001356
IPR009057
SMART SM00389

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005634

nucleus

PMID:17509893[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:17509893[1]

ECO:0000314

C

Fig. 7 Shows Rhox5 proteins in NIH3T3 cells using indirect fluorescence, the protein were tagged using anti-Rhox5 polyclonal antibody (a), the nucleus is shown by being tagged with Hochest 33258 in (d).

complete
CACAO 7185

acts_upstream_of_or_within

GO:0035234

ectopic germ cell programmed cell death

PMID:15707895[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2447572

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030317

flagellated sperm motility

PMID:15707895[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2447572

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:9769172[3]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:18686)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:9769172[3]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:16578)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:9537288[4]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:17972)
  • part_of:(CL:0000216)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:9175728[5]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:16053)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:7958444[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:18077458[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • occurs_in:(EMAPA:17972)
  • has_regulation_target:(MGI:MGI:1095412)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:18077458[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001356

F

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR040069

P

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037
GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238
UniProtKB-KW:KW-0371

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Guo, F et al. (2007) High-level expression, polyclonal antibody preparation and sub-cellular localization analysis of mouse Rhox5 protein. Protein Expr. Purif. 54 247-52 PubMed GONUTS page
  2. 2.0 2.1 Maclean, JA 2nd et al. (2005) Rhox: a new homeobox gene cluster. Cell 120 369-82 PubMed GONUTS page
  3. 3.0 3.1 Pitman, JL et al. (1998) Normal reproductive and macrophage function in Pem homeobox gene-deficient mice. Dev. Biol. 202 196-214 PubMed GONUTS page
  4. Sutton, KA et al. () Androgen regulation of the Pem homeodomain gene in mice and rat Sertoli and epididymal cells. J. Androl. 19 21-30 PubMed GONUTS page
  5. Williamson, RA et al. (1997) Dystroglycan is essential for early embryonic development: disruption of Reichert's membrane in Dag1-null mice. Hum. Mol. Genet. 6 831-41 PubMed GONUTS page
  6. Lin, TP et al. (1994) The Pem homeobox gene is X-linked and exclusively expressed in extraembryonic tissues during early murine development. Dev. Biol. 166 170-9 PubMed GONUTS page
  7. 7.0 7.1 Hu, Z et al. (2008) The RHOX5 homeodomain protein mediates transcriptional repression of the netrin-1 receptor gene Unc5c. J. Biol. Chem. 283 3866-76 PubMed GONUTS page