MOUSE:RAF1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Raf1 (synonyms: Craf)
Protein Name(s)	RAF proto-oncogene serine/threonine-protein kinase Proto-oncogene c-RAF cRaf Raf-1
External Links
UniProt	Q99N57
EMBL	AB057655 AB057663 AK141745 BC015273 BC092040 X55432
CCDS	CCDS20441.1
RefSeq	NP_084056.1 XP_006505426.1 XP_006505427.1 XP_006505428.1
UniGene	Mm.184163
ProteinModelPortal	Q99N57
SMR	Q99N57
BioGrid	225343
DIP	DIP-31555N
IntAct	Q99N57
MINT	MINT-1582303
PhosphoSite	Q99N57
MaxQB	Q99N57
PaxDb	Q99N57
PRIDE	Q99N57
Ensembl	ENSMUST00000000451 ENSMUST00000112949
GeneID	110157
KEGG	mmu:110157
UCSC	uc009dix.1
CTD	5894
MGI	MGI:97847
eggNOG	COG0515
GeneTree	ENSGT00760000118807
HOGENOM	HOG000252972
HOVERGEN	HBG001886
InParanoid	Q99N57
KO	K04366
OMA	RMIENNN
OrthoDB	EOG7F5128
PhylomeDB	Q99N57
TreeFam	TF317006
Reactome	REACT_196640 REACT_198246 REACT_237640 REACT_237855 REACT_245546 REACT_247566 REACT_257146
ChiTaRS	Raf1
NextBio	363431
PRO	PR:Q99N57
Proteomes	UP000000589
Bgee	Q99N57
CleanEx	MM_RAF1
ExpressionAtlas	Q99N57
Genevestigator	Q99N57
GO	GO:0005737 GO:0005829 GO:0005794 GO:0005739 GO:0005634 GO:0005886 GO:0031143 GO:0005524 GO:0004709 GO:0046872 GO:0004672 GO:0017016 GO:0030154 GO:0071550 GO:0007507 GO:0045104 GO:0035556 GO:0008285 GO:1902042 GO:0031333 GO:0048011 GO:0033138 GO:0001666 GO:0035019
InterPro	IPR020454 IPR011009 IPR002219 IPR000719 IPR017441 IPR003116 IPR001245 IPR008271 IPR029071
Pfam	PF00130 PF07714 PF02196
PRINTS	PR00008
SMART	SM00109 SM00455
SUPFAM	SSF54236 SSF56112
PROSITE	PS00107 PS50011 PS00108 PS50898 PS00479 PS50081

