MOUSE:RHOC

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Rhoc (synonyms: Arhc)
Protein Name(s)	Rho-related GTP-binding protein RhoC Silica-induced gene 61 protein SIG-61
External Links
UniProt	Q62159
EMBL	X80638 AK011599 AK152802 AK160650 BC004627
CCDS	CCDS17704.1
RefSeq	NP_001278788.1 NP_031510.2
UniGene	Mm.262
ProteinModelPortal	Q62159
SMR	Q62159
BioGrid	198197
IntAct	Q62159
MINT	MINT-4132345
PhosphoSite	Q62159
MaxQB	Q62159
PaxDb	Q62159
PRIDE	Q62159
Ensembl	ENSMUST00000002303 ENSMUST00000106787
GeneID	11853
KEGG	mmu:11853
UCSC	uc008qul.2
CTD	389
MGI	MGI:106028
eggNOG	COG1100
GeneTree	ENSGT00760000119020
HOGENOM	HOG000233974
HOVERGEN	HBG009351
InParanoid	Q62159
KO	K07857
OMA	KKRKGCP
OrthoDB	EOG73FQPD
PhylomeDB	Q62159
TreeFam	TF300837
Reactome	REACT_204733 REACT_210090 REACT_246650
NextBio	279829
PRO	PR:Q62159
Proteomes	UP000000589
Bgee	Q62159
CleanEx	MM_RHOC
ExpressionAtlas	Q62159
Genevestigator	Q62159
GO	GO:0032154 GO:0005829 GO:0070062 GO:0005634 GO:0005886 GO:0005525 GO:0004871 GO:0043297 GO:0000910 GO:0043123 GO:0007264
Gene3D	3.40.50.300
InterPro	IPR027417 IPR005225 IPR001806 IPR003578
Pfam	PF00071
PRINTS	PR00449
SMART	SM00174
SUPFAM	SSF52540
TIGRFAMs	TIGR00231
PROSITE	PS51420

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0032420	stereocilium	PMID:27269051^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0032464	positive regulation of protein homooligomerization	PMID:27269051^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1902766	skeletal muscle satellite cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:F1CG58	P	Seeded From UniProt	complete
involved_in	GO:0044319	wound healing, spreading of cells	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:F1CG58	P	Seeded From UniProt	complete
involved_in	GO:1902766	skeletal muscle satellite cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:G1MTS2	P	Seeded From UniProt	complete
involved_in	GO:0044319	wound healing, spreading of cells	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:G1MTS2	P	Seeded From UniProt	complete
involved_in	GO:0043297	apical junction assembly	PMID:20974804^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0032154	cleavage furrow	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08134	C	Seeded From UniProt	complete
involved_in	GO:0000281	mitotic cytokinesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08134	P	Seeded From UniProt	complete
involved_in	GO:0051017	actin filament bundle assembly	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0014020 PANTHER:PTN000632672 UniProtKB:O00212	P	Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000632672 UniProtKB:Q92730	C	Seeded From UniProt	complete
involved_in	GO:0032956	regulation of actin cytoskeleton organization	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1096342 PANTHER:PTN000632672 PomBase:SPAC16A10.04 PomBase:SPAC1F7.04 UniProtKB:P61586 ZFIN:ZDB-GENE-040322-2	P	Seeded From UniProt	complete
part_of	GO:0032153	cell division site	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000632672 PomBase:SPAC16.01 PomBase:SPAC16A10.04 PomBase:SPAC20H4.11c PomBase:SPAC23C4.08	C	Seeded From UniProt	complete
involved_in	GO:0030950	establishment or maintenance of actin cytoskeleton polarity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0014020 PANTHER:PTN000632672 PomBase:SPAC16.01 PomBase:SPAC1F7.04 SGD:S000001380 UniProtKB:I3LVS7	P	Seeded From UniProt	complete
involved_in	GO:0030334	regulation of cell migration	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0014020 PANTHER:PTN000632672 UniProtKB:P61586 UniProtKB:P62745	P	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108446 PANTHER:PTN000632672 WB:WBGene00004357	F	Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001178055 UniProtKB:P61586	P	Seeded From UniProt	complete
involved_in	GO:0008360	regulation of cell shape	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000632672 PomBase:SPAC16A10.04	P	Seeded From UniProt	complete
involved_in	GO:0007266	Rho protein signal transduction	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010341 FB:FBgn0014011 MGI:MGI:1931551 PANTHER:PTN000632671 RGD:619921 UniProtKB:I3LVS7 UniProtKB:P61586 UniProtKB:P84095	P	Seeded From UniProt	complete
involved_in	GO:0007015	actin filament organization	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0014020 PANTHER:PTN000632672 UniProtKB:Q92730 UniProtKB:Q9HBH0	P	Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0014020 PANTHER:PTN000632672 PomBase:SPAC16A10.04 UniProtKB:I3LVS7 UniProtKB:P61586 WB:WBGene00004357	C	Seeded From UniProt	complete
colocalizes_with	GO:0005886	plasma membrane	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000192659 MGI:MGI:106028 MGI:MGI:107949 MGI:MGI:1096342 PANTHER:PTN000632672 PomBase:SPAC23C4.08 SGD:S000001763 UniProtKB:A0A1D8PH96 UniProtKB:P62745 UniProtKB:Q92730	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0014020 PANTHER:PTN000632672 RGD:619921	C	Seeded From UniProt	complete
enables	GO:0005525	GTP binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0039140 MGI:MGI:108446 MGI:MGI:97845 PANTHER:PTN000632671 RGD:619755 RGD:619921 RGD:71043 SGD:S000001380 TAIR:locus:2131606 TAIR:locus:2204380 UniProtKB:A0A1D8PDV5 UniProtKB:P15153 UniProtKB:P60953 UniProtKB:P61586 UniProtKB:P63000 UniProtKB:Q15669 UniProtKB:Q9SSX0 WB:WBGene00000390 WB:WBGene00000424 WB:WBGene00004287 WB:WBGene00004357	F	Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010333 FB:FBgn0010341 FB:FBgn0014011 FB:FBgn0014020 MGI:MGI:106211 MGI:MGI:1096342 MGI:MGI:1916831 MGI:MGI:97845 MGI:MGI:97846 PANTHER:PTN000632671 PomBase:SPAC110.03 PomBase:SPAC16.01 PomBase:SPAC16A10.04 PomBase:SPAC1F7.04 PomBase:SPAC23C4.08 RGD:619755 RGD:619921 SGD:S000000046 SGD:S000001380 SGD:S000001763 SGD:S000004219 SGD:S000005034 SGD:S000005124 SGD:S000006369 TAIR:locus:2099232 TAIR:locus:2131606 UniProtKB:A0A1D8PCX9 UniProtKB:A0A1D8PH96 UniProtKB:P17081 UniProtKB:P60763 UniProtKB:P60953 UniProtKB:P61586 UniProtKB:P63000 UniProtKB:P84095 UniProtKB:Q5A904 WB:WBGene00000390 WB:WBGene00000424 WB:WBGene00003239 WB:WBGene00004287 WB:WBGene00004357	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060193	positive regulation of lipase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08134	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051496	positive regulation of stress fiber assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08134	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043297	apical junction assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08134	P	Seeded From UniProt	complete
part_of	GO:0032154	cleavage furrow	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08134	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030335	positive regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08134	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1304965	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15093731^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1304965	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15093731^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000281	mitotic cytokinesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08134	P	Seeded From UniProt	complete
involved_in	GO:0060193	positive regulation of lipase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08134 ensembl:ENSP00000285735	P	Seeded From UniProt	complete
involved_in	GO:0051496	positive regulation of stress fiber assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08134 ensembl:ENSP00000285735	P	Seeded From UniProt	complete
involved_in	GO:0043297	apical junction assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08134 ensembl:ENSP00000285735	P	Seeded From UniProt	complete
part_of	GO:0032154	cleavage furrow	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08134 ensembl:ENSP00000285735	C	Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08134 ensembl:ENSP00000285735	P	Seeded From UniProt	complete
involved_in	GO:0000281	mitotic cytokinesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08134 ensembl:ENSP00000285735	P	Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001806	F	Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001806 InterPro:IPR003578 InterPro:IPR005225	F	Seeded From UniProt	complete
involved_in	GO:0007264	small GTPase mediated signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003578	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-MMU-8981447 Reactome:R-MMU-5666183 Reactome:R-MMU-5625893	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0342	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
part_of	GO:0032154	cleavage furrow	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0467	C	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Zhao, B et al. (2016) Murine Fam65b forms ring-like structures at the base of stereocilia critical for mechanosensory hair cell function. Elife 5 PubMed GONUTS page
↑ Wallace, SW et al. (2011) The Rho target PRK2 regulates apical junction formation in human bronchial epithelial cells. Mol. Cell. Biol. 31 81-91 PubMed GONUTS page
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 ^3.13 ^3.14 ^3.15 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 Yonemura, S et al. (2004) Rho localization in cells and tissues. Exp. Cell Res. 295 300-14 PubMed GONUTS page

[PMID:27269051-1] 1.0 ^1.1 Zhao, B et al. (2016) Murine Fam65b forms ring-like structures at the base of stereocilia critical for mechanosensory hair cell function. Elife 5 PubMed GONUTS page

[PMID:20974804-2] Wallace, SW et al. (2011) The Rho target PRK2 regulates apical junction formation in human bronchial epithelial cells. Mol. Cell. Biol. 31 81-91 PubMed GONUTS page

[PMID:21873635-3] 3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 ^3.13 ^3.14 ^3.15 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15093731-4] 4.0 ^4.1 Yonemura, S et al. (2004) Rho localization in cells and tissues. Exp. Cell Res. 295 300-14 PubMed GONUTS page

[1]

[2]

[3]

[4]

MOUSE:RHOC

Contents

Annotations

Notes

References

a

c

e

g

i

m

n

p

r

s

v

w

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools