MOUSE:PLCG2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Plcg2
Protein Name(s)	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 Phosphoinositide phospholipase C-gamma-2 Phospholipase C-gamma-2 PLC-gamma-2
External Links
UniProt	Q8CIH5
EMBL	AK142173 AK151039 BC019654 BC023877
CCDS	CCDS22700.1
RefSeq	NP_758489.1
UniGene	Mm.192699
PDB	2DX0 2EQI
PDBsum	2DX0 2EQI
ProteinModelPortal	Q8CIH5
SMR	Q8CIH5
IntAct	Q8CIH5
MINT	MINT-1348529
STRING	10090.ENSMUSP00000079991
PhosphoSite	Q8CIH5
MaxQB	Q8CIH5
PaxDb	Q8CIH5
PRIDE	Q8CIH5
Ensembl	ENSMUST00000081232
GeneID	234779
KEGG	mmu:234779
UCSC	uc009npc.1
CTD	5336
MGI	MGI:97616
eggNOG	NOG268751
GeneTree	ENSGT00730000110782
HOGENOM	HOG000230864
HOVERGEN	HBG053611
InParanoid	Q8CIH5
KO	K05859
OMA	MLMRIPR
OrthoDB	EOG7W419X
PhylomeDB	Q8CIH5
TreeFam	TF313216
Reactome	REACT_188185 REACT_188194 REACT_188202 REACT_188530 REACT_196473 REACT_210240 REACT_220092 REACT_246719
EvolutionaryTrace	Q8CIH5
NextBio	382355
PRO	PR:Q8CIH5
Proteomes	UP000000589
Bgee	Q8CIH5
Genevestigator	Q8CIH5
GO	GO:0005829 GO:0070062 GO:0005886 GO:0004435 GO:0004629 GO:0004871 GO:0032237 GO:0030183 GO:0050853 GO:0002316 GO:0032959 GO:0035556 GO:0043069 GO:0006661 GO:0009395 GO:0010468 GO:0051209 GO:0032496 GO:0050852
Gene3D	2.30.29.30 2.60.40.150 3.20.20.190 3.30.505.10
InterPro	IPR000008 IPR001849 IPR011993 IPR001192 IPR016279 IPR028381 IPR017946 IPR015359 IPR000909 IPR001711 IPR000980 IPR001452
PANTHER	PTHR10336 PTHR10336:SF25
Pfam	PF00168 PF09279 PF00388 PF00387 PF00017 PF00018
PIRSF	PIRSF000952
PRINTS	PR00390 PR00401
SMART	SM00239 SM00233 SM00148 SM00149 SM00252 SM00326
SUPFAM	SSF49562 SSF50044 SSF51695 SSF55550
PROSITE	PS50004 PS50003 PS50007 PS50008 PS50001 PS50002

