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MOUSE:PTPRH

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Ptprh (ECO:0000312 with MGI:MGI:3026877) (synonyms: SAP-1 (ECO:0000312 with MGI:MGI:3026877))
Protein Name(s) Receptor-type tyrosine-protein phosphatase H (ECO:0000312 with MGI:MGI:3026877)

R-PTP-H (ECO:0000250 with UniProtKB:Q9HD43) Stomach cancer-associated protein tyrosine phosphatase 1 (ECO:0000250 with UniProtKB:Q9HD43) SAP-1 (ECO:0000250 with UniProtKB:Q9HD43)

External Links
UniProt E9Q0N2
EMBL AB217856
AK078884
AC161197
AC161218
CCDS CCDS51974.1
RefSeq NP_997153.2
UniGene Mm.188925
SMR E9Q0N2
STRING 10090.ENSMUSP00000042396
Ensembl ENSMUST00000049113
ENSMUST00000166650
ENSMUST00000206999
GeneID 545902
KEGG mmu:545902
UCSC uc009exz.1
CTD 5794
MGI MGI:3026877
eggNOG KOG0791
COG5599
GeneTree ENSGT00870000136384
KO K18034
OMA RVEGQNT
OrthoDB EOG091G08FR
PhylomeDB E9Q0N2
TreeFam TF351926
PRO PR:E9Q0N2
Proteomes UP000000589
Bgee ENSMUSG00000035429
GO GO:0016324
GO:0005737
GO:0016021
GO:0005902
GO:0031528
GO:0005001
CDD cd00063
Gene3D 2.60.40.10
3.90.190.10
InterPro IPR003961
IPR013783
IPR029021
IPR000242
IPR028855
IPR016130
IPR003595
IPR000387
PANTHER PTHR19134:SF407
Pfam PF00041
PF00102
PRINTS PR00700
SMART SM00060
SM00194
SM00404
SUPFAM SSF49265
SSF52799
PROSITE PS50853
PS00383
PS50056
PS50055

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0035335

peptidyl-tyrosine dephosphorylation

PMID:26063811[1]

ECO:0000314

P

Figure 1B: mouse Ptprh dephosphorylates tyrosine-phosphorylated IR in vitro

complete
CACAO 12417

GO:1990264

peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

PMID:26063811[1]

ECO:0000314

P

Figure 2B and 2C: mouse Ptprh dephosphorylates tyrosine 1146 in the activation loop of the insulin receptor (a member of the receptor protein tyrosine kinase superfamily) in HEK293T (human embryonic kidney) cells

complete
CACAO 12418

acts_upstream_of_or_within

GO:0008150

biological_process

GO_REF:0000015

ECO:0000307

no biological data found used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005902

microvillus

PMID:26195794[2]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0011108)

Seeded From UniProt

complete

part_of

GO:0005902

microvillus

PMID:19170756[3]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(CL:0000239)
  • part_of:(EMAPA:16246)

Seeded From UniProt

complete

involved_in

GO:0035335

peptidyl-tyrosine dephosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004725

P

Seeded From UniProt

complete

involved_in

GO:0035335

peptidyl-tyrosine dephosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005001

P

Seeded From UniProt

complete

involved_in

GO:0035335

peptidyl-tyrosine dephosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004725

P

Seeded From UniProt

complete

enables

GO:0004725

protein tyrosine phosphatase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000242
InterPro:IPR016130

F

Seeded From UniProt

complete

enables

GO:0005001

transmembrane receptor protein tyrosine phosphatase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028855

F

Seeded From UniProt

complete

involved_in

GO:0006470

protein dephosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000242

P

Seeded From UniProt

complete

involved_in

GO:0016311

dephosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000387
InterPro:IPR016130

P

Seeded From UniProt

complete

enables

GO:0016791

phosphatase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000387

F

Seeded From UniProt

complete

enables

GO:0004725

protein tyrosine phosphatase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.1.3.48

F

Seeded From UniProt

complete

part_of

GO:0042995

cell projection

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0966

C

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

enables

GO:0004721

phosphoprotein phosphatase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0904

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0031528

microvillus membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0294

C

Seeded From UniProt

complete

part_of

GO:0016324

apical plasma membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0015

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Shintani, T et al. (2015) The R3 receptor-like protein tyrosine phosphatase subfamily inhibits insulin signalling by dephosphorylating the insulin receptor at specific sites. J. Biochem. 158 235-43 PubMed GONUTS page
  2. Murata, Y et al. (2015) Protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epithelium. Proc. Natl. Acad. Sci. U.S.A. 112 E4264-71 PubMed GONUTS page
  3. Sadakata, H et al. (2009) SAP-1 is a microvillus-specific protein tyrosine phosphatase that modulates intestinal tumorigenesis. Genes Cells 14 295-308 PubMed GONUTS page