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MOUSE:PRDX6
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Prdx6 (synonyms: Aop2, Ltw4, Prdx5) | |
| Protein Name(s) | Peroxiredoxin-6
1-Cys peroxiredoxin 1-Cys PRX Acidic calcium-independent phospholipase A2 aiPLA2 Antioxidant protein 2 Non-selenium glutathione peroxidase NSGPx | |
| External Links | ||
| UniProt | O08709 | |
| EMBL | AF004670 Y12883 AF093852 AF093853 AF093857 AF093854 AF093855 AF093856 AK030413 BC013489 | |
| CCDS | CCDS15415.1 | |
| RefSeq | NP_031479.1 XP_006544594.1 | |
| UniGene | Mm.186185 | |
| ProteinModelPortal | O08709 | |
| SMR | O08709 | |
| BioGrid | 198118 | |
| IntAct | O08709 | |
| MINT | MINT-1869428 | |
| PhosphoSite | O08709 | |
| COMPLUYEAST-2DPAGE | O08709 | |
| REPRODUCTION-2DPAGE | O08709 | |
| SWISS-2DPAGE | O08709 | |
| UCD-2DPAGE | O08709 | |
| MaxQB | O08709 | |
| PaxDb | O08709 | |
| PRIDE | O08709 | |
| GeneID | 102642619 11758 | |
| KEGG | mmu:102642619 mmu:11758 | |
| CTD | 9588 | |
| MGI | MGI:894320 | |
| eggNOG | COG0450 | |
| HOVERGEN | HBG105234 | |
| InParanoid | O08709 | |
| KO | K11188 | |
| BRENDA | 1.11.1.15 | |
| ChiTaRS | Prdx6 | |
| NextBio | 279511 | |
| PRO | PR:O08709 | |
| Proteomes | UP000000589 | |
| CleanEx | MM_PRDX5 MM_PRDX6 | |
| Genevestigator | O08709 | |
| GO | GO:0016023 GO:0005829 GO:0005764 GO:0005739 GO:0004602 GO:0016787 GO:0004601 GO:0051920 GO:0032060 GO:0016042 GO:0000302 | |
| Gene3D | 3.40.30.10 | |
| InterPro | IPR000866 IPR024706 IPR019479 IPR012336 | |
| Pfam | PF10417 PF00578 | |
| PIRSF | PIRSF000239 | |
| SUPFAM | SSF52833 | |
| PROSITE | PS51352 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0042744 |
hydrogen peroxide catabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0031479 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034599 |
cellular response to oxidative stress |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002460592 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0031479 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004601 |
peroxidase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0031479 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0098869 |
cellular oxidant detoxification |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0048026 |
positive regulation of mRNA splicing, via spliceosome |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0047499 |
calcium-independent phospholipase A2 activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0046475 |
glycerophospholipid catabolic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0042744 |
hydrogen peroxide catabolic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:71005 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0032060 |
bleb assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(CL:0000062) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0031625 |
ubiquitin protein ligase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006979 |
response to oxidative stress |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000581) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004602 |
glutathione peroxidase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004602 |
glutathione peroxidase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:71005 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004601 |
peroxidase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2668338 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0000302 |
response to reactive oxygen species |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2668338 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016209 |
antioxidant activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045454 |
cell redox homeostasis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0051920 |
peroxiredoxin activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0051920 |
peroxiredoxin activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004623 |
phospholipase A2 activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0102567 |
phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0102568 |
phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016209 |
antioxidant activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005764 |
lysosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004601 |
peroxidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008152 |
metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003824 |
catalytic activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016042 |
lipid catabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Panupinthu, N et al. (2007) P2X7 nucleotide receptors mediate blebbing in osteoblasts through a pathway involving lysophosphatidic acid. J. Biol. Chem. 282 3403-12 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Wang, X et al. (2003) Mice with targeted mutation of peroxiredoxin 6 develop normally but are susceptible to oxidative stress. J. Biol. Chem. 278 25179-90 PubMed GONUTS page
- ↑ Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page
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- GO:0048471 ! perinuclear region of cytoplasm
- GO:0004601 ! peroxidase activity
- GO:0051920 ! peroxiredoxin activity
- GO:0102568 ! phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
- GO:0102567 ! phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
- GO:0004623 ! phospholipase A2 activity
- GO:0048026 ! positive regulation of mRNA splicing, via spliceosome
- GO:0042803 ! protein homodimerization activity
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