MOUSE:Q8C0K8

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	No Information Provided.
Protein Name(s)	Protein Uvrag (ECO:0000313 with Ensembl:ENSMUSP00000045297)
External Links
UniProt	Q8C0K8
EMBL	AC093351 AC115850 AK030814 AK154903
RefSeq	NP_848750.3
UniGene	Mm.323072
Ensembl	ENSMUST00000037968
GeneID	78610
KEGG	mmu:78610
UCSC	uc009ikz.2
CTD	7405
MGI	MGI:1925860
GeneTree	ENSGT00390000012877
HOVERGEN	HBG059846
OMA	LPGEFHP
OrthoDB	EOG7NW68R
PhylomeDB	Q8C0K8
TreeFam	TF323546
ChiTaRS	Uvrag
NextBio	349185
PRO	PR:Q8C0K8
Proteomes	UP000000589
Genevestigator	Q8C0K8
GO	GO:0005769 GO:0005770 GO:0005764 GO:0045335 GO:0043234 GO:0017124 GO:0000149 GO:0010508 GO:0035493 GO:0046718
Gene3D	2.60.40.150
InterPro	IPR000008 IPR018791
Pfam	PF10186 PF00168
SMART	SM00239
SUPFAM	SSF49562

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:2000156	regulation of retrograde vesicle-mediated transport, Golgi to ER	PMID:24056303^[1]	ECO:0000315			P	Figure 5a shows that a knockdown mutation of UVRAG impairs the ability of a protein complex associated with retrograde transport, and in figure 5b it is shown that the same knockdown results in inhibition of retrograde transport from the Golgi to the ER.	complete CACAO 8788
	GO:0051684	maintenance of Golgi location	PMID:24056303^[1]	ECO:0000315			P	In Figure 6b, it is shown that knockdown mutations of UVRAG result in the dispersion of cis Golgi, whereas it is maintained maintained in a discrete structure in the control.	complete CACAO 8793
	GO:0010508	positive regulation of autophagy	PMID:24056303^[1]	ECO:0000315			P	In Figure 8d, it is shown that knockdown mutations of UVRAG resulted in the improper autophagy induced dispersal of fluorescent Atg9, compared to the even dispersal seen in the control.	complete CACAO 8795
part_of	GO:0000421	autophagosome membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9P2Y5	C	Seeded From UniProt	complete
involved_in	GO:0097352	autophagosome maturation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9P2Y5	P	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	PMID:22542840^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007098	centrosome cycle	PMID:22542840^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007051	spindle organization	PMID:22542840^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007059	chromosome segregation	PMID:22542840^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035493	SNARE complex assembly	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1925860 PANTHER:PTN000389174	P	Seeded From UniProt	complete
enables	GO:0000149	SNARE binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1925860 PANTHER:PTN000389174	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097680	double-strand break repair via classical nonhomologous end joining	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9P2Y5	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071900	regulation of protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9P2Y5	P	Seeded From UniProt	complete
colocalizes_with	GO:0070418	DNA-dependent protein kinase complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9P2Y5	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051684	maintenance of Golgi location	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9P2Y5	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046718	viral entry into host cell	PMID:24550300^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0045335	phagocytic vesicle	PMID:22493499^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9QUM4	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035493	SNARE complex assembly	PMID:24550300^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:17891140^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032801	receptor catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9P2Y5	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032465	regulation of cytokinesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9P2Y5	P	Seeded From UniProt	complete
part_of	GO:0030496	midbody	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9P2Y5	C	Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	PMID:17891140^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9JK48	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007098	centrosome cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9P2Y5	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006914	autophagy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9P2Y5	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9P2Y5	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006281	DNA repair	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9P2Y5	P	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9P2Y5	C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9P2Y5	C	Seeded From UniProt	complete
part_of	GO:0005770	late endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9P2Y5	C	Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9P2Y5	C	Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9P2Y5	C	Seeded From UniProt	complete
enables	GO:0000149	SNARE binding	PMID:24550300^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0097680	double-strand break repair via classical nonhomologous end joining	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9P2Y5 ensembl:ENSP00000348455	P	Seeded From UniProt	complete
involved_in	GO:0097352	autophagosome maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9P2Y5 ensembl:ENSP00000348455	P	Seeded From UniProt	complete
involved_in	GO:0071900	regulation of protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9P2Y5 ensembl:ENSP00000348455	P	Seeded From UniProt	complete
part_of	GO:0070418	DNA-dependent protein kinase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9P2Y5 ensembl:ENSP00000348455	C	Seeded From UniProt	complete
involved_in	GO:0051684	maintenance of Golgi location	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9P2Y5 ensembl:ENSP00000348455	P	Seeded From UniProt	complete
involved_in	GO:0032801	receptor catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9P2Y5 ensembl:ENSP00000348455	P	Seeded From UniProt	complete
involved_in	GO:0032465	regulation of cytokinesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9P2Y5 ensembl:ENSP00000348455	P	Seeded From UniProt	complete
part_of	GO:0030496	midbody	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9P2Y5 ensembl:ENSP00000348455	C	Seeded From UniProt	complete
involved_in	GO:0007098	centrosome cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9P2Y5 ensembl:ENSP00000348455	P	Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9P2Y5 ensembl:ENSP00000348455	P	Seeded From UniProt	complete
involved_in	GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9P2Y5 ensembl:ENSP00000348455	P	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9P2Y5 ensembl:ENSP00000348455	P	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9P2Y5 ensembl:ENSP00000348455	C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9P2Y5 ensembl:ENSP00000348455	C	Seeded From UniProt	complete
part_of	GO:0005770	late endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9P2Y5 ensembl:ENSP00000348455	C	Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9P2Y5 ensembl:ENSP00000348455	C	Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9P2Y5 ensembl:ENSP00000348455	C	Seeded From UniProt	complete
part_of	GO:0000421	autophagosome membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9P2Y5 ensembl:ENSP00000348455	C	Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158	C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256 UniProtKB-SubCell:SL-0095	C	Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0458 UniProtKB-SubCell:SL-0158	C	Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P	Seeded From UniProt	complete
part_of	GO:0000775	chromosome, centromeric region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0137 UniProtKB-SubCell:SL-0047	C	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P	Seeded From UniProt	complete
part_of	GO:0005770	late endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0152	C	Seeded From UniProt	complete
part_of	GO:0030496	midbody	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0469	C	Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0094	C	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 He, S et al. (2013) PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex. Nat. Cell Biol. 15 1206-19 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Zhao, Z et al. (2012) A dual role for UVRAG in maintaining chromosomal stability independent of autophagy. Dev. Cell 22 1001-16 PubMed GONUTS page
↑ ^3.0 ^3.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Pirooz, SD et al. (2014) UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs. Proc. Natl. Acad. Sci. U.S.A. 111 2716-21 PubMed GONUTS page
↑ Ma, C et al. (2012) Receptor signaling lymphocyte-activation molecule family 1 (Slamf1) regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by recruiting a Beclin-1/Vps34/ultraviolet radiation resistance-associated gene (UVRAG) complex. J. Biol. Chem. 287 18359-65 PubMed GONUTS page
↑ ^6.0 ^6.1 Takahashi, Y et al. (2007) Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat. Cell Biol. 9 1142-51 PubMed GONUTS page

[PMID:24056303-1] 1.0 ^1.1 ^1.2 He, S et al. (2013) PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex. Nat. Cell Biol. 15 1206-19 PubMed GONUTS page

[PMID:22542840-2] 2.0 ^2.1 ^2.2 ^2.3 Zhao, Z et al. (2012) A dual role for UVRAG in maintaining chromosomal stability independent of autophagy. Dev. Cell 22 1001-16 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24550300-4] 4.0 ^4.1 ^4.2 Pirooz, SD et al. (2014) UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs. Proc. Natl. Acad. Sci. U.S.A. 111 2716-21 PubMed GONUTS page

[PMID:22493499-5] Ma, C et al. (2012) Receptor signaling lymphocyte-activation molecule family 1 (Slamf1) regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by recruiting a Beclin-1/Vps34/ultraviolet radiation resistance-associated gene (UVRAG) complex. J. Biol. Chem. 287 18359-65 PubMed GONUTS page

[PMID:17891140-6] 6.0 ^6.1 Takahashi, Y et al. (2007) Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat. Cell Biol. 9 1142-51 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

MOUSE:Q8C0K8

Contents

Annotations

Notes

References

a

c

d

e

g

l

m

p

r

s

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools