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MOUSE:RABP2
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Crabp2 | |
| Protein Name(s) | Cellular retinoic acid-binding protein 2
Cellular retinoic acid-binding protein II CRABP-II | |
| External Links | ||
| UniProt | P22935 | |
| EMBL | M35523 M87539 M87538 BC018397 | |
| CCDS | CCDS17460.1 | |
| PIR | A42495 | |
| RefSeq | NP_031785.1 | |
| UniGene | Mm.4757 | |
| ProteinModelPortal | P22935 | |
| SMR | P22935 | |
| STRING | 10090.ENSMUSP00000005019 | |
| BindingDB | P22935 | |
| ChEMBL | CHEMBL4172 | |
| iPTMnet | P22935 | |
| PhosphoSitePlus | P22935 | |
| EPD | P22935 | |
| MaxQB | P22935 | |
| PaxDb | P22935 | |
| PeptideAtlas | P22935 | |
| PRIDE | P22935 | |
| Ensembl | ENSMUST00000005019 | |
| GeneID | 12904 | |
| KEGG | mmu:12904 | |
| UCSC | uc008ptk.1 | |
| CTD | 1382 | |
| MGI | MGI:88491 | |
| eggNOG | KOG4015 ENOG4111US8 | |
| GeneTree | ENSGT00760000118898 | |
| HOGENOM | HOG000004831 | |
| HOVERGEN | HBG005633 | |
| InParanoid | P22935 | |
| KO | K17289 | |
| OMA | GELVLTM | |
| OrthoDB | EOG091G0QSV | |
| PhylomeDB | P22935 | |
| TreeFam | TF316894 | |
| Reactome | [www.reactome.org/content/detail/R-MMU-5362517 R-MMU-5362517] | |
| PRO | PR:P22935 | |
| Proteomes | UP000000589 | |
| Bgee | ENSMUSG00000004885 | |
| CleanEx | MM_CRABP2 | |
| Genevisible | P22935 | |
| GO | GO:0005737 GO:0005783 GO:0070062 GO:0005654 GO:0005634 GO:0030332 GO:0016918 GO:0001972 GO:0019841 GO:0005215 GO:0035115 GO:0048672 GO:0048385 GO:0042573 | |
| Gene3D | 2.40.128.20 | |
| InterPro | IPR012674 IPR011038 IPR031281 IPR000463 IPR031259 IPR000566 | |
| PANTHER | PTHR11955 PTHR11955:SF60 | |
| Pfam | PF00061 | |
| PRINTS | PR00178 | |
| SUPFAM | SSF50814 | |
| PROSITE | PS00214 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
| GO:0005783 |
endoplasmic reticulum |
ECO:0000314 |
C |
Mouse CRABP2 Parental cells and cells with reduced expression of HuR were co-immunostained for Flag–CRABP2 and the ER marker calnexin (Fig. 1C). As expected, CRABP2 co-localized with calnexin in parental cells, reflecting its ER association. |
complete | |||||
|
acts_upstream_of_or_within |
GO:0048672 |
positive regulation of collateral sprouting |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0005634 |
nucleus |
ECO:0000314 |
C |
Mouse CRABP2 Fig. 2. HuR is required for RA-induced nuclear translocation of CRABP2. |
complete | |||||
|
acts_upstream_of_or_within |
GO:0042573 |
retinoic acid metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0042573 |
retinoic acid metabolic process |
ECO:0000314 |
P |
Mouse CRABP2/ Cells were treated with RA, immunostained for CRABP2, and imaged. Endogenous CRABP2 in parental MCF-7 cells underwent nuclear translocation in response to RA, which was similar to its behavior in M2−/− cells that ectopically overexpress CRABP2. By contrast, in MCF-7 cells with reduced expression of HuR, treatment with RA resulted in accumulation of CRABP2 around the nucleus but, again, failed to affect complete nuclear import (Fig. 2C). |
complete | |||||
|
acts_upstream_of_or_within |
GO:0035115 |
embryonic forelimb morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857508 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0030332 |
cyclin binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
EMBL:M68867 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
EMBL:M68867 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
EMBL:M68867 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0001972 |
retinoic acid binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P29373 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P29373 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P51673 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P51673 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0002138 |
retinoic acid biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P51673 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0001972 |
retinoic acid binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P51673 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0001972 |
retinoic acid binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008289 |
lipid binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048385 |
regulation of retinoic acid receptor signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016918 |
retinal binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019841 |
retinol binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Flajollet, S et al. (2006) Distinct roles of the steroid receptor coactivator 1 and of MED1 in retinoid-induced transcription and cellular differentiation. J. Biol. Chem. 281 20338-48 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Zhang, W et al. (2016) RNA-binding protein HuR regulates nuclear import of protein. J. Cell. Sci. 129 4025-4033 PubMed GONUTS page
- ↑ Dieplinger, B et al. (2007) The transcriptional corepressor TPA-inducible sequence 7 regulates adult axon growth through cellular retinoic acid binding protein II expression. Eur. J. Neurosci. 26 3358-67 PubMed GONUTS page
- ↑ 4.0 4.1 Yamamoto, M et al. (1998) Retinoid-binding proteins in the cerebellum and choroid plexus and their relationship to regionalized retinoic acid synthesis and degradation. Eur. J. Biochem. 257 344-50 PubMed GONUTS page
- ↑ Fawcett, D et al. (1995) Postaxial polydactyly in forelimbs of CRABP-II mutant mice. Development 121 671-9 PubMed GONUTS page
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