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0002092	positive regulation of receptor internalization	PMID:22078883^[1]	ECO:0000315			P		Figure 6 B and C graph 1 shows that upon stimulation with LPS there is more retaining of TLR4 receptors in knockouts of Phospholipase C in Macrophages and dendritic cells than there is when phospholipase C is present.	complete CACAO 9482
	GO:0032728	positive regulation of interferon-beta production	PMID:22078883^[1]	ECO:0000315			P		When PLC is knocked down, figure 6 B and C graphs 3 show that IFN beta production is decreased when compared to the WT in macrophages and dendritic cells.	complete CACAO 9483
	GO:0032481	positive regulation of type I interferon production	PMID:22078883^[1]	ECO:0000315			P		Fig 6 B and C graph 3 shows that when PLC is knocked down there is a decrease in the production of IFN alpha in macrophages and dendritic cells.	complete CACAO 9484
involved_in	GO:0032481	positive regulation of type I interferon production	PMID:22078883^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002092	positive regulation of receptor internalization	PMID:22078883^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051209	release of sequestered calcium ion into cytosol	PMID:10925250^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050853	B cell receptor signaling pathway	PMID:10925250^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030183	B cell differentiation	PMID:10925250^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006661	phosphatidylinositol biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16885	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16885	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:10925250^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004435	phosphatidylinositol phospholipase C activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16885	F		Seeded From UniProt	complete
involved_in	GO:0051209	release of sequestered calcium ion into cytosol	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97616 PANTHER:PTN000036885 UniProtKB:P16885	P		Seeded From UniProt	complete
involved_in	GO:0048015	phosphatidylinositol-mediated signaling	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000036885 RGD:61993 UniProtKB:Q4KWH8	P		Seeded From UniProt	complete
involved_in	GO:0032959	inositol trisphosphate biosynthetic process	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97616 PANTHER:PTN000036828 RGD:3347 dictyBase:DDB_G0292736	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2443078 PANTHER:PTN000818423 UniProtKB:P16885 UniProtKB:P19174	C		Seeded From UniProt	complete
enables	GO:0004435	phosphatidylinositol phospholipase C activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97613 MGI:MGI:97615 MGI:MGI:97616 PANTHER:PTN000036885 RGD:3344 RGD:3348 RGD:61993 RGD:621004 RGD:69424 SGD:S000006189 TAIR:locus:2075696 UniProtKB:P10894 UniProtKB:P16885 UniProtKB:P19174 UniProtKB:Q00722 UniProtKB:Q9P212 WB:WBGene00004036	F		Seeded From UniProt	complete
enables	GO:0004435	phosphatidylinositol phospholipase C activity	PMID:8615781^[4]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051209	release of sequestered calcium ion into cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16885	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050852	T cell receptor signaling pathway	PMID:15728238^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043069	negative regulation of programmed cell death	PMID:12928432^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386100	P	regulates_o_occurs_in:(CL:0000236)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033198	response to ATP	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3348	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032959	inositol trisphosphate biosynthetic process	PMID:9013981^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032496	response to lipopolysaccharide	PMID:9013981^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032237	activation of store-operated calcium channel activity	PMID:15611229^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032026	response to magnesium ion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3348	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3348	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	PMID:12928432^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386100	P	occurs_in:(CL:0000236) has_regulation_target:(MGI:MGI:88138)\|occurs_in(CL:0000236) has_regulation_target:(MGI:MGI:102687)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3348	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006661	phosphatidylinositol biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16885	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16885	C		Seeded From UniProt	complete
enables	GO:0004435	phosphatidylinositol phospholipase C activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16885	F		Seeded From UniProt	complete
enables	GO:0004435	phosphatidylinositol phospholipase C activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3348	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002316	follicular B cell differentiation	PMID:12928432^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386100	P	results_in_acquisition_of_features_of:(CL:0000843)	Seeded From UniProt	complete
enables	GO:0001784	phosphotyrosine residue binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16885	F		Seeded From UniProt	complete
involved_in	GO:0051209	release of sequestered calcium ion into cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16885 ensembl:ENSP00000482457	P		Seeded From UniProt	complete
involved_in	GO:0006661	phosphatidylinositol biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16885 ensembl:ENSP00000482457	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16885 ensembl:ENSP00000482457	C		Seeded From UniProt	complete
enables	GO:0004435	phosphatidylinositol phospholipase C activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16885 ensembl:ENSP00000482457	F		Seeded From UniProt	complete
enables	GO:0001784	phosphotyrosine residue binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16885 ensembl:ENSP00000482457	F		Seeded From UniProt	complete
enables	GO:0004435	phosphatidylinositol phospholipase C activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001711 InterPro:IPR016279 InterPro:IPR028381	F		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001711 InterPro:IPR017946	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001711 InterPro:IPR016279 InterPro:IPR028381	P		Seeded From UniProt	complete
enables	GO:0008081	phosphoric diester hydrolase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017946	F		Seeded From UniProt	complete
involved_in	GO:0009395	phospholipid catabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016279	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001192 InterPro:IPR001711	P		Seeded From UniProt	complete
enables	GO:0004435	phosphatidylinositol phospholipase C activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.4.11	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-MMU-9032476 Reactome:R-MMU-9027436 Reactome:R-MMU-9027429 Reactome:R-MMU-5607754	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004629	phospholipase C activity	PMID:11744703^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P		Seeded From UniProt	complete
involved_in	GO:0016042	lipid catabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0442	P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Zanoni, I et al. (2011) CD14 controls the LPS-induced endocytosis of Toll-like receptor 4. Cell 147 868-80 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Hashimoto, A et al. (2000) Cutting edge: essential role of phospholipase C-gamma 2 in B cell development and function. J. Immunol. 165 1738-42 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Beckman, BS et al. (1996) Molecular species of phospholipids in a murine stem-cell line responsive to erythropoietin. Biochem. J. 314 ( Pt 3) 861-7 PubMed GONUTS page
↑ Mandal, M et al. (2005) The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. J. Exp. Med. 201 603-14 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Wen, R et al. (2003) Phospholipase Cgamma2 provides survival signals via Bcl2 and A1 in different subpopulations of B cells. J. Biol. Chem. 278 43654-62 PubMed GONUTS page
↑ ^7.0 ^7.1 Shinji, H et al. (1997) Lipopolysaccharide-induced biphasic inositol 1,4,5-trisphosphate response and tyrosine phosphorylation of 140-kilodalton protein in mouse peritoneal macrophages. J. Immunol. 158 1370-6 PubMed GONUTS page
↑ Liu, QH et al. (2005) Distinct calcium channels regulate responses of primary B lymphocytes to B cell receptor engagement and mechanical stimuli. J. Immunol. 174 68-79 PubMed GONUTS page
↑ Liao, HJ et al. (2002) Absence of erythrogenesis and vasculogenesis in Plcg1-deficient mice. J. Biol. Chem. 277 9335-41 PubMed GONUTS page

