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MOUSE:QKI

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Qki (synonyms: Qk, Qk1, Qka1)
Protein Name(s) Protein quaking

MqkI qkI

External Links
UniProt Q9QYS9
EMBL U44940
AF090402
AF090403
AF090404
AF091047
AF090401
AF090392
AF090393
AF090394
AF090395
AF090396
AF090397
AF090400
AF090397
AF090392
AF090393
AF090394
AF090395
AF090396
AF090397
AF090392
AF090393
AF090395
AF090396
AF090394
AF090396
AF090392
AF090393
AF090394
AF090395
AF467890
AF467890
AF467890
AF467890
AF467890
AK005169
AK132303
BC053426
BC056346
AJ012812
AJ012813
AJ012814
AJ012816
AJ012817
AJ012815
AJ012812
AJ012813
AJ012814
AJ012818
AJ012816
AJ012815
AJ012812
AJ012813
AJ012814
AJ012816
AJ012820
AJ012819
AJ012815
CCDS CCDS28387.1
CCDS49947.1
RefSeq NP_001152988.1
NP_001152989.1
NP_068681.1
UniGene Mm.130694
Mm.384135
Mm.393248
PDB 4DNN
PDBsum 4DNN
ProteinModelPortal Q9QYS9
SMR Q9QYS9
BioGrid 202529
IntAct Q9QYS9
MINT MINT-4105681
PhosphoSite Q9QYS9
MaxQB Q9QYS9
PaxDb Q9QYS9
PRIDE Q9QYS9
Ensembl ENSMUST00000042296
ENSMUST00000097414
GeneID 19317
KEGG mmu:19317
UCSC uc008akb.2
uc008ake.2
uc012ajv.1
CTD 19317
MGI MGI:97837
eggNOG COG5176
GeneTree ENSGT00550000074434
HOVERGEN HBG093883
InParanoid Q9QYS9
KO K14945
OMA CLTHLKF
OrthoDB EOG75MVX3
PhylomeDB Q9QYS9
TreeFam TF314878
NextBio 296279
PRO PR:Q9QYS9
Proteomes UP000000589
Bgee Q9QYS9
CleanEx MM_QK
ExpressionAtlas Q9QYS9
Genevestigator Q9QYS9
GO GO:0005737
GO:0005634
GO:0003729
GO:0003723
GO:0061158
GO:0008366
GO:0042759
GO:0006397
GO:0051028
GO:0042692
GO:0042552
GO:0010628
GO:0006417
GO:0008380
GO:0007286
GO:0001570
Gene3D 3.30.1370.10
InterPro IPR004087
IPR004088
Pfam PF00013
SMART SM00322
SUPFAM SSF54791

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005634

nucleus

PMID:10506177[1]

ECO:0000314

C

Fig.4

complete
CACAO 7322

GO:0005634

nucleus

PMID:10506177[1]

ECO:0000315

C

Fig.4

complete
CACAO 7323

GO:0005737

cytoplasm

PMID:10506177[1]

ECO:0000314

C

Fig.6

complete
CACAO 7325

part_of

GO:0005737

cytoplasm

PMID:10506177[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:10506177[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:10506177[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0045202

synapse

PMID:16452087[2]

ECO:0006042

cell fractionation evidence used in manual assertion

C

part_of:(UBERON:0000955)

Seeded From UniProt

complete

part_of

GO:0045202

synapse

PMID:16452087[2]

ECO:0001230

mass spectrometry evidence used in manual assertion

C

part_of:(UBERON:0000955)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048714

positive regulation of oligodendrocyte differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1584886

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048255

mRNA stabilization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1584886

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042759

long-chain fatty acid biosynthetic process

PMID:1150661[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1856539

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042692

muscle cell differentiation

PMID:14706070[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3033861

P

results_in_acquisition_of_features_of:(CL:0000359)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042552

myelination

PMID:1373175[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042552

myelination

PMID:1150661[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1856539

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010976

positive regulation of neuron projection development

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1584886

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010667

negative regulation of cardiac muscle cell apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1584886

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010628

positive regulation of gene expression

PMID:1373175[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008366

axon ensheathment

PMID:14169723[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1856539

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007286

spermatid development

PMID:15148410[7]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1916560

P

occurs_in:(CL:0000018)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006397

mRNA processing

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1584886

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:25145264[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1584886

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001570

vasculogenesis

PMID:11892011[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857100

P

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004087

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004088
InterPro:IPR036612

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0061158

3'-UTR-mediated mRNA destabilization

PMID:20631256[10]

ECO:0000314

direct assay evidence used in manual assertion

P

has_direct_input:(RefSeq:NM_011715)

Seeded From UniProt

complete

enables

GO:0003729

mRNA binding

PMID:20631256[10]

ECO:0000314

direct assay evidence used in manual assertion

F

has_direct_input:(RefSeq:NM_011715)

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:11892011[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:11892011[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:11892011[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006417

regulation of translation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0810

P

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

involved_in

GO:0006397

mRNA processing

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0507

P

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

involved_in

GO:0051028

mRNA transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0509

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0008380

RNA splicing

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0508

P

Seeded From UniProt

complete

enables

GO:0017124

SH3 domain binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0729

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Wu, J et al. (1999) The quaking I-5 protein (QKI-5) has a novel nuclear localization signal and shuttles between the nucleus and the cytoplasm. J. Biol. Chem. 274 29202-10 PubMed GONUTS page
  2. 2.0 2.1 Trinidad, JC et al. (2006) Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Mol. Cell Proteomics 5 914-22 PubMed GONUTS page
  3. 3.0 3.1 Murad, S & Kishimoto, Y (1975) Alpha hydroxylation of lignoceric acid to cerebronic acid during brain development. Diminished hydroxylase activity in myelin-deficient mouse mutants. J. Biol. Chem. 250 5841-6 PubMed GONUTS page
  4. Li, Z et al. () Defective smooth muscle development in qkI-deficient mice. Dev. Growth Differ. 45 449-62 PubMed GONUTS page
  5. 5.0 5.1 Amiguet, P et al. (1992) Purification and partial structural and functional characterization of mouse myelin/oligodendrocyte glycoprotein. J. Neurochem. 58 1676-82 PubMed GONUTS page
  6. SIDMAN, RL et al. (1964) MUTANT MICE (QUAKING AND JIMPY) WITH DEFICIENT MYELINATION IN THE CENTRAL NERVOUS SYSTEM. Science 144 309-11 PubMed GONUTS page
  7. Lorenzetti, D et al. (2004) Deletion of the Parkin coregulated gene causes male sterility in the quaking(viable) mouse mutant. Proc. Natl. Acad. Sci. U.S.A. 101 8402-7 PubMed GONUTS page
  8. Ishizuka, A et al. (2014) Formation of nuclear bodies by the lncRNA Gomafu-associating proteins Celf3 and SF1. Genes Cells 19 704-21 PubMed GONUTS page
  9. 9.0 9.1 9.2 9.3 Noveroske, JK et al. (2002) Quaking is essential for blood vessel development. Genesis 32 218-30 PubMed GONUTS page
  10. 10.0 10.1 Doukhanine, E et al. (2010) The QKI-6 RNA binding protein regulates actin-interacting protein-1 mRNA stability during oligodendrocyte differentiation. Mol. Biol. Cell 21 3029-40 PubMed GONUTS page