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MOUSE:PTPRE

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Ptpre (synonyms: Ptpe)
Protein Name(s) Receptor-type tyrosine-protein phosphatase epsilon

Protein-tyrosine phosphatase epsilon R-PTP-epsilon

External Links
UniProt P49446
EMBL U35368
U36758
U40280
D83484
U62387
AK154910
CH466531
CH466531
Z23052
Z23053
CCDS CCDS21944.1
PIR B61180
JC6132
S40284
RefSeq NP_035342.3
XP_006507522.1
XP_006507523.1
XP_006507524.1
UniGene Mm.945
ProteinModelPortal P49446
SMR P49446
BioGrid 202496
IntAct P49446
PhosphoSite P49446
MaxQB P49446
PaxDb P49446
PRIDE P49446
DNASU 19267
Ensembl ENSMUST00000073961
GeneID 19267
KEGG mmu:19267
UCSC uc009kee.1
uc009kek.1
CTD 5791
MGI MGI:97813
eggNOG COG5599
GeneTree ENSGT00760000118900
HOVERGEN HBG053758
InParanoid P49446
KO K18033
OMA IVIDAMI
OrthoDB EOG7B31M8
PhylomeDB P49446
TreeFam TF351829
ChiTaRS Ptpre
NextBio 296146
PRO PR:P49446
Proteomes UP000000589
Bgee P49446
CleanEx MM_PTPRE
Genevestigator P49446
GO GO:0005737
GO:0016021
GO:0005634
GO:0005886
GO:0042803
GO:0004725
GO:0046627
GO:0035335
GO:0033003
GO:0007185
Gene3D 3.90.190.10
InterPro IPR029021
IPR000387
IPR016130
IPR000242
IPR016336
Pfam PF00102
PIRSF PIRSF002006
PRINTS PR00700
SMART SM00194
SUPFAM SSF52799
PROSITE PS00383
PS50056
PS50055

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0046627

negative regulation of insulin receptor signaling pathway

PMID:18006633[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0033003

regulation of mast cell activation

PMID:19508371[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:18006633[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:18006633[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046627

negative regulation of insulin receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620771

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:12861030[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007185

transmembrane receptor protein tyrosine phosphatase signaling pathway

PMID:12861030[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P23469

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P23469

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P23469

C

Seeded From UniProt

complete

enables

GO:0004725

protein tyrosine phosphatase activity

PMID:12861030[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0035335

peptidyl-tyrosine dephosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004725

P

Seeded From UniProt

complete

involved_in

GO:0035335

peptidyl-tyrosine dephosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004725

P

Seeded From UniProt

complete

involved_in

GO:0035335

peptidyl-tyrosine dephosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004725

P

Seeded From UniProt

complete

enables

GO:0004725

protein tyrosine phosphatase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000242
InterPro:IPR016130
InterPro:IPR016336

F

Seeded From UniProt

complete

involved_in

GO:0006470

protein dephosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000242
InterPro:IPR016336

P

Seeded From UniProt

complete

involved_in

GO:0016311

dephosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000387
InterPro:IPR016130

P

Seeded From UniProt

complete

enables

GO:0016791

phosphatase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000387

F

Seeded From UniProt

complete

enables

GO:0004725

protein tyrosine phosphatase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.1.3.48

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

enables

GO:0004721

phosphoprotein phosphatase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0904

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Aga-Mizrachi, S et al. (2008) Cytosolic protein tyrosine phosphatase-epsilon is a negative regulator of insulin signaling in skeletal muscle. Endocrinology 149 605-14 PubMed GONUTS page
  2. Akimoto, M et al. (2009) Protein tyrosine phosphatase epsilon is a negative regulator of FcepsilonRI-mediated mast cell responses. Scand. J. Immunol. 69 401-11 PubMed GONUTS page
  3. 3.0 3.1 3.2 Toledano-Katchalski, H et al. (2003) Dimerization in vivo and inhibition of the nonreceptor form of protein tyrosine phosphatase epsilon. Mol. Cell. Biol. 23 5460-71 PubMed GONUTS page