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0031143	pseudopodium	PMID:12821670^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11345	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11345	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000584576 RGD:2148 UniProtKB:P04049 UniProtKB:P15056	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88065 MGI:MGI:88190 PANTHER:PTN000584576	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003079 MGI:MGI:1346881 MGI:MGI:2443258 PANTHER:PTN001908122 RGD:1359261 RGD:619908 RGD:620063 TAIR:locus:2144613 UniProtKB:O43283 UniProtKB:P04049 UniProtKB:P10398 UniProtKB:P15056 UniProtKB:P80192 UniProtKB:Q02779 UniProtKB:Q13418 UniProtKB:Q13546 UniProtKB:Q16584	F		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001907370 RGD:3531 WB:WBGene00003030	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	PMID:16365167^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95484 MGI:MGI:99255	P	regulates_o_occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	PMID:16365167^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2388026	P	regulates_o_occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071550	death-inducing signaling complex assembly	PMID:16365167^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2388026	P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060324	face development	PMID:18952847^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88190	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048538	thymus development	PMID:18952847^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88190	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048011	neurotrophin TRK receptor signaling pathway	PMID:9852579^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:16668) occurs_in:(CL:0000540)	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3531	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21817126^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3497907	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045104	intermediate filament cytoskeleton organization	PMID:16365167^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2388026	P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04049	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04049	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035994	response to muscle stretch	PMID:20442316^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:17701)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035773	insulin secretion involved in cellular response to glucose stimulus	PMID:21817126^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3497907	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035019	somatic stem cell population maintenance	PMID:23022482^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88190	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04049	P		Seeded From UniProt	complete
enables	GO:0031434	mitogen-activated protein kinase kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3531	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031333	negative regulation of protein complex assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04049	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030878	thyroid gland development	PMID:18952847^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88190	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030154	cell differentiation	PMID:10704835^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88190	P	occurs_in:(EMAPA:25765)	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04049	F		Seeded From UniProt	complete
enables	GO:0017016	Ras GTPase binding	PMID:16954213^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q61411	F		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04049	C		Seeded From UniProt	complete
enables	GO:0010856	adenylate cyclase activator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3531	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04049	P		Seeded From UniProt	complete
enables	GO:0008179	adenylate cyclase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3531	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007190	activation of adenylate cyclase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04049	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3531	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17724343^[11]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04049	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3531	C		Seeded From UniProt	complete
colocalizes_with	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04049	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04049	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:17724343^[11]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04049	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17724343^[11]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04049	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3531	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3531	F		Seeded From UniProt	complete
enables	GO:0004709	MAP kinase kinase kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3531	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04049	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	PMID:21817126^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3497907	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001678	cellular glucose homeostasis	PMID:21817126^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3497907	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001666	response to hypoxia	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3531	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000186	activation of MAPKK activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04049	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000165	MAPK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3531	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04049 ensembl:ENSP00000401888	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04049 ensembl:ENSP00000401888	F		Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04049 ensembl:ENSP00000401888	P		Seeded From UniProt	complete
involved_in	GO:0031333	negative regulation of protein complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04049 ensembl:ENSP00000401888	P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04049 ensembl:ENSP00000401888	F		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04049 ensembl:ENSP00000401888	C		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04049 ensembl:ENSP00000401888	P		Seeded From UniProt	complete
involved_in	GO:0007190	activation of adenylate cyclase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04049 ensembl:ENSP00000401888	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04049 ensembl:ENSP00000401888	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04049 ensembl:ENSP00000401888	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04049 ensembl:ENSP00000401888	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04049 ensembl:ENSP00000401888	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04049 ensembl:ENSP00000401888	F		Seeded From UniProt	complete
involved_in	GO:0000186	activation of MAPKK activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04049 ensembl:ENSP00000401888	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11345 ensembl:ENSRNOP00000013831	F		Seeded From UniProt	complete
enables	GO:0031434	mitogen-activated protein kinase kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11345 ensembl:ENSRNOP00000013831	F		Seeded From UniProt	complete
enables	GO:0010856	adenylate cyclase activator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11345 ensembl:ENSRNOP00000013831	F		Seeded From UniProt	complete
enables	GO:0008179	adenylate cyclase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11345 ensembl:ENSRNOP00000013831	F		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11345 ensembl:ENSRNOP00000013831	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11345 ensembl:ENSRNOP00000013831	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11345 ensembl:ENSRNOP00000013831	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11345 ensembl:ENSRNOP00000013831	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11345 ensembl:ENSRNOP00000013831	F		Seeded From UniProt	complete
enables	GO:0004709	MAP kinase kinase kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11345 ensembl:ENSRNOP00000013831	F		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11345 ensembl:ENSRNOP00000013831	P		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11345 ensembl:ENSRNOP00000013831	P		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0S2Z559 ensembl:ENSP00000401888	C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008271	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003116	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002219	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035556	intracellular signal transduction	PMID:10329666^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:10329666^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:10329666^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:10329666^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Ge, L et al. (2003) A beta-arrestin-dependent scaffold is associated with prolonged MAPK activation in pseudopodia during protease-activated receptor-2-induced chemotaxis. J. Biol. Chem. 278 34418-26 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Piazzolla, D et al. (2005) Raf-1 sets the threshold of Fas sensitivity by modulating Rok-alpha signaling. J. Cell Biol. 171 1013-22 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Newbern, J et al. (2008) Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development. Proc. Natl. Acad. Sci. U.S.A. 105 17115-20 PubMed GONUTS page
↑ Klesse, LJ & Parada, LF (1998) p21 ras and phosphatidylinositol-3 kinase are required for survival of wild-type and NF1 mutant sensory neurons. J. Neurosci. 18 10420-8 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Alejandro, EU et al. (2011) Pancreatic β-cell Raf-1 is required for glucose tolerance, insulin secretion, and insulin 2 transcription. FASEB J. 25 3884-95 PubMed GONUTS page
↑ Mohamed, JS et al. (2010) Anisotropic regulation of Ankrd2 gene expression in skeletal muscle by mechanical stretch. FASEB J. 24 3330-40 PubMed GONUTS page
↑ Valluet, A et al. (2012) B-Raf and C-Raf are required for melanocyte stem cell self-maintenance. Cell Rep 2 774-80 PubMed GONUTS page
↑ Wojnowski, L et al. (2000) Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis. Mech. Dev. 91 97-104 PubMed GONUTS page
↑ An, HJ et al. (2006) Activation of Ras up-regulates pro-apoptotic BNIP3 in nitric oxide-induced cell death. J. Biol. Chem. 281 33939-48 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Feng, L et al. (2007) Spatial regulation of Raf kinase signaling by RKTG. Proc. Natl. Acad. Sci. U.S.A. 104 14348-53 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Lin, JH et al. (1999) The ankyrin repeat-containing adaptor protein Tvl-1 is a novel substrate and regulator of Raf-1. J. Biol. Chem. 274 14706-15 PubMed GONUTS page

[PMID:12821670-1] Ge, L et al. (2003) A beta-arrestin-dependent scaffold is associated with prolonged MAPK activation in pseudopodia during protease-activated receptor-2-induced chemotaxis. J. Biol. Chem. 278 34418-26 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16365167-3] 3.0 ^3.1 ^3.2 ^3.3 Piazzolla, D et al. (2005) Raf-1 sets the threshold of Fas sensitivity by modulating Rok-alpha signaling. J. Cell Biol. 171 1013-22 PubMed GONUTS page

[PMID:18952847-4] 4.0 ^4.1 ^4.2 Newbern, J et al. (2008) Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development. Proc. Natl. Acad. Sci. U.S.A. 105 17115-20 PubMed GONUTS page

[PMID:9852579-5] Klesse, LJ & Parada, LF (1998) p21 ras and phosphatidylinositol-3 kinase are required for survival of wild-type and NF1 mutant sensory neurons. J. Neurosci. 18 10420-8 PubMed GONUTS page

[PMID:21817126-6] 6.0 ^6.1 ^6.2 ^6.3 Alejandro, EU et al. (2011) Pancreatic β-cell Raf-1 is required for glucose tolerance, insulin secretion, and insulin 2 transcription. FASEB J. 25 3884-95 PubMed GONUTS page

[PMID:20442316-7] Mohamed, JS et al. (2010) Anisotropic regulation of Ankrd2 gene expression in skeletal muscle by mechanical stretch. FASEB J. 24 3330-40 PubMed GONUTS page

[PMID:23022482-8] Valluet, A et al. (2012) B-Raf and C-Raf are required for melanocyte stem cell self-maintenance. Cell Rep 2 774-80 PubMed GONUTS page

[PMID:10704835-9] Wojnowski, L et al. (2000) Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis. Mech. Dev. 91 97-104 PubMed GONUTS page

[PMID:16954213-10] An, HJ et al. (2006) Activation of Ras up-regulates pro-apoptotic BNIP3 in nitric oxide-induced cell death. J. Biol. Chem. 281 33939-48 PubMed GONUTS page

[PMID:17724343-11] 11.0 ^11.1 ^11.2 Feng, L et al. (2007) Spatial regulation of Raf kinase signaling by RKTG. Proc. Natl. Acad. Sci. U.S.A. 104 14348-53 PubMed GONUTS page

[PMID:10329666-12] 12.0 ^12.1 ^12.2 ^12.3 Lin, JH et al. (1999) The ankyrin repeat-containing adaptor protein Tvl-1 is a novel substrate and regulator of Raf-1. J. Biol. Chem. 274 14706-15 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

MOUSE:RAF1

Contents

Annotations

Notes

References

a

c

d

e

f

g

h

i

k

m

n

o

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools