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MOUSE:PTGDS

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Ptgds
Protein Name(s) Prostaglandin-H2 D-isomerase

Glutathione-independent PGD synthase Lipocalin-type prostaglandin-D synthase Prostaglandin-D2 synthase L-PGDS PGD2 synthase PGDS2

External Links
UniProt O09114
EMBL X89222
Y10138
AB006361
D83329
AK131859
CH466542
CH466542
BC038083
BC043015
CCDS CCDS38074.1
PIR S57748
RefSeq NP_032989.2
XP_006497849.1
XP_006497850.1
UniGene Mm.1008
PDB 2CZT
2CZU
2E4J
2KTD
2RQ0
PDBsum 2CZT
2CZU
2E4J
2KTD
2RQ0
ProteinModelPortal O09114
SMR O09114
BindingDB O09114
ChEMBL CHEMBL4334
PhosphoSite O09114
MaxQB O09114
PaxDb O09114
PRIDE O09114
Ensembl ENSMUST00000015234
ENSMUST00000114251
ENSMUST00000114259
GeneID 19215
KEGG mmu:19215
UCSC uc008isf.1
CTD 5730
MGI MGI:99261
eggNOG NOG45731
GeneTree ENSGT00620000088005
HOGENOM HOG000231660
HOVERGEN HBG106490
InParanoid O09114
KO K01830
OMA KGPGQDF
OrthoDB EOG78PVBH
PhylomeDB O09114
TreeFam TF336103
BRENDA 5.3.99.2
Reactome REACT_188623
EvolutionaryTrace O09114
NextBio 295972
PRO PR:O09114
Proteomes UP000000589
Bgee O09114
CleanEx MM_PTGDS
Genevestigator O09114
GO GO:0005576
GO:0005615
GO:0070062
GO:0005794
GO:0031965
GO:0048471
GO:0005791
GO:0005504
GO:0004667
GO:0005501
GO:0005215
GO:0001516
GO:0045187
GO:0051384
GO:0006810
Gene3D 2.40.128.20
InterPro IPR012674
IPR011038
IPR002345
IPR022272
IPR000566
IPR002972
Pfam PF00061
PRINTS PR00179
PR01254
SUPFAM SSF50814
PROSITE PS00213

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0045187

regulation of circadian sleep/wake cycle, sleep

PMID:10781097[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P22057

C

Seeded From UniProt

complete

part_of

GO:0005791

rough endoplasmic reticulum

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P41222

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:8922532[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005501

retinoid binding

PMID:17715133[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005501

retinoid binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P22057

F

Seeded From UniProt

complete

enables

GO:0004667

prostaglandin-D synthase activity

PMID:17715133[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004667

prostaglandin-D synthase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P22057

F

Seeded From UniProt

complete

involved_in

GO:0001516

prostaglandin biosynthetic process

PMID:17715133[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001516

prostaglandin biosynthetic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P22057

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2000255

negative regulation of male germ cell proliferation

PMID:25142465[4]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1859384

P

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3433

C

Seeded From UniProt

complete

part_of

GO:0005791

rough endoplasmic reticulum

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P41222

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P41222

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3433

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P41222

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3433

C

Seeded From UniProt

complete

enables

GO:0005504

fatty acid binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P41222

F

Seeded From UniProt

complete

enables

GO:0005501

retinoid binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3433

F

Seeded From UniProt

complete

enables

GO:0004667

prostaglandin-D synthase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P41222

F

Seeded From UniProt

complete

enables

GO:0004667

prostaglandin-D synthase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3433

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001516

prostaglandin biosynthetic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P41222

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001516

prostaglandin biosynthetic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3433

P

Seeded From UniProt

complete

involved_in

GO:0051384

response to glucocorticoid

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22057
ensembl:ENSRNOP00000020926

P

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22057
ensembl:ENSRNOP00000020926

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22057
ensembl:ENSRNOP00000020926

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22057
ensembl:ENSRNOP00000020926

C

Seeded From UniProt

complete

enables

GO:0005501

retinoid binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22057
ensembl:ENSRNOP00000020926

F

Seeded From UniProt

complete

enables

GO:0004667

prostaglandin-D synthase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22057
ensembl:ENSRNOP00000020926

F

Seeded From UniProt

complete

involved_in

GO:0001516

prostaglandin biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22057
ensembl:ENSRNOP00000020926

P

Seeded From UniProt

complete

enables

GO:0036094

small molecule binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002345

F

Seeded From UniProt

complete

enables

GO:0004667

prostaglandin-D synthase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:5.3.99.2

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0256

C

Seeded From UniProt

complete

involved_in

GO:0006631

fatty acid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0276

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0333
UniProtKB-SubCell:SL-0132

C

Seeded From UniProt

complete

involved_in

GO:0006633

fatty acid biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0275

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

enables

GO:0016853

isomerase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0413

F

Seeded From UniProt

complete

involved_in

GO:0001516

prostaglandin biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0643

P

Seeded From UniProt

complete

involved_in

GO:0006693

prostaglandin metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0644

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

involved_in

GO:0006629

lipid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0443

P

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0198

C

Seeded From UniProt

complete

part_of

GO:0005791

rough endoplasmic reticulum

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0235

C

Seeded From UniProt

complete

part_of

GO:0031965

nuclear membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0182

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Pinzar, E et al. (2000) Prostaglandin D synthase gene is involved in the regulation of non-rapid eye movement sleep. Proc. Natl. Acad. Sci. U.S.A. 97 4903-7 PubMed GONUTS page
  2. ↑ Hoffmann, A et al. (1996) Developmental expression of murine Beta-trace in embryos and adult animals suggests a function in maturation and maintenance of blood-tissue barriers. Dev. Dyn. 207 332-43 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Shimamoto, S et al. (2007) NMR solution structure of lipocalin-type prostaglandin D synthase: evidence for partial overlapping of catalytic pocket and retinoic acid-binding pocket within the central cavity. J. Biol. Chem. 282 31373-9 PubMed GONUTS page
  4. ↑ Moniot, B et al. (2014) Prostaglandin D2 acts through the Dp2 receptor to influence male germ cell differentiation in the foetal mouse testis. Development 141 3561-71 PubMed GONUTS page
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