MOUSE:QKI

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Qki (synonyms: Qk, Qk1, Qka1)
Protein Name(s)	Protein quaking MqkI qkI
External Links
UniProt	Q9QYS9
EMBL	U44940 AF090402 AF090403 AF090404 AF091047 AF090401 AF090392 AF090393 AF090394 AF090395 AF090396 AF090397 AF090400 AF090397 AF090392 AF090393 AF090394 AF090395 AF090396 AF090397 AF090392 AF090393 AF090395 AF090396 AF090394 AF090396 AF090392 AF090393 AF090394 AF090395 AF467890 AF467890 AF467890 AF467890 AF467890 AK005169 AK132303 BC053426 BC056346 AJ012812 AJ012813 AJ012814 AJ012816 AJ012817 AJ012815 AJ012812 AJ012813 AJ012814 AJ012818 AJ012816 AJ012815 AJ012812 AJ012813 AJ012814 AJ012816 AJ012820 AJ012819 AJ012815
CCDS	CCDS28387.1 CCDS49947.1
RefSeq	NP_001152988.1 NP_001152989.1 NP_068681.1
UniGene	Mm.130694 Mm.384135 Mm.393248
PDB	4DNN
PDBsum	4DNN
ProteinModelPortal	Q9QYS9
SMR	Q9QYS9
BioGrid	202529
IntAct	Q9QYS9
MINT	MINT-4105681
PhosphoSite	Q9QYS9
MaxQB	Q9QYS9
PaxDb	Q9QYS9
PRIDE	Q9QYS9
Ensembl	ENSMUST00000042296 ENSMUST00000097414
GeneID	19317
KEGG	mmu:19317
UCSC	uc008akb.2 uc008ake.2 uc012ajv.1
CTD	19317
MGI	MGI:97837
eggNOG	COG5176
GeneTree	ENSGT00550000074434
HOVERGEN	HBG093883
InParanoid	Q9QYS9
KO	K14945
OMA	CLTHLKF
OrthoDB	EOG75MVX3
PhylomeDB	Q9QYS9
TreeFam	TF314878
NextBio	296279
PRO	PR:Q9QYS9
Proteomes	UP000000589
Bgee	Q9QYS9
CleanEx	MM_QK
ExpressionAtlas	Q9QYS9
Genevestigator	Q9QYS9
GO	GO:0005737 GO:0005634 GO:0003729 GO:0003723 GO:0061158 GO:0008366 GO:0042759 GO:0006397 GO:0051028 GO:0042692 GO:0042552 GO:0010628 GO:0006417 GO:0008380 GO:0007286 GO:0001570
Gene3D	3.30.1370.10
InterPro	IPR004087 IPR004088
Pfam	PF00013
SMART	SM00322
SUPFAM	SSF54791

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005634	nucleus	PMID:10506177^[1]	ECO:0000314			C		Fig.4	complete CACAO 7322
	GO:0005634	nucleus	PMID:10506177^[1]	ECO:0000315			C		Fig.4	complete CACAO 7323
	GO:0005737	cytoplasm	PMID:10506177^[1]	ECO:0000314			C		Fig.6	complete CACAO 7325
part_of	GO:0005737	cytoplasm	PMID:10506177^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10506177^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10506177^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:16452087^[2]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(UBERON:0000955)	Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:16452087^[2]	ECO:0001230	mass spectrometry evidence used in manual assertion		C	part_of:(UBERON:0000955)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048714	positive regulation of oligodendrocyte differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1584886	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048255	mRNA stabilization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1584886	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042759	long-chain fatty acid biosynthetic process	PMID:1150661^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856539	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042692	muscle cell differentiation	PMID:14706070^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3033861	P	results_in_acquisition_of_features_of:(CL:0000359)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042552	myelination	PMID:1373175^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042552	myelination	PMID:1150661^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856539	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010976	positive regulation of neuron projection development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1584886	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1584886	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	PMID:1373175^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008366	axon ensheathment	PMID:14169723^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856539	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007286	spermatid development	PMID:15148410^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1916560	P	occurs_in:(CL:0000018)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006397	mRNA processing	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1584886	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:25145264^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1584886	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001570	vasculogenesis	PMID:11892011^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857100	P		Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004087	F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004088 InterPro:IPR036612	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061158	3'-UTR-mediated mRNA destabilization	PMID:20631256^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(RefSeq:NM_011715)	Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	PMID:20631256^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(RefSeq:NM_011715)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11892011^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11892011^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:11892011^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006417	regulation of translation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0810	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
involved_in	GO:0006397	mRNA processing	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0507	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
involved_in	GO:0051028	mRNA transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0509	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0008380	RNA splicing	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0508	P		Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0729	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Wu, J et al. (1999) The quaking I-5 protein (QKI-5) has a novel nuclear localization signal and shuttles between the nucleus and the cytoplasm. J. Biol. Chem. 274 29202-10 PubMed GONUTS page
↑ ^2.0 ^2.1 Trinidad, JC et al. (2006) Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Mol. Cell Proteomics 5 914-22 PubMed GONUTS page
↑ ^3.0 ^3.1 Murad, S & Kishimoto, Y (1975) Alpha hydroxylation of lignoceric acid to cerebronic acid during brain development. Diminished hydroxylase activity in myelin-deficient mouse mutants. J. Biol. Chem. 250 5841-6 PubMed GONUTS page
↑ Li, Z et al. () Defective smooth muscle development in qkI-deficient mice. Dev. Growth Differ. 45 449-62 PubMed GONUTS page
↑ ^5.0 ^5.1 Amiguet, P et al. (1992) Purification and partial structural and functional characterization of mouse myelin/oligodendrocyte glycoprotein. J. Neurochem. 58 1676-82 PubMed GONUTS page
↑ SIDMAN, RL et al. (1964) MUTANT MICE (QUAKING AND JIMPY) WITH DEFICIENT MYELINATION IN THE CENTRAL NERVOUS SYSTEM. Science 144 309-11 PubMed GONUTS page
↑ Lorenzetti, D et al. (2004) Deletion of the Parkin coregulated gene causes male sterility in the quaking(viable) mouse mutant. Proc. Natl. Acad. Sci. U.S.A. 101 8402-7 PubMed GONUTS page
↑ Ishizuka, A et al. (2014) Formation of nuclear bodies by the lncRNA Gomafu-associating proteins Celf3 and SF1. Genes Cells 19 704-21 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Noveroske, JK et al. (2002) Quaking is essential for blood vessel development. Genesis 32 218-30 PubMed GONUTS page
↑ ^10.0 ^10.1 Doukhanine, E et al. (2010) The QKI-6 RNA binding protein regulates actin-interacting protein-1 mRNA stability during oligodendrocyte differentiation. Mol. Biol. Cell 21 3029-40 PubMed GONUTS page

[PMID:10506177-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Wu, J et al. (1999) The quaking I-5 protein (QKI-5) has a novel nuclear localization signal and shuttles between the nucleus and the cytoplasm. J. Biol. Chem. 274 29202-10 PubMed GONUTS page

[PMID:16452087-2] 2.0 ^2.1 Trinidad, JC et al. (2006) Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Mol. Cell Proteomics 5 914-22 PubMed GONUTS page

[PMID:1150661-3] 3.0 ^3.1 Murad, S & Kishimoto, Y (1975) Alpha hydroxylation of lignoceric acid to cerebronic acid during brain development. Diminished hydroxylase activity in myelin-deficient mouse mutants. J. Biol. Chem. 250 5841-6 PubMed GONUTS page

[PMID:14706070-4] Li, Z et al. () Defective smooth muscle development in qkI-deficient mice. Dev. Growth Differ. 45 449-62 PubMed GONUTS page

[PMID:1373175-5] 5.0 ^5.1 Amiguet, P et al. (1992) Purification and partial structural and functional characterization of mouse myelin/oligodendrocyte glycoprotein. J. Neurochem. 58 1676-82 PubMed GONUTS page

[PMID:14169723-6] SIDMAN, RL et al. (1964) MUTANT MICE (QUAKING AND JIMPY) WITH DEFICIENT MYELINATION IN THE CENTRAL NERVOUS SYSTEM. Science 144 309-11 PubMed GONUTS page

[PMID:15148410-7] Lorenzetti, D et al. (2004) Deletion of the Parkin coregulated gene causes male sterility in the quaking(viable) mouse mutant. Proc. Natl. Acad. Sci. U.S.A. 101 8402-7 PubMed GONUTS page

[PMID:25145264-8] Ishizuka, A et al. (2014) Formation of nuclear bodies by the lncRNA Gomafu-associating proteins Celf3 and SF1. Genes Cells 19 704-21 PubMed GONUTS page

[PMID:11892011-9] 9.0 ^9.1 ^9.2 ^9.3 Noveroske, JK et al. (2002) Quaking is essential for blood vessel development. Genesis 32 218-30 PubMed GONUTS page

[PMID:20631256-10] 10.0 ^10.1 Doukhanine, E et al. (2010) The QKI-6 RNA binding protein regulates actin-interacting protein-1 mRNA stability during oligodendrocyte differentiation. Mol. Biol. Cell 21 3029-40 PubMed GONUTS page

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MOUSE:QKI

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References

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