[PMID:22078883-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Zanoni, I et al. (2011) CD14 controls the LPS-induced endocytosis of Toll-like receptor 4. Cell 147 868-80 PubMed GONUTS page

[PMID:10925250-2] 2.0 ^2.1 ^2.2 ^2.3 Hashimoto, A et al. (2000) Cutting edge: essential role of phospholipase C-gamma 2 in B cell development and function. J. Immunol. 165 1738-42 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:8615781-4] Beckman, BS et al. (1996) Molecular species of phospholipids in a murine stem-cell line responsive to erythropoietin. Biochem. J. 314 ( Pt 3) 861-7 PubMed GONUTS page

[PMID:15728238-5] Mandal, M et al. (2005) The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. J. Exp. Med. 201 603-14 PubMed GONUTS page

[PMID:12928432-6] 6.0 ^6.1 ^6.2 Wen, R et al. (2003) Phospholipase Cgamma2 provides survival signals via Bcl2 and A1 in different subpopulations of B cells. J. Biol. Chem. 278 43654-62 PubMed GONUTS page

[PMID:9013981-7] 7.0 ^7.1 Shinji, H et al. (1997) Lipopolysaccharide-induced biphasic inositol 1,4,5-trisphosphate response and tyrosine phosphorylation of 140-kilodalton protein in mouse peritoneal macrophages. J. Immunol. 158 1370-6 PubMed GONUTS page

[PMID:15611229-8] Liu, QH et al. (2005) Distinct calcium channels regulate responses of primary B lymphocytes to B cell receptor engagement and mechanical stimuli. J. Immunol. 174 68-79 PubMed GONUTS page

[PMID:11744703-9] Liao, HJ et al. (2002) Absence of erythrogenesis and vasculogenesis in Plcg1-deficient mice. J. Biol. Chem. 277 9335-41 PubMed GONUTS page

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MOUSE:PLCG2

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