GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
MOUSE:Q3TTI9
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | No Information Provided. | |
| Protein Name(s) | Phosphodiesterase (ECO:0000256 with RuleBase:RU363067) | |
| External Links | ||
| UniProt | Q3TTI9 | |
| EMBL | AL732551 AL772293 AL772358 AL807794 AK161341 | |
| RefSeq | NP_001171453.1 | |
| Ensembl | ENSMUST00000030251 | |
| GeneID | 18578 | |
| UCSC | uc012dhn.1 | |
| CTD | 5142 | |
| MGI | MGI:99557 | |
| eggNOG | KOG3689 ENOG410XRI7 | |
| GeneTree | ENSGT00940000155190 | |
| OrthoDB | 904682at2759 | |
| ChiTaRS | Pde4b | |
| Proteomes | UP000000589 | |
| Bgee | ENSMUSG00000028525 | |
| GO | GO:0071944 GO:0005813 GO:0005737 GO:0005829 GO:0043197 GO:0060076 GO:0000930 GO:0016020 GO:0005634 GO:0048471 GO:0014069 GO:0008021 GO:0004115 GO:0030552 GO:0043015 GO:0044325 GO:0046872 GO:0035690 GO:0071222 GO:0050900 GO:0030593 GO:0001780 GO:0032729 GO:0032743 GO:0009408 GO:0050852 | |
| CDD | cd00077 | |
| Gene3D | 1.10.1300.10 | |
| InterPro | IPR003607 IPR040844 IPR023088 IPR002073 IPR036971 IPR023174 | |
| Pfam | PF18100 PF00233 | |
| PRINTS | PR00387 | |
| SMART | SM00471 | |
| PROSITE | PS00126 PS51845 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0030552 |
cAMP binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
||||
|
part_of |
GO:0016020 |
membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
||||
|
part_of |
GO:0014069 |
postsynaptic density |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
||||
|
acts_upstream_of_or_within |
GO:0009408 |
response to heat |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3280 |
P |
Seeded From UniProt |
|||
|
part_of |
GO:0008021 |
synaptic vesicle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
||||
|
NOT|acts_upstream_of_or_within |
GO:0006939 |
smooth muscle contraction |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2181444 |
P |
Seeded From UniProt |
|||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
||||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3280 |
C |
Seeded From UniProt |
|||
|
part_of |
GO:0005813 |
centrosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
||||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3280 |
C |
Seeded From UniProt |
|||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3280 |
C |
Seeded From UniProt |
|||
|
enables |
GO:0004115 |
3',5'-cyclic-AMP phosphodiesterase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
||||
|
enables |
GO:0004115 |
3',5'-cyclic-AMP phosphodiesterase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3280 |
F |
Seeded From UniProt |
|||
|
enables |
GO:0004115 |
3',5'-cyclic-AMP phosphodiesterase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
||||
|
acts_upstream_of_or_within |
GO:0001780 |
neutrophil homeostasis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2181444 |
P |
Seeded From UniProt |
|||
|
part_of |
GO:0000930 |
gamma-tubulin complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
||||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
F |
Seeded From UniProt |
||||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
F |
Seeded From UniProt |
||||
|
enables |
GO:0004114 |
3',5'-cyclic-nucleotide phosphodiesterase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
||||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
||||
|
enables |
GO:0008081 |
phosphoric diester hydrolase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
||||
|
acts_upstream_of_or_within |
GO:0030593 |
neutrophil chemotaxis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2181444 |
P |
Seeded From UniProt |
|||
|
acts_upstream_of_or_within |
GO:0032729 |
positive regulation of interferon-gamma production |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
||||
|
acts_upstream_of_or_within |
GO:0032743 |
positive regulation of interleukin-2 production |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
||||
|
acts_upstream_of_or_within |
GO:0035690 |
cellular response to drug |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
||||
|
enables |
GO:0043015 |
gamma-tubulin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
||||
|
part_of |
GO:0043197 |
dendritic spine |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
||||
|
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3280 |
C |
Seeded From UniProt |
|||
|
acts_upstream_of_or_within |
GO:0050852 |
T cell receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
||||
|
acts_upstream_of_or_within |
GO:0050900 |
leukocyte migration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2181444 |
P |
Seeded From UniProt |
|||
|
part_of |
GO:0060076 |
excitatory synapse |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
||||
|
part_of |
GO:0071944 |
cell periphery |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
||||
|
acts_upstream_of_or_within |
GO:0071222 |
cellular response to lipopolysaccharide |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2181444 |
P |
Seeded From UniProt |
|||
|
enables |
GO:0030552 |
cAMP binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
||||
|
part_of |
GO:0016020 |
membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
||||
|
part_of |
GO:0014069 |
postsynaptic density |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
||||
|
acts_upstream_of_or_within |
GO:0009408 |
response to heat |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3280 |
P |
Seeded From UniProt |
|||
|
part_of |
GO:0008021 |
synaptic vesicle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
||||
|
NOT|acts_upstream_of_or_within |
GO:0006939 |
smooth muscle contraction |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2181444 |
P |
Seeded From UniProt |
|||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
||||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3280 |
C |
Seeded From UniProt |
|||
|
part_of |
GO:0005813 |
centrosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
||||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3280 |
C |
Seeded From UniProt |
|||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3280 |
C |
Seeded From UniProt |
|||
|
enables |
GO:0005515 |
protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
||||
|
enables |
GO:0005515 |
protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
||||
|
enables |
GO:0005515 |
protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
||||
|
enables |
GO:0005515 |
protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
||||
|
enables |
GO:0005515 |
protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
||||
|
enables |
GO:0005515 |
protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
||||
|
enables |
GO:0004115 |
3',5'-cyclic-AMP phosphodiesterase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
||||
|
enables |
GO:0004115 |
3',5'-cyclic-AMP phosphodiesterase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3280 |
F |
Seeded From UniProt |
|||
|
enables |
GO:0004115 |
3',5'-cyclic-AMP phosphodiesterase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
||||
|
acts_upstream_of_or_within |
GO:0001780 |
neutrophil homeostasis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2181444 |
P |
Seeded From UniProt |
|||
|
part_of |
GO:0000930 |
gamma-tubulin complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
||||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
F |
Seeded From UniProt |
||||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
F |
Seeded From UniProt |
||||
|
enables |
GO:0004114 |
3',5'-cyclic-nucleotide phosphodiesterase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
||||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
||||
|
enables |
GO:0008081 |
phosphoric diester hydrolase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
||||
|
acts_upstream_of_or_within |
GO:0030593 |
neutrophil chemotaxis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2181444 |
P |
Seeded From UniProt |
|||
|
acts_upstream_of_or_within |
GO:0032729 |
positive regulation of interferon-gamma production |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
||||
|
acts_upstream_of_or_within |
GO:0032743 |
positive regulation of interleukin-2 production |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
||||
|
acts_upstream_of_or_within |
GO:0035690 |
cellular response to drug |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
||||
|
enables |
GO:0043015 |
gamma-tubulin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
||||
|
part_of |
GO:0043197 |
dendritic spine |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
||||
|
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3280 |
C |
Seeded From UniProt |
|||
|
acts_upstream_of_or_within |
GO:0050852 |
T cell receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
||||
|
acts_upstream_of_or_within |
GO:0050900 |
leukocyte migration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2181444 |
P |
Seeded From UniProt |
|||
|
part_of |
GO:0060076 |
excitatory synapse |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
||||
|
part_of |
GO:0071944 |
cell periphery |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
||||
|
acts_upstream_of_or_within |
GO:0071222 |
cellular response to lipopolysaccharide |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2181444 |
P |
Seeded From UniProt |
|||
|
Contributes to |
GO:0004115 |
3',5'-cyclic-AMP phosphodiesterase activity |
ECO:0000112 |
F |
Figure 2 PDE4B−/− mice displayed decreases in PDE4B expression and PDE4 activity and an increase in neurogenesis. (a) Mice deficient in PDE4B (−/−) displayed a decrease in the expression of PDE4B1/3, but did not show any changes in that of PDE4A (A5) and PDE4D (D3) in cerebral cortices, relative to PDE4B wild-type (+ / +) controls. PDE4B heterozygous (+/ −) mice displayed intermediate expression in PDE4B1/3 relative to PDE4B + / + and PDE4B −/− mice. The tissues were homogenized and immunoprecipitated as described in the Methods section. The proteins of PDE4B1/3, PDE4A5, and PDE4D3 were detected by western blot analysis. Molecular weights of the PDE4 variants are shown in parentheses (Dlaboga et al, 2006). (b and c) PDE4B−/− mice displayed decreased PDE4 activity, but no change in non-PDE4 activity in both the cerebral cortex (b) and the amygdala (c). In contrast, these mice exhibited decreases in total PDE activity in the amygdala and a tendency toward decreased total PDE activity in the cerebral cortex. PDE4 activity was obtained by subtracting non-PDE4 (ie rolipram-sensitive PDE) activity from total PDE activity. (d and e) Representative photomicrographs of the hippocampal dentate gyrus from PDE4B+ / + (d) and PDE4B−/− (e) immunofluorescent staining for BrdU-positive cells (arrowhead), which were predominantly localized in the subgranular zone (SGZ) and within the granule cell layer (GCL). (f–h) Representative photomicrographs of cells double immunostaining (h; yellow) for Tuj1 (f; green) and BrdU (g; red) in the GCL of the dentate gyrus of the hippocampus from PDE4B−/− mice. (i) Quantification of BrdU and Tuj1 double-positive cells. PDE4B−/− mice displayed an increase in cell proliferation. Data shown represent the mean±SEM of 7–8 mice per group. *P < 0.05; **P < 0.01; ***P < 0.001 vs PDE4B + / + (two-tailed Student’s t-test). |
complete | ||||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Ghigo, A et al. (2012) Phosphoinositide 3-kinase γ protects against catecholamine-induced ventricular arrhythmia through protein kinase A-mediated regulation of distinct phosphodiesterases. Circulation 126 2073-83 PubMed GONUTS page
- ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 2.13 2.14 2.15 2.16 2.17 2.18 2.19 Bradshaw, NJ et al. (2008) DISC1, PDE4B, and NDE1 at the centrosome and synapse. Biochem. Biophys. Res. Commun. 377 1091-6 PubMed GONUTS page
- ↑ 3.0 3.1 Méhats, C et al. (2003) PDE4D plays a critical role in the control of airway smooth muscle contraction. FASEB J. 17 1831-41 PubMed GONUTS page
- ↑ 4.0 4.1 Cherry, JA & Davis, RL (1999) Cyclic AMP phosphodiesterases are localized in regions of the mouse brain associated with reinforcement, movement, and affect. J. Comp. Neurol. 407 287-301 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 Ariga, M et al. (2004) Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation. J. Immunol. 173 7531-8 PubMed GONUTS page
- ↑ 6.0 6.1 Cherry, JA et al. (2001) Diazepam and rolipram differentially inhibit cyclic AMP-specific phosphodiesterases PDE4A1 and PDE4B3 in the mouse. Biochim. Biophys. Acta 1518 27-35 PubMed GONUTS page
- ↑ 7.0 7.1 Nishi, A et al. (2008) Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum. J. Neurosci. 28 10460-71 PubMed GONUTS page
- ↑ Zhang, HT et al. (2008) Anxiogenic-like behavioral phenotype of mice deficient in phosphodiesterase 4B (PDE4B). Neuropsychopharmacology 33 1611-23 PubMed GONUTS page
3
c
m
p
s
