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MOUSE:PTPRH
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Ptprh (ECO:0000312 with MGI:MGI:3026877) (synonyms: SAP-1 (ECO:0000312 with MGI:MGI:3026877)) | |
| Protein Name(s) | Receptor-type tyrosine-protein phosphatase H (ECO:0000312 with MGI:MGI:3026877)
R-PTP-H (ECO:0000250 with UniProtKB:Q9HD43) Stomach cancer-associated protein tyrosine phosphatase 1 (ECO:0000250 with UniProtKB:Q9HD43) SAP-1 (ECO:0000250 with UniProtKB:Q9HD43) | |
| External Links | ||
| UniProt | E9Q0N2 | |
| EMBL | AB217856 AK078884 AC161197 AC161218 | |
| CCDS | CCDS51974.1 | |
| RefSeq | NP_997153.2 | |
| UniGene | Mm.188925 | |
| SMR | E9Q0N2 | |
| STRING | 10090.ENSMUSP00000042396 | |
| Ensembl | ENSMUST00000049113 ENSMUST00000166650 ENSMUST00000206999 | |
| GeneID | 545902 | |
| KEGG | mmu:545902 | |
| UCSC | uc009exz.1 | |
| CTD | 5794 | |
| MGI | MGI:3026877 | |
| eggNOG | KOG0791 COG5599 | |
| GeneTree | ENSGT00870000136384 | |
| KO | K18034 | |
| OMA | RVEGQNT | |
| OrthoDB | EOG091G08FR | |
| PhylomeDB | E9Q0N2 | |
| TreeFam | TF351926 | |
| PRO | PR:E9Q0N2 | |
| Proteomes | UP000000589 | |
| Bgee | ENSMUSG00000035429 | |
| GO | GO:0016324 GO:0005737 GO:0016021 GO:0005902 GO:0031528 GO:0005001 | |
| CDD | cd00063 | |
| Gene3D | 2.60.40.10 3.90.190.10 | |
| InterPro | IPR003961 IPR013783 IPR029021 IPR000242 IPR028855 IPR016130 IPR003595 IPR000387 | |
| PANTHER | PTHR19134:SF407 | |
| Pfam | PF00041 PF00102 | |
| PRINTS | PR00700 | |
| SMART | SM00060 SM00194 SM00404 | |
| SUPFAM | SSF49265 SSF52799 | |
| PROSITE | PS50853 PS00383 PS50056 PS50055 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0035335 |
peptidyl-tyrosine dephosphorylation |
ECO:0000314 |
P |
Figure 1B: mouse Ptprh dephosphorylates tyrosine-phosphorylated IR in vitro |
complete | |||||
| GO:1990264 |
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity |
ECO:0000314 |
P |
Figure 2B and 2C: mouse Ptprh dephosphorylates tyrosine 1146 in the activation loop of the insulin receptor (a member of the receptor protein tyrosine kinase superfamily) in HEK293T (human embryonic kidney) cells |
complete | |||||
|
acts_upstream_of_or_within |
GO:0008150 |
biological_process |
ECO:0000307 |
no biological data found used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005902 |
microvillus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0011108) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005902 |
microvillus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035335 |
peptidyl-tyrosine dephosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004725 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035335 |
peptidyl-tyrosine dephosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005001 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035335 |
peptidyl-tyrosine dephosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004725 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004725 |
protein tyrosine phosphatase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005001 |
transmembrane receptor protein tyrosine phosphatase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006470 |
protein dephosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016311 |
dephosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016791 |
phosphatase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004725 |
protein tyrosine phosphatase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042995 |
cell projection |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004721 |
phosphoprotein phosphatase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031528 |
microvillus membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016324 |
apical plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Shintani, T et al. (2015) The R3 receptor-like protein tyrosine phosphatase subfamily inhibits insulin signalling by dephosphorylating the insulin receptor at specific sites. J. Biochem. 158 235-43 PubMed GONUTS page
- ↑ Murata, Y et al. (2015) Protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epithelium. Proc. Natl. Acad. Sci. U.S.A. 112 E4264-71 PubMed GONUTS page
- ↑ Sadakata, H et al. (2009) SAP-1 is a microvillus-specific protein tyrosine phosphatase that modulates intestinal tumorigenesis. Genes Cells 14 295-308 PubMed GONUTS page
g
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- GO:0035335 ! peptidyl-tyrosine dephosphorylation
- GO:1990264 ! peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
- GO:0016791 ! phosphatase activity
- GO:0004721 ! phosphoprotein phosphatase activity
- GO:0005886 ! plasma membrane
- GO:0006470 ! protein dephosphorylation
- GO:0004725 ! protein tyrosine phosphatase activity
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