MOUSE:PMP22

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Pmp22 (synonyms: Gas-3, Gas3, Pmp-22)
Protein Name(s)	Peripheral myelin protein 22 PMP-22 Growth arrest-specific protein 3 GAS-3
External Links
UniProt	P16646
EMBL	M32240 Z38110 BC010765
PIR	A36324 S21721
RefSeq	NP_001289184.1 NP_001289186.1 NP_001289187.1 NP_001289188.1 NP_001289189.1 NP_032911.1
UniGene	Mm.1237
ProteinModelPortal	P16646
SMR	P16646
GeneID	18858
KEGG	mmu:18858
UCSC	uc007jkm.1
CTD	5376
MGI	MGI:97631
eggNOG	NOG43599
HOGENOM	HOG000059542
HOVERGEN	HBG001690
InParanoid	P16646
PhylomeDB	P16646
NextBio	295240
PRO	PR:P16646
Proteomes	UP000000589
Bgee	P16646
CleanEx	MM_PMP22
ExpressionAtlas	P16646
Genevestigator	P16646
GO	GO:0043218 GO:0016021 GO:0005886 GO:0005923 GO:0007050 GO:0032288 GO:0008285 GO:0010977
InterPro	IPR003936 IPR004031 IPR004032
Pfam	PF00822
PRINTS	PR01453 PR01458
PROSITE	PS01221 PS01222

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0032289	central nervous system myelin formation	PMID:12111804^[1]	ECO:0000315			P	plays an important role in myelin construction and maintenance	complete CACAO 9626
	GO:0032290	peripheral nervous system myelin formation	PMID:12111804^[1]	ECO:0000315			P	Figure 2. Examines the association of proteins with GEMs is TX-100 extraction at 37°C. This figure indicates that GEMs play a role in myelin construction.	complete CACAO 9816
involved_in	GO:0042552	myelination	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000072455 RGD:3359	P	Seeded From UniProt	complete
involved_in	GO:0032288	myelin assembly	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97631 PANTHER:PTN000072455	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1098726 PANTHER:PTN002369799 RGD:2552 RGD:621482 UniProtKB:P54849 UniProtKB:P54851 UniProtKB:P54852 UniProtKB:Q01453 WB:WBGene00000523 WB:WBGene00021415	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001233	regulation of apoptotic signaling pathway	PMID:23847051^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856217	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098529	neuromuscular junction development, skeletal muscle fiber	PMID:25014022^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856217	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071900	regulation of protein serine/threonine kinase activity	PMID:27583434^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447704	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071711	basement membrane organization	PMID:16436605^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3614822	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070842	aggresome assembly	PMID:15748170^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856217	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061744	motor behavior	PMID:16436605^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3614822	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061744	motor behavior	PMID:12359155^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1862010 MGI:MGI:1862011 MGI:MGI:2388488	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061564	axon development	PMID:20071523^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447704	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060005	vestibular reflex	PMID:12359155^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1862010 MGI:MGI:1862011 MGI:MGI:2388488	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051641	cellular localization	PMID:15703401^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856217	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051259	protein complex oligomerization	PMID:12359155^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051146	striated muscle cell differentiation	PMID:16436605^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3614822	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050905	neuromuscular process	PMID:12359155^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2388488	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050727	regulation of inflammatory response	PMID:23847051^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856217	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048936	peripheral nervous system neuron axonogenesis	PMID:25014022^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856217	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048936	peripheral nervous system neuron axonogenesis	PMID:12359155^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1862010 MGI:MGI:1862011 MGI:MGI:2388488	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048747	muscle fiber development	PMID:28108290^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:12359155^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045161	neuronal ion channel clustering	PMID:15703401^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856217	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044255	cellular lipid metabolic process	PMID:22337502^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447704	P	Seeded From UniProt	complete
part_of	GO:0043256	laminin complex	PMID:16436605^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0043218	compact myelin	PMID:29315582^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0043218	compact myelin	PMID:11114256^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0043218	compact myelin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3359	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	PMID:15748170^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856217	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042552	myelination	PMID:28108290^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042552	myelination	PMID:20731761^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447704	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042552	myelination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3359	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042063	gliogenesis	PMID:14627652^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447704	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0036135	Schwann cell migration	PMID:25429154^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3614822	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035264	multicellular organism growth	PMID:16436605^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3614822	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034976	response to endoplasmic reticulum stress	PMID:23847051^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856217	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034620	cellular response to unfolded protein	PMID:23847051^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	GO:0034620	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034605	cellular response to heat	PMID:23847051^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856217	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034350	regulation of glial cell apoptotic process	PMID:11673320^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447704	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032288	myelin assembly	PMID:27583434^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447704	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032288	myelin assembly	PMID:25453108^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856217	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032288	myelin assembly	PMID:20427655^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856217	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032288	myelin assembly	PMID:20071523^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447704	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032288	myelin assembly	PMID:16405874^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856420	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032060	bleb assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01453	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031579	membrane raft organization	PMID:17971504^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3614822	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030913	paranodal junction assembly	PMID:16436605^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3614822	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030154	cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3359	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030036	actin cytoskeleton organization	PMID:27583434^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447704	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030036	actin cytoskeleton organization	PMID:25429154^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3614822	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030032	lamellipodium assembly	PMID:25429154^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3614822	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022011	myelination in peripheral nervous system	PMID:29315582^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96613	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022011	myelination in peripheral nervous system	PMID:20553714^[23]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97384 MGI:MGI:97385	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022011	myelination in peripheral nervous system	PMID:25453108^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856217	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022011	myelination in peripheral nervous system	PMID:25429154^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3614822	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022011	myelination in peripheral nervous system	PMID:25014022^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856217	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022011	myelination in peripheral nervous system	PMID:22337502^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447704	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022011	myelination in peripheral nervous system	PMID:20553714^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856217	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022011	myelination in peripheral nervous system	PMID:16436605^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3614822	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022011	myelination in peripheral nervous system	PMID:12359155^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2388488	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019228	neuronal action potential	PMID:27583434^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447704	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019227	neuronal action potential propagation	PMID:20071523^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447704	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019226	transmission of nerve impulse	PMID:29315582^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96613	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019226	transmission of nerve impulse	PMID:27583434^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1339975	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019226	transmission of nerve impulse	PMID:20553714^[23]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97384 MGI:MGI:97385	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019226	transmission of nerve impulse	PMID:28108290^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019226	transmission of nerve impulse	PMID:20071523^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447704	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019226	transmission of nerve impulse	PMID:15363066^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856217	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3359	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:12359155^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014044	Schwann cell development	PMID:25429154^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3614822	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014037	Schwann cell differentiation	PMID:28108290^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014037	Schwann cell differentiation	PMID:25150498^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447704	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014037	Schwann cell differentiation	PMID:15748170^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856217	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014037	Schwann cell differentiation	PMID:14627652^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447704	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010977	negative regulation of neuron projection development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3359	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010761	fibroblast migration	PMID:25429154^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3614822	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	PMID:23847051^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856217	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	PMID:16436605^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3614822	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010624	regulation of Schwann cell proliferation	PMID:11673320^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447704	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010498	proteasomal protein catabolic process	PMID:14627652^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447704	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	PMID:28108290^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	PMID:25429154^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3614822	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010259	multicellular organism aging	PMID:22337502^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447704	P	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:16436605^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009617	response to bacterium	PMID:23012479^[26]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008344	adult locomotory behavior	PMID:25014022^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856217	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008344	adult locomotory behavior	PMID:12359155^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1862010 MGI:MGI:1862011 MGI:MGI:2388488	P	Seeded From UniProt	complete
part_of	GO:0008305	integrin complex	PMID:16436605^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3359	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008219	cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01453	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008203	cholesterol metabolic process	PMID:25429154^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3614822	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007628	adult walking behavior	PMID:12359155^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1862010 MGI:MGI:1862011 MGI:MGI:2388488	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007618	mating	PMID:16436605^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3614822	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007422	peripheral nervous system development	PMID:22337502^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447704	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007422	peripheral nervous system development	PMID:2022965^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007422	peripheral nervous system development	PMID:16436605^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3614822	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007155	cell adhesion	PMID:25429154^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3614822	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006955	immune response	PMID:22337502^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447704	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006914	autophagy	PMID:25014022^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856217	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006914	autophagy	PMID:17174099^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856217	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006914	autophagy	PMID:14627652^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447704	P	Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3359	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01453	C	Seeded From UniProt	complete
enables	GO:0003774	motor activity	PMID:28108290^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003936	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004031 InterPro:IPR004032	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0338	P	Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Hasse, B et al. (2002) Proteins of peripheral myelin are associated with glycosphingolipid/cholesterol-enriched membranes. J. Neurosci. Res. 69 227-32 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Okamoto, Y et al. (2013) Curcumin facilitates a transitory cellular stress response in Trembler-J mice. Hum. Mol. Genet. 22 4698-705 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Nicks, J et al. (2014) Rapamycin improves peripheral nerve myelination while it fails to benefit neuromuscular performance in neuropathic mice. Neurobiol. Dis. 70 224-36 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Hu, B et al. (2016) Tuning PAK Activity to Rescue Abnormal Myelin Permeability in HNPP. PLoS Genet. 12 e1006290 PubMed GONUTS page
↑ ^6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 Amici, SA et al. (2006) Peripheral myelin protein 22 is in complex with alpha6beta4 integrin, and its absence alters the Schwann cell basal lamina. J. Neurosci. 26 1179-89 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Fortun, J et al. (2005) Impaired proteasome activity and accumulation of ubiquitinated substrates in a hereditary neuropathy model. J. Neurochem. 92 1531-41 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 ^8.8 ^8.9 Isaacs, AM et al. (2002) Identification of a new Pmp22 mouse mutant and trafficking analysis of a Pmp22 allelic series suggesting that protein aggregates may be protective in Pmp22-associated peripheral neuropathy. Mol. Cell. Neurosci. 21 114-25 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Bai, Y et al. (2010) Conduction block in PMP22 deficiency. J. Neurosci. 30 600-8 PubMed GONUTS page
↑ ^10.0 ^10.1 Devaux, JJ & Scherer, SS (2005) Altered ion channels in an animal model of Charcot-Marie-Tooth disease type IA. J. Neurosci. 25 1470-80 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 Lee, JS et al. (2017) Pmp22 mutant allele-specific siRNA alleviates demyelinating neuropathic phenotype in vivo. Neurobiol. Dis. 100 99-107 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 Verdier, V et al. (2012) Aging of myelinating glial cells predominantly affects lipid metabolism and immune response pathways. Glia 60 751-60 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Poitelon, Y et al. (2018) A dual role for Integrin α6β4 in modulating hereditary neuropathy with liability to pressure palsies. J. Neurochem. 145 245-257 PubMed GONUTS page
↑ Colby, J et al. (2000) PMP22 carrying the trembler or trembler-J mutation is intracellularly retained in myelinating Schwann cells. Neurobiol. Dis. 7 561-73 PubMed GONUTS page
↑ Khazaei, MR et al. (2010) Bex1 is involved in the regeneration of axons after injury. J. Neurochem. 115 910-20 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 Fortun, J et al. (2003) Emerging role for autophagy in the removal of aggresomes in Schwann cells. J. Neurosci. 23 10672-80 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 ^17.6 ^17.7 ^17.8 Lee, S et al. (2014) PMP22 is critical for actin-mediated cellular functions and for establishing lipid rafts. J. Neurosci. 34 16140-52 PubMed GONUTS page
↑ ^18.0 ^18.1 Sancho, S et al. (2001) Regulation of Schwann cell proliferation and apoptosis in PMP22-deficient mice and mouse models of Charcot-Marie-Tooth disease type 1A. Brain 124 2177-87 PubMed GONUTS page
↑ ^19.0 ^19.1 Lim, H et al. (2014) Label-free imaging of Schwann cell myelination by third harmonic generation microscopy. Proc. Natl. Acad. Sci. U.S.A. 111 18025-30 PubMed GONUTS page
↑ Coulpier, F et al. (2010) CNS/PNS boundary transgression by central glia in the absence of Schwann cells or Krox20/Egr2 function. J. Neurosci. 30 5958-67 PubMed GONUTS page
↑ Fukazawa, N et al. (2006) Identification and functional characterization of mouse TPO1 as a myelin membrane protein. Brain Res. 1070 1-14 PubMed GONUTS page
↑ McClintock, TS et al. (2008) Tissue expression patterns identify mouse cilia genes. Physiol. Genomics 32 198-206 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 Sahenk, Z et al. (2010) TrkB and TrkC agonist antibodies improve function, electrophysiologic and pathologic features in Trembler J mice. Exp. Neurol. 224 495-506 PubMed GONUTS page
↑ Meekins, GD et al. (2004) Nerve conduction abnormalities in the trembler-j mouse: a model for Charcot-Marie-Tooth disease type 1A? J. Peripher. Nerv. Syst. 9 177-82 PubMed GONUTS page
↑ Fledrich, R et al. (2014) Soluble neuregulin-1 modulates disease pathogenesis in rodent models of Charcot-Marie-Tooth disease 1A. Nat. Med. 20 1055-61 PubMed GONUTS page
↑ Archambaud, C et al. (2012) Impact of lactobacilli on orally acquired listeriosis. Proc. Natl. Acad. Sci. U.S.A. 109 16684-9 PubMed GONUTS page
↑ Johnson, D et al. (1991) An analysis of mast cell frequency in the rodent nervous system: numbers vary between different strains and can be reconstituted in mast cell-deficient mice. J. Neuropathol. Exp. Neurol. 50 227-34 PubMed GONUTS page
↑ Fortun, J et al. (2007) The formation of peripheral myelin protein 22 aggregates is hindered by the enhancement of autophagy and expression of cytoplasmic chaperones. Neurobiol. Dis. 25 252-65 PubMed GONUTS page

[PMID:12111804-1] 1.0 ^1.1 Hasse, B et al. (2002) Proteins of peripheral myelin are associated with glycosphingolipid/cholesterol-enriched membranes. J. Neurosci. Res. 69 227-32 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23847051-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Okamoto, Y et al. (2013) Curcumin facilitates a transitory cellular stress response in Trembler-J mice. Hum. Mol. Genet. 22 4698-705 PubMed GONUTS page

[PMID:25014022-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Nicks, J et al. (2014) Rapamycin improves peripheral nerve myelination while it fails to benefit neuromuscular performance in neuropathic mice. Neurobiol. Dis. 70 224-36 PubMed GONUTS page

[PMID:27583434-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Hu, B et al. (2016) Tuning PAK Activity to Rescue Abnormal Myelin Permeability in HNPP. PLoS Genet. 12 e1006290 PubMed GONUTS page

[PMID:16436605-6] 6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 Amici, SA et al. (2006) Peripheral myelin protein 22 is in complex with alpha6beta4 integrin, and its absence alters the Schwann cell basal lamina. J. Neurosci. 26 1179-89 PubMed GONUTS page

[PMID:15748170-7] 7.0 ^7.1 ^7.2 Fortun, J et al. (2005) Impaired proteasome activity and accumulation of ubiquitinated substrates in a hereditary neuropathy model. J. Neurochem. 92 1531-41 PubMed GONUTS page

[PMID:12359155-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 ^8.8 ^8.9 Isaacs, AM et al. (2002) Identification of a new Pmp22 mouse mutant and trafficking analysis of a Pmp22 allelic series suggesting that protein aggregates may be protective in Pmp22-associated peripheral neuropathy. Mol. Cell. Neurosci. 21 114-25 PubMed GONUTS page

[PMID:20071523-9] 9.0 ^9.1 ^9.2 ^9.3 Bai, Y et al. (2010) Conduction block in PMP22 deficiency. J. Neurosci. 30 600-8 PubMed GONUTS page

[PMID:15703401-10] 10.0 ^10.1 Devaux, JJ & Scherer, SS (2005) Altered ion channels in an animal model of Charcot-Marie-Tooth disease type IA. J. Neurosci. 25 1470-80 PubMed GONUTS page

[PMID:28108290-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 Lee, JS et al. (2017) Pmp22 mutant allele-specific siRNA alleviates demyelinating neuropathic phenotype in vivo. Neurobiol. Dis. 100 99-107 PubMed GONUTS page

[PMID:22337502-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 Verdier, V et al. (2012) Aging of myelinating glial cells predominantly affects lipid metabolism and immune response pathways. Glia 60 751-60 PubMed GONUTS page

[PMID:29315582-13] 13.0 ^13.1 ^13.2 Poitelon, Y et al. (2018) A dual role for Integrin α6β4 in modulating hereditary neuropathy with liability to pressure palsies. J. Neurochem. 145 245-257 PubMed GONUTS page

[PMID:11114256-14] Colby, J et al. (2000) PMP22 carrying the trembler or trembler-J mutation is intracellularly retained in myelinating Schwann cells. Neurobiol. Dis. 7 561-73 PubMed GONUTS page

[PMID:20731761-15] Khazaei, MR et al. (2010) Bex1 is involved in the regeneration of axons after injury. J. Neurochem. 115 910-20 PubMed GONUTS page

[PMID:14627652-16] 16.0 ^16.1 ^16.2 ^16.3 Fortun, J et al. (2003) Emerging role for autophagy in the removal of aggresomes in Schwann cells. J. Neurosci. 23 10672-80 PubMed GONUTS page

[PMID:25429154-17] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 ^17.6 ^17.7 ^17.8 Lee, S et al. (2014) PMP22 is critical for actin-mediated cellular functions and for establishing lipid rafts. J. Neurosci. 34 16140-52 PubMed GONUTS page

[PMID:11673320-18] 18.0 ^18.1 Sancho, S et al. (2001) Regulation of Schwann cell proliferation and apoptosis in PMP22-deficient mice and mouse models of Charcot-Marie-Tooth disease type 1A. Brain 124 2177-87 PubMed GONUTS page

[PMID:25453108-19] 19.0 ^19.1 Lim, H et al. (2014) Label-free imaging of Schwann cell myelination by third harmonic generation microscopy. Proc. Natl. Acad. Sci. U.S.A. 111 18025-30 PubMed GONUTS page

[PMID:20427655-20] Coulpier, F et al. (2010) CNS/PNS boundary transgression by central glia in the absence of Schwann cells or Krox20/Egr2 function. J. Neurosci. 30 5958-67 PubMed GONUTS page

[PMID:16405874-21] Fukazawa, N et al. (2006) Identification and functional characterization of mouse TPO1 as a myelin membrane protein. Brain Res. 1070 1-14 PubMed GONUTS page

[PMID:17971504-22] McClintock, TS et al. (2008) Tissue expression patterns identify mouse cilia genes. Physiol. Genomics 32 198-206 PubMed GONUTS page

[PMID:20553714-23] 23.0 ^23.1 ^23.2 Sahenk, Z et al. (2010) TrkB and TrkC agonist antibodies improve function, electrophysiologic and pathologic features in Trembler J mice. Exp. Neurol. 224 495-506 PubMed GONUTS page

[PMID:15363066-24] Meekins, GD et al. (2004) Nerve conduction abnormalities in the trembler-j mouse: a model for Charcot-Marie-Tooth disease type 1A? J. Peripher. Nerv. Syst. 9 177-82 PubMed GONUTS page

[PMID:25150498-25] Fledrich, R et al. (2014) Soluble neuregulin-1 modulates disease pathogenesis in rodent models of Charcot-Marie-Tooth disease 1A. Nat. Med. 20 1055-61 PubMed GONUTS page

[PMID:23012479-26] Archambaud, C et al. (2012) Impact of lactobacilli on orally acquired listeriosis. Proc. Natl. Acad. Sci. U.S.A. 109 16684-9 PubMed GONUTS page

[PMID:2022965-27] Johnson, D et al. (1991) An analysis of mast cell frequency in the rodent nervous system: numbers vary between different strains and can be reconstituted in mast cell-deficient mice. J. Neuropathol. Exp. Neurol. 50 227-34 PubMed GONUTS page

[PMID:17174099-28] Fortun, J et al. (2007) The formation of peripheral myelin protein 22 aggregates is hindered by the enhancement of autophagy and expression of cytoplasmic chaperones. Neurobiol. Dis. 25 252-65 PubMed GONUTS